PL438209A1 - Hydroksyapatytowa warstwa biobójczo-osteoindukcyjna i sposób wytwarzania takiej warstwy - Google Patents

Hydroksyapatytowa warstwa biobójczo-osteoindukcyjna i sposób wytwarzania takiej warstwy

Info

Publication number
PL438209A1
PL438209A1 PL438209A PL43820921A PL438209A1 PL 438209 A1 PL438209 A1 PL 438209A1 PL 438209 A PL438209 A PL 438209A PL 43820921 A PL43820921 A PL 43820921A PL 438209 A1 PL438209 A1 PL 438209A1
Authority
PL
Poland
Prior art keywords
layer
hydroxyapatite
biocidal
osteoinductive
less
Prior art date
Application number
PL438209A
Other languages
English (en)
Inventor
Witold ŁOJKOWSKI
Elżbieta PIETRZYKOWSKA
Khaled ABOU AITAH
Damian FUDALA
Urszula Szałaj
Anna ŚWIDERSKA-ŚRODA
Monika BIL
Maciej Łojkowski
Wojciech ŚWIĘSZKOWSKI
Justyna Nasiłowska
Barbara Sokołowska
Bartosz WOŹNIAK
Original Assignee
Instytut Wysokich Ciśnień Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Wysokich Ciśnień Polskiej Akademii Nauk filed Critical Instytut Wysokich Ciśnień Polskiej Akademii Nauk
Priority to PL438209A priority Critical patent/PL438209A1/pl
Priority to EP22461575.7A priority patent/EP4104874A1/en
Publication of PL438209A1 publication Critical patent/PL438209A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Przedmiotem zgłoszenia jest hydroksyapatytowa warstwa biobójczo-osteoindukcyjna naniesiona na podłoże nośne implantu medycznego, składająca się z nanokrystalitów syntetycznego hydroksyapatytu o stosunku molowym wapni do fosforu większym niż 1,55 i mniejszym niż 1,67, charakteryzująca się tym, że jest porowata i powierzchnia właściwa materiału warstwy jest nie mniejsza niż 155 m<sup>2</sup>/g, syntetyczny hydroksyapatyt tworzący warstwę ma postać ziaren o średnim rozmiarze mierzonym przy pomocy transmisyjnej mkoroskopii elektronowej lub przy pomocy rentgenowskiej dyfrakcji proszkowej XRD nie większym niż 25 nm i nie mniejszym niż 7 nm, poddanych działaniu kawitacji ultradźwiękowej i zawierających od 4 do 6% wagowo wody strukturalnej, zaś grubość warstwy wynosi od 350 nm do 1000 nm. Zgłoszenie obejmuje także sposób wytwarzania hydroksyapatytowej warstwy biobójczo-osteoindukcyjnej.
PL438209A 2021-06-20 2021-06-20 Hydroksyapatytowa warstwa biobójczo-osteoindukcyjna i sposób wytwarzania takiej warstwy PL438209A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL438209A PL438209A1 (pl) 2021-06-20 2021-06-20 Hydroksyapatytowa warstwa biobójczo-osteoindukcyjna i sposób wytwarzania takiej warstwy
EP22461575.7A EP4104874A1 (en) 2021-06-20 2022-06-20 Hydroxyapatite antimicrobial and osteoinductive coating and method of producing such a coating

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL438209A PL438209A1 (pl) 2021-06-20 2021-06-20 Hydroksyapatytowa warstwa biobójczo-osteoindukcyjna i sposób wytwarzania takiej warstwy

Publications (1)

Publication Number Publication Date
PL438209A1 true PL438209A1 (pl) 2022-12-27

Family

ID=82319607

Family Applications (1)

Application Number Title Priority Date Filing Date
PL438209A PL438209A1 (pl) 2021-06-20 2021-06-20 Hydroksyapatytowa warstwa biobójczo-osteoindukcyjna i sposób wytwarzania takiej warstwy

Country Status (2)

Country Link
EP (1) EP4104874A1 (pl)
PL (1) PL438209A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4727558A1 (en) * 2023-06-15 2026-04-22 Moroxite I AB Novel method employing antibiotics with accretion to apatite coated implants preventing bacterial attachment and infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143948A (en) 1996-05-10 2000-11-07 Isotis B.V. Device for incorporation and release of biologically active agents
US6730324B2 (en) 2001-04-20 2004-05-04 The University Of British Columbia Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation
US6596338B2 (en) * 2001-10-24 2003-07-22 Howmedica Osteonics Corp. Antibiotic calcium phosphate coating
US20090276053A1 (en) 2008-04-22 2009-11-05 Timothy Brown Coated Implants
EP2467176B1 (en) 2009-08-21 2017-04-05 Ajay P. Malshe Nanostructured hydroxyapatite coating for dental and orthopedic implants
PL226891B1 (pl) 2015-05-05 2017-09-29 Inst Wysokich Ciśnień Polskiej Akademii Nauk Sposób wytwarzania implantu kostnego iimplant kostny
RO132032B1 (ro) 2016-01-26 2019-06-28 Institutul De Chimie Fizică "Ilie Murgulescu" Procedeu de acoperire antibacteriană a unei suprafeţe dintr-un aliaj ternar de titan prin metoda sonochimică
WO2018042430A1 (en) 2016-08-29 2018-03-08 Ramot At Tel-Aviv University Ltd. Coatings of hydroxyapatite nanoparticles
CN107261202A (zh) 2017-06-29 2017-10-20 中国医科大学附属第医院 一种钛金属骨科内植物表面制备抗菌生物复合涂层的方法

Also Published As

Publication number Publication date
EP4104874A1 (en) 2022-12-21

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