BRPI0017067B8 - inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto - Google Patents

inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto

Info

Publication number
BRPI0017067B8
BRPI0017067B8 BRPI0017067A BRPI0017067A BRPI0017067B8 BR PI0017067 B8 BRPI0017067 B8 BR PI0017067B8 BR PI0017067 A BRPI0017067 A BR PI0017067A BR PI0017067 A BRPI0017067 A BR PI0017067A BR PI0017067 B8 BRPI0017067 B8 BR PI0017067B8
Authority
BR
Brazil
Prior art keywords
cell division
division inhibitor
dehydrogenase
producing
compound
Prior art date
Application number
BRPI0017067A
Other languages
English (en)
Inventor
Kazumi Akazawa
Kaneo Kanoh
Hiroshi Kanzaki
Teruhiko Nitoda
Satohiro Yanagisawa
Original Assignee
Beyondspring Pharmaceuticals Inc
Dalian Wanchun Biotechnology Co Ltd
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beyondspring Pharmaceuticals Inc, Dalian Wanchun Biotechnology Co Ltd, Nereus Pharmaceuticals Inc filed Critical Beyondspring Pharmaceuticals Inc
Publication of BRPI0017067B1 publication Critical patent/BRPI0017067B1/pt
Publication of BRPI0017067B8 publication Critical patent/BRPI0017067B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto". a presente invenção se refere a um inibidor de divisão de célula o qual compreende diversas dehidrodiceto piperazinas tais como dehidrofenilaistina, ou análogos da mesma como o ingrediente ativo, e uma desidrogenase e a um método para a produção do mesmo inibidor.
BRPI0017067A 2000-01-18 2000-09-29 inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto BRPI0017067B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000009370 2000-01-18
PCT/JP2000/006807 WO2001053290A1 (fr) 2000-01-18 2000-09-29 Inhibiteurs de la division cellulaire et procede de production de ces inhibiteurs

Publications (2)

Publication Number Publication Date
BRPI0017067B1 BRPI0017067B1 (pt) 2019-08-27
BRPI0017067B8 true BRPI0017067B8 (pt) 2021-05-25

Family

ID=18537534

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0017067-4A BR0017067A (pt) 2000-01-18 2000-09-29 Inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto
BRPI0017067A BRPI0017067B8 (pt) 2000-01-18 2000-09-29 inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0017067-4A BR0017067A (pt) 2000-01-18 2000-09-29 Inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto

Country Status (12)

Country Link
US (2) US6972289B1 (pt)
EP (1) EP1264831A4 (pt)
JP (1) JP4810043B2 (pt)
KR (1) KR100831400B1 (pt)
AU (2) AU782917C (pt)
BR (2) BR0017067A (pt)
CA (1) CA2403790C (pt)
IL (2) IL150430A0 (pt)
MX (1) MXPA02006826A (pt)
NZ (1) NZ519989A (pt)
WO (1) WO2001053290A1 (pt)
ZA (1) ZA200206576B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2240118C (en) 1997-06-09 2005-11-22 Hitachi Ltd. Image sequence coding method and decoding method
US7026322B2 (en) * 1998-11-12 2006-04-11 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
IL150430A0 (en) * 2000-01-18 2002-12-01 Nereus Pharmaceuticals Inc Cell division inhibitors and process for producing the same
CN101633655B (zh) * 2002-08-02 2014-04-30 大连万春药业有限公司 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成
US7935704B2 (en) 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
CN100540548C (zh) * 2002-08-02 2009-09-16 尼瑞斯药品公司 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
RU2005119172A (ru) * 2002-12-18 2006-01-20 Пфайзер Продактс Инк. (Us) Производные 4-анилинхиназолина для лечения патологического роста клеток
GR1004602B (el) 2003-07-03 2004-06-18 Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων
EP1711487A1 (en) * 2004-02-04 2006-10-18 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
CN1934101B (zh) * 2004-02-04 2011-10-12 尼瑞斯药品公司 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成
US7732605B2 (en) * 2005-03-29 2010-06-08 Nereus Pharmaceuticals, Inc. Synthesis of diketopiperazines
AR058408A1 (es) 2006-01-02 2008-01-30 Basf Ag Compuestos de piperazina con accion herbicida
PE20071051A1 (es) * 2006-01-05 2007-11-29 Basf Ag Compuestos de piperazina con accion herbicida
US8129527B2 (en) * 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
PE20090334A1 (es) * 2007-06-12 2009-04-26 Basf Se Compuestos de piperazina con accion herbicida
WO2008152074A1 (de) * 2007-06-12 2008-12-18 Basf Se Herbizid wirksame zusammensetzung
WO2008152073A2 (de) * 2007-06-12 2008-12-18 Basf Se Piperazinverbindungen mit herbizider wirkung
US20110130286A1 (en) * 2008-07-29 2011-06-02 Basf Se Piperazine Compounds with Herbicidal Effect
JP2011530559A (ja) * 2008-08-13 2011-12-22 ビーエーエスエフ ソシエタス・ヨーロピア ピペラジンジオン誘導体を調製する方法
WO2010037727A1 (de) * 2008-10-02 2010-04-08 Basf Se Piperazinverbindungen mit herbizider wirkung
JP6904570B2 (ja) 2015-03-06 2021-07-21 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 脳腫瘍の治療方法
CN107530341B (zh) 2015-03-06 2021-10-01 大连万春布林医药有限公司 治疗与ras突变相关的癌症的方法
BR112018000229A2 (pt) 2015-07-13 2018-09-04 Beyondspring Pharmaceuticals Inc composições de plinabulina
SG11201806583XA (en) 2016-02-08 2018-09-27 Beyondspring Pharmaceuticals Inc Compositions containing tucaresol or its analogs
AU2017278245B2 (en) 2016-06-06 2022-09-15 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing neutropenia
EP4089085B1 (en) 2016-08-12 2024-04-03 Shenzhen Huahong Marine Biomedicine Co., Ltd Manufacturing and purification method of polycrystalline form of dehydrophenylahistin-like compound
CN106565686B (zh) * 2016-10-11 2019-03-01 深圳海王医药科技研究院有限公司 微管蛋白抑制剂
CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
KR20190109479A (ko) 2017-02-01 2019-09-25 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
JP7350015B2 (ja) 2018-01-24 2023-09-25 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド プリナブリンの投与による血小板減少症を軽減するための組成物および方法
KR20220117501A (ko) 2021-02-17 2022-08-24 주식회사 티제이 카드리더기 모듈의 슬림화장치

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0725858A (ja) * 1993-07-13 1995-01-27 Otsuka Pharmaceut Co Ltd ピペラジン誘導体
GB9402809D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9426224D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
JP3131574B2 (ja) * 1996-09-04 2001-02-05 新日本製鐵株式会社 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤
US6069146A (en) * 1998-03-25 2000-05-30 The Regents Of The University Of California Halimide, a cytotoxic marine natural product, and derivatives thereof
US6358957B1 (en) * 1998-11-12 2002-03-19 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
IL150430A0 (en) * 2000-01-18 2002-12-01 Nereus Pharmaceuticals Inc Cell division inhibitors and process for producing the same
US7919497B2 (en) * 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
CN100540548C (zh) * 2002-08-02 2009-09-16 尼瑞斯药品公司 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成

Also Published As

Publication number Publication date
JP4810043B2 (ja) 2011-11-09
IL150430A0 (en) 2002-12-01
CA2403790A1 (en) 2001-07-26
BR0017067A (pt) 2002-10-22
AU782917B2 (en) 2005-09-08
AU782917C (en) 2006-11-23
WO2001053290A1 (fr) 2001-07-26
EP1264831A1 (en) 2002-12-11
AU2005242133A1 (en) 2006-01-05
AU7451100A (en) 2001-07-31
US6972289B1 (en) 2005-12-06
NZ519989A (en) 2004-05-28
US20060079534A1 (en) 2006-04-13
EP1264831A4 (en) 2005-11-23
KR20020082484A (ko) 2002-10-31
CA2403790C (en) 2011-09-27
MXPA02006826A (es) 2004-04-05
BRPI0017067B1 (pt) 2019-08-27
ZA200206576B (en) 2003-05-12
IL150430A (en) 2011-03-31
KR100831400B1 (ko) 2008-05-21
AU2005242133B2 (en) 2009-09-03

Similar Documents

Publication Publication Date Title
BRPI0017067B8 (pt) inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto
ID29076A (id) Kombinasi senyawa aktif fungisida
ES2156603T3 (es) Medicamentos a base de una mezcla sinergetica de metronidazol y de clindamicina.
PT857718E (pt) Antagonista da endotelina
BR0306870A (pt) Composição farmacêutica oral, e, método para preparar a mesma
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
PT1379520E (pt) Antagonistas (nao-aril)-heterociclicos n-substituidos de nmda/nr2b
DK1324776T3 (da) Koncentrerede proteinformuleringer med mindsket viskositet
ES2243579T3 (es) Derivados de pirazolopirideno.
BRPI0409105A (pt) análogos de quinobenzoxazina substituìdos
ES2188984T3 (es) Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.
MXPA03009602A (es) Analogos de nociceptina.
NO20014241D0 (no) C16-umettede FP-selektive prostaglandinanaloger
BRPI9916820B8 (pt) composição compreendendo 9[2[[bis[(pivaloilóxi)metil]fosfono]metóxi]etil]adenina, comprimido ou cápsula e método
BRPI0317188A2 (pt) Novo derivado de 2,4-diamino-1,3,5-triazina
IL139354A (en) Method for making hydroxy-25 ene-vitamin d compounds
BR0311245A (pt) Fosfonatos e seus derivados como realçadores da atividade de inseticidas
ES2173586T3 (es) Derivados de ciclohexandiol.
HRP20010885B1 (en) Ethanesulfonyl-piperidine derivatives
NO20022000L (no) 6-metoksy-2-naftyleddiksyre-prodrogesammensetninger til behandling av inflammasjon
ATE491709T1 (de) Pyrrolidinohydrochinazoline
BR9908511A (pt) Processo para a preparação de um composto, e, composto
ATE503471T1 (de) Mittel zur linderung von niereninsuffizienz
MXPA04001852A (es) Uso de sistemas indan-1-ol c2-sustituidas para la produccion de medicamentos para la profilaxis o tratamiento de obesidad.
MXPA04001856A (es) Indan-1-oles c2-sustituidos y sus derivados, metodo para su produccion y su uso como medicamentos.