ZA200206576B - Cell division inhibitors and process for producing the same. - Google Patents
Cell division inhibitors and process for producing the same. Download PDFInfo
- Publication number
- ZA200206576B ZA200206576B ZA200206576A ZA200206576A ZA200206576B ZA 200206576 B ZA200206576 B ZA 200206576B ZA 200206576 A ZA200206576 A ZA 200206576A ZA 200206576 A ZA200206576 A ZA 200206576A ZA 200206576 B ZA200206576 B ZA 200206576B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbon
- substituted
- alkyl
- alkenyl
- alkoxy
- Prior art date
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 238000003541 multi-stage reaction Methods 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 108010073025 phenylalanylphenylalanine Proteins 0.000 description 1
- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000009370 | 2000-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200206576B true ZA200206576B (en) | 2003-05-12 |
Family
ID=18537534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206576A ZA200206576B (en) | 2000-01-18 | 2002-08-16 | Cell division inhibitors and process for producing the same. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6972289B1 (ja) |
| EP (1) | EP1264831A4 (ja) |
| JP (1) | JP4810043B2 (ja) |
| KR (1) | KR100831400B1 (ja) |
| AU (2) | AU782917C (ja) |
| BR (2) | BR0017067A (ja) |
| CA (1) | CA2403790C (ja) |
| IL (2) | IL150430A0 (ja) |
| MX (1) | MXPA02006826A (ja) |
| NZ (1) | NZ519989A (ja) |
| WO (1) | WO2001053290A1 (ja) |
| ZA (1) | ZA200206576B (ja) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2205323T3 (es) | 1997-06-09 | 2004-05-01 | Hitachi, Ltd. | Procedimiento de docdificacion de secuencias de imagenes. |
| US7026322B2 (en) | 1998-11-12 | 2006-04-11 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
| IL150430A0 (en) * | 2000-01-18 | 2002-12-01 | Nereus Pharmaceuticals Inc | Cell division inhibitors and process for producing the same |
| EP1529044B1 (en) * | 2002-08-02 | 2007-10-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US7919497B2 (en) * | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| CN101633655B (zh) * | 2002-08-02 | 2014-04-30 | 大连万春药业有限公司 | 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成 |
| US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| RU2005119172A (ru) * | 2002-12-18 | 2006-01-20 | Пфайзер Продактс Инк. (Us) | Производные 4-анилинхиназолина для лечения патологического роста клеток |
| GR1004602B (el) * | 2003-07-03 | 2004-06-18 | Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων | |
| CN1934101B (zh) * | 2004-02-04 | 2011-10-12 | 尼瑞斯药品公司 | 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成 |
| KR101228104B1 (ko) * | 2004-02-04 | 2013-02-01 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의합성방법 |
| WO2006105051A2 (en) * | 2005-03-29 | 2006-10-05 | Nereus Pharmaceuticals, Inc. | Synthesis of diketopiperazines |
| AR058408A1 (es) * | 2006-01-02 | 2008-01-30 | Basf Ag | Compuestos de piperazina con accion herbicida |
| JP5015174B2 (ja) * | 2006-01-05 | 2012-08-29 | ビーエーエスエフ ソシエタス・ヨーロピア | 除草作用を有するピペラジン化合物 |
| US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| DE502008000206D1 (de) * | 2007-06-12 | 2009-12-31 | Basf Se | Piperazinverbindungen mit herbizider wirkung |
| JP2010529169A (ja) * | 2007-06-12 | 2010-08-26 | ビーエーエスエフ ソシエタス・ヨーロピア | 除草作用を有するピペラジン化合物 |
| KR20100018066A (ko) * | 2007-06-12 | 2010-02-16 | 바스프 에스이 | 제초적 활성 조성물 |
| WO2010012649A1 (de) * | 2008-07-29 | 2010-02-04 | Basf Se | Piperazinverbindungen mit herbizider wirkung |
| BRPI0916949A2 (pt) | 2008-08-13 | 2015-08-18 | Basf Se | Processo para a preparação de derivados de piperazinadiona, e, uso dos compostos. |
| CN102171203A (zh) * | 2008-10-02 | 2011-08-31 | 巴斯夫欧洲公司 | 具有除草作用的哌嗪化合物 |
| EP3265091A4 (en) | 2015-03-06 | 2018-08-01 | Beyondspring Pharmaceuticals Inc. | Method of treating a brain tumor |
| JP6769982B2 (ja) | 2015-03-06 | 2020-10-14 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | Ｒａｓ変異と関連するがんの治療方法 |
| SG10202108194XA (en) | 2015-07-13 | 2021-09-29 | Beyondspring Pharmaceuticals Inc | Plinabulin compositions |
| MX2018009413A (es) | 2016-02-08 | 2019-05-15 | Beyondspring Pharmaceuticals Inc | Composiciones que contienen tucaresol o sus analogos. |
| KR20230018545A (ko) | 2016-06-06 | 2023-02-07 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증을 줄이는 조성물 및 방법 |
| US10851086B2 (en) | 2016-08-12 | 2020-12-01 | Marine Biomedical Research Institute Of Qingdao Co., Ltd. | Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof |
| CN106565686B (zh) * | 2016-10-11 | 2019-03-01 | 深圳海王医药科技研究院有限公司 | 微管蛋白抑制剂 |
| US11633393B2 (en) | 2017-01-06 | 2023-04-25 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| SG11201907023UA (en) | 2017-02-01 | 2019-08-27 | Beyondspring Pharmaceuticals Inc | Method of reducing neutropenia |
| WO2019147615A1 (en) | 2018-01-24 | 2019-08-01 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
| KR20220117501A (ko) | 2021-02-17 | 2022-08-24 | 주식회사 티제이 | 카드리더기 모듈의 슬림화장치 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0725858A (ja) * | 1993-07-13 | 1995-01-27 | Otsuka Pharmaceut Co Ltd | ピペラジン誘導体 |
| GB9402809D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| GB9426224D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
| JP3131574B2 (ja) * | 1996-09-04 | 2001-02-05 | 新日本製鐵株式会社 | 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤 |
| US6069146A (en) * | 1998-03-25 | 2000-05-30 | The Regents Of The University Of California | Halimide, a cytotoxic marine natural product, and derivatives thereof |
| US6358957B1 (en) * | 1998-11-12 | 2002-03-19 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
| IL150430A0 (en) * | 2000-01-18 | 2002-12-01 | Nereus Pharmaceuticals Inc | Cell division inhibitors and process for producing the same |
| EP1529044B1 (en) * | 2002-08-02 | 2007-10-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US7919497B2 (en) * | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
-
2000
- 2000-09-29 IL IL15043000A patent/IL150430A0/xx active IP Right Grant
- 2000-09-29 AU AU74511/00A patent/AU782917C/en not_active Expired
- 2000-09-29 BR BR0017067-4A patent/BR0017067A/pt not_active IP Right Cessation
- 2000-09-29 EP EP00963011A patent/EP1264831A4/en not_active Withdrawn
- 2000-09-29 CA CA2403790A patent/CA2403790C/en not_active Expired - Lifetime
- 2000-09-29 WO PCT/JP2000/006807 patent/WO2001053290A1/ja active IP Right Grant
- 2000-09-29 BR BRPI0017067A patent/BRPI0017067B8/pt unknown
- 2000-09-29 JP JP2001553764A patent/JP4810043B2/ja not_active Expired - Lifetime
- 2000-09-29 US US10/181,786 patent/US6972289B1/en not_active Expired - Lifetime
- 2000-09-29 KR KR1020027009268A patent/KR100831400B1/ko active IP Right Grant
- 2000-09-29 NZ NZ519989A patent/NZ519989A/en not_active IP Right Cessation
- 2000-09-29 MX MXPA02006826A patent/MXPA02006826A/es active IP Right Grant
-
2002
- 2002-06-26 IL IL150430A patent/IL150430A/en unknown
- 2002-08-16 ZA ZA200206576A patent/ZA200206576B/en unknown
-
2005
- 2005-11-17 US US11/281,773 patent/US20060079534A1/en not_active Abandoned
- 2005-12-07 AU AU2005242133A patent/AU2005242133B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US20060079534A1 (en) | 2006-04-13 |
| US6972289B1 (en) | 2005-12-06 |
| CA2403790C (en) | 2011-09-27 |
| AU7451100A (en) | 2001-07-31 |
| KR20020082484A (ko) | 2002-10-31 |
| BRPI0017067B8 (pt) | 2021-05-25 |
| BRPI0017067B1 (pt) | 2019-08-27 |
| AU782917B2 (en) | 2005-09-08 |
| CA2403790A1 (en) | 2001-07-26 |
| EP1264831A1 (en) | 2002-12-11 |
| IL150430A (en) | 2011-03-31 |
| KR100831400B1 (ko) | 2008-05-21 |
| EP1264831A4 (en) | 2005-11-23 |
| WO2001053290A1 (fr) | 2001-07-26 |
| MXPA02006826A (es) | 2004-04-05 |
| AU2005242133B2 (en) | 2009-09-03 |
| BR0017067A (pt) | 2002-10-22 |
| JP4810043B2 (ja) | 2011-11-09 |
| AU782917C (en) | 2006-11-23 |
| IL150430A0 (en) | 2002-12-01 |
| AU2005242133A1 (en) | 2006-01-05 |
| NZ519989A (en) | 2004-05-28 |
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