ZA200108719B - Polymorph of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazoldine-2,4-dione, maleic acid salt. - Google Patents
Polymorph of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazoldine-2,4-dione, maleic acid salt. Download PDFInfo
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- ZA200108719B ZA200108719B ZA200108719A ZA200108719A ZA200108719B ZA 200108719 B ZA200108719 B ZA 200108719B ZA 200108719 A ZA200108719 A ZA 200108719A ZA 200108719 A ZA200108719 A ZA 200108719A ZA 200108719 B ZA200108719 B ZA 200108719B
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- polymorph
- provides
- diabetes mellitus
- polymorph according
- exemplified
- Prior art date
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title claims 2
- 150000002688 maleic acid derivatives Chemical class 0.000 title claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 33
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 206010012601 diabetes mellitus Diseases 0.000 claims description 22
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 13
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
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- -1 MALEIC ACID SALT Chemical class 0.000 description 3
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- 238000006243 chemical reaction Methods 0.000 description 3
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- 239000011976 maleic acid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 230000003893 regulation of appetite Effects 0.000 description 1
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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- 235000010199 sorbic acid Nutrition 0.000 description 1
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- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9909473.2A GB9909473D0 (en) | 1999-04-23 | 1999-04-23 | Novel compounds |
| GBGB9912196.4A GB9912196D0 (en) | 1999-05-25 | 1999-05-25 | Novel pharmaceutical |
| PCT/GB2000/001520 WO2000064896A1 (en) | 1999-04-23 | 2000-04-19 | Polymorph of 5-[4-[2- (n-methyl-n-( 2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2,4-dione, maleic acid salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200108719B true ZA200108719B (en) | 2002-06-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200108719A ZA200108719B (en) | 1999-04-23 | 2001-10-23 | Polymorph of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazoldine-2,4-dione, maleic acid salt. |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US6806280B1 (no) |
| EP (2) | EP1304330A3 (no) |
| JP (1) | JP2002543077A (no) |
| KR (1) | KR100744360B1 (no) |
| CN (1) | CN1167702C (no) |
| AP (1) | AP1598A (no) |
| AR (2) | AR023561A1 (no) |
| AT (1) | ATE246191T1 (no) |
| AU (1) | AU765005B2 (no) |
| BG (1) | BG65485B1 (no) |
| BR (1) | BR0009932A (no) |
| CA (1) | CA2370280A1 (no) |
| CO (1) | CO5170421A1 (no) |
| CZ (1) | CZ20013800A3 (no) |
| DE (1) | DE60004196T2 (no) |
| DK (1) | DK1173435T3 (no) |
| DZ (1) | DZ3156A1 (no) |
| EA (1) | EA004541B1 (no) |
| ES (1) | ES2203453T3 (no) |
| HK (1) | HK1045153B (no) |
| HR (1) | HRP20010772B1 (no) |
| HU (1) | HUP0200931A3 (no) |
| IL (1) | IL146111A0 (no) |
| MA (1) | MA25356A1 (no) |
| MX (1) | MXPA01010821A (no) |
| MY (1) | MY131973A (no) |
| NO (1) | NO320574B1 (no) |
| NZ (1) | NZ515168A (no) |
| OA (1) | OA11872A (no) |
| PE (1) | PE20010044A1 (no) |
| PL (1) | PL351684A1 (no) |
| PT (1) | PT1173435E (no) |
| SK (1) | SK286427B6 (no) |
| TR (1) | TR200103062T2 (no) |
| TW (1) | TWI283677B (no) |
| UA (1) | UA67844C2 (no) |
| UY (1) | UY26121A1 (no) |
| WO (1) | WO2000064896A1 (no) |
| YU (1) | YU75301A (no) |
| ZA (1) | ZA200108719B (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9726568D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
| US20020137940A1 (en) * | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
| TR200103062T2 (tr) * | 1999-04-23 | 2002-05-21 | Smithkline Beecham P.L.C. | Yeni farmasötik maddeler |
| US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
| RS50114B (sr) | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
| GB0006133D0 (en) | 2000-03-14 | 2000-05-03 | Smithkline Beecham Plc | Novel pharmaceutical |
| PL360661A1 (en) * | 2000-09-26 | 2004-09-20 | Dr.Reddy's Research Foundation | Novel polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation |
| US7241895B2 (en) | 2000-09-26 | 2007-07-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation |
| US7612095B2 (en) * | 2002-04-19 | 2009-11-03 | Faes Farma, S.A. | Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1-piperidinyl]ethyl]-αα-dimethyl-benzeneacetic acid |
| GB0307259D0 (en) * | 2003-03-28 | 2003-05-07 | Glaxo Group Ltd | Process |
| EP1468997A3 (en) * | 2003-04-18 | 2004-11-03 | CHEMI S.p.A. | Polymorphous forms of rosiglitazone maleate |
| GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
| WO2005073227A2 (en) * | 2004-01-28 | 2005-08-11 | Usv Limited | A process for the preparation of 5-[4-[2-[n-methyl-n-(2-pyridyl) amino] ethoxy] phenyl methyl] thiazolidine-2, 4-dione maleate |
| ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| US20090076093A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched rosiglitazone |
| EP2184055A1 (en) | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Process for preparing solid dosage forms of rosiglitazone maleate |
| JP2010013472A (ja) * | 2009-09-09 | 2010-01-21 | Faes Farma Sa | ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体 |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0842925A1 (en) | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB9124513D0 (en) | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| US6462337B1 (en) * | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
| US5741803A (en) | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| GB9218830D0 (en) | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| US5478852C1 (en) * | 1993-09-15 | 2001-03-13 | Sankyo Co | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus |
| DE4404198A1 (de) | 1994-02-10 | 1995-08-17 | Henkel Kgaa | 2-Fluor-6-nitroaniline |
| US6632947B2 (en) * | 1997-02-18 | 2003-10-14 | Smithkline Beecham Plc | Process for the preparation of substituted thiazolidinedione |
| UY24886A1 (es) * | 1997-02-18 | 2001-08-27 | Smithkline Beecham Plc | Tiazolidindiona |
| GB9711683D0 (en) * | 1997-06-05 | 1997-08-06 | Smithkline Beecham Plc | Composition |
| US7091359B2 (en) * | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
| GB9726566D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB9726563D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
| US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
| US6613785B2 (en) * | 1998-07-21 | 2003-09-02 | Smithkline Beecham Plc | Use of glucose uptake enhancer for reducing post-ischemic injury of the heart |
| RS50114B (sr) | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
| YU75401A (sh) | 1999-04-23 | 2004-09-03 | Smithkline Beecham P.L.C. | Polimorfni oblik soli maleinske kiseline 5-/4-/2-(n-metil- -(2-piridil)amino)etoksi/-benzil/tiazolidin-2,4-dion |
| TR200103062T2 (tr) * | 1999-04-23 | 2002-05-21 | Smithkline Beecham P.L.C. | Yeni farmasötik maddeler |
| CN1277965A (zh) | 2000-06-14 | 2000-12-27 | 中国医药研究开发中心 | 盐酸罗格列酮及其应用 |
| PL360661A1 (en) | 2000-09-26 | 2004-09-20 | Dr.Reddy's Research Foundation | Novel polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation |
-
2000
- 2000-04-19 TR TR2001/03062T patent/TR200103062T2/xx unknown
- 2000-04-19 BR BR0009932-5A patent/BR0009932A/pt not_active Application Discontinuation
- 2000-04-19 OA OA1200100276A patent/OA11872A/en unknown
- 2000-04-19 DK DK00920892T patent/DK1173435T3/da active
- 2000-04-19 AP APAP/P/2001/002330A patent/AP1598A/en active
- 2000-04-19 AR ARP000101862A patent/AR023561A1/es unknown
- 2000-04-19 AT AT00920892T patent/ATE246191T1/de not_active IP Right Cessation
- 2000-04-19 CZ CZ20013800A patent/CZ20013800A3/cs unknown
- 2000-04-19 UA UA2001117939A patent/UA67844C2/uk unknown
- 2000-04-19 IL IL14611100A patent/IL146111A0/xx unknown
- 2000-04-19 EA EA200101121A patent/EA004541B1/ru not_active IP Right Cessation
- 2000-04-19 ES ES00920892T patent/ES2203453T3/es not_active Expired - Lifetime
- 2000-04-19 SK SK1492-2001A patent/SK286427B6/sk not_active IP Right Cessation
- 2000-04-19 EP EP02080321A patent/EP1304330A3/en not_active Withdrawn
- 2000-04-19 YU YU75301A patent/YU75301A/sh unknown
- 2000-04-19 US US10/048,123 patent/US6806280B1/en not_active Expired - Fee Related
- 2000-04-19 DE DE60004196T patent/DE60004196T2/de not_active Expired - Fee Related
- 2000-04-19 CA CA002370280A patent/CA2370280A1/en not_active Abandoned
- 2000-04-19 WO PCT/GB2000/001520 patent/WO2000064896A1/en not_active Application Discontinuation
- 2000-04-19 EP EP00920892A patent/EP1173435B1/en not_active Expired - Lifetime
- 2000-04-19 DZ DZ003156A patent/DZ3156A1/xx active
- 2000-04-19 PE PE2000000365A patent/PE20010044A1/es not_active Application Discontinuation
- 2000-04-19 CN CNB008091463A patent/CN1167702C/zh not_active Expired - Fee Related
- 2000-04-19 AR ARP000101867A patent/AR023565A1/es unknown
- 2000-04-19 AU AU41308/00A patent/AU765005B2/en not_active Ceased
- 2000-04-19 PL PL00351684A patent/PL351684A1/xx not_active Application Discontinuation
- 2000-04-19 HU HU0200931A patent/HUP0200931A3/hu unknown
- 2000-04-19 CO CO00028929A patent/CO5170421A1/es not_active Application Discontinuation
- 2000-04-19 NZ NZ515168A patent/NZ515168A/xx unknown
- 2000-04-19 PT PT00920892T patent/PT1173435E/pt unknown
- 2000-04-19 JP JP2000614248A patent/JP2002543077A/ja active Pending
- 2000-04-19 KR KR1020017013540A patent/KR100744360B1/ko not_active IP Right Cessation
- 2000-04-19 MX MXPA01010821A patent/MXPA01010821A/es active IP Right Grant
- 2000-04-21 MY MYPI20001708A patent/MY131973A/en unknown
- 2000-04-24 UY UY26121A patent/UY26121A1/es not_active Application Discontinuation
- 2000-05-11 TW TW089108962A patent/TWI283677B/zh not_active IP Right Cessation
-
2001
- 2001-10-22 HR HR20010772A patent/HRP20010772B1/xx not_active IP Right Cessation
- 2001-10-22 MA MA26378A patent/MA25356A1/fr unknown
- 2001-10-22 NO NO20015147A patent/NO320574B1/no unknown
- 2001-10-23 ZA ZA200108719A patent/ZA200108719B/en unknown
- 2001-11-20 BG BG106121A patent/BG65485B1/bg unknown
-
2002
- 2002-06-28 HK HK02104879.6A patent/HK1045153B/zh not_active IP Right Cessation
-
2004
- 2004-09-08 US US10/935,939 patent/US20050080114A1/en not_active Abandoned
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