CN101633655B - 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成 - Google Patents
脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成 Download PDFInfo
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- CN101633655B CN101633655B CN200910160084.4A CN200910160084A CN101633655B CN 101633655 B CN101633655 B CN 101633655B CN 200910160084 A CN200910160084 A CN 200910160084A CN 101633655 B CN101633655 B CN 101633655B
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Abstract
Description
可替换的名称 | 此处所用的名称 |
NPI-2350 | (-)-苯基阿夕斯丁 |
NPI-2352 | KPU-01 |
NPI-2353 | KPU-03 |
NPI-2354 | KPU-04 |
NPI-2355 | KPU-05 |
NPI-2356 | KPU-06 |
NPI-2357 | KPU-07 |
NPI-2358 | KPU-02 |
NPI-2359 | KPU-08 |
NPI-2360 | KPU-09 |
NPI-2361 | KPU-10 |
NPI-2362 | KPU-11 |
NPI-2363 | KPU-12 |
NPI-2364 | KPU-13 |
NPI-2365 | KPU-14 |
NPI-2366 | KPU-15 |
NPI-2367 | KPU-16 |
NPI-2368 | KPU-17 |
NPI-2369 | KPU-18 |
NPI-2370 | KPU-19 |
NPI-2371 | KPU-21 |
NPI-2372 | KPU-22 |
NPI-2373 | KPU-23 |
NPI-2374 | KPU-24 |
NPI-2375 | KPU-25 |
NPI-2376 | KPU-28 |
NPI-2377 | KPU-26 |
NPI-2378 | KPU-27 |
NPI-2379 | KPU-29 |
NPI-2380 | KPU-20 |
NPI-2381 | KPU-30 |
NPI-2382 | KPU-31 |
NPI-2383 | KPU-32 |
NPI-2384 | KPU-33 |
NPI-2385 | KPU-34 |
NPI-2386 | KPU-35 |
NPI-2387 | KPU-36 |
NPI-2388 | KPU-37 |
NPI-2389 | KPU-38 |
NPI-2390 | KPU-39 |
NPI-2391 | KPU-40 |
NPI-2392 | KPU-41 |
NPI-2393 | KPU-42 |
NPI-2394 | KPU-43 |
NPI-2395 | KPU-44 |
NPI-2396 | KPU-45 |
NPI-2397 | KPU-46 |
NPI-2398 | KPU-47 |
NPI-2399 | KPU-48 |
NPI-2400 | KPU-49 |
NPI-2401 | KPU-50 |
NPI-2402 | KPU-51 |
NPI-2403 | KPU-52 |
NPI-2404 | KPU-53 |
NPI-2405 | KPU-54 |
NPI-2406 | KPU-55 |
NPI-2407 | KPU-56 |
NPI-2408 | KPU-57 |
NPI-2409 | KPU-58 |
NPI-2410 | KPU-59 |
NPI-2411 | KPU-60 |
NPI-2412 | KPU-61 |
NPI-2413 | KPU-62 |
NPI-2414 | KPU-63 |
NPI-2415 | KPU-64 |
NPI-2416 | KPU-65 |
NPI-2417 | KPU-66 |
NPI-2418 | KPU-67 |
NPI-2419 | KPU-68 |
NPI-2420 | KPU-69 |
NPI-2421 | KPU-70 |
NPI-2422 | KPU-71 |
NPI-2423 | KPU-72 |
NPI-2424 | KPU-73 |
NPI-2425 | KPU-74 |
NPI-2426 | KPU-75 |
NPI-2427 | KPU-76 |
NPI-2428 | KPU-77 |
NPI-2429 | KPU-79 |
NPI-2430 | KPU-80 |
NPI-2431 | KPU-81 |
NPI-2432 | KPU-82 |
NPI-2433 | KPU-83 |
NPI-2434 | KPU-84 |
NPI-2435 | KPU-86 |
NPI-2436 | KPU-87 |
NPI-2437 | KPU-88 |
NPI-2438 | KPU-89 |
NPI-2439 | KPU-90 |
NPI-2440 | KPU-91 |
NPI-2441 | KPU-92 |
NPI-2442 | KPU-80 |
NPI-2455 | KPU-94 |
NPI-2456 | KPU-95 |
NPI-2457 | KPU-96 |
NPI-2458 | KPU-97 |
NPI-2459 | KPU-98 |
NPI-2460 | 叔丁基苯基阿夕斯丁 |
激酶 | IC50(μM) |
CDK1/Cyclin B(人) | 10.1 |
c-RAF(人) | 8.9 |
JNK3(大鼠) | 6.8 |
Lyn(小鼠) | 11.1 |
Claims (31)
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US60/411,128 | 2002-09-16 | ||
US45006303P | 2003-02-24 | 2003-02-24 | |
US60/450,063 | 2003-02-24 |
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EP3334726B1 (en) * | 2015-07-13 | 2022-03-16 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
CN107011331A (zh) * | 2016-08-12 | 2017-08-04 | 青岛海洋生物医药研究院股份有限公司 | 脱氢苯基阿夕斯丁类化合物的多晶型及其制备方法 |
CN107011322B (zh) * | 2016-08-12 | 2020-02-18 | 青岛海洋生物医药研究院股份有限公司 | 一种脱氢苯基阿夕斯丁类化合物的制备纯化方法 |
CN114276332B (zh) | 2016-08-12 | 2023-08-18 | 深圳华大海洋科技有限公司 | 脱氢苯基阿夕斯丁类化合物的多晶型及其制备纯化方法和应用 |
CN111840291B (zh) * | 2020-07-14 | 2021-12-21 | 深圳海王医药科技研究院有限公司 | 一种在肿瘤治疗中具有增效作用的化合物的应用 |
CN115252616B (zh) * | 2022-08-09 | 2024-05-17 | 中国科学院长春应用化学研究所 | 一种自激活血管阻断剂前药及其制备方法和应用 |
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2003
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Non-Patent Citations (2)
Title |
---|
Total Synthesis of Anti-microtubule Diketopiperazine Derivatives: Phenylahistin and Aurantiamine;Yoshio Hayashi et al.;《J. Org. Chem.》;20001108;第65卷(第24期);8402-8405 * |
Yoshio Hayashi et al..Total Synthesis of Anti-microtubule Diketopiperazine Derivatives: Phenylahistin and Aurantiamine.《J. Org. Chem.》.2000,第65卷(第24期),8402-8405. |
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