ZA200203455B - 3-methylene steroid derivatives for the treatment of autoimmune diseases. - Google Patents

3-methylene steroid derivatives for the treatment of autoimmune diseases.

Info

Publication number
ZA200203455B
ZA200203455B ZA200203455A ZA200203455A ZA200203455B ZA 200203455 B ZA200203455 B ZA 200203455B ZA 200203455 A ZA200203455 A ZA 200203455A ZA 200203455 A ZA200203455 A ZA 200203455A ZA 200203455 B ZA200203455 B ZA 200203455B
Authority
ZA
South Africa
Prior art keywords
treatment
autoimmune diseases
steroid derivatives
methylene steroid
methylene
Prior art date
Application number
ZA200203455A
Other languages
English (en)
Inventor
Ralf Plate
Wilhelmina Maria Bagchus
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ZA200203455B publication Critical patent/ZA200203455B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200203455A 1999-11-29 2002-04-30 3-methylene steroid derivatives for the treatment of autoimmune diseases. ZA200203455B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99204000 1999-11-29

Publications (1)

Publication Number Publication Date
ZA200203455B true ZA200203455B (en) 2004-04-28

Family

ID=8240918

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200203455A ZA200203455B (en) 1999-11-29 2002-04-30 3-methylene steroid derivatives for the treatment of autoimmune diseases.

Country Status (30)

Country Link
US (2) US6579864B1 (fr)
EP (1) EP1240179B1 (fr)
JP (1) JP2003517472A (fr)
KR (1) KR100720326B1 (fr)
CN (1) CN1254479C (fr)
AR (1) AR033503A1 (fr)
AT (1) ATE319732T1 (fr)
AU (1) AU778773B2 (fr)
BR (1) BR0015950A (fr)
CA (1) CA2391096A1 (fr)
CO (1) CO5251432A1 (fr)
CY (1) CY1106088T1 (fr)
CZ (1) CZ20021837A3 (fr)
DE (1) DE60026608T2 (fr)
DK (1) DK1240179T3 (fr)
ES (1) ES2259624T3 (fr)
HK (1) HK1047595B (fr)
HU (1) HUP0203596A3 (fr)
IL (2) IL149412A0 (fr)
MX (1) MXPA02005334A (fr)
NO (1) NO323136B1 (fr)
NZ (1) NZ518756A (fr)
PE (1) PE20010980A1 (fr)
PL (1) PL355968A1 (fr)
PT (1) PT1240179E (fr)
RU (1) RU2248358C2 (fr)
SK (1) SK285398B6 (fr)
TW (1) TWI265167B (fr)
WO (1) WO2001040253A2 (fr)
ZA (1) ZA200203455B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
JP5599136B2 (ja) 2004-04-14 2014-10-01 ジェネンテック， インコーポレイテッド 血管の発達を調節するための、ｅｇｆｌ７アンタゴニストを含む組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1085035A (en) * 1913-05-01 1914-01-20 George H Greimann Ditch-digging machine.
US1171221A (en) * 1915-12-13 1916-02-08 Charles Ephriam Marion Combination-tool.
US3213117A (en) * 1963-07-03 1965-10-19 Syntex Corp Process for preparation of delta1(10)-5alpha-estren-17beta-ol-2-one and derivatives thereof
NL299654A (fr) 1963-10-23
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
EP0157739B1 (fr) 1984-03-29 1987-08-12 Ciba-Geigy Ag Propanoles-(1) substitués, procédé pour leur préparation, esters de l'acide chloroformique et leur utilisation
GB8513723D0 (en) 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids
IE63051B1 (en) * 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives

Also Published As

Publication number Publication date
KR20030024656A (ko) 2003-03-26
EP1240179B1 (fr) 2006-03-08
WO2001040253A3 (fr) 2002-05-02
AU778773B2 (en) 2004-12-23
RU2248358C2 (ru) 2005-03-20
WO2001040253A2 (fr) 2001-06-07
CA2391096A1 (fr) 2001-06-07
NO20022521D0 (no) 2002-05-28
DE60026608T2 (de) 2006-12-28
CY1106088T1 (el) 2011-06-08
HK1047595B (zh) 2006-05-04
IL149412A (en) 2007-07-24
US20040043972A1 (en) 2004-03-04
ES2259624T3 (es) 2006-10-16
TWI265167B (en) 2006-11-01
NO323136B1 (no) 2007-01-08
KR100720326B1 (ko) 2007-05-22
CN1402734A (zh) 2003-03-12
SK7272002A3 (en) 2002-09-10
SK285398B6 (sk) 2007-01-04
DK1240179T3 (da) 2006-07-03
HUP0203596A3 (en) 2003-12-29
ATE319732T1 (de) 2006-03-15
JP2003517472A (ja) 2003-05-27
PL355968A1 (en) 2004-05-31
CO5251432A1 (es) 2003-02-28
AR033503A1 (es) 2003-12-26
CN1254479C (zh) 2006-05-03
CZ20021837A3 (cs) 2002-08-14
NO20022521L (no) 2002-05-28
NZ518756A (en) 2004-05-28
EP1240179A2 (fr) 2002-09-18
US6579864B1 (en) 2003-06-17
HK1047595A1 (en) 2003-02-28
IL149412A0 (en) 2002-11-10
PE20010980A1 (es) 2001-10-02
DE60026608D1 (de) 2006-05-04
MXPA02005334A (es) 2003-04-10
HUP0203596A2 (hu) 2003-02-28
BR0015950A (pt) 2002-11-12
PT1240179E (pt) 2006-05-31
AU2508701A (en) 2001-06-12

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