ZA200307478B - Sapogenin derivatives, their synthesis and use - Google Patents
Sapogenin derivatives, their synthesis and useInfo
- Publication number
- ZA200307478B ZA200307478B ZA200307478A ZA200307478A ZA200307478B ZA 200307478 B ZA200307478 B ZA 200307478B ZA 200307478 A ZA200307478 A ZA 200307478A ZA 200307478 A ZA200307478 A ZA 200307478A ZA 200307478 B ZA200307478 B ZA 200307478B
- Authority
- ZA
- South Africa
- Prior art keywords
- synthesis
- sapogenin derivatives
- sapogenin
- derivatives
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 title 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0107822.9A GB0107822D0 (en) | 2001-03-28 | 2001-03-28 | Sapogenin derivatives their synthesis and use methods based upon their use |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200307478B true ZA200307478B (en) | 2009-04-29 |
Family
ID=9911795
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200307478A ZA200307478B (en) | 2001-03-28 | 2003-09-25 | Sapogenin derivatives, their synthesis and use |
ZA200407460A ZA200407460B (en) | 2001-03-28 | 2004-09-16 | Therapeutic methods and uses of sapogenins and their derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200407460A ZA200407460B (en) | 2001-03-28 | 2004-09-16 | Therapeutic methods and uses of sapogenins and their derivatives |
Country Status (24)
Country | Link |
---|---|
US (1) | US20040147495A1 (de) |
EP (1) | EP1383787B1 (de) |
JP (1) | JP2004525945A (de) |
KR (1) | KR20040007479A (de) |
CN (1) | CN1678325A (de) |
AR (2) | AR033079A1 (de) |
AT (1) | ATE416185T1 (de) |
AU (1) | AU2002242894B2 (de) |
BR (1) | BR0208533A (de) |
CA (1) | CA2442150A1 (de) |
CZ (1) | CZ20032620A3 (de) |
GB (1) | GB0107822D0 (de) |
HR (1) | HRP20030770A2 (de) |
IL (1) | IL158115A0 (de) |
MX (1) | MXPA03008800A (de) |
NO (1) | NO20034364L (de) |
NZ (1) | NZ529136A (de) |
PE (1) | PE20021042A1 (de) |
PL (1) | PL364825A1 (de) |
RU (1) | RU2311423C2 (de) |
TR (2) | TR200700134T1 (de) |
UA (1) | UA78696C2 (de) |
WO (1) | WO2002079221A2 (de) |
ZA (2) | ZA200307478B (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
CA2477787C (en) * | 2002-03-27 | 2011-12-20 | Phytopharm Plc | Therapeutic methods and uses of sapogenins and their derivatives |
PT1490071E (pt) * | 2002-03-27 | 2009-05-25 | Phytopharm Plc | Métodos terapêuticos e utilizações de sapogeninas e seus derivados |
KR101092150B1 (ko) * | 2002-10-28 | 2011-12-12 | 파이토팜 피엘씨 | 사포겐-3-온의 입체특이적 환원 |
GB0409567D0 (en) | 2004-04-28 | 2004-06-02 | Phytopharm Plc | Chemical compounds |
EP1618881A1 (de) * | 2004-07-20 | 2006-01-25 | Santhera Pharmaceuticals (Schweiz) GmbH | Verwendung von steroiden ohne glucocorticoid aktivität zur behandlung von muskulärer dystrophie |
GB0424528D0 (en) | 2004-11-05 | 2004-12-08 | Phytopharm Plc | Chemical compounds |
AU2010207597A1 (en) | 2009-01-24 | 2011-08-18 | Phytopharm Plc | Treatment of neurotrophic factor mediated disorders |
CN101768202B (zh) * | 2009-02-18 | 2013-10-30 | 沈阳药科大学 | 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 |
US20130210786A1 (en) | 2010-07-20 | 2013-08-15 | Patrick Alexander Howson | Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders |
TWI422378B (zh) * | 2010-11-18 | 2014-01-11 | Univ Chung Shan Medical | 使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷 |
CN107936076B (zh) | 2011-09-08 | 2021-10-15 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
CU20110244A7 (es) * | 2011-12-27 | 2013-08-29 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
JP6255082B2 (ja) | 2013-03-13 | 2017-12-27 | セージ セラピューティクス, インコーポレイテッド | 神経刺激性ステロイドおよびその使用方法 |
KR101480982B1 (ko) * | 2013-03-20 | 2015-02-03 | (주)셀인바이오 | 골형성 유도 화합물 및 이의 응용 |
CN104177469A (zh) * | 2013-05-28 | 2014-12-03 | 江苏柯菲平医药有限公司 | 一种知母中菝葜皂苷元衍生物的制备方法 |
CN104324038B (zh) * | 2013-07-24 | 2018-11-06 | 四川京华创生物科技有限公司 | 一种薯蓣皂苷元-3-位衍生物的用途 |
EP3157528B1 (de) | 2014-06-18 | 2023-09-13 | Sage Therapeutics, Inc. | Oxysterole und verfahren zur verwendung davon |
KR20180026742A (ko) | 2015-07-06 | 2018-03-13 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
JP2018519351A (ja) | 2015-07-06 | 2018-07-19 | セージ セラピューティクス, インコーポレイテッド | オキシステロールおよびそれらの使用の方法 |
AU2016289965B2 (en) | 2015-07-06 | 2021-09-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
BR112018070123A2 (pt) | 2016-04-01 | 2019-02-05 | Sage Therapeutics Inc | oxiesterós e métodos de uso dos mesmos |
WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
LT3481846T (lt) | 2016-07-07 | 2021-08-25 | Sage Therapeutics, Inc. | 11-pakeistieji 24-hidroksisteroliai, skirti naudoti gydant su nmda susijusias būkles |
MA46351A (fr) | 2016-09-30 | 2021-06-02 | Sage Therapeutics Inc | Oxystérols substitués en c7 et procédés en tant que modulateurs nmda |
KR20230051723A (ko) | 2016-10-18 | 2023-04-18 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
CN115181153A (zh) | 2016-10-18 | 2022-10-14 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
CN109053854B (zh) * | 2018-09-29 | 2021-05-14 | 深圳清博汇能医药科技有限公司 | 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用 |
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BE794362A (fr) * | 1972-01-22 | 1973-07-23 | Merck Patent Gmbh | Sulfates hydrosolubles de sterine |
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CA985172A (en) * | 1972-10-06 | 1976-03-09 | Dushan M. Dvornik | Compositions and methods for reducing blood cholesterol |
DE2416978A1 (de) * | 1974-04-08 | 1975-10-09 | Degussa | Arzneimittel mit dem hauptsapogenin der helleborus-arten als wirkstoff |
LU81256A1 (fr) * | 1979-05-15 | 1980-12-16 | Oreal | Composition cosmetique capillaire notamment pour le lavage et/ou le demelage des cheveux,a base d'un extrait de plantes contenant des saponosides |
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DE4303214A1 (de) * | 1993-02-04 | 1994-08-11 | Wolfgang Marks | Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone |
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GB9905275D0 (en) * | 1999-03-08 | 1999-04-28 | Phytopharm Ltd | Treatment of conditions associated with membrane-bound receptors and their function |
DE69929177T2 (de) * | 1998-03-26 | 2006-08-24 | Phytopharm Plc, Godmanchester | Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit |
GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
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US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
-
2001
- 2001-03-28 GB GBGB0107822.9A patent/GB0107822D0/en not_active Ceased
-
2002
- 2002-03-27 AR ARP020101170A patent/AR033079A1/es unknown
- 2002-03-27 PE PE2002000253A patent/PE20021042A1/es not_active Application Discontinuation
- 2002-03-28 AT AT02708534T patent/ATE416185T1/de not_active IP Right Cessation
- 2002-03-28 TR TR2007/00134T patent/TR200700134T1/xx unknown
- 2002-03-28 CZ CZ20032620A patent/CZ20032620A3/cs unknown
- 2002-03-28 AU AU2002242894A patent/AU2002242894B2/en not_active Ceased
- 2002-03-28 RU RU2003131883/04A patent/RU2311423C2/ru not_active IP Right Cessation
- 2002-03-28 EP EP02708534A patent/EP1383787B1/de not_active Expired - Lifetime
- 2002-03-28 KR KR10-2003-7012755A patent/KR20040007479A/ko not_active Application Discontinuation
- 2002-03-28 WO PCT/GB2002/001578 patent/WO2002079221A2/en active Application Filing
- 2002-03-28 NZ NZ529136A patent/NZ529136A/en unknown
- 2002-03-28 CA CA002442150A patent/CA2442150A1/en not_active Abandoned
- 2002-03-28 TR TR2003/01613T patent/TR200301613T2/xx unknown
- 2002-03-28 MX MXPA03008800A patent/MXPA03008800A/es unknown
- 2002-03-28 IL IL15811502A patent/IL158115A0/xx unknown
- 2002-03-28 PL PL02364825A patent/PL364825A1/xx unknown
- 2002-03-28 JP JP2002577845A patent/JP2004525945A/ja active Pending
- 2002-03-28 CN CNA028074270A patent/CN1678325A/zh active Pending
- 2002-03-28 US US10/472,892 patent/US20040147495A1/en not_active Abandoned
- 2002-03-28 BR BR0208533-0A patent/BR0208533A/pt not_active IP Right Cessation
- 2002-03-28 UA UA2003108904A patent/UA78696C2/uk unknown
-
2003
- 2003-03-27 AR AR20030101078A patent/AR040402A1/es unknown
- 2003-09-24 HR HR20030770A patent/HRP20030770A2/hr not_active Application Discontinuation
- 2003-09-25 ZA ZA200307478A patent/ZA200307478B/xx unknown
- 2003-09-29 NO NO20034364A patent/NO20034364L/no not_active Application Discontinuation
-
2004
- 2004-09-16 ZA ZA200407460A patent/ZA200407460B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN1678325A (zh) | 2005-10-05 |
PE20021042A1 (es) | 2002-11-19 |
JP2004525945A (ja) | 2004-08-26 |
AR033079A1 (es) | 2003-12-03 |
NO20034364L (no) | 2003-11-28 |
EP1383787A2 (de) | 2004-01-28 |
RU2003131883A (ru) | 2005-05-10 |
AU2002242894B2 (en) | 2008-08-21 |
WO2002079221A2 (en) | 2002-10-10 |
BR0208533A (pt) | 2004-04-20 |
IL158115A0 (en) | 2004-03-28 |
NZ529136A (en) | 2005-12-23 |
MXPA03008800A (es) | 2004-10-15 |
TR200700134T1 (tr) | 2007-02-21 |
ZA200407460B (en) | 2009-09-30 |
AR040402A1 (es) | 2005-04-06 |
CA2442150A1 (en) | 2002-10-10 |
UA78696C2 (en) | 2007-04-25 |
WO2002079221A3 (en) | 2003-04-17 |
PL364825A1 (en) | 2004-12-27 |
NO20034364D0 (no) | 2003-09-29 |
ATE416185T1 (de) | 2008-12-15 |
HRP20030770A2 (en) | 2005-08-31 |
CZ20032620A3 (cs) | 2004-04-14 |
EP1383787B1 (de) | 2008-12-03 |
TR200301613T2 (tr) | 2004-08-23 |
US20040147495A1 (en) | 2004-07-29 |
RU2311423C2 (ru) | 2007-11-27 |
KR20040007479A (ko) | 2004-01-24 |
GB0107822D0 (en) | 2001-05-23 |
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