ZA200206731B - 1-[1-(hetero) aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds. - Google Patents

1-[1-(hetero) aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds.

Info

Publication number
ZA200206731B
ZA200206731B ZA200206731A ZA200206731A ZA200206731B ZA 200206731 B ZA200206731 B ZA 200206731B ZA 200206731 A ZA200206731 A ZA 200206731A ZA 200206731 A ZA200206731 A ZA 200206731A ZA 200206731 B ZA200206731 B ZA 200206731B
Authority
ZA
South Africa
Prior art keywords
compounds
perhydroxyalkylmethyl
hetero
aryl
preparation
Prior art date
Application number
ZA200206731A
Other languages
English (en)
Inventor
Daniel Jasserand
Ulf Preuschoff
Jochen Antel
Samuel David
Holger Sann
Reinhard Brueckner
Dania Reiche
Christian Eeckhout
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of ZA200206731B publication Critical patent/ZA200206731B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
ZA200206731A 2001-09-13 2002-08-22 1-[1-(hetero) aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds. ZA200206731B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10145044A DE10145044A1 (de) 2001-09-13 2001-09-13 Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ZA200206731B true ZA200206731B (en) 2003-04-11

Family

ID=7698848

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200206731A ZA200206731B (en) 2001-09-13 2002-08-22 1-[1-(hetero) aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds.

Country Status (27)

Country Link
US (1) US6770649B2 (hu)
EP (1) EP1293506B1 (hu)
JP (1) JP4353684B2 (hu)
KR (1) KR100909746B1 (hu)
CN (1) CN1232513C (hu)
AR (1) AR036487A1 (hu)
AT (1) ATE305464T1 (hu)
AU (1) AU2002301141B2 (hu)
BR (1) BR0203716A (hu)
CA (1) CA2403139C (hu)
DE (2) DE10145044A1 (hu)
DK (1) DK1293506T3 (hu)
DZ (1) DZ3292A1 (hu)
ES (1) ES2250561T3 (hu)
HK (1) HK1053648A1 (hu)
HU (1) HU227612B1 (hu)
IL (1) IL151497A (hu)
MX (1) MXPA02008789A (hu)
NO (1) NO324867B1 (hu)
NZ (1) NZ521154A (hu)
PL (1) PL356018A1 (hu)
PT (1) PT1293506E (hu)
RU (1) RU2301807C2 (hu)
SI (1) SI1293506T1 (hu)
TW (1) TWI254046B (hu)
UA (1) UA75590C2 (hu)
ZA (1) ZA200206731B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1870396B1 (en) * 2005-03-31 2012-10-31 Nippon Zoki Pharmaceutical Co. Ltd. Benzyloxypropylamine derivative
US7592344B2 (en) 2005-11-30 2009-09-22 Solvay Pharmaceuticals Gmbh NK1 and NK2-antagonists and compositions and methods of using the same
ATE550324T1 (de) * 2005-11-30 2012-04-15 Abbott Products Gmbh Neue nk1- und nk2-antagonisten
CN103387549A (zh) * 2012-05-10 2013-11-13 广州医学院 三个苯并三氮唑类芳基哌嗪化合物的消旋体和光学异构体及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
EP0709375B1 (en) * 1994-10-25 2005-05-18 AstraZeneca AB Therapeutic heterocycles
DE60114597T2 (de) * 2000-04-06 2006-07-20 Astrazeneca Ab Naphthamid-neurokinin antagonisten zur verwendung als medikamente

Also Published As

Publication number Publication date
AR036487A1 (es) 2004-09-15
HUP0202967A3 (en) 2004-04-28
DK1293506T3 (da) 2005-10-17
HUP0202967A2 (hu) 2003-06-28
NO324867B1 (no) 2007-12-17
NO20024351L (no) 2003-03-14
DE50204379D1 (de) 2006-02-09
US20030125557A1 (en) 2003-07-03
NO20024351D0 (no) 2002-09-12
DE10145044A1 (de) 2003-04-03
HK1053648A1 (en) 2003-10-31
ES2250561T3 (es) 2006-04-16
EP1293506A1 (de) 2003-03-19
ATE305464T1 (de) 2005-10-15
AU2002301141B2 (en) 2008-11-06
KR20030023500A (ko) 2003-03-19
JP2003113160A (ja) 2003-04-18
CA2403139A1 (en) 2003-03-13
HU227612B1 (en) 2011-09-28
EP1293506B1 (de) 2005-09-28
KR100909746B1 (ko) 2009-07-29
NZ521154A (en) 2004-02-27
CN1406937A (zh) 2003-04-02
CN1232513C (zh) 2005-12-21
IL151497A0 (en) 2003-04-10
US6770649B2 (en) 2004-08-03
PL356018A1 (en) 2003-03-24
PT1293506E (pt) 2005-11-30
UA75590C2 (en) 2006-05-15
TWI254046B (en) 2006-05-01
MXPA02008789A (es) 2003-03-18
SI1293506T1 (sl) 2005-12-31
CA2403139C (en) 2011-02-22
RU2301807C2 (ru) 2007-06-27
JP4353684B2 (ja) 2009-10-28
BR0203716A (pt) 2003-06-03
HU0202967D0 (hu) 2002-10-28
IL151497A (en) 2011-10-31
DZ3292A1 (fr) 2005-05-14
RU2002124199A (ru) 2004-03-20

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