ZA200300172B - Pyrrolidine-2-carboxylic acid hydrazide derivatives for use as metalloprotease inhibitors. - Google Patents
Pyrrolidine-2-carboxylic acid hydrazide derivatives for use as metalloprotease inhibitors. Download PDFInfo
- Publication number
- ZA200300172B ZA200300172B ZA200300172A ZA200300172A ZA200300172B ZA 200300172 B ZA200300172 B ZA 200300172B ZA 200300172 A ZA200300172 A ZA 200300172A ZA 200300172 A ZA200300172 A ZA 200300172A ZA 200300172 B ZA200300172 B ZA 200300172B
- Authority
- ZA
- South Africa
- Prior art keywords
- sulfonyl
- pyrrolidine
- hydrazide
- carboxylic acid
- alkyl
- Prior art date
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- CMCFIGZTTYAYIZ-UHFFFAOYSA-N pyrrolidine-2-carbohydrazide Chemical class NNC(=O)C1CCCN1 CMCFIGZTTYAYIZ-UHFFFAOYSA-N 0.000 title description 2
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
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- 125000000217 alkyl group Chemical group 0.000 claims description 61
- 125000003118 aryl group Chemical group 0.000 claims description 55
- 229910052739 hydrogen Inorganic materials 0.000 claims description 39
- 239000001257 hydrogen Substances 0.000 claims description 39
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 37
- -1 alkoxycarbonylatkyl Chemical group 0.000 claims description 33
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- 150000002431 hydrogen Chemical group 0.000 claims description 30
- 238000006243 chemical reaction Methods 0.000 claims description 23
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
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- Communicable Diseases (AREA)
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- Reproductive Health (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00114948 | 2000-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200300172B true ZA200300172B (en) | 2004-04-07 |
Family
ID=8169225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200300172A ZA200300172B (en) | 2000-07-19 | 2003-01-07 | Pyrrolidine-2-carboxylic acid hydrazide derivatives for use as metalloprotease inhibitors. |
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| US (1) | US6444829B1 (enExample) |
| EP (1) | EP1317428B1 (enExample) |
| JP (1) | JP2004504298A (enExample) |
| KR (1) | KR100580056B1 (enExample) |
| CN (1) | CN1318402C (enExample) |
| AR (1) | AR033543A1 (enExample) |
| AT (1) | ATE323673T1 (enExample) |
| AU (1) | AU2001276396A1 (enExample) |
| BR (1) | BR0112543A (enExample) |
| CA (1) | CA2415665A1 (enExample) |
| DE (1) | DE60118941T2 (enExample) |
| ES (1) | ES2261443T3 (enExample) |
| MX (1) | MXPA03000363A (enExample) |
| PA (1) | PA8522401A1 (enExample) |
| PE (1) | PE20020339A1 (enExample) |
| UY (1) | UY26844A1 (enExample) |
| WO (1) | WO2002006224A1 (enExample) |
| ZA (1) | ZA200300172B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589997B2 (en) * | 2001-06-29 | 2003-07-08 | North Shore-Long Island Jewish Health System | Small-molecule modulators of hepatocyte growth factor/scatter factor activities |
| CN1294120C (zh) * | 2003-10-21 | 2007-01-10 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其应用 |
| AT509045B1 (de) | 2010-01-29 | 2011-06-15 | Planta Naturstoffe Vertriebsges M B H | Verbindungen zur behandlung von asthma bronchiale |
| CN103145572A (zh) * | 2013-03-20 | 2013-06-12 | 康化（上海）新药研发有限公司 | 天然产物氯化γ-正缬氨酸盐酸盐的不对称合成方法 |
| CN105712910B (zh) * | 2016-03-08 | 2017-06-06 | 北京化工大学 | （n‑芳基亚磺酰基）磺酰肼及其制备方法 |
| WO2021029158A1 (ja) * | 2019-08-09 | 2021-02-18 | サンアプロ株式会社 | スルホンアミド化合物、非イオン系光酸発生剤、およびフォトリソグラフィー用樹脂組成物 |
| CN113030292A (zh) * | 2021-01-29 | 2021-06-25 | 京博农化科技有限公司 | 一种对三氟甲氧基苯胺基甲酰肼含量的分析方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US493333A (en) * | 1893-03-14 | Air-heating furnace | ||
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| IL117440A0 (en) * | 1995-03-31 | 1996-07-23 | Pfizer | Pyrrolidinyl hydroxamic acid compounds and their production process |
| BR9713465A (pt) * | 1996-08-28 | 2000-03-28 | Procter & Gamble | Inibidores metalotprotease de amina cìclica sibstituìda |
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2001
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- 2001-07-11 CA CA002415665A patent/CA2415665A1/en not_active Abandoned
- 2001-07-11 BR BR0112543-5A patent/BR0112543A/pt not_active IP Right Cessation
- 2001-07-11 DE DE60118941T patent/DE60118941T2/de not_active Expired - Fee Related
- 2001-07-11 KR KR1020037000825A patent/KR100580056B1/ko not_active Expired - Fee Related
- 2001-07-11 WO PCT/EP2001/007995 patent/WO2002006224A1/en not_active Ceased
- 2001-07-11 AT AT01954031T patent/ATE323673T1/de not_active IP Right Cessation
- 2001-07-11 ES ES01954031T patent/ES2261443T3/es not_active Expired - Lifetime
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- 2001-07-11 EP EP01954031A patent/EP1317428B1/en not_active Expired - Lifetime
- 2001-07-11 AU AU2001276396A patent/AU2001276396A1/en not_active Abandoned
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2003
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Also Published As
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| US6444829B1 (en) | 2002-09-03 |
| BR0112543A (pt) | 2003-07-01 |
| US20020040048A1 (en) | 2002-04-04 |
| WO2002006224A1 (en) | 2002-01-24 |
| CN1443163A (zh) | 2003-09-17 |
| EP1317428B1 (en) | 2006-04-19 |
| KR100580056B1 (ko) | 2006-05-12 |
| AR033543A1 (es) | 2003-12-26 |
| ES2261443T3 (es) | 2006-11-16 |
| JP2004504298A (ja) | 2004-02-12 |
| MXPA03000363A (es) | 2003-05-27 |
| AU2001276396A1 (en) | 2002-01-30 |
| ATE323673T1 (de) | 2006-05-15 |
| DE60118941T2 (de) | 2006-12-21 |
| CN1318402C (zh) | 2007-05-30 |
| PA8522401A1 (es) | 2002-09-30 |
| DE60118941D1 (de) | 2006-05-24 |
| KR20030024797A (ko) | 2003-03-26 |
| EP1317428A1 (en) | 2003-06-11 |
| CA2415665A1 (en) | 2002-01-24 |
| PE20020339A1 (es) | 2002-04-23 |
| UY26844A1 (es) | 2002-01-31 |
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