AU2002359126A8 - Benzodiazepine derivatives, preparation thereof and use thereof - Google Patents

Benzodiazepine derivatives, preparation thereof and use thereof

Info

Publication number
AU2002359126A8
AU2002359126A8 AU2002359126A AU2002359126A AU2002359126A8 AU 2002359126 A8 AU2002359126 A8 AU 2002359126A8 AU 2002359126 A AU2002359126 A AU 2002359126A AU 2002359126 A AU2002359126 A AU 2002359126A AU 2002359126 A8 AU2002359126 A8 AU 2002359126A8
Authority
AU
Australia
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002359126A
Other versions
AU2002359126A1 (en
Inventor
Vijayaratnam Santhakumar
Miroslaw Tomaszewski
Carmen Leung
Simon Woo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2002359126A8 publication Critical patent/AU2002359126A8/en
Publication of AU2002359126A1 publication Critical patent/AU2002359126A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
AU2002359126A 2001-12-14 2002-12-11 Benzodiazepine derivatives, preparation thereof and use thereof Abandoned AU2002359126A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0104248-0 2001-12-14
SE0104248A SE0104248D0 (en) 2001-12-14 2001-12-14 Method of treatment
PCT/SE2002/002309 WO2003051275A2 (en) 2001-12-14 2002-12-11 Benzodiazepine derivatives, preparation thereof and use thereof

Publications (2)

Publication Number Publication Date
AU2002359126A8 true AU2002359126A8 (en) 2003-06-30
AU2002359126A1 AU2002359126A1 (en) 2003-06-30

Family

ID=20286350

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002359126A Abandoned AU2002359126A1 (en) 2001-12-14 2002-12-11 Benzodiazepine derivatives, preparation thereof and use thereof

Country Status (3)

Country Link
AU (1) AU2002359126A1 (en)
SE (1) SE0104248D0 (en)
WO (1) WO2003051275A2 (en)

Families Citing this family (25)

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CA2522024A1 (en) * 2003-04-15 2004-10-28 Merck & Co., Inc. Cgrp receptor antagonists
JP4705912B2 (en) * 2003-06-26 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Benzodiazepine CGRP receptor antagonist
EP1641781B1 (en) * 2003-06-26 2013-03-06 Merck Sharp & Dohme Corp. Benzodiazepine CGRP receptor antagonists
CA2554351A1 (en) * 2004-01-29 2005-08-11 Merck & Co., Inc. Cgrp receptor antagonists
ZA200709038B (en) * 2005-04-13 2009-01-28 Neuraxon Inc Substituted indole compounds having nos inhibitory activity
CN101466709B (en) 2006-04-13 2013-03-20 轴突公司 1,5 and 3,6- substituted indole compounds having NOS inhibitory activity
CN101563318A (en) 2006-12-20 2009-10-21 艾博特公司 N- (5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
WO2009062319A1 (en) 2007-11-16 2009-05-22 Neuraxon, Inc. Indole compounds and methods for treating visceral pain
MX369142B (en) 2011-05-13 2019-10-30 Array Biopharma Inc Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors.
US8710043B2 (en) 2011-06-24 2014-04-29 Amgen Inc. TRPM8 antagonists and their use in treatments
WO2012177896A1 (en) * 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
US9828360B2 (en) 2012-11-13 2017-11-28 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9969694B2 (en) 2012-11-13 2018-05-15 Array Biopharma Inc. N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9809578B2 (en) 2012-11-13 2017-11-07 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
MY178262A (en) 2012-11-13 2020-10-07 Array Biopharma Inc Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9546156B2 (en) 2012-11-13 2017-01-17 Array Biopharma Inc. N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors
BR112015011010B1 (en) 2012-11-13 2023-03-07 Array Biopharma Inc BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS, THEIR USES, THEIR PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM
US9790210B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9981959B2 (en) 2012-11-13 2018-05-29 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2015039334A1 (en) * 2013-09-22 2015-03-26 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
SG10201903532XA (en) 2014-05-15 2019-05-30 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
UA115205C2 (en) * 2016-10-03 2017-09-25 Товариство З Додатковою Відповідальністю "Інтерхім" APPLICATION OF 7-BROMY-5- (O-CHLOROPHENYL) -3-PROPOXY-1,2-DIGIDRO-3H-1,4-BENZDIAZEPINE-2-ONE FOR BRAKING OF NEUROPATIC PAIN

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96613A0 (en) * 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
WO1993007131A1 (en) * 1991-10-10 1993-04-15 Merck Sharp & Dohme Limited Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
US5696110A (en) * 1991-10-24 1997-12-09 Merck, Sharp & Dohme, Ltd. Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
DE69204040T2 (en) * 1991-12-20 1996-03-28 Merck Sharp & Dohme 3-phenylureido-1,4-benzodiazepinones and their use as cholecystokinin or gastrin antagonists.
AU670431B2 (en) * 1992-03-24 1996-07-18 Merck Sharp & Dohme Limited 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy
CA2140008A1 (en) * 1992-07-29 1994-02-17 Jose Luis Castro Pineiro Benzodiazepine derivatives
US5378838A (en) * 1993-01-13 1995-01-03 Merck & Co., Inc. Benzodiazepine cholecystokinin antagonists
CA2196062A1 (en) * 1994-07-29 1996-02-15 Yoshinari Sato Benzodiazepine derivatives

Also Published As

Publication number Publication date
SE0104248D0 (en) 2001-12-14
WO2003051275A3 (en) 2003-10-30
AU2002359126A1 (en) 2003-06-30
WO2003051275A2 (en) 2003-06-26

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase