ZA200206072B - Aniline-derived ligands for the thyroid receptor. - Google Patents
Aniline-derived ligands for the thyroid receptor. Download PDFInfo
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- ZA200206072B ZA200206072B ZA200206072A ZA200206072A ZA200206072B ZA 200206072 B ZA200206072 B ZA 200206072B ZA 200206072 A ZA200206072 A ZA 200206072A ZA 200206072 A ZA200206072 A ZA 200206072A ZA 200206072 B ZA200206072 B ZA 200206072B
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- compound
- disease
- composition
- hydrogen
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- 108090000721 thyroid hormone receptors Proteins 0.000 title description 11
- 102000004217 thyroid hormone receptors Human genes 0.000 title description 11
- 239000003446 ligand Substances 0.000 title description 7
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 title 2
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
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- 125000005907 alkyl ester group Chemical group 0.000 claims description 8
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- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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| US6664291B2 (en) | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| DE10131462A1 (de) * | 2001-06-29 | 2003-01-09 | Bayer Ag | Phenol-Derivate |
| US6806381B2 (en) | 2001-11-02 | 2004-10-19 | Bristol-Myers Squibb Company | Process for the preparation of aniline-derived thyroid receptor ligands |
| WO2003042162A1 (en) * | 2001-11-17 | 2003-05-22 | Neurosearch A/S | Prodrugs of antidepressants and their use for treating depressions |
| GB0208384D0 (en) * | 2002-04-11 | 2002-05-22 | Karobio Ab | Novel compounds |
| US20040176425A1 (en) * | 2003-01-24 | 2004-09-09 | Washburn William N. | Cycloalkyl containing anilide ligands for the thyroid receptor |
| TW200504021A (en) | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
| ES2399427T3 (es) * | 2003-08-14 | 2013-04-01 | Array Biopharma, Inc. | Análogos de quinazolina como inhibidores de los receptores de la tirosina-quinasa |
| US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| EP2428516A1 (en) | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| GB0406378D0 (en) * | 2004-03-22 | 2004-04-21 | Karobio Ab | Novel pharmaceutical compositions |
| CA2606499C (en) | 2005-05-26 | 2017-06-13 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| GB0606201D0 (en) * | 2006-03-28 | 2006-05-10 | Karobio Ab | Improved crytalline material |
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| US20070238770A1 (en) * | 2006-04-05 | 2007-10-11 | Bristol-Myers Squibb Company | Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations |
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| US20090197947A1 (en) * | 2008-02-01 | 2009-08-06 | The Research Foundation Of State University Of New York | Medicaments and methods for lowering plasma lipid levels and screening drugs |
| US8922530B2 (en) * | 2010-01-06 | 2014-12-30 | Apple Inc. | Communicating stylus |
| EP2609910A1 (en) | 2011-12-30 | 2013-07-03 | Deva Holding Anonim Sirketi | Formulations of eprotirome |
| DK2695611T3 (da) * | 2012-08-06 | 2015-01-05 | Wolff August Gmbh & Co Kg Arzneimittel Dr | Eprotirome til anvendelse i forebyggelse og/eller behandling af hårlidelser samt sammensætninger deraf |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| JP6982004B2 (ja) * | 2016-05-18 | 2021-12-17 | オレゴン ヘルス アンド サイエンス ユニバーシティ | ソベチロム誘導体 |
| WO2018094265A2 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| EP3634426A4 (en) | 2017-06-05 | 2021-04-07 | Viking Therapeutics, Inc. | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS |
| JP2021518403A (ja) | 2018-03-22 | 2021-08-02 | バイキング・セラピューティクス・インコーポレイテッド | 化合物の結晶形態及び化合物の結晶形態を生成する方法 |
| US11827596B2 (en) | 2018-12-12 | 2023-11-28 | Autobahn Therapeutics, Inc. | Thyromimetics |
| EP3927693A4 (en) | 2019-02-21 | 2023-04-05 | Nanjing Ruijie Pharma Co., Ltd. | NOVEL COMPOUNDS AND THEIR USES AS THYROID HORMONE RECEPTOR AGONISTS |
| EP3931180A1 (en) | 2019-03-01 | 2022-01-05 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| KR20230048481A (ko) | 2020-06-02 | 2023-04-11 | 쳉두 캉홍 파마슈티칼 코., 엘티디. | 새로운 갑상선 호르몬 β 수용체 효능제 |
| WO2023177667A1 (en) * | 2022-03-16 | 2023-09-21 | Brii Biosciences, Inc. | Thyroid hormone receptor agonists |
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| DE1078582B (de) * | 1958-10-29 | 1960-03-31 | Hoechst Ag | Verfahren zur Herstellung substituierter Thyropropionsaeuren |
| JPS6061747A (ja) * | 1983-09-16 | 1985-04-09 | Konishiroku Photo Ind Co Ltd | 熱現像感光材料 |
| ATE159515T1 (de) | 1992-07-21 | 1997-11-15 | Ciba Geigy Ag | Oxamidsäure-derivate als hypocholesterämische mittel |
| GB9713739D0 (en) * | 1997-06-27 | 1997-09-03 | Karobio Ab | Thyroid receptor ligands |
| IL144765A0 (en) | 1999-03-01 | 2002-06-30 | Pfizer Prod Inc | Oxamic acids and derivatives as thyroid receptor ligands |
| DE60018225T2 (de) | 1999-03-01 | 2005-12-29 | Pfizer Products Inc., Groton | Oxamsäuren mit einer Cyanogruppe als Liganden für den Thyroidrezeptor |
| CO5160290A1 (es) | 1999-03-29 | 2002-05-30 | Novartis Ag | Derivados de acido fenoxifeniloxamico sustituido . |
| DE60020786T2 (de) | 1999-09-30 | 2006-03-23 | Pfizer Products Inc., Groton | 6-Azauracilderivate als Liganden der Thyroidrezeptoren |
| CA2403902C (en) * | 2000-03-31 | 2007-04-24 | Pfizer Products Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| US6664291B2 (en) | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| AU4884701A (en) * | 2000-05-12 | 2001-11-20 | Kissei Pharmaceutical Co. Ltd. | Malonanilic acid derivatives, medicinal compositions containing the same and usethereof |
| JP4225791B2 (ja) * | 2001-05-18 | 2009-02-18 | キッセイ薬品工業株式会社 | 肝癌の予防または再発抑制剤 |
| TW200504021A (en) * | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
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