ZA200308332B - Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation. - Google Patents
Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation. Download PDFInfo
- Publication number
- ZA200308332B ZA200308332B ZA200308332A ZA200308332A ZA200308332B ZA 200308332 B ZA200308332 B ZA 200308332B ZA 200308332 A ZA200308332 A ZA 200308332A ZA 200308332 A ZA200308332 A ZA 200308332A ZA 200308332 B ZA200308332 B ZA 200308332B
- Authority
- ZA
- South Africa
- Prior art keywords
- calcium phosphate
- precursors
- film
- phosphate phase
- cpc
- Prior art date
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims description 113
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims description 112
- 239000003814 drug Substances 0.000 title claims description 93
- 229940079593 drug Drugs 0.000 title claims description 92
- 238000000576 coating method Methods 0.000 title claims description 81
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- 238000011065 in-situ storage Methods 0.000 title description 14
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 75
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 12
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- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229910052586 apatite Inorganic materials 0.000 description 30
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 30
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- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 8
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 6
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- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
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- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
- C04B41/50—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials
- C04B41/5076—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials with masses bonded by inorganic cements
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- C—CHEMISTRY; METALLURGY
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- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
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- C04B41/60—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone of only artificial stone
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- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C30/00—Coating with metallic material characterised only by the composition of the metallic material, i.e. not characterised by the coating process
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- C—CHEMISTRY; METALLURGY
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- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
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- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
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| US09/838,331 US6730324B2 (en) | 2001-04-20 | 2001-04-20 | Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation |
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| EP (1) | EP1383481B1 (fr) |
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| AT (1) | ATE278393T1 (fr) |
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| IL (1) | IL158474A0 (fr) |
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| ZA (1) | ZA200308332B (fr) |
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| US5055307A (en) | 1988-12-29 | 1991-10-08 | Asahi Kagaku Kogyo Kabushiki Kaisha | Slow release drug delivery granules and process for production thereof |
| JP2756703B2 (ja) * | 1989-06-15 | 1998-05-25 | 日本化学工業株式会社 | 球状アパタイトおよびその製造法並びに多孔質構造成形体 |
| US5525148A (en) | 1993-09-24 | 1996-06-11 | American Dental Association Health Foundation | Self-setting calcium phosphate cements and methods for preparing and using them |
| US5496399A (en) * | 1994-08-23 | 1996-03-05 | Norian Corporation | Storage stable calcium phosphate cements |
| US5783217A (en) * | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
| DE69738398T2 (de) | 1996-10-16 | 2008-12-04 | Etex Corp., Cambridge | Biokeramische zusammensetzung |
| DK0936929T3 (da) | 1996-10-16 | 2004-11-08 | Etex Corp | Fremgangsmåde til fremstilling af svag krystallinsk calciumphosphat samt fremgangsmåder til dens anvendelse |
| DE69840069D1 (de) * | 1997-04-01 | 2008-11-13 | Cap Biotechnology Inc | Kalziumphosphat-mikroträger und -mikrokugeln |
| EP0899247B1 (fr) | 1997-08-28 | 2002-11-06 | Ngk Spark Plug Co., Ltd | Ciment de phosphate de calcium et composition de ciment de phosphate de calcium |
| US5958430A (en) | 1998-02-20 | 1999-09-28 | Battelle Memorial Institute | Thin film composition with biological substance and method of making |
| DE69810165T2 (de) | 1998-10-19 | 2003-07-17 | Synthes Ag | Aushärtbarer keramischer hydraulischer zement |
-
2001
- 2001-04-20 US US09/838,331 patent/US6730324B2/en not_active Expired - Fee Related
-
2002
- 2002-04-19 DE DE60201528T patent/DE60201528T2/de not_active Expired - Fee Related
- 2002-04-19 AT AT02721913T patent/ATE278393T1/de not_active IP Right Cessation
- 2002-04-19 WO PCT/CA2002/000565 patent/WO2002085330A1/fr active IP Right Grant
- 2002-04-19 BR BR0209040-6A patent/BR0209040A/pt not_active IP Right Cessation
- 2002-04-19 JP JP2002582904A patent/JP4309660B2/ja not_active Expired - Fee Related
- 2002-04-19 IL IL15847402A patent/IL158474A0/xx unknown
- 2002-04-19 EP EP02721913A patent/EP1383481B1/fr not_active Expired - Lifetime
- 2002-04-19 CA CA002444561A patent/CA2444561C/fr not_active Expired - Fee Related
- 2002-04-19 CN CNB028112857A patent/CN1276748C/zh not_active Expired - Fee Related
-
2003
- 2003-10-27 ZA ZA200308332A patent/ZA200308332B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4309660B2 (ja) | 2009-08-05 |
| CN1276748C (zh) | 2006-09-27 |
| EP1383481A1 (fr) | 2004-01-28 |
| DE60201528T2 (de) | 2006-02-02 |
| DE60201528D1 (de) | 2004-11-11 |
| BR0209040A (pt) | 2004-08-10 |
| EP1383481B1 (fr) | 2004-10-06 |
| WO2002085330A1 (fr) | 2002-10-31 |
| JP2004530675A (ja) | 2004-10-07 |
| US20020155144A1 (en) | 2002-10-24 |
| US6730324B2 (en) | 2004-05-04 |
| CN1512876A (zh) | 2004-07-14 |
| CA2444561C (fr) | 2008-03-11 |
| IL158474A0 (en) | 2004-05-12 |
| ATE278393T1 (de) | 2004-10-15 |
| CA2444561A1 (fr) | 2002-10-31 |
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