IL146281A0 - Indoline derivatives as progesterone antagonists - Google Patents
Indoline derivatives as progesterone antagonistsInfo
- Publication number
- IL146281A0 IL146281A0 IL14628100A IL14628100A IL146281A0 IL 146281 A0 IL146281 A0 IL 146281A0 IL 14628100 A IL14628100 A IL 14628100A IL 14628100 A IL14628100 A IL 14628100A IL 146281 A0 IL146281 A0 IL 146281A0
- Authority
- IL
- Israel
- Prior art keywords
- indoline derivatives
- progesterone antagonists
- antagonists
- progesterone
- benign
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18305899P | 1999-05-04 | 1999-05-04 | |
US09/552,632 US6391907B1 (en) | 1999-05-04 | 2000-04-19 | Indoline derivatives |
PCT/US2000/011847 WO2000066556A1 (en) | 1999-05-04 | 2000-05-01 | Indoline derivatives as progesterone antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IL146281A0 true IL146281A0 (en) | 2002-07-25 |
Family
ID=26878706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14628100A IL146281A0 (en) | 1999-05-04 | 2000-05-01 | Indoline derivatives as progesterone antagonists |
Country Status (21)
Country | Link |
---|---|
US (5) | US6391907B1 (xx) |
EP (1) | EP1175398B1 (xx) |
JP (1) | JP2002543183A (xx) |
KR (1) | KR20010114252A (xx) |
CN (1) | CN1141295C (xx) |
AT (1) | ATE366721T1 (xx) |
AU (1) | AU4814100A (xx) |
BR (1) | BR0010215A (xx) |
CA (1) | CA2371638A1 (xx) |
CZ (1) | CZ20013953A3 (xx) |
DE (1) | DE60035496T2 (xx) |
DK (1) | DK1175398T3 (xx) |
EA (1) | EA200101177A1 (xx) |
ES (1) | ES2290035T3 (xx) |
HU (1) | HUP0200992A3 (xx) |
IL (1) | IL146281A0 (xx) |
MX (1) | MXPA01011298A (xx) |
NO (1) | NO20015379L (xx) |
PL (1) | PL351954A1 (xx) |
WO (1) | WO2000066556A1 (xx) |
ZA (1) | ZA200107631B (xx) |
Families Citing this family (55)
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US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6417214B1 (en) * | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
WO2002040036A1 (fr) * | 2000-11-15 | 2002-05-23 | Masao Sugamata | Medicaments destines a la prevention ou au traitement de l'endometriose ou du myome uterin |
WO2004000227A2 (en) * | 2002-06-25 | 2003-12-31 | Wyeth | Use of thio-oxindole derivatives in treatment of skin disorders |
MXPA04012419A (es) | 2002-06-25 | 2005-04-19 | Wyeth Corp | Uso de derivados de tio-oxindol en el tratamiento de condiciones relacionadas con la hormona. |
CA2501833A1 (en) * | 2002-10-11 | 2004-04-22 | Ligand Pharmaceuticals Incorporated | 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5h-chromeno[3,4-f]quinolines as selective progesterone receptor modulator compounds |
HK1055058A2 (en) * | 2002-10-11 | 2003-12-05 | Ligand Pharm Inc | 5-CYCLOALKENYL 5H-CHROMENO[3,4-f]QUINOLINE DERIVATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS |
WO2004037247A1 (en) * | 2002-10-21 | 2004-05-06 | Irm Llc | Oxindoles with anti-hiv activity |
US7247625B2 (en) | 2003-10-09 | 2007-07-24 | Wyeth | 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators |
US7323455B2 (en) * | 2004-03-24 | 2008-01-29 | Wyeth | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
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ATE413398T1 (de) * | 2004-04-08 | 2008-11-15 | Wyeth Corp | Thioamidderivate als progesteronrezeptormodulatoren |
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CN1953967B (zh) * | 2004-04-27 | 2013-03-13 | 惠氏公司 | 孕酮受体调节剂的纯化 |
GT200500186A (es) * | 2004-07-07 | 2006-03-02 | Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits | |
GT200500183A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
ES2513115T3 (es) * | 2004-10-27 | 2014-10-24 | Janssen Pharmaceutica Nv | Piridina imidazoles y aza-indoles como moduladores de los receptores de progesterona |
US7414142B2 (en) * | 2005-09-19 | 2008-08-19 | Wyeth | 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators |
US20070066628A1 (en) * | 2005-09-19 | 2007-03-22 | Wyeth | 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators |
US7319152B2 (en) * | 2005-09-19 | 2008-01-15 | Wyeth | 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators |
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US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
CA2673128C (en) | 2006-10-24 | 2018-07-03 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
TW200848021A (en) * | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
US20080312306A1 (en) * | 2007-06-15 | 2008-12-18 | Wyeth | Polymorphs, solvates, and hydrate of 5-(4'-fluoro-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-5'-yl)-1-methyl-1h-pyrrole-2-carbonitrile |
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JP5894143B2 (ja) | 2010-03-22 | 2016-03-23 | リプロス セラピューティクス インコーポレイテッド | 抗黄体ホルモンの無毒送達のための組成物および方法 |
CN102516151B (zh) * | 2011-11-11 | 2013-09-11 | 华东师范大学 | 一种3-取代-3-羟基吲哚酮衍生物及其制备方法和应用 |
US9309261B2 (en) | 2012-10-12 | 2016-04-12 | Okinawa Institute Of Science And Technology School Corporation | Spirooxindole derivative and process for producing the same |
CN103242332B (zh) * | 2013-05-13 | 2015-11-04 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物 |
CN104530065A (zh) * | 2013-05-13 | 2015-04-22 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物的应用 |
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US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
CN106316922B (zh) * | 2016-08-17 | 2019-02-01 | 华东师范大学 | 一种含c-3全取代氧化吲哚衍生物及其合成方法和应用 |
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WO2020227549A1 (en) | 2019-05-08 | 2020-11-12 | Aligos Therapeutics, Inc. | MODULATORS OF THR-β AND METHODS OF USE THEREOF |
CN113456631B (zh) * | 2021-08-06 | 2022-06-21 | 徐州医科大学 | 一种靶向acsl1的小分子药物及其在治疗子宫内膜癌中的应用 |
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-
2000
- 2000-04-19 US US09/552,632 patent/US6391907B1/en not_active Expired - Fee Related
- 2000-05-01 AU AU48141/00A patent/AU4814100A/en not_active Abandoned
- 2000-05-01 CZ CZ20013953A patent/CZ20013953A3/cs unknown
- 2000-05-01 CN CNB008071411A patent/CN1141295C/zh not_active Expired - Fee Related
- 2000-05-01 MX MXPA01011298A patent/MXPA01011298A/es active IP Right Grant
- 2000-05-01 CA CA002371638A patent/CA2371638A1/en not_active Abandoned
- 2000-05-01 EA EA200101177A patent/EA200101177A1/ru unknown
- 2000-05-01 DK DK00930289T patent/DK1175398T3/da active
- 2000-05-01 EP EP00930289A patent/EP1175398B1/en not_active Expired - Lifetime
- 2000-05-01 AT AT00930289T patent/ATE366721T1/de not_active IP Right Cessation
- 2000-05-01 DE DE60035496T patent/DE60035496T2/de not_active Expired - Fee Related
- 2000-05-01 WO PCT/US2000/011847 patent/WO2000066556A1/en not_active Application Discontinuation
- 2000-05-01 BR BR0010215-6A patent/BR0010215A/pt not_active Application Discontinuation
- 2000-05-01 IL IL14628100A patent/IL146281A0/xx unknown
- 2000-05-01 ES ES00930289T patent/ES2290035T3/es not_active Expired - Lifetime
- 2000-05-01 PL PL00351954A patent/PL351954A1/xx not_active Application Discontinuation
- 2000-05-01 JP JP2000615387A patent/JP2002543183A/ja not_active Withdrawn
- 2000-05-01 KR KR1020017014012A patent/KR20010114252A/ko not_active Application Discontinuation
- 2000-05-01 HU HU0200992A patent/HUP0200992A3/hu unknown
-
2001
- 2001-09-17 ZA ZA200107631A patent/ZA200107631B/xx unknown
- 2001-11-02 NO NO20015379A patent/NO20015379L/no not_active Application Discontinuation
- 2001-12-11 US US10/014,173 patent/US6608068B2/en not_active Expired - Fee Related
-
2003
- 2003-06-06 US US10/456,892 patent/US7084168B2/en not_active Expired - Fee Related
-
2006
- 2006-03-17 US US11/378,851 patent/US7253203B2/en not_active Expired - Fee Related
-
2007
- 2007-06-22 US US11/821,384 patent/US7645761B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7645761B2 (en) | 2010-01-12 |
CZ20013953A3 (cs) | 2002-06-12 |
HUP0200992A3 (en) | 2004-12-28 |
US20070259944A1 (en) | 2007-11-08 |
EP1175398A1 (en) | 2002-01-30 |
AU4814100A (en) | 2000-11-17 |
MXPA01011298A (es) | 2003-07-14 |
ES2290035T3 (es) | 2008-02-16 |
US20020086874A1 (en) | 2002-07-04 |
HUP0200992A2 (hu) | 2002-07-29 |
ATE366721T1 (de) | 2007-08-15 |
EP1175398B1 (en) | 2007-07-11 |
WO2000066556A1 (en) | 2000-11-09 |
JP2002543183A (ja) | 2002-12-17 |
KR20010114252A (ko) | 2001-12-31 |
CN1350523A (zh) | 2002-05-22 |
US6391907B1 (en) | 2002-05-21 |
EA200101177A1 (ru) | 2002-04-25 |
DE60035496T2 (de) | 2008-03-13 |
DK1175398T3 (da) | 2007-11-05 |
US7253203B2 (en) | 2007-08-07 |
CN1141295C (zh) | 2004-03-10 |
NO20015379D0 (no) | 2001-11-02 |
US20030220388A1 (en) | 2003-11-27 |
US7084168B2 (en) | 2006-08-01 |
US6608068B2 (en) | 2003-08-19 |
NO20015379L (no) | 2002-01-03 |
PL351954A1 (en) | 2003-07-14 |
DE60035496D1 (de) | 2007-08-23 |
BR0010215A (pt) | 2002-02-13 |
US20060160882A1 (en) | 2006-07-20 |
ZA200107631B (en) | 2002-05-14 |
CA2371638A1 (en) | 2000-11-09 |
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