ATE323673T1 - Pyrrolidin-2-carbonsäure-hydrazid-derivate als metalloprotease-inhibitoren - Google Patents
Pyrrolidin-2-carbonsäure-hydrazid-derivate als metalloprotease-inhibitorenInfo
- Publication number
- ATE323673T1 ATE323673T1 AT01954031T AT01954031T ATE323673T1 AT E323673 T1 ATE323673 T1 AT E323673T1 AT 01954031 T AT01954031 T AT 01954031T AT 01954031 T AT01954031 T AT 01954031T AT E323673 T1 ATE323673 T1 AT E323673T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidine
- carbonic acid
- acid hydrazide
- metalloprotease inhibitors
- hydrazide derivatives
- Prior art date
Links
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00114948 | 2000-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323673T1 true ATE323673T1 (de) | 2006-05-15 |
Family
ID=8169225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01954031T ATE323673T1 (de) | 2000-07-19 | 2001-07-11 | Pyrrolidin-2-carbonsäure-hydrazid-derivate als metalloprotease-inhibitoren |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6444829B1 (de) |
| EP (1) | EP1317428B1 (de) |
| JP (1) | JP2004504298A (de) |
| KR (1) | KR100580056B1 (de) |
| CN (1) | CN1318402C (de) |
| AR (1) | AR033543A1 (de) |
| AT (1) | ATE323673T1 (de) |
| AU (1) | AU2001276396A1 (de) |
| BR (1) | BR0112543A (de) |
| CA (1) | CA2415665A1 (de) |
| DE (1) | DE60118941T2 (de) |
| ES (1) | ES2261443T3 (de) |
| MX (1) | MXPA03000363A (de) |
| PA (1) | PA8522401A1 (de) |
| PE (1) | PE20020339A1 (de) |
| UY (1) | UY26844A1 (de) |
| WO (1) | WO2002006224A1 (de) |
| ZA (1) | ZA200300172B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589997B2 (en) * | 2001-06-29 | 2003-07-08 | North Shore-Long Island Jewish Health System | Small-molecule modulators of hepatocyte growth factor/scatter factor activities |
| CN1294120C (zh) * | 2003-10-21 | 2007-01-10 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其应用 |
| AT509045B1 (de) | 2010-01-29 | 2011-06-15 | Planta Naturstoffe Vertriebsges M B H | Verbindungen zur behandlung von asthma bronchiale |
| CN103145572A (zh) * | 2013-03-20 | 2013-06-12 | 康化（上海）新药研发有限公司 | 天然产物氯化γ-正缬氨酸盐酸盐的不对称合成方法 |
| CN105712910B (zh) * | 2016-03-08 | 2017-06-06 | 北京化工大学 | （n‑芳基亚磺酰基）磺酰肼及其制备方法 |
| WO2021029158A1 (ja) * | 2019-08-09 | 2021-02-18 | サンアプロ株式会社 | スルホンアミド化合物、非イオン系光酸発生剤、およびフォトリソグラフィー用樹脂組成物 |
| CN113030292A (zh) * | 2021-01-29 | 2021-06-25 | 京博农化科技有限公司 | 一种对三氟甲氧基苯胺基甲酰肼含量的分析方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US493333A (en) * | 1893-03-14 | Air-heating furnace | ||
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| IL117440A0 (en) * | 1995-03-31 | 1996-07-23 | Pfizer | Pyrrolidinyl hydroxamic acid compounds and their production process |
| CZ63199A3 (cs) * | 1996-08-28 | 1999-08-11 | The Procter & Gamble Company | Sloučeniny typu substituovaných cyklických aminů jako inhibitory metaloproteáz, způsob jejich přípravy a použití jako léčiv |
-
2001
- 2001-07-06 US US09/900,350 patent/US6444829B1/en not_active Expired - Fee Related
- 2001-07-11 AU AU2001276396A patent/AU2001276396A1/en not_active Abandoned
- 2001-07-11 EP EP01954031A patent/EP1317428B1/de not_active Expired - Lifetime
- 2001-07-11 JP JP2002512130A patent/JP2004504298A/ja not_active Ceased
- 2001-07-11 AT AT01954031T patent/ATE323673T1/de not_active IP Right Cessation
- 2001-07-11 MX MXPA03000363A patent/MXPA03000363A/es active IP Right Grant
- 2001-07-11 ES ES01954031T patent/ES2261443T3/es not_active Expired - Lifetime
- 2001-07-11 KR KR1020037000825A patent/KR100580056B1/ko not_active Expired - Fee Related
- 2001-07-11 DE DE60118941T patent/DE60118941T2/de not_active Expired - Fee Related
- 2001-07-11 BR BR0112543-5A patent/BR0112543A/pt not_active IP Right Cessation
- 2001-07-11 WO PCT/EP2001/007995 patent/WO2002006224A1/en not_active Ceased
- 2001-07-11 CN CNB018130488A patent/CN1318402C/zh not_active Expired - Fee Related
- 2001-07-11 CA CA002415665A patent/CA2415665A1/en not_active Abandoned
- 2001-07-16 PA PA20018522401A patent/PA8522401A1/es unknown
- 2001-07-16 PE PE2001000710A patent/PE20020339A1/es not_active Application Discontinuation
- 2001-07-17 AR ARP010103426A patent/AR033543A1/es unknown
- 2001-07-17 UY UY26844A patent/UY26844A1/es not_active Application Discontinuation
-
2003
- 2003-01-07 ZA ZA200300172A patent/ZA200300172B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002006224A1 (en) | 2002-01-24 |
| KR20030024797A (ko) | 2003-03-26 |
| AU2001276396A1 (en) | 2002-01-30 |
| DE60118941D1 (de) | 2006-05-24 |
| ES2261443T3 (es) | 2006-11-16 |
| AR033543A1 (es) | 2003-12-26 |
| JP2004504298A (ja) | 2004-02-12 |
| US20020040048A1 (en) | 2002-04-04 |
| DE60118941T2 (de) | 2006-12-21 |
| PA8522401A1 (es) | 2002-09-30 |
| BR0112543A (pt) | 2003-07-01 |
| MXPA03000363A (es) | 2003-05-27 |
| EP1317428B1 (de) | 2006-04-19 |
| US6444829B1 (en) | 2002-09-03 |
| CN1443163A (zh) | 2003-09-17 |
| PE20020339A1 (es) | 2002-04-23 |
| UY26844A1 (es) | 2002-01-31 |
| ZA200300172B (en) | 2004-04-07 |
| CN1318402C (zh) | 2007-05-30 |
| EP1317428A1 (de) | 2003-06-11 |
| CA2415665A1 (en) | 2002-01-24 |
| KR100580056B1 (ko) | 2006-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE437862T1 (de) | Pyrimidin-5-onderivate als ldl-pla2 inhibitoren | |
| DE60002193D1 (de) | Metalloprotease inhibitoren | |
| ATE256127T1 (de) | Betacarbolinderivate als phosphodiesterase- inhibitoren | |
| ATE278690T1 (de) | Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren | |
| ATE376999T1 (de) | Hydroxamate-derivate als deacetylase inhibitoren | |
| CY2012007I2 (el) | Πεπτιδομιμητικοι αναστολεις πρωτεασης | |
| DE69906311D1 (de) | Diarylbenzopyranderivate als cyclooxygenase-2-inhibitoren | |
| ATE325791T1 (de) | Hydroxypipecolate-hydroxamsäure-derivative als mmp inhibitoren | |
| NO20024521D0 (no) | Heterocyklisk sidekjede-inneholdende metalloproteaseinhibitorer | |
| DK1244647T3 (da) | Quinzolinderivater som VIGF-inhibitorer | |
| EE200100486A (et) | Amiinderivaadid proteaasi inhibiitoritena | |
| NO20025588D0 (no) | Inhibitorer for 11-beta-hydroxy steroid dehydrogenase type 1 | |
| ATE273288T1 (de) | 2,3,4,5-tetrahydro-1h-(1,4)benzodiazepin-3- hydroxamsäure als matrix metalloproteinaseinhibitoren | |
| NO20014243D0 (no) | Dihetero-substituerte metalloprotease inhibitorer | |
| DK1272488T3 (da) | Tri-aryl-substitueret ethan-PDE4-inhibitorer | |
| DE60008548D1 (de) | Hydroxamsäurederivate als matrix-metalloproteinase-inhibitoren | |
| ATE428420T1 (de) | Substituierte 8-arylchinoline als phosphodiesterase-4-hemmer | |
| ATE332895T1 (de) | Tetrazolderivate | |
| NO20014875D0 (no) | Promedikamenter for trombin inhibitorer | |
| DE60012303D1 (de) | Alkinylische hydroxamsäureverbindungen als tace inhibitoren | |
| NO20025786L (no) | Protaseinhibitorer | |
| NO20023001D0 (no) | Substituerte piperazinderivater som MTP inhibitorer | |
| NO20024481D0 (no) | Difluorbutyrsyre metalloproteaseinhibitorer | |
| ATE300945T1 (de) | Isoxazolderivate als phosphodiesterase vii-hemmer | |
| PL357084A1 (en) | Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1317428 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |