ZA200305535B - Urea derivatives as integrin alpha 4 antagonists. - Google Patents
Urea derivatives as integrin alpha 4 antagonists. Download PDFInfo
- Publication number
- ZA200305535B ZA200305535B ZA200305535A ZA200305535A ZA200305535B ZA 200305535 B ZA200305535 B ZA 200305535B ZA 200305535 A ZA200305535 A ZA 200305535A ZA 200305535 A ZA200305535 A ZA 200305535A ZA 200305535 B ZA200305535 B ZA 200305535B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- propionic acid
- ureido
- methyl ester
- acid methyl
- Prior art date
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- 150000003672 ureas Chemical class 0.000 title description 4
- 239000005557 antagonist Substances 0.000 title description 3
- 102100032818 Integrin alpha-4 Human genes 0.000 title description 2
- 108010041012 Integrin alpha4 Proteins 0.000 title 1
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- 235000019260 propionic acid Nutrition 0.000 claims description 146
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 117
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 83
- -1 aryl-C o. Chemical group 0.000 claims description 75
- 125000000217 alkyl group Chemical group 0.000 claims description 60
- 150000001875 compounds Chemical class 0.000 claims description 53
- RJUFJBKOKNCXHH-UHFFFAOYSA-N Methyl propionate Chemical compound CCC(=O)OC RJUFJBKOKNCXHH-UHFFFAOYSA-N 0.000 claims description 44
- 125000001424 substituent group Chemical group 0.000 claims description 44
- 125000003118 aryl group Chemical group 0.000 claims description 42
- 125000001072 heteroaryl group Chemical group 0.000 claims description 36
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Classifications
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ES200100126A ES2200617B1 (es) | 2001-01-19 | 2001-01-19 | Derivados de urea como antagonistas de integrinas alfa 4. |
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WO2005019193A2 (en) * | 2003-08-20 | 2005-03-03 | Smithkline Beecham Corporation | Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk) |
KR101484741B1 (ko) * | 2005-08-18 | 2015-01-21 | 닛산 가가쿠 고교 가부시키 가이샤 | 술포닐기를 갖는 티오펜 화합물 및 그 제조법 |
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BR112021007213A2 (pt) | 2018-10-30 | 2021-08-10 | Gilead Sciences, Inc. | derivados de quinolina como inibidores de integrina alfa4beta7 |
CN112969504B (zh) | 2018-10-30 | 2024-04-09 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
KR102652797B1 (ko) | 2018-10-30 | 2024-04-02 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린의 억제를 위한 화합물 |
KR102641718B1 (ko) | 2018-10-30 | 2024-02-29 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체 |
JP2022543465A (ja) | 2019-08-14 | 2022-10-12 | ギリアード サイエンシーズ, インコーポレイテッド | α4β7インテグリンの阻害のための化合物 |
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