ZA200200783B - Purine derivatives inhibitors of tyrosine protein kinase syk. - Google Patents
Purine derivatives inhibitors of tyrosine protein kinase syk. Download PDFInfo
- Publication number
- ZA200200783B ZA200200783B ZA200200783A ZA200200783A ZA200200783B ZA 200200783 B ZA200200783 B ZA 200200783B ZA 200200783 A ZA200200783 A ZA 200200783A ZA 200200783 A ZA200200783 A ZA 200200783A ZA 200200783 B ZA200200783 B ZA 200200783B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- hydrogen
- ring
- group
- formula
- Prior art date
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- 102100038183 Tyrosine-protein kinase SYK Human genes 0.000 title description 3
- 101710104879 Tyrosine-protein kinase SYK Proteins 0.000 title description 3
- 239000003112 inhibitor Substances 0.000 title description 2
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title description 2
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 239000001257 hydrogen Substances 0.000 claims description 125
- 229910052739 hydrogen Inorganic materials 0.000 claims description 125
- 150000001875 compounds Chemical class 0.000 claims description 93
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 84
- 229910052757 nitrogen Inorganic materials 0.000 claims description 75
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 73
- 125000000217 alkyl group Chemical group 0.000 claims description 70
- 125000006413 ring segment Chemical group 0.000 claims description 60
- 125000000623 heterocyclic group Chemical group 0.000 claims description 53
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 44
- -1 benzocycloalkyl Chemical group 0.000 claims description 43
- 125000004432 carbon atom Chemical group C* 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 43
- 150000003839 salts Chemical group 0.000 claims description 39
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 34
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 33
- 229910052717 sulfur Chemical group 0.000 claims description 28
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 27
- 229910052760 oxygen Inorganic materials 0.000 claims description 27
- 239000001301 oxygen Substances 0.000 claims description 27
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 24
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 22
- 239000011593 sulfur Substances 0.000 claims description 22
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- 125000005842 heteroatom Chemical group 0.000 claims description 20
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 19
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims description 17
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 102000000551 Syk Kinase Human genes 0.000 claims description 9
- 108010016672 Syk Kinase Proteins 0.000 claims description 9
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- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 5
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (1)
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| GBGB9918035.8A GB9918035D0 (en) | 1999-07-30 | 1999-07-30 | Organic compounds |
Publications (1)
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| ZA200200783B true ZA200200783B (en) | 2003-04-30 |
Family
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| ZA200200783A ZA200200783B (en) | 1999-07-30 | 2002-01-29 | Purine derivatives inhibitors of tyrosine protein kinase syk. |
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- 2000-07-28 MY MYPI20003444 patent/MY126862A/en unknown
- 2000-07-28 NZ NZ516667A patent/NZ516667A/en unknown
- 2000-07-28 RU RU2002103305/04A patent/RU2248977C2/ru not_active IP Right Cessation
- 2000-07-28 HU HU0201935A patent/HUP0201935A3/hu unknown
- 2000-07-28 ES ES00953112T patent/ES2208395T3/es not_active Expired - Lifetime
- 2000-07-28 SK SK126-2002A patent/SK285730B6/sk not_active IP Right Cessation
- 2000-07-28 US US10/048,577 patent/US6589950B1/en not_active Expired - Lifetime
-
2002
- 2002-01-29 ZA ZA200200783A patent/ZA200200783B/en unknown
- 2002-01-29 NO NO20020467A patent/NO20020467L/no not_active Application Discontinuation
- 2002-09-25 HK HK02107013.6A patent/HK1046679A1/zh unknown
-
2007
- 2007-05-16 JP JP2007130684A patent/JP2007217426A/ja active Pending
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