PE20020767A1 - Ligandos derivados de anilina para el receptor de aparato para triturar material la tiroides - Google Patents

Ligandos derivados de anilina para el receptor de aparato para triturar material la tiroides

Info

Publication number
PE20020767A1
PE20020767A1 PE20010001762002000058A PE2001000176A PE20020767A1 PE 20020767 A1 PE20020767 A1 PE 20020767A1 PE 20010001762002000058 A PE20010001762002000058 A PE 20010001762002000058A PE 2001000176 A PE2001000176 A PE 2001000176A PE 20020767 A1 PE20020767 A1 PE 20020767A1
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PE
Peru
Prior art keywords
acid
rollers
methylethyl
alkyl
oxopropanoic
Prior art date
Application number
PE20010001762002000058A
Other languages
English (en)
Inventor
Todd Jason Bond Neville James Friends
Denis E Ryono
Minsheng Zhang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20020767A1 publication Critical patent/PE20020767A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

Abstract

CARACTERIZADO PORQUE INCLUYE DOS RODILLOS MONTADOSSE REFIERE A DERIVADOS DE ANILINA DE FORMULA I DONDE X ES O, S, METILENO, CARBONILO, -NH-, ENTRE OTR EN PARALELO PARA DEFINIR UN ESPACIO ENTRE LOS MISMOS. ADEMAS TROZOS DE MATERIAL TAL COMO: ROCA, MINOS; Y ES -(CH2)n- DONDE n ES 1-5, -C=C- EL CUAL PUEDE SER CIS O TRANS; R1 ES HALOGENO, TRIFLUOROMETIERAL, CARBON, PIEDRA Y SIMILARES, SE ALIMENTAN POR UN TRANSPORTADOR DENTRO UNA PRENSA ENTRE LOS RODILO, ALQUILO C1-C6, CICLOALQUILO C3-C7; R2 Y R3 SONLLOS. CADA RODILLO ES SIMILAR E INCLUYE ESCALONES H, HALOGENO, ALQUILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; R4 Y R5 SON H, ALQUILO; R6 ES ACIDO CAQUE SE EXTIENDEN LONGITUDINALMENTE PROVISTOS POR CARAS QUE SE EXTIENDEN HACIA AFUERA ; Y, DONDE CADARBOXILICO O UN ESTER DEL MISMO; R7 ES H, ALCANOILO RODILLO PRESENTA SEGMENTOS DE SUPERFICIE CURVAS Q, AROILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS AUE SE EXTIENDEN ENTRE EL PUNTO EXTREMO EXTERNO DE CIDO 3-[[3,5-DIBROMO-[4-HIDROXI-3-(1-METILETIL)FENLA CARA DE UN ESCALON AL PUNTO EXTREMO INTERNO DE OXI]-FENIL]AMINO]-3-OXOPROPANOICO, ACIDO 3-[[3,5-DICLORO-[4-HIDROXI-3-(1-METILETIL)FENOXI]-FENIL]AMILA CARA DE UN ESCALON SIGUIENTE DE MANERA QUE EL ENO]-3-OXOPROPANOICO, ACIDO 3-[[3,5-DICLORO-[4-HIDRSPACIO ENTRE LOS RODILLOS SE MANTIENE CONSTANTE A OXI-3-(1-METILETIL)FENOXI]-2-METILFENIL]AMINO]-3-OMEDIDA QUE EL MISMO ALTERNA TRANSVERSALMENTE ANTE XOPROPANOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNLA CONTRAROTACION DE LOS RODILLOS A COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON LIGANDOS PARA EL RECEPTOR DE LA TIROIDES Y SON UTILES PARA EL TRATAMIENTO DE OBESIDAD, HIPERCOLESTEROLEMIA, ARTEROESCLEROSIS
PE20010001762002000058A 2000-02-17 2001-02-16 Ligandos derivados de anilina para el receptor de aparato para triturar material la tiroides PE20020767A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18322300P 2000-02-17 2000-02-17

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PE20020767A1 true PE20020767A1 (es) 2002-08-17

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PE20010001762002000058A PE20020767A1 (es) 2000-02-17 2001-02-16 Ligandos derivados de anilina para el receptor de aparato para triturar material la tiroides

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Country Link
US (2) US6800605B1 (es)
EP (1) EP1257526B1 (es)
JP (1) JP4629294B2 (es)
KR (1) KR100740383B1 (es)
CN (1) CN1216857C (es)
AR (1) AR031094A1 (es)
AT (1) ATE295348T1 (es)
AU (2) AU2001230929B2 (es)
BR (1) BR0108134A (es)
CA (1) CA2400486C (es)
CO (1) CO5271672A1 (es)
CZ (1) CZ20022771A3 (es)
DE (1) DE60110753T2 (es)
DK (1) DK1257526T3 (es)
EG (1) EG25009A (es)
ES (1) ES2242723T3 (es)
HK (1) HK1047925B (es)
HU (1) HUP0301777A3 (es)
IL (2) IL150449A0 (es)
MX (1) MXPA02007929A (es)
MY (1) MY124534A (es)
NO (1) NO329639B1 (es)
NZ (1) NZ520023A (es)
PE (1) PE20020767A1 (es)
PL (1) PL201790B1 (es)
PT (1) PT1257526E (es)
RU (1) RU2260586C2 (es)
UY (1) UY26581A1 (es)
WO (1) WO2001060784A1 (es)
ZA (1) ZA200206072B (es)

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Also Published As

Publication number Publication date
AR031094A1 (es) 2003-09-10
HUP0301777A2 (hu) 2003-09-29
CA2400486A1 (en) 2001-08-23
EP1257526A1 (en) 2002-11-20
DE60110753D1 (de) 2005-06-16
PT1257526E (pt) 2005-09-30
NZ520023A (en) 2004-05-28
HK1047925A1 (en) 2003-03-14
HUP0301777A3 (en) 2010-09-28
US20050032890A1 (en) 2005-02-10
CA2400486C (en) 2011-01-11
IL150449A0 (en) 2002-12-01
EG25009A (en) 2011-05-16
CN1216857C (zh) 2005-08-31
NO20023895L (no) 2002-10-16
US6800605B1 (en) 2004-10-05
MY124534A (en) 2006-06-30
PL366149A1 (en) 2005-01-24
RU2002123349A (ru) 2004-01-10
AU3092901A (en) 2001-08-27
DK1257526T3 (da) 2005-09-12
MXPA02007929A (es) 2003-02-10
NO329639B1 (no) 2010-11-22
UY26581A1 (es) 2001-09-28
NO20023895D0 (no) 2002-08-16
AU2001230929B2 (en) 2004-09-23
KR100740383B1 (ko) 2007-07-16
CO5271672A1 (es) 2003-04-30
JP4629294B2 (ja) 2011-02-09
WO2001060784A1 (en) 2001-08-23
ATE295348T1 (de) 2005-05-15
HK1047925B (zh) 2005-11-11
DE60110753T2 (de) 2006-02-23
JP2004500382A (ja) 2004-01-08
CN1418185A (zh) 2003-05-14
BR0108134A (pt) 2003-09-30
ZA200206072B (en) 2004-02-11
CZ20022771A3 (cs) 2003-09-17
KR20020075799A (ko) 2002-10-05
PL201790B1 (pl) 2009-05-29
US7109164B2 (en) 2006-09-19
EP1257526B1 (en) 2005-05-11
RU2260586C2 (ru) 2005-09-20
ES2242723T3 (es) 2005-11-16
IL150449A (en) 2008-03-20

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