ZA200202576B - Treatment of emphysema using RAR selective retinoid agonists. - Google Patents
Treatment of emphysema using RAR selective retinoid agonists. Download PDFInfo
- Publication number
- ZA200202576B ZA200202576B ZA200202576A ZA200202576A ZA200202576B ZA 200202576 B ZA200202576 B ZA 200202576B ZA 200202576 A ZA200202576 A ZA 200202576A ZA 200202576 A ZA200202576 A ZA 200202576A ZA 200202576 B ZA200202576 B ZA 200202576B
- Authority
- ZA
- South Africa
- Prior art keywords
- rar
- alkyl
- agonist
- carbons
- substance
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
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| US16041599P | 1999-10-19 | 1999-10-19 |
Publications (1)
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| ZA200202576B true ZA200202576B (en) | 2003-09-23 |
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| ZA200202576A ZA200202576B (en) | 1999-10-19 | 2002-04-02 | Treatment of emphysema using RAR selective retinoid agonists. |
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| CN (1) | CN1201730C (pt) |
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| AT (1) | ATE344661T1 (pt) |
| AU (1) | AU777325B2 (pt) |
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| CA (1) | CA2387844C (pt) |
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| CZ (1) | CZ20021657A3 (pt) |
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| HR (1) | HRP20020329A2 (pt) |
| HU (1) | HUP0203295A3 (pt) |
| IL (1) | IL149151A0 (pt) |
| JO (1) | JO2178B1 (pt) |
| MA (1) | MA26835A1 (pt) |
| MX (1) | MXPA02003843A (pt) |
| MY (1) | MY129001A (pt) |
| NO (1) | NO328738B1 (pt) |
| NZ (1) | NZ518118A (pt) |
| PE (1) | PE20010678A1 (pt) |
| PL (1) | PL357499A1 (pt) |
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| TR (1) | TR200201071T2 (pt) |
| TW (1) | TWI288639B (pt) |
| WO (1) | WO2001030326A1 (pt) |
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Families Citing this family (17)
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| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| JP4421293B2 (ja) * | 2001-09-18 | 2010-02-24 | エフ．ホフマン−ラ ロシュ アーゲー | アルキル尿素レチノイドアゴニストｉ |
| MXPA04002305A (es) | 2001-09-18 | 2004-06-29 | Hoffmann La Roche | Agonistas ii de retinoides de urea sustituida. |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| GB2388581A (en) | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| DK1656026T3 (da) | 2003-08-22 | 2014-07-14 | Dupont Nutrition Biosci Aps | Sammensætning, der omfatter et bakteriocin og et ekstrakt fra en plante fra læbeblomstfamilien |
| WO2008063842A2 (en) * | 2006-11-02 | 2008-05-29 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
| JP5986570B2 (ja) | 2010-09-01 | 2016-09-06 | トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 筋修復および再生のための組成物および方法 |
| EP2723347B1 (en) | 2011-06-24 | 2019-09-04 | GRI Bio, Inc. | Prevention and treatment of inflammatory conditions |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US20140155381A1 (en) * | 2011-07-29 | 2014-06-05 | Erkan Baloglu | Compounds and methods |
| BR112015014178A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida |
| RS55618B1 (sr) | 2012-12-17 | 2017-06-30 | Parion Sciences Inc | Derivati hloropirazin karboksamida korisni za lečenje bolesti kojima pogoduje nedovoljna hidracija sluznica |
| ES2909884T3 (es) | 2013-08-20 | 2022-05-10 | Univ Washington Through Its Center For Commercialization | Inhibidores nuevos y específicos de la hidroxilasa del ácido retinoico del citocromo P450 26 |
| US10500232B2 (en) | 2013-08-26 | 2019-12-10 | The J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0139216B1 (ko) | 1988-04-11 | 1998-05-01 | 제임스 엠. 캐내지 | 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 |
| CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
| US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5726191A (en) | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
| FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
| BR9814957A (pt) * | 1997-11-12 | 2000-10-03 | Hoffmann La Roche | Tratamento de doenças imune mediadas por célula auxiliar "t" tipo 2 com antagonistas retinóides |
| US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
| WO2000061232A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist |
| AU4222400A (en) | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| WO2001009076A2 (en) * | 1999-08-02 | 2001-02-08 | F. Hoffmann-La Roche Ag | Retinoids for the treatment of emphysema |
| US6479670B1 (en) * | 1999-08-25 | 2002-11-12 | Hoffmann-La Roche Inc. | Selective retinoid acid receptor agonists |
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2000
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- 2000-10-13 IL IL14915100A patent/IL149151A0/xx not_active IP Right Cessation
- 2000-10-13 NZ NZ518118A patent/NZ518118A/en not_active IP Right Cessation
- 2000-10-13 RS YUP-290/02A patent/RS50165B/sr unknown
- 2000-10-13 DK DK00972754T patent/DK1225878T3/da active
- 2000-10-13 BR BR0015225-0A patent/BR0015225A/pt not_active Application Discontinuation
- 2000-10-13 KR KR10-2002-7004950A patent/KR100485581B1/ko not_active IP Right Cessation
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2002
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2003
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2007
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