GR1004602B - Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων - Google Patents

Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων

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Publication number
GR1004602B
GR1004602B GR20030100287A GR20030100287A GR1004602B GR 1004602 B GR1004602 B GR 1004602B GR 20030100287 A GR20030100287 A GR 20030100287A GR 20030100287 A GR20030100287 A GR 20030100287A GR 1004602 B GR1004602 B GR 1004602B
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GR
Greece
Prior art keywords
preparation
dehydro
group
main text
cycl
Prior art date
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GR20030100287A
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English (en)
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority to GR20030100287A priority Critical patent/GR1004602B/el
Priority to AU2003244878A priority patent/AU2003244878A1/en
Priority to PCT/GR2003/000028 priority patent/WO2005003102A1/en
Priority to EP03738352A priority patent/EP1675835B1/en
Priority to AT03738352T priority patent/ATE525363T1/de
Publication of GR1004602B publication Critical patent/GR1004602B/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

παρούσα εφεύρεση αφορά μια νέα μέθοδο δεϋδρο-δικετοπιπεριζανίων του γενικού τύπου: (χημικός τύπος) όπου: τα R1 και R2 περιγράφονται στο κείμενο. Το Cycl- είναι μία ομάδα η οποία περιγράφεται με έναν από τους παρακάτω χημικούς τύπους. (χημικός τύπος). Όπου: Τα R3 έως R8, τα Χ και Υ περιγράφονται στο κείμενο. Η διακεκομένη γραμμή αναφέρεται σε απλό ή διπλό δεσμό. Οι ενώσεις αυτές μπορούν να χρησιμοποιηθούν σαν αναστολείς ανάπτυξης καρικινικών κυττάρων. Η μέθοδος περιλαμβάνει διαδοχικά τη σύζευξη της αμινομάδας ενός φωσφονικού εστέρα της γλυκίνης με την καρβοξυλική ομάδα ενός αμινοξέος και την σύζευξη του προϊόντος με ένα φορμυλο-παράγωγο. Ακολουθεί αποπροστασία και εφαρμογή ήπιων αλκαλικών συνθηκών για το σχηματισμό της δεϋδρο -δικετοπιπεραζίνης. Η μέθοδος επεκτείνεται για εφαρμογή σε στερεή φάση, για την παρασκευή μεμονωμένων παραγώγων ή ομάδων παραγώγων (βιβλιοθήκες), δεϋδρο-δικετοπιπεραζινών. Για την περίπτωση αυτή παρασκευάζονται φωσφινικοί εστέρες της γλυκίνης ακινητοποιημένοι σε στερεό υπόστρωμα του γενικού τύπου (χημικός τύπος). Όπου το Res και R περιγράφονται στο κείμενο. ΰ
GR20030100287A 2003-07-03 2003-07-03 Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων GR1004602B (el)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GR20030100287A GR1004602B (el) 2003-07-03 2003-07-03 Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων
AU2003244878A AU2003244878A1 (en) 2003-07-03 2003-07-07 Methods of preparation of dehydro-diketopiperazines in liquid phase or of solid supported phase
PCT/GR2003/000028 WO2005003102A1 (en) 2003-07-03 2003-07-07 Methods of preparation of dehydro-diketopiperazines in liquid phase or of solid supported phase
EP03738352A EP1675835B1 (en) 2003-07-03 2003-07-07 Methods of preparation of dehydro-diketopiperazines in liquid phase or on solid supported phase
AT03738352T ATE525363T1 (de) 2003-07-03 2003-07-07 Verfahren zur herstellung von dehydro- diketopyperazinen in flüssiger phase oder per festphasensynthese

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20030100287A GR1004602B (el) 2003-07-03 2003-07-03 Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων

Publications (1)

Publication Number Publication Date
GR1004602B true GR1004602B (el) 2004-06-18

Family

ID=41003643

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20030100287A GR1004602B (el) 2003-07-03 2003-07-03 Μεθοδοι παρασκευης παραγωγων δεϋδρο-δικετοπιπεραζινων

Country Status (5)

Country Link
EP (1) EP1675835B1 (el)
AT (1) ATE525363T1 (el)
AU (1) AU2003244878A1 (el)
GR (1) GR1004602B (el)
WO (1) WO2005003102A1 (el)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358957B1 (en) * 1998-11-12 2002-03-19 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
EP1264831A1 (en) * 2000-01-18 2002-12-11 Nereus Pharmaceuticals, Inc. Cell division inhibitors and process for producing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358957B1 (en) * 1998-11-12 2002-03-19 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
EP1264831A1 (en) * 2000-01-18 2002-12-11 Nereus Pharmaceuticals, Inc. Cell division inhibitors and process for producing the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DEL FRESNO M ET AL: "Solid-Phase Synthesis of Diketopiperazines, Useful Scaffolds for Combinatorial Chemistry", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 17, 23 April 1998 (1998-04-23), pages 2639 - 2642, XP004112118, ISSN: 0040-4039 *
JAMES I W: "Linkers for Solid Phase Organic Synthesis", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 55, no. 16, 16 April 1999 (1999-04-16), pages 4855 - 4946, XP004161079, ISSN: 0040-4020 *
JOHNSON C R ET AL: "Solid Phase Synthesis of Alkenes Using The Horner-Wadsworth-Emmons Reaction and Monitoring by Gel Phase P NMR", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 36, no. 51, 18 December 1995 (1995-12-18), pages 9253 - 9256, XP004026728, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
AU2003244878A1 (en) 2005-01-21
EP1675835A1 (en) 2006-07-05
ATE525363T1 (de) 2011-10-15
EP1675835B1 (en) 2011-09-21
WO2005003102A1 (en) 2005-01-13

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