DK2813512T3 - Fremgangsmåde til cyklisering af en peptidforbindelse - Google Patents
Fremgangsmåde til cyklisering af en peptidforbindelse Download PDFInfo
- Publication number
- DK2813512T3 DK2813512T3 DK12861199.3T DK12861199T DK2813512T3 DK 2813512 T3 DK2813512 T3 DK 2813512T3 DK 12861199 T DK12861199 T DK 12861199T DK 2813512 T3 DK2813512 T3 DK 2813512T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclizing
- procedure
- peptide connection
- peptide
- connection
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011288865 | 2011-12-28 | ||
| JP2012156943 | 2012-07-12 | ||
| PCT/JP2012/084103 WO2013100132A1 (ja) | 2011-12-28 | 2012-12-28 | ペプチド化合物の環化方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2813512T3 true DK2813512T3 (da) | 2021-04-26 |
Family
ID=48697609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12861199.3T DK2813512T3 (da) | 2011-12-28 | 2012-12-28 | Fremgangsmåde til cyklisering af en peptidforbindelse |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9409952B2 (da) |
| EP (2) | EP2813512B1 (da) |
| JP (5) | JP6294080B2 (da) |
| DK (1) | DK2813512T3 (da) |
| HU (1) | HUE054006T2 (da) |
| TW (5) | TWI713889B (da) |
| WO (1) | WO2013100132A1 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI713889B (zh) | 2011-12-28 | 2020-12-21 | 中外製藥股份有限公司 | 胜肽化合物之環化方法 |
| JP7020910B2 (ja) | 2015-03-13 | 2022-02-16 | 中外製薬株式会社 | 改変アミノアシルｔＲＮＡ合成酵素およびその用途 |
| JP6824903B2 (ja) * | 2015-04-23 | 2021-02-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ペプチド環化およびプロテアーゼ処理のための方法および組成物 |
| US10011631B2 (en) * | 2015-12-01 | 2018-07-03 | The University Of Hong Kong | Stapled helical peptides and methods of synthesis |
| EP3424941A4 (en) * | 2016-03-03 | 2019-10-23 | Chugai Seiyaku Kabushiki Kaisha | METHOD OF PRODUCTION OF NON-CYCLIC PEPTIDE NUCLEIC ACID COMPLEX WITH AMINO ACID WITH THIOL GROUP, IN ADDITION TO THE AMINO GROUP ON N-TERMINUS, LIBRARY THEREOF, AND CYCLIC PEPTIDE NUCLEIC ACID COMPLEX LIBRARY THEREOF |
| BR112019009485A2 (pt) * | 2016-12-09 | 2019-07-30 | Fujifilm Corp | veículo de cromatografia por afinidade de modo misto |
| JP7173870B2 (ja) * | 2016-12-28 | 2022-11-16 | 中外製薬株式会社 | 化合物の膜透過性を改善するための自己乳化型製剤 |
| JP7187323B2 (ja) * | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| WO2018201050A1 (en) * | 2017-04-28 | 2018-11-01 | Board Of Trustees Of Michigan State University | Tryptathionine biosynthesis by flavin mono-oxygenase 1 (fmo1) |
| KR20200007863A (ko) | 2017-05-12 | 2020-01-22 | 추가이 세이야쿠 가부시키가이샤 | 환상 유기 화합물의 제조 방법 |
| WO2018225851A1 (ja) | 2017-06-09 | 2018-12-13 | 中外製薬株式会社 | Ｎ－置換アミノ酸を含むペプチドの合成方法 |
| JP7232758B2 (ja) * | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| EA202090346A1 (ru) * | 2017-07-20 | 2020-08-18 | Бристол-Маерс Сквибб Компани | СПОСОБ ПОЛУЧЕНИЯ N-((1R,2S,5R)-5-(ТРЕТ-БУТИЛАМИНО)-2-((S)-3-(7-ТРЕТ-БУТИЛПИРАЗОЛО[1,5-a][1,3,5]ТРИАЗИН-4-ИЛАМИНО)-2-ОКСОПИРРОЛИДИН-1-ИЛ)ЦИКЛОГЕКСИЛ)АЦЕТАМИДА |
| WO2019117274A1 (ja) | 2017-12-15 | 2019-06-20 | 中外製薬株式会社 | ペプチドの製造方法、及び塩基の処理方法 |
| US11814621B2 (en) | 2018-06-01 | 2023-11-14 | Northwestern University | Expanding the chemical substrates for genetic code reprogramming |
| JP7370322B2 (ja) | 2018-06-04 | 2023-10-27 | 中外製薬株式会社 | 複合体を検出する方法 |
| EP3804759A4 (en) | 2018-06-06 | 2022-07-20 | Osaka University | METHODS OF TREATMENT OF DANDRUFF OR PREVENTION OF GNASE 1 SECONDARY DISEASES |
| JPWO2020111238A1 (ja) | 2018-11-30 | 2021-10-21 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| KR20210102326A (ko) | 2018-12-12 | 2021-08-19 | 추가이 세이야쿠 가부시키가이샤 | 분자내 수소 결합 가능한 작용기를 갖는 아미노산과 그들 아미노산을 포함하는 펩타이드 화합물, 및 그들의 제조 방법 |
| WO2020138336A1 (ja) | 2018-12-26 | 2020-07-02 | 中外製薬株式会社 | コドン拡張のための変異ｔＲＮＡ |
| CN109824622B (zh) * | 2019-02-27 | 2022-12-30 | 中国科学技术大学 | 一类细胞内形成纳米结构杀死癌细胞的前体药物及其制法 |
| US20220193113A1 (en) | 2019-05-31 | 2022-06-23 | Osaka University | Novel therapeutic agent for gastrointestinal cancer and method for screening for the same |
| WO2021070696A1 (ja) | 2019-10-08 | 2021-04-15 | ジーンフロンティア株式会社 | Ｃｔｌａ－４阻害活性を有する環状ペプチド、及びその用途 |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR MANUFACTURING A PEPTIDE COMPOUND CONTAINING A HIGHLY STERICALLY HINDERED AMINO ACID |
| PE20221323A1 (es) * | 2019-11-07 | 2022-09-09 | Chugai Pharmaceutical Co Ltd | Compuesto de peptidos ciclicos que tiene accion inhibidora de kras |
| KR20220113729A (ko) | 2019-12-12 | 2022-08-16 | 추가이 세이야쿠 가부시키가이샤 | 비천연 아미노산을 포함하는 펩타이드의 제조 방법 |
| JPWO2021132546A1 (da) | 2019-12-26 | 2021-07-01 | ||
| US20230295221A1 (en) | 2020-06-03 | 2023-09-21 | Chugai Seiyaku Kabushiki Kaisha | Efficient peptide condensation method for difficult sequences |
| US20240052340A1 (en) | 2020-06-25 | 2024-02-15 | Chugai Seiyaku Kabushiki Kaisha | Translation system provided with modified genetic code table |
| EP4242219A1 (en) | 2020-11-05 | 2023-09-13 | Chugai Seiyaku Kabushiki Kaisha | Peptide synthesis method for suppressing defect caused by diketopiperazine formation |
| WO2022138892A1 (ja) | 2020-12-25 | 2022-06-30 | 中外製薬株式会社 | 複数の標的分子と共に複合体を形成し得る候補分子のスクリーニング方法 |
| JPWO2022138891A1 (da) | 2020-12-25 | 2022-06-30 | ||
| US20240067674A1 (en) | 2020-12-28 | 2024-02-29 | Chugai Seiyaku Kabushiki Kaisha | Method for loading amino acid on resin for solid-phase synthesis |
| US20240124910A1 (en) * | 2021-02-02 | 2024-04-18 | Northwestern University | Ribosome-mediated polymerization of novel chemistries |
| KR20240074875A (ko) | 2021-05-07 | 2024-05-28 | 추가이 세이야쿠 가부시키가이샤 | 환상 펩타이드 화합물의 의약 용도 |
| WO2022234639A1 (ja) | 2021-05-07 | 2022-11-10 | 中外製薬株式会社 | 変異型ｒａｓ（ｇ１２ｄ）に対する選択的結合性を示す結合分子 |
| AU2022268781A1 (en) | 2021-05-07 | 2023-12-21 | Chugai Seiyaku Kabushiki Kaisha | Cyclic Compound having Selective Inhibitory Action on KRAS over HRAS and NRAS |
| MX2023013098A (es) * | 2021-05-07 | 2023-11-16 | Chugai Pharmaceutical Co Ltd | Metodos para producir compuestos ciclicos que comprenden residuos de aminoacidos n-sustituidos. |
| WO2022234864A1 (ja) * | 2021-05-07 | 2022-11-10 | 中外製薬株式会社 | Ｎ－置換アミノ酸残基を含む環状化合物の製造方法 |
| JP7181442B1 (ja) | 2021-05-07 | 2022-11-30 | 中外製薬株式会社 | 環状ペプチド化合物を含む製剤及びその製造方法 |
| KR20240082357A (ko) | 2021-09-30 | 2024-06-10 | 추가이 세이야쿠 가부시키가이샤 | 광개열성 부위를 갖는 화합물, 연결체 및 이를 이용한 스크리닝 방법 |
| EP4166133A1 (en) | 2021-10-13 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Composition containing peptide compound and surfactant |
| TW202402319A (zh) | 2022-03-28 | 2024-01-16 | 日商中外製藥股份有限公司 | 含有包含聚氧乙烯構造的油性成分之化合物製劑 |
| TW202406566A (zh) | 2022-05-02 | 2024-02-16 | 日商中外製藥股份有限公司 | 包含用於與界面活性劑結合使用之胜肽化合物的組合物 |
| CN115286671B (zh) * | 2022-07-13 | 2023-06-23 | 康龙化成(宁波)科技发展有限公司 | 一种寡聚核酸-噻唑烷类化合物、合成方法、应用 |
| WO2024085235A1 (ja) * | 2022-10-20 | 2024-04-25 | 中外製薬株式会社 | 環状ペプチドの結晶の製造方法 |
| KR20240082196A (ko) | 2022-11-09 | 2024-06-10 | 추가이 세이야쿠 가부시키가이샤 | Hras 및 nras에 대해서 선택적인 kras 저해 작용을 갖는 환상 화합물을 포함하는 의약 조성물 |
| WO2024126687A1 (en) * | 2022-12-16 | 2024-06-20 | Silence Therapeutics Gmbh | Nucleic acids conjugated to an albumin binding moiety |
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-
2012
- 2012-12-28 TW TW107130626A patent/TWI713889B/zh active
- 2012-12-28 TW TW109139943A patent/TWI787670B/zh active
- 2012-12-28 DK DK12861199.3T patent/DK2813512T3/da active
- 2012-12-28 JP JP2013551857A patent/JP6294080B2/ja active Active
- 2012-12-28 EP EP12861199.3A patent/EP2813512B1/en active Active
- 2012-12-28 TW TW106103188A patent/TWI640541B/zh active
- 2012-12-28 TW TW101150926A patent/TWI579296B/zh active
- 2012-12-28 HU HUE12861199A patent/HUE054006T2/hu unknown
- 2012-12-28 WO PCT/JP2012/084103 patent/WO2013100132A1/ja active Application Filing
- 2012-12-28 EP EP21165014.8A patent/EP3974563A1/en active Pending
- 2012-12-28 TW TW111144798A patent/TW202313654A/zh unknown
- 2012-12-28 US US14/368,564 patent/US9409952B2/en active Active
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2016
- 2016-05-27 US US15/166,550 patent/US20160311858A1/en not_active Abandoned
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2018
- 2018-02-15 JP JP2018024856A patent/JP2018118968A/ja not_active Ceased
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2020
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2021
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- 2023-09-01 US US18/460,300 patent/US20240166689A1/en active Pending
Also Published As
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|---|---|
| TW201720841A (zh) | 2017-06-16 |
| US9409952B2 (en) | 2016-08-09 |
| TW201333029A (zh) | 2013-08-16 |
| WO2013100132A1 (ja) | 2013-07-04 |
| JP2020109120A (ja) | 2020-07-16 |
| JPWO2013100132A1 (ja) | 2015-05-11 |
| US20160311858A1 (en) | 2016-10-27 |
| JP2018118968A (ja) | 2018-08-02 |
| JP2022003092A (ja) | 2022-01-11 |
| US20150080549A1 (en) | 2015-03-19 |
| TW202112802A (zh) | 2021-04-01 |
| US20210061860A1 (en) | 2021-03-04 |
| TW201900670A (zh) | 2019-01-01 |
| JP7297027B2 (ja) | 2023-06-23 |
| US20240166689A1 (en) | 2024-05-23 |
| EP2813512A1 (en) | 2014-12-17 |
| TWI787670B (zh) | 2022-12-21 |
| EP2813512B1 (en) | 2021-03-31 |
| EP3974563A1 (en) | 2022-03-30 |
| TWI579296B (zh) | 2017-04-21 |
| JP6961742B2 (ja) | 2021-11-05 |
| EP2813512A4 (en) | 2016-02-10 |
| TW202313654A (zh) | 2023-04-01 |
| US11891457B2 (en) | 2024-02-06 |
| JP2023123570A (ja) | 2023-09-05 |
| HUE054006T2 (hu) | 2021-08-30 |
| JP6294080B2 (ja) | 2018-03-14 |
| TWI640541B (zh) | 2018-11-11 |
| TWI713889B (zh) | 2020-12-21 |
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