ZA200208014B - Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties. - Google Patents
Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties. Download PDFInfo
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- ZA200208014B ZA200208014B ZA200208014A ZA200208014A ZA200208014B ZA 200208014 B ZA200208014 B ZA 200208014B ZA 200208014 A ZA200208014 A ZA 200208014A ZA 200208014 A ZA200208014 A ZA 200208014A ZA 200208014 B ZA200208014 B ZA 200208014B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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ZA200208014A ZA200208014B (en) | 2000-04-19 | 2002-10-04 | Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties. |
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US11834515B2 (en) * | 2017-10-11 | 2023-12-05 | Cornell University | Macrocyclic compounds as proteasome inhibitors |
JP7411414B2 (ja) | 2017-12-15 | 2024-01-11 | 中外製薬株式会社 | ペプチドの製造方法、及び塩基の処理方法 |
JPWO2020111238A1 (ja) | 2018-11-30 | 2021-10-21 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
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JPS5377083A (en) * | 1976-12-16 | 1978-07-08 | Asahi Chem Ind Co Ltd | Penicillins and their derivatives |
US4260601A (en) * | 1979-10-23 | 1981-04-07 | Nyegaard & Co. A/S | Chemical compounds |
FI77875C (fi) * | 1982-11-26 | 1989-05-10 | Nyegaard & Co As | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara peptider. |
US4956344A (en) * | 1987-09-17 | 1990-09-11 | Hafslund Nycomed A/S | Method for treatment of lesions in the large intestinal epithelium with a tripeptide |
JPH02500880A (ja) | 1987-11-18 | 1990-03-29 | カイロン コーポレイション | Nanbvの診断用薬およびワクチン |
DE69024378T2 (de) | 1989-02-01 | 1996-09-12 | Asahi Glass Co Ltd | Azeotrope oder azeotropähnliche Zusammensetzung auf der Basis von Chlorfluorkohlenwasserstoffen |
DE69133402T2 (de) | 1990-04-04 | 2004-11-11 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Protease von hepatitis-c-virus |
JPH07228594A (ja) * | 1994-02-18 | 1995-08-29 | Suntory Ltd | エンドセリン受容体拮抗ペプチド |
IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
WO1998007734A1 (en) | 1996-08-21 | 1998-02-26 | Hybridon, Inc. | Oligonucleotide prodrugs |
NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
ES2234144T3 (es) * | 1997-08-11 | 2005-06-16 | Boehringer Ingelheim (Canada) Ltd. | Analogos de peptidos inhibidores de la hepatitis c. |
PL347103A1 (en) * | 1998-04-15 | 2002-03-25 | Aventis Pharm Prod Inc | Process for the preparation of resin-bound cyclic peptides |
GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
US6407066B1 (en) * | 1999-01-26 | 2002-06-18 | Elan Pharmaceuticals, Inc. | Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4 |
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2001
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- 2001-04-17 NZ NZ521456A patent/NZ521456A/en unknown
- 2001-04-17 AU AU2001253621A patent/AU2001253621A1/en not_active Abandoned
- 2001-04-17 CN CNA2006101537103A patent/CN1935833A/zh active Pending
- 2001-04-17 CA CA002406532A patent/CA2406532A1/en not_active Abandoned
- 2001-04-17 PE PE2001000348A patent/PE20011288A1/es not_active Application Discontinuation
- 2001-04-17 WO PCT/US2001/012530 patent/WO2001081325A2/en active IP Right Grant
- 2001-04-17 PL PL01358591A patent/PL358591A1/xx not_active Application Discontinuation
- 2001-04-17 CN CNA2009100067369A patent/CN101580536A/zh active Pending
- 2001-04-17 KR KR1020027013965A patent/KR20020097220A/ko not_active Application Discontinuation
- 2001-04-17 AR ARP010101794A patent/AR030558A1/es unknown
- 2001-04-17 MX MXPA02010375A patent/MXPA02010375A/es active IP Right Grant
- 2001-04-17 HU HU0302957A patent/HUP0302957A2/hu unknown
- 2001-04-17 JP JP2001578418A patent/JP4748912B2/ja not_active Expired - Fee Related
- 2001-04-17 CN CN01810566A patent/CN1432022A/zh active Pending
- 2001-04-17 BR BR0110104-8A patent/BR0110104A/pt not_active IP Right Cessation
- 2001-04-17 RU RU2002131163/04A patent/RU2002131163A/ru not_active Application Discontinuation
- 2001-04-17 IL IL15193501A patent/IL151935A0/xx unknown
- 2001-04-17 SK SK1495-2002A patent/SK14952002A3/sk not_active Application Discontinuation
- 2001-04-17 CZ CZ20023473A patent/CZ20023473A3/cs unknown
- 2001-04-17 EP EP01927142A patent/EP1274724A2/en not_active Withdrawn
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2002
- 2002-10-04 ZA ZA200208014A patent/ZA200208014B/en unknown
- 2002-10-18 NO NO20025030A patent/NO20025030L/no not_active Application Discontinuation
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2003
- 2003-01-18 HK HK03100478.8A patent/HK1048479A1/zh unknown
Also Published As
Publication number | Publication date |
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AR030558A1 (es) | 2003-08-27 |
NO20025030L (no) | 2002-12-18 |
JP2003531199A (ja) | 2003-10-21 |
RU2002131163A (ru) | 2004-06-27 |
CN101580536A (zh) | 2009-11-18 |
EP1274724A2 (en) | 2003-01-15 |
US20020016294A1 (en) | 2002-02-07 |
HUP0302957A2 (hu) | 2003-12-29 |
CN1935833A (zh) | 2007-03-28 |
WO2001081325A2 (en) | 2001-11-01 |
BR0110104A (pt) | 2003-01-07 |
PE20011288A1 (es) | 2001-12-12 |
US6914122B2 (en) | 2005-07-05 |
KR20020097220A (ko) | 2002-12-31 |
CA2406532A1 (en) | 2001-11-01 |
WO2001081325A3 (en) | 2002-08-01 |
SK14952002A3 (sk) | 2003-03-04 |
AU2001253621A1 (en) | 2001-11-07 |
CN1432022A (zh) | 2003-07-23 |
NZ521456A (en) | 2004-07-30 |
PL358591A1 (en) | 2004-08-09 |
IL151935A0 (en) | 2003-04-10 |
JP4748912B2 (ja) | 2011-08-17 |
NO20025030D0 (no) | 2002-10-18 |
CZ20023473A3 (cs) | 2003-01-15 |
MXPA02010375A (es) | 2003-04-25 |
HK1048479A1 (zh) | 2003-04-04 |
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