WO2003051275A3 - Benzodiazepine derivatives, preparation thereof and use thereof - Google Patents

Benzodiazepine derivatives, preparation thereof and use thereof Download PDF

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Publication number
WO2003051275A3
WO2003051275A3 PCT/SE2002/002309 SE0202309W WO03051275A3 WO 2003051275 A3 WO2003051275 A3 WO 2003051275A3 SE 0202309 W SE0202309 W SE 0202309W WO 03051275 A3 WO03051275 A3 WO 03051275A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
benzodiazepine derivatives
animal
formula
ofadministering
Prior art date
Application number
PCT/SE2002/002309
Other languages
French (fr)
Other versions
WO2003051275A2 (en
Inventor
Carmen Leung
Vijayaratnam Santhakumar
Miroslaw Tomaszewski
Simon Woo
Original Assignee
Astrazeneca Ab
Carmen Leung
Vijayaratnam Santhakumar
Miroslaw Tomaszewski
Simon Woo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Carmen Leung, Vijayaratnam Santhakumar, Miroslaw Tomaszewski, Simon Woo filed Critical Astrazeneca Ab
Priority to AU2002359126A priority Critical patent/AU2002359126A1/en
Publication of WO2003051275A2 publication Critical patent/WO2003051275A2/en
Publication of WO2003051275A3 publication Critical patent/WO2003051275A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

A method of treating pain in a warm-blooded animal, comprising the step ofadministering to said animal a therapeutically effective amount of a compound of formula(I), pharmaceutically acceptable salts thereof, diasteriomers thereof, enantiomers thereof, or mixtures thereof:[Chemical formula should be inserted here. Please see paper copy]wherein R 1 , R 3 , R 4 , R 5 and X are as defined in the specification.
PCT/SE2002/002309 2001-12-14 2002-12-11 Benzodiazepine derivatives, preparation thereof and use thereof WO2003051275A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002359126A AU2002359126A1 (en) 2001-12-14 2002-12-11 Benzodiazepine derivatives, preparation thereof and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104248A SE0104248D0 (en) 2001-12-14 2001-12-14 Method of treatment
SE0104248-0 2001-12-14

Publications (2)

Publication Number Publication Date
WO2003051275A2 WO2003051275A2 (en) 2003-06-26
WO2003051275A3 true WO2003051275A3 (en) 2003-10-30

Family

ID=20286350

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2002/002309 WO2003051275A2 (en) 2001-12-14 2002-12-11 Benzodiazepine derivatives, preparation thereof and use thereof

Country Status (3)

Country Link
AU (1) AU2002359126A1 (en)
SE (1) SE0104248D0 (en)
WO (1) WO2003051275A2 (en)

Families Citing this family (25)

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DE602004027021D1 (en) * 2003-04-15 2010-06-17 Merck Sharp & Dohme CGRP RECEPTOR ANTAGONISTS
US7476665B2 (en) * 2003-06-26 2009-01-13 Merck & Co., Inc. Benzodiazepine CGRP receptor antagonists
CN1812982B (en) * 2003-06-26 2010-10-27 默沙东公司 Benzodiazepine CGRP receptor antagonists
CA2554351A1 (en) * 2004-01-29 2005-08-11 Merck & Co., Inc. Cgrp receptor antagonists
CN101247853B (en) 2005-04-13 2014-11-12 轴突公司 Substituted indole compounds having NOS inhibitory activity
EP2010527B1 (en) 2006-04-13 2013-08-14 Neuraxon Inc. 1,5 and 3,6- substituted indole compounds having nos inhibitory activity
WO2008079683A2 (en) 2006-12-20 2008-07-03 Abbott Laboratories N- (5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
EA201000808A1 (en) 2007-11-16 2011-04-29 Ньюраксон, Инк. INDOL CONNECTIONS AND METHODS OF TREATMENT OF VISCERAL PAIN
SI2712358T1 (en) 2011-05-13 2017-03-31 Array Biopharma, Inc. Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors
AU2012272898A1 (en) * 2011-06-24 2013-04-11 Amgen Inc. TRPM8 antagonists and their use in treatments
EA201490152A1 (en) 2011-06-24 2014-05-30 Эмджен Инк. TRPM8 ANTAGONISTS AND THEIR APPLICATION IN TREATMENT
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
US9969694B2 (en) 2012-11-13 2018-05-15 Array Biopharma Inc. N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078325A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078417A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078372A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078322A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9828360B2 (en) 2012-11-13 2017-11-28 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078328A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
CN104781255B (en) 2012-11-13 2017-10-24 阵列生物制药公司 It is used as the N pyrrolidinyls of TRKA kinase inhibitors, N ' pyrazolyls urea, thiocarbamide, guanidine and cyanoguandine compounds
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
SI2920166T1 (en) * 2012-11-13 2017-01-31 Array Biopharma, Inc. Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
WO2015039334A1 (en) * 2013-09-22 2015-03-26 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
CR20160583A (en) 2014-05-15 2017-02-23 Array Biopharma Inc 1 - ((3S, 4R) -4- (3-FLUOROPHENYL) -1- (2-METOXYETHYL) PIRROLIDIN-3-IL) -3- (4-METHYL-3- (2-METHYLPIRIMIDIN-5-IL) - 1-FENIL-1H-PIRAZOL-5-IL) UREA AS INHIBITOR OF TRKA CINASA
UA115205C2 (en) * 2016-10-03 2017-09-25 Товариство З Додатковою Відповідальністю "Інтерхім" APPLICATION OF 7-BROMY-5- (O-CHLOROPHENYL) -3-PROPOXY-1,2-DIGIDRO-3H-1,4-BENZDIAZEPINE-2-ONE FOR BRAKING OF NEUROPATIC PAIN

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434364A2 (en) * 1989-12-18 1991-06-26 Merck & Co. Inc. Benzodiazepine analogs for treating panic syndrome and for directly inducing analgesia
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
EP0549039A1 (en) * 1991-12-20 1993-06-30 MERCK SHARP & DOHME LTD. 3-Phenylureido-1,4-Benzodiazepinones and their use as cholecystokinin or gastrin antagonists
WO1993019052A1 (en) * 1992-03-24 1993-09-30 Merck Sharp & Dohme Limited 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy
US5378838A (en) * 1993-01-13 1995-01-03 Merck & Co., Inc. Benzodiazepine cholecystokinin antagonists
US5478933A (en) * 1991-10-10 1995-12-26 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
WO1996004254A2 (en) * 1994-07-29 1996-02-15 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US5521175A (en) * 1992-07-29 1996-05-28 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
US5696110A (en) * 1991-10-24 1997-12-09 Merck, Sharp & Dohme, Ltd. Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434364A2 (en) * 1989-12-18 1991-06-26 Merck & Co. Inc. Benzodiazepine analogs for treating panic syndrome and for directly inducing analgesia
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5478933A (en) * 1991-10-10 1995-12-26 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
US5696110A (en) * 1991-10-24 1997-12-09 Merck, Sharp & Dohme, Ltd. Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
EP0549039A1 (en) * 1991-12-20 1993-06-30 MERCK SHARP & DOHME LTD. 3-Phenylureido-1,4-Benzodiazepinones and their use as cholecystokinin or gastrin antagonists
WO1993019052A1 (en) * 1992-03-24 1993-09-30 Merck Sharp & Dohme Limited 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy
US5521175A (en) * 1992-07-29 1996-05-28 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
US5378838A (en) * 1993-01-13 1995-01-03 Merck & Co., Inc. Benzodiazepine cholecystokinin antagonists
WO1996004254A2 (en) * 1994-07-29 1996-02-15 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives

Also Published As

Publication number Publication date
AU2002359126A1 (en) 2003-06-30
SE0104248D0 (en) 2001-12-14
AU2002359126A8 (en) 2003-06-30
WO2003051275A2 (en) 2003-06-26

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