IL158474A0 - Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation - Google Patents

Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation

Info

Publication number
IL158474A0
IL158474A0 IL15847402A IL15847402A IL158474A0 IL 158474 A0 IL158474 A0 IL 158474A0 IL 15847402 A IL15847402 A IL 15847402A IL 15847402 A IL15847402 A IL 15847402A IL 158474 A0 IL158474 A0 IL 158474A0
Authority
IL
Israel
Prior art keywords
microspheres
coatings
biofunctional
delivery
drug encapsulation
Prior art date
Application number
IL15847402A
Other languages
English (en)
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Publication of IL158474A0 publication Critical patent/IL158474A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B40/00—Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/009—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone characterised by the material treated
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
    • C04B41/50—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials
    • C04B41/5076—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials with masses bonded by inorganic cements
    • C04B41/5092—Phosphate cements
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/60—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone of only artificial stone
    • C04B41/61—Coating or impregnation
    • C04B41/65—Coating or impregnation with inorganic materials
    • C04B41/67—Phosphates
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C30/00—Coating with metallic material characterised only by the composition of the metallic material, i.e. not characterised by the coating process
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
IL15847402A 2001-04-20 2002-04-19 Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation IL158474A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/838,331 US6730324B2 (en) 2001-04-20 2001-04-20 Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation
PCT/CA2002/000565 WO2002085330A1 (en) 2001-04-20 2002-04-19 Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation

Publications (1)

Publication Number Publication Date
IL158474A0 true IL158474A0 (en) 2004-05-12

Family

ID=25276830

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15847402A IL158474A0 (en) 2001-04-20 2002-04-19 Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation

Country Status (11)

Country Link
US (1) US6730324B2 (xx)
EP (1) EP1383481B1 (xx)
JP (1) JP4309660B2 (xx)
CN (1) CN1276748C (xx)
AT (1) ATE278393T1 (xx)
BR (1) BR0209040A (xx)
CA (1) CA2444561C (xx)
DE (1) DE60201528T2 (xx)
IL (1) IL158474A0 (xx)
WO (1) WO2002085330A1 (xx)
ZA (1) ZA200308332B (xx)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7563874B2 (en) * 1998-08-31 2009-07-21 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US7163541B2 (en) * 2002-12-03 2007-01-16 Arthrosurface Incorporated Tibial resurfacing system
US6610067B2 (en) 2000-05-01 2003-08-26 Arthrosurface, Incorporated System and method for joint resurface repair
US6520964B2 (en) 2000-05-01 2003-02-18 Std Manufacturing, Inc. System and method for joint resurface repair
US8177841B2 (en) 2000-05-01 2012-05-15 Arthrosurface Inc. System and method for joint resurface repair
US7678151B2 (en) * 2000-05-01 2010-03-16 Ek Steven W System and method for joint resurface repair
US7013182B1 (en) * 2000-05-04 2006-03-14 Cardiac Pacemakers, Inc. Conductive polymer sheath on defibrillator shocking coils
US20030134811A1 (en) * 2001-10-09 2003-07-17 John Jackson Methods and compositions comprising hydroxyapatite useful for the administration of therapeutic agents
WO2010096826A1 (en) * 2002-06-04 2010-08-26 Arthrosurface Incorporated Nanorough alloy substrate
CA2498743A1 (en) * 2002-09-13 2004-03-25 The University Of British Columbia Calcium phosphate coated implantable medical devices and processes for making same
SE0203224D0 (sv) * 2002-10-31 2002-10-31 Cerbio Tech Ab Method of making structured ceramic coatings and coated devices prepared with the method
SE525236C2 (sv) * 2002-10-31 2005-01-11 Cerbio Tech Ab Förfarande för framställning av strukturerade keramiska beläggningar och belagda anordningar framställda med detta förfarande
US7901408B2 (en) 2002-12-03 2011-03-08 Arthrosurface, Inc. System and method for retrograde procedure
FR2849436B1 (fr) * 2002-12-27 2007-01-05 Patrick Frayssinet Particules et ceramiques de phosphates de calcium pour transfection in vivo et in vitro
US8388624B2 (en) 2003-02-24 2013-03-05 Arthrosurface Incorporated Trochlear resurfacing system and method
US20040180091A1 (en) * 2003-03-13 2004-09-16 Chang-Yi Lin Carbonated hydroxyapatite-based microspherical composites for biomedical uses
AU2007229327B2 (en) * 2003-03-13 2010-02-11 Nanotrend Ino-Tech Inc. Stable and taste masked pharmaceutical dosage form using porous apatite grains
JP4215595B2 (ja) * 2003-08-21 2009-01-28 安正 赤川 インプラント固定部材およびインプラント複合材
EP1845890A4 (en) 2003-11-20 2010-06-09 Arthrosurface Inc SYSTEM AND METHOD FOR RETURNING PROCESS
WO2005051231A2 (en) 2003-11-20 2005-06-09 Arthrosurface, Inc. Retrograde delivery of resurfacing devices
SE527610C2 (sv) * 2004-06-15 2006-04-25 Promimic Ab Förfarande för framställning av syntetiskt, kristallint kalciumfosfat i nanostorlek
AU2005260590A1 (en) 2004-06-28 2006-01-12 Arthrosurface, Inc. System for articular surface replacement
JP2006034200A (ja) * 2004-07-28 2006-02-09 Pentax Corp 細胞培養担体、細胞培養担体の製造方法および細胞培養方法
US8119153B2 (en) * 2004-08-26 2012-02-21 Boston Scientific Scimed, Inc. Stents with drug eluting coatings
US8313524B2 (en) 2004-08-31 2012-11-20 C. R. Bard, Inc. Self-sealing PTFE graft with kink resistance
US20060045822A1 (en) * 2004-09-01 2006-03-02 Board Of Regents, The University Of Texas System Plasma polymerization for encapsulating particles
US7828853B2 (en) 2004-11-22 2010-11-09 Arthrosurface, Inc. Articular surface implant and delivery system
US20060199876A1 (en) * 2005-03-04 2006-09-07 The University Of British Columbia Bioceramic composite coatings and process for making same
US8535722B2 (en) * 2005-03-16 2013-09-17 North Carolina State University Functionally graded biocompatible coating and coated implant
US8491936B2 (en) * 2005-03-16 2013-07-23 North Carolina State University Functionally graded biocompatible coating and coated implant
WO2006099748A1 (en) 2005-03-25 2006-09-28 Innovative Bioceramix, Inc. Hydraulic cement compositions and methods of making and using the same
US20060216327A1 (en) * 2005-03-28 2006-09-28 Bacterin, Inc. Multilayer coating for releasing biologically-active agents and method of making
US20060257358A1 (en) * 2005-05-13 2006-11-16 Depuy Products, Inc. Suspension of calcium phosphate particulates for local delivery of therapeutic agents
US20060257492A1 (en) * 2005-05-13 2006-11-16 Depuy Products, Inc. Suspension of calcium phosphate particulates for local delivery of therapeutic agents
WO2006133373A2 (en) * 2005-06-08 2006-12-14 C.R. Bard Inc. Grafts and stents having inorganic bio-compatible calcium salt
JP2009501027A (ja) 2005-06-17 2009-01-15 シー・アール・バード・インコーポレイテツド 締付後のよじれ耐性を有する血管移植片
ES2574780T3 (es) * 2005-09-06 2016-06-22 C.R. Bard, Inc. Injerto de liberación de fármacos
US20070051531A1 (en) * 2005-09-08 2007-03-08 Harshad Borgaonkar Drug eluting coatings for a medical lead and method therefor
CA2626598A1 (en) 2005-11-09 2007-05-18 C.R. Bard Inc. Grafts and stent grafts having a radiopaque marker
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
WO2007095376A2 (en) * 2006-02-15 2007-08-23 Kennametal Inc. Method and apparatus for coating particulates utilizing physical vapor deposition
KR101378174B1 (ko) * 2006-03-14 2014-03-27 리드스 에이비 생재흡수성의 방출 제어형 조성물
US7881808B2 (en) * 2006-03-29 2011-02-01 Cardiac Pacemakers, Inc. Conductive polymeric coating with optional biobeneficial topcoat for a medical lead
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices
US7959940B2 (en) 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
WO2008063780A2 (en) 2006-10-12 2008-05-29 C.R. Bard Inc. Vascular grafts with multiple channels and methods for making
US10772987B2 (en) 2006-10-30 2020-09-15 Trs Holdings Llc Mineral coated scaffolds
US20080119927A1 (en) * 2006-11-17 2008-05-22 Medtronic Vascular, Inc. Stent Coating Including Therapeutic Biodegradable Glass, and Method of Making
AU2007332787A1 (en) 2006-12-11 2008-06-19 Arthrosurface Incorporated Retrograde resection apparatus and method
EP2106217B1 (en) * 2006-12-12 2019-03-13 Firmenich S.A. Active ingredient delivery system with an amorphous metal salt as carrier
US8598321B2 (en) 2007-03-22 2013-12-03 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US20080241256A1 (en) * 2007-03-30 2008-10-02 Liisa Kuhn Targeted active agent delivery system based on calcium phosphate nanoparticles
US8753831B2 (en) 2007-06-05 2014-06-17 City Of Hope Methods for detection of botulinum neurotoxin
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
KR101165455B1 (ko) * 2007-09-10 2012-07-12 한스바이오메드 주식회사 인산칼슘 마이크로스피어 약물전달체 및 이의 제조방법
US20090076116A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched carvediolo
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
EP2262448A4 (en) 2008-03-03 2014-03-26 Arthrosurface Inc BONE RESURFACING SYSTEM AND METHOD
US8088451B2 (en) 2008-03-13 2012-01-03 Board Of Regents, The University Of Texas System Covalently functionalized particles for synthesis of new composite materials
WO2009132411A1 (en) * 2008-04-28 2009-11-05 The University Of British Columbia Polymer-free drug delivery system for implantable medical devices
WO2010009390A2 (en) * 2008-07-18 2010-01-21 North Carolina State University Processing of biocompatible coating on polymeric implants
WO2010014854A2 (en) 2008-07-31 2010-02-04 The Regents Of The University Of California Antibodies that neutralize botulinum neurotoxins
EP2349212B1 (en) * 2008-09-25 2022-01-19 TRS Holdings LLC Mineral-coated microspheres
JP5638003B2 (ja) 2009-01-12 2014-12-10 ユニバーシティ オブ マサチューセッツ ローウェル ポリイソブチレン系ポリウレタン
US9408393B2 (en) 2010-02-03 2016-08-09 Microbion Corporation Bismuth-thiols as antiseptics for agricultural, industrial and other uses
JP5674684B2 (ja) * 2009-02-03 2015-02-25 マイクロビオン コーポレーション 上皮組織、急性および慢性創傷、細菌性バイオフィルムならびに他の適応症のための消毒剤としてのビスマス−チオール
US9028878B2 (en) 2009-02-03 2015-05-12 Microbion Corporation Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
BRPI1014961A2 (pt) 2009-04-17 2016-04-26 Arthrosurface Inc "sistema e método para reparar um defeito em uma parte de uma superfície articular de um glenoídeo de paciente"
US10945743B2 (en) 2009-04-17 2021-03-16 Arthrosurface Incorporated Glenoid repair system and methods of use thereof
US9662126B2 (en) 2009-04-17 2017-05-30 Arthrosurface Incorporated Glenoid resurfacing system and method
EP2467174B1 (en) 2009-08-21 2018-09-26 Cardiac Pacemakers, Inc. Crosslinkable polyisobutylene-based polymers and medical devices containing the same
US8374704B2 (en) 2009-09-02 2013-02-12 Cardiac Pacemakers, Inc. Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same
US8644952B2 (en) 2009-09-02 2014-02-04 Cardiac Pacemakers, Inc. Medical devices including polyisobutylene based polymers and derivatives thereof
US8753708B2 (en) * 2009-09-02 2014-06-17 Cardiac Pacemakers, Inc. Solventless method for forming a coating on a medical electrical lead body
AU2011222404A1 (en) 2010-03-05 2012-09-27 Arthrosurface Incorporated Tibial resurfacing system and method
RU2456253C2 (ru) * 2010-06-24 2012-07-20 Государственное учебно-научное учреждение Факультет Наук о Материалах Московского Государственного Университета им. М.В. Ломоносова Способ подготовки шихты для получения керамического биодеградируемого материала
WO2012047427A2 (en) 2010-08-31 2012-04-12 The Regents Of The University Of California Antibodies for botulinum neurotoxins
EP2460585B1 (en) 2010-12-03 2017-10-18 Holcim Technology Ltd. Microcapsule
US9066716B2 (en) 2011-03-30 2015-06-30 Arthrosurface Incorporated Suture coil and suture sheath for tissue repair
US20130165982A1 (en) 2011-12-22 2013-06-27 Arthrosurface Incorporated System and Method for Bone Fixation
DE112013003358T5 (de) 2012-07-03 2015-03-19 Arthrosurface, Inc. System und Verfahren für Gelenkoberflächenersatz und -reparatur
EP2922888B1 (en) 2012-11-21 2021-08-18 The University of Massachusetts High strength polyisobutylene polyurethanes
US9492200B2 (en) 2013-04-16 2016-11-15 Arthrosurface Incorporated Suture system and method
US10624748B2 (en) 2014-03-07 2020-04-21 Arthrosurface Incorporated System and method for repairing articular surfaces
US11607319B2 (en) 2014-03-07 2023-03-21 Arthrosurface Incorporated System and method for repairing articular surfaces
US9962265B2 (en) 2014-03-07 2018-05-08 Arthrosurface Incorporated System and method for repairing articular surfaces
AU2016226095B2 (en) 2015-03-03 2020-07-09 Trs Holdings Llc Coating scaffolds
EP3592786B1 (en) 2017-03-07 2023-05-10 Cardiac Pacemakers, Inc. Hydroboration/oxidation of allyl-terminated polyisobutylene
CA3108761A1 (en) 2017-08-04 2019-02-07 Arthrosurface Incorporated Multicomponent articular surface implant
EP3668912B1 (en) 2017-08-17 2021-06-30 Cardiac Pacemakers, Inc. Photocrosslinked polymers for enhanced durability
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
EP3740253B1 (en) 2018-01-17 2023-08-16 Cardiac Pacemakers, Inc. End-capped polyisobutylene polyurethane
US11260144B2 (en) * 2018-05-21 2022-03-01 Ossdsign Ab Two-paste cement-forming compositions
WO2020028558A1 (en) 2018-07-31 2020-02-06 Microbion Corporation Bismuth-thiol compositions and methods of use
WO2020028561A1 (en) 2018-07-31 2020-02-06 Microbion Corporation Bismuth-thiol compositions and methods for treating wounds
GB2609338B (en) 2019-03-12 2023-06-14 Arthrosurface Inc Humeral and glenoid articular surface implant systems and methods
CN112843090A (zh) * 2019-11-28 2021-05-28 华东理工大学 逆转肿瘤耐药性的羟基磷灰石纳米粒子制备方法和应用
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
PL438209A1 (pl) 2021-06-20 2022-12-27 Instytut Wysokich Ciśnień Polskiej Akademii Nauk Hydroksyapatytowa warstwa biobójczo-osteoindukcyjna i sposób wytwarzania takiej warstwy
CN114057173B (zh) * 2021-09-13 2023-12-15 曲阜师范大学 一种利用晶种合成大比表面积羟基磷灰石的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055307A (en) 1988-12-29 1991-10-08 Asahi Kagaku Kogyo Kabushiki Kaisha Slow release drug delivery granules and process for production thereof
JP2756703B2 (ja) * 1989-06-15 1998-05-25 日本化学工業株式会社 球状アパタイトおよびその製造法並びに多孔質構造成形体
US5525148A (en) 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5496399A (en) * 1994-08-23 1996-03-05 Norian Corporation Storage stable calcium phosphate cements
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
DE69738398T2 (de) 1996-10-16 2008-12-04 Etex Corp., Cambridge Biokeramische zusammensetzung
DK0936929T3 (da) 1996-10-16 2004-11-08 Etex Corp Fremgangsmåde til fremstilling af svag krystallinsk calciumphosphat samt fremgangsmåder til dens anvendelse
DE69840069D1 (de) * 1997-04-01 2008-11-13 Cap Biotechnology Inc Kalziumphosphat-mikroträger und -mikrokugeln
EP0899247B1 (en) 1997-08-28 2002-11-06 Ngk Spark Plug Co., Ltd Calcium phosphate cement and calcium phosphate cement composition
US5958430A (en) 1998-02-20 1999-09-28 Battelle Memorial Institute Thin film composition with biological substance and method of making
DE69810165T2 (de) 1998-10-19 2003-07-17 Synthes Ag Aushärtbarer keramischer hydraulischer zement

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CN1276748C (zh) 2006-09-27
EP1383481A1 (en) 2004-01-28
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DE60201528D1 (de) 2004-11-11
BR0209040A (pt) 2004-08-10
EP1383481B1 (en) 2004-10-06
WO2002085330A1 (en) 2002-10-31
JP2004530675A (ja) 2004-10-07
US20020155144A1 (en) 2002-10-24
US6730324B2 (en) 2004-05-04
CN1512876A (zh) 2004-07-14
CA2444561C (en) 2008-03-11
ATE278393T1 (de) 2004-10-15
CA2444561A1 (en) 2002-10-31
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