WO1998049300A3 - Truncated vegf-related proteins - Google Patents
Truncated vegf-related proteins Download PDFInfo
- Publication number
- WO1998049300A3 WO1998049300A3 PCT/US1998/007801 US9807801W WO9849300A3 WO 1998049300 A3 WO1998049300 A3 WO 1998049300A3 US 9807801 W US9807801 W US 9807801W WO 9849300 A3 WO9849300 A3 WO 9849300A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vrps
- truncated
- related proteins
- useful
- nucleic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98919794A EP0977854A2 (en) | 1997-04-25 | 1998-04-20 | Truncated vegf-related proteins |
JP54706298A JP2001524828A (en) | 1997-04-25 | 1998-04-20 | Truncated VEGF-related protein |
NZ500530A NZ500530A (en) | 1997-04-25 | 1998-04-20 | Truncated VEGF-B, VEGF-C, VEGF-3, PlGF, VRF-2, poxvirus ORF-1 and ORF-2 proteins |
AU72502/98A AU7250298A (en) | 1997-04-25 | 1998-04-20 | Truncated vegf-related proteins |
EA199900861A EA199900861A1 (en) | 1997-04-25 | 1998-04-20 | TRACKED PROTEINS, RELATED GROWTH ENDOTHELIUM GROWTH FACTOR |
IL13253798A IL132537A0 (en) | 1997-04-25 | 1998-04-20 | Truncated vegf-related proteins |
CA002287538A CA2287538A1 (en) | 1997-04-25 | 1998-04-20 | Truncated vegf-related proteins |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84298497A | 1997-04-25 | 1997-04-25 | |
US08/842,984 | 1997-04-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998049300A2 WO1998049300A2 (en) | 1998-11-05 |
WO1998049300A3 true WO1998049300A3 (en) | 1999-03-11 |
Family
ID=25288752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/007801 WO1998049300A2 (en) | 1997-04-25 | 1998-04-20 | Truncated vegf-related proteins |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0977854A2 (en) |
JP (1) | JP2001524828A (en) |
KR (1) | KR20010020259A (en) |
CN (2) | CN1680442A (en) |
AU (1) | AU7250298A (en) |
CA (1) | CA2287538A1 (en) |
EA (1) | EA199900861A1 (en) |
IL (1) | IL132537A0 (en) |
NZ (2) | NZ514872A (en) |
WO (1) | WO1998049300A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9228205B2 (en) | 2000-11-15 | 2016-01-05 | Crucell Holland B.V. | Complementing cell lines |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
ES2249762T3 (en) | 1994-03-08 | 2006-04-01 | Human Genome Sciences, Inc. | GROWTH FACTOR OF THE VASCULAR ENDOTELIUM 2. |
US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US7727761B2 (en) | 1995-08-01 | 2010-06-01 | Vegenics Limited | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
DK0848755T4 (en) | 1995-09-08 | 2011-05-23 | Genentech Inc | VEGF related protein |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
AU3072099A (en) * | 1998-03-13 | 1999-09-27 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
DE19813774A1 (en) * | 1998-03-27 | 1999-09-30 | Max Planck Gesellschaft | Parapox virus-encoded vascular endothelial cell growth factor (PPV-VEGF) |
EP1121143A2 (en) * | 1998-03-27 | 2001-08-08 | Dorothea J. Eicher | Vegf and vegf-c as infant formula supplements |
AU760008B2 (en) | 1998-09-08 | 2003-05-08 | Agouron Pharmaceuticals, Inc. | Modifications of the VEGF receptor-2 protein and methods of use |
US6958147B1 (en) | 1998-10-26 | 2005-10-25 | Licentia Ltd | Use of VEGF-C to prevent restenosis |
PT1126870E (en) * | 1998-10-26 | 2005-01-31 | Licentia Ltd | USE OF VEGF-C OR VEGF-D GENE OR A PROTEIN IN THE PREVENTION OF RESTENOSIS |
EP1568375A1 (en) * | 1998-10-26 | 2005-08-31 | Ludwig Institute For Cancer Research | Use of VEGF-C or VEGF-D gene or protein to prevent restenosis |
ATE406907T1 (en) | 1998-10-28 | 2008-09-15 | Cornell Res Foundation Inc | METHODS FOR REGULATION OF ANGIOGENESIS AND VASCULAR INTEGRITY USING TRK RECEPTOR LIGANDS BDNF, NT-3 AND NT-4 |
US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
US7727971B2 (en) | 2000-02-04 | 2010-06-01 | Life Sciences Research Partners Vzw | Use of placental growth factor for treating ischemic muscle disease |
AU4643501A (en) * | 2000-02-04 | 2001-08-14 | Flanders Interuniversity Institute For Biotechnology (Vib) | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic diseases or stroke |
AU2001255237B2 (en) * | 2000-04-06 | 2005-12-15 | Wayne P. Franco | Methods of using growth factors for treating heart disease |
EP1157999A1 (en) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Methods and means for enhancing skin transplantation using gene delivery vehicles having tropism for primary fibroblasts, as well as other uses thereof |
NZ518077A (en) | 2000-08-04 | 2003-11-28 | Human Genome Sciences Inc | Biologically active fragments, analogues and derivatives of VEGF-2 for the treatment of peripheral artery diseases such as critical limb ischemia and coronary disease |
US7405278B2 (en) | 2000-08-10 | 2008-07-29 | Masabumi Shibuya | Chimeric human-type vascular endothelial cell growth factor |
EP1191104A1 (en) * | 2000-09-26 | 2002-03-27 | Introgene B.V. | Gene delivery vehicles and use thereof in the preparation of a medicament and/or vaccine |
EP1341914A2 (en) | 2000-12-07 | 2003-09-10 | Sangamo Biosciences Inc. | Regulation of angiogenesis with zinc finger proteins |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
ATE470676T1 (en) | 2001-04-13 | 2010-06-15 | Human Genome Sciences Inc | ANTI-VEGF-2 ANTIBODIES |
US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
CA2451311A1 (en) | 2001-06-20 | 2003-01-03 | Ludwig Institute For Cancer Research | Stimulation of vascularization with vegf-b |
ATE345799T1 (en) | 2001-10-15 | 2006-12-15 | Janssen Pharmaceutica Nv | SUBSTITUTED 4-PHENYL-4-(1H-IMIDAZOLE-2-YL)-PIPERIDINE DERIVATIVES FOR REDUCING ISCHEMIC INJURY |
EP1827494A4 (en) * | 2004-11-18 | 2010-02-17 | Wayne Franco | Combination growth therapy and cell therapy for treatment of acute and chronic diseases of the organs |
WO2010078624A1 (en) * | 2009-01-07 | 2010-07-15 | Vegenics Limited | Materials and methods for the treatment of hypertension |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006194A1 (en) * | 1990-09-27 | 1992-04-16 | Consiglio Nazionale Delle Ricerche | Nucleotide sequences coding for a human protein with angiogenesis regulative properties |
WO1994011506A1 (en) * | 1992-11-18 | 1994-05-26 | Arch Development Corporation | Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle |
WO1996027007A1 (en) * | 1995-03-02 | 1996-09-06 | Amrad Operations Pty. Ltd. | A novel growth factor and a genetic sequence encoding same |
WO1996026736A1 (en) * | 1995-03-01 | 1996-09-06 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b |
WO1996026742A1 (en) * | 1995-02-28 | 1996-09-06 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
WO1996039421A1 (en) * | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 3 |
WO1997005250A2 (en) * | 1995-08-01 | 1997-02-13 | Helsinki University Licensing Ltd. Oy | Receptor ligand vegf-c |
-
1998
- 1998-04-20 NZ NZ514872A patent/NZ514872A/en unknown
- 1998-04-20 CN CNA200510009104XA patent/CN1680442A/en active Pending
- 1998-04-20 AU AU72502/98A patent/AU7250298A/en not_active Abandoned
- 1998-04-20 KR KR1019997009857A patent/KR20010020259A/en not_active Application Discontinuation
- 1998-04-20 WO PCT/US1998/007801 patent/WO1998049300A2/en not_active Application Discontinuation
- 1998-04-20 IL IL13253798A patent/IL132537A0/en unknown
- 1998-04-20 CN CN98806232A patent/CN1260835A/en active Pending
- 1998-04-20 CA CA002287538A patent/CA2287538A1/en not_active Abandoned
- 1998-04-20 JP JP54706298A patent/JP2001524828A/en not_active Ceased
- 1998-04-20 NZ NZ500530A patent/NZ500530A/en unknown
- 1998-04-20 EP EP98919794A patent/EP0977854A2/en not_active Withdrawn
- 1998-04-20 EA EA199900861A patent/EA199900861A1/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006194A1 (en) * | 1990-09-27 | 1992-04-16 | Consiglio Nazionale Delle Ricerche | Nucleotide sequences coding for a human protein with angiogenesis regulative properties |
WO1994011506A1 (en) * | 1992-11-18 | 1994-05-26 | Arch Development Corporation | Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle |
WO1996026742A1 (en) * | 1995-02-28 | 1996-09-06 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
WO1996026736A1 (en) * | 1995-03-01 | 1996-09-06 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b |
WO1996027007A1 (en) * | 1995-03-02 | 1996-09-06 | Amrad Operations Pty. Ltd. | A novel growth factor and a genetic sequence encoding same |
WO1996039421A1 (en) * | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 3 |
WO1997005250A2 (en) * | 1995-08-01 | 1997-02-13 | Helsinki University Licensing Ltd. Oy | Receptor ligand vegf-c |
Non-Patent Citations (1)
Title |
---|
PEPPER M.S. ET AL.: "Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 189, no. 2, 15 December 1992 (1992-12-15), pages 824 - 831, XP002078851 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9228205B2 (en) | 2000-11-15 | 2016-01-05 | Crucell Holland B.V. | Complementing cell lines |
Also Published As
Publication number | Publication date |
---|---|
EA199900861A1 (en) | 2000-06-26 |
NZ500530A (en) | 2001-12-21 |
WO1998049300A2 (en) | 1998-11-05 |
CN1680442A (en) | 2005-10-12 |
CA2287538A1 (en) | 1998-11-05 |
KR20010020259A (en) | 2001-03-15 |
JP2001524828A (en) | 2001-12-04 |
EP0977854A2 (en) | 2000-02-09 |
CN1260835A (en) | 2000-07-19 |
AU7250298A (en) | 1998-11-24 |
NZ514872A (en) | 2005-01-28 |
IL132537A0 (en) | 2001-03-19 |
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