ZA200202576B - Treatment of emphysema using RAR selective retinoid agonists. - Google Patents
Treatment of emphysema using RAR selective retinoid agonists. Download PDFInfo
- Publication number
- ZA200202576B ZA200202576B ZA200202576A ZA200202576A ZA200202576B ZA 200202576 B ZA200202576 B ZA 200202576B ZA 200202576 A ZA200202576 A ZA 200202576A ZA 200202576 A ZA200202576 A ZA 200202576A ZA 200202576 B ZA200202576 B ZA 200202576B
- Authority
- ZA
- South Africa
- Prior art keywords
- rar
- alkyl
- agonist
- carbons
- substance
- Prior art date
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
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| US16041599P | 1999-10-19 | 1999-10-19 |
Publications (1)
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| ZA200202576B true ZA200202576B (en) | 2003-09-23 |
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| ZA200202576A ZA200202576B (en) | 1999-10-19 | 2002-04-02 | Treatment of emphysema using RAR selective retinoid agonists. |
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| AT (1) | ATE344661T1 (zh) |
| AU (1) | AU777325B2 (zh) |
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| CA (1) | CA2387844C (zh) |
| CY (1) | CY1105941T1 (zh) |
| CZ (1) | CZ20021657A3 (zh) |
| DE (1) | DE60031790T2 (zh) |
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| HR (1) | HRP20020329A2 (zh) |
| HU (1) | HUP0203295A3 (zh) |
| IL (1) | IL149151A0 (zh) |
| JO (1) | JO2178B1 (zh) |
| MA (1) | MA26835A1 (zh) |
| MX (1) | MXPA02003843A (zh) |
| MY (1) | MY129001A (zh) |
| NO (1) | NO328738B1 (zh) |
| NZ (1) | NZ518118A (zh) |
| PE (1) | PE20010678A1 (zh) |
| PL (1) | PL357499A1 (zh) |
| PT (1) | PT1225878E (zh) |
| RS (1) | RS50165B (zh) |
| RU (1) | RU2257383C2 (zh) |
| TR (1) | TR200201071T2 (zh) |
| TW (1) | TWI288639B (zh) |
| WO (1) | WO2001030326A1 (zh) |
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Families Citing this family (17)
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| WO2000061233A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist |
| MXPA04002590A (es) | 2001-09-18 | 2004-06-18 | Hoffmann La Roche | Agonistas retinoides i de alquil urea. |
| KR100891224B1 (ko) | 2001-09-18 | 2009-04-01 | 에프. 호프만-라 로슈 아게 | 치환된 우레아 레티노이드 작용제 ⅱ |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| JP4926707B2 (ja) | 2003-08-22 | 2012-05-09 | ダニスコ エイ／エス | 封入化抗菌材料 |
| GB2388581A (en) | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| EP2394647A1 (en) * | 2006-11-02 | 2011-12-14 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain by modulation of glycogenolysis or glycolysis pathways |
| EP4066826B1 (en) | 2010-09-01 | 2024-03-06 | Thomas Jefferson University | Retinoic acid receptor gamma agonists for muscle repair and regeneration |
| EP3616701A1 (en) | 2011-06-24 | 2020-03-04 | GRI Bio, Inc. | Prevention and treatment of inflammatory conditions |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| WO2013019653A1 (en) * | 2011-07-29 | 2013-02-07 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| BR112015014178A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida |
| PT2931713T (pt) | 2012-12-17 | 2017-02-22 | Parion Sciences Inc | Derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por insuficiente hidratação das mucosas |
| ES2909884T3 (es) | 2013-08-20 | 2022-05-10 | Univ Washington Through Its Center For Commercialization | Inhibidores nuevos y específicos de la hidroxilasa del ácido retinoico del citocromo P450 26 |
| WO2015041809A2 (en) | 2013-08-26 | 2015-03-26 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU618590B2 (en) | 1988-04-11 | 1992-01-02 | Allergan, Inc. | Tetralin esters of phenols or benzoic acids having retinoid like activity |
| CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
| US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5726191A (en) | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
| FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
| AU749810B2 (en) * | 1997-11-12 | 2002-07-04 | Basilea Pharmaceutica Ag | Treatment of T-helper cell type 2 mediated immune diseases |
| US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
| WO2000061182A2 (en) | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a selective rar-alpha agonist |
| AU4225500A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| WO2000061233A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist |
| MXPA02000828A (es) * | 1999-08-02 | 2002-07-30 | Hoffmann La Roche | Nuevos antagonistas retinoiides selectivos. |
| US6479670B1 (en) * | 1999-08-25 | 2002-11-12 | Hoffmann-La Roche Inc. | Selective retinoid acid receptor agonists |
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- 2000-10-13 WO PCT/EP2000/010076 patent/WO2001030326A1/en active IP Right Grant
- 2000-10-13 PT PT00972754T patent/PT1225878E/pt unknown
- 2000-10-13 HU HU0203295A patent/HUP0203295A3/hu unknown
- 2000-10-13 CA CA002387844A patent/CA2387844C/en not_active Expired - Fee Related
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2003
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