ZA200107631B - Indoline derivatives as progesterone antagonists. - Google Patents
Indoline derivatives as progesterone antagonists.Info
- Publication number
- ZA200107631B ZA200107631B ZA200107631A ZA200107631A ZA200107631B ZA 200107631 B ZA200107631 B ZA 200107631B ZA 200107631 A ZA200107631 A ZA 200107631A ZA 200107631 A ZA200107631 A ZA 200107631A ZA 200107631 B ZA200107631 B ZA 200107631B
- Authority
- ZA
- South Africa
- Prior art keywords
- indoline derivatives
- progesterone antagonists
- antagonists
- progesterone
- benign
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18305899P | 1999-05-04 | 1999-05-04 | |
US09/552,632 US6391907B1 (en) | 1999-05-04 | 2000-04-19 | Indoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200107631B true ZA200107631B (en) | 2002-05-14 |
Family
ID=26878706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200107631A ZA200107631B (en) | 1999-05-04 | 2001-09-17 | Indoline derivatives as progesterone antagonists. |
Country Status (21)
Country | Link |
---|---|
US (5) | US6391907B1 (sh) |
EP (1) | EP1175398B1 (sh) |
JP (1) | JP2002543183A (sh) |
KR (1) | KR20010114252A (sh) |
CN (1) | CN1141295C (sh) |
AT (1) | ATE366721T1 (sh) |
AU (1) | AU4814100A (sh) |
BR (1) | BR0010215A (sh) |
CA (1) | CA2371638A1 (sh) |
CZ (1) | CZ20013953A3 (sh) |
DE (1) | DE60035496T2 (sh) |
DK (1) | DK1175398T3 (sh) |
EA (1) | EA200101177A1 (sh) |
ES (1) | ES2290035T3 (sh) |
HU (1) | HUP0200992A3 (sh) |
IL (1) | IL146281A0 (sh) |
MX (1) | MXPA01011298A (sh) |
NO (1) | NO20015379L (sh) |
PL (1) | PL351954A1 (sh) |
WO (1) | WO2000066556A1 (sh) |
ZA (1) | ZA200107631B (sh) |
Families Citing this family (55)
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US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6417214B1 (en) * | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
US7119076B2 (en) * | 2000-11-15 | 2006-10-10 | Masao Sugamata | Preventives or remedies for endometriosis or uterine myoma |
IL165395A0 (en) * | 2002-06-25 | 2006-01-15 | Wyeth Corp | Use of thio-oxubdile derivatives in treatment of hormone-related conditions |
US7115649B2 (en) | 2002-06-25 | 2006-10-03 | Wyeth | Methods of treating skin disorders using thio-oxindole derivatives |
EP1558618A1 (en) * | 2002-10-11 | 2005-08-03 | Ligand Pharmaceuticals, Inc. | 5-(1 ,1 -CYCLOALKYL/ALKENYL)METHYLIDENE 1,2-DIHYDRO- 5H /-CHROMENO[3,4-f ] QUINOLINES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS |
EP1551845A1 (en) * | 2002-10-11 | 2005-07-13 | Ligand Pharmaceuticals, Inc. | 5-CYCLOALKENYL 5 i H /i -CHROMENO 3,4-F QUINOLINE DERIV ATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS |
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US7323455B2 (en) * | 2004-03-24 | 2008-01-29 | Wyeth | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators |
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US20070066628A1 (en) * | 2005-09-19 | 2007-03-22 | Wyeth | 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators |
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US7414142B2 (en) * | 2005-09-19 | 2008-08-19 | Wyeth | 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators |
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SI3263112T1 (sl) | 2006-10-24 | 2020-10-30 | Allergan Pharmaceuticals International Limited | Sestavki in metode za zaviranje endometrijskih proliferacij |
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-
2000
- 2000-04-19 US US09/552,632 patent/US6391907B1/en not_active Expired - Fee Related
- 2000-05-01 DK DK00930289T patent/DK1175398T3/da active
- 2000-05-01 BR BR0010215-6A patent/BR0010215A/pt not_active Application Discontinuation
- 2000-05-01 JP JP2000615387A patent/JP2002543183A/ja not_active Withdrawn
- 2000-05-01 MX MXPA01011298A patent/MXPA01011298A/es active IP Right Grant
- 2000-05-01 EP EP00930289A patent/EP1175398B1/en not_active Expired - Lifetime
- 2000-05-01 HU HU0200992A patent/HUP0200992A3/hu unknown
- 2000-05-01 CA CA002371638A patent/CA2371638A1/en not_active Abandoned
- 2000-05-01 CZ CZ20013953A patent/CZ20013953A3/cs unknown
- 2000-05-01 EA EA200101177A patent/EA200101177A1/ru unknown
- 2000-05-01 DE DE60035496T patent/DE60035496T2/de not_active Expired - Fee Related
- 2000-05-01 PL PL00351954A patent/PL351954A1/xx not_active Application Discontinuation
- 2000-05-01 AT AT00930289T patent/ATE366721T1/de not_active IP Right Cessation
- 2000-05-01 ES ES00930289T patent/ES2290035T3/es not_active Expired - Lifetime
- 2000-05-01 WO PCT/US2000/011847 patent/WO2000066556A1/en not_active Application Discontinuation
- 2000-05-01 IL IL14628100A patent/IL146281A0/xx unknown
- 2000-05-01 CN CNB008071411A patent/CN1141295C/zh not_active Expired - Fee Related
- 2000-05-01 KR KR1020017014012A patent/KR20010114252A/ko not_active Application Discontinuation
- 2000-05-01 AU AU48141/00A patent/AU4814100A/en not_active Abandoned
-
2001
- 2001-09-17 ZA ZA200107631A patent/ZA200107631B/xx unknown
- 2001-11-02 NO NO20015379A patent/NO20015379L/no not_active Application Discontinuation
- 2001-12-11 US US10/014,173 patent/US6608068B2/en not_active Expired - Fee Related
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2003
- 2003-06-06 US US10/456,892 patent/US7084168B2/en not_active Expired - Fee Related
-
2006
- 2006-03-17 US US11/378,851 patent/US7253203B2/en not_active Expired - Fee Related
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Also Published As
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US20020086874A1 (en) | 2002-07-04 |
BR0010215A (pt) | 2002-02-13 |
US7084168B2 (en) | 2006-08-01 |
IL146281A0 (en) | 2002-07-25 |
KR20010114252A (ko) | 2001-12-31 |
EP1175398A1 (en) | 2002-01-30 |
US6391907B1 (en) | 2002-05-21 |
CA2371638A1 (en) | 2000-11-09 |
US20070259944A1 (en) | 2007-11-08 |
JP2002543183A (ja) | 2002-12-17 |
CN1350523A (zh) | 2002-05-22 |
EP1175398B1 (en) | 2007-07-11 |
US7253203B2 (en) | 2007-08-07 |
US20030220388A1 (en) | 2003-11-27 |
NO20015379D0 (no) | 2001-11-02 |
HUP0200992A2 (hu) | 2002-07-29 |
HUP0200992A3 (en) | 2004-12-28 |
US20060160882A1 (en) | 2006-07-20 |
CZ20013953A3 (cs) | 2002-06-12 |
US7645761B2 (en) | 2010-01-12 |
DK1175398T3 (da) | 2007-11-05 |
ES2290035T3 (es) | 2008-02-16 |
NO20015379L (no) | 2002-01-03 |
EA200101177A1 (ru) | 2002-04-25 |
WO2000066556A1 (en) | 2000-11-09 |
DE60035496T2 (de) | 2008-03-13 |
MXPA01011298A (es) | 2003-07-14 |
DE60035496D1 (de) | 2007-08-23 |
AU4814100A (en) | 2000-11-17 |
PL351954A1 (en) | 2003-07-14 |
ATE366721T1 (de) | 2007-08-15 |
CN1141295C (zh) | 2004-03-10 |
US6608068B2 (en) | 2003-08-19 |
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