ZA200105070B - Apparatus and process for preparing crystalline particles. - Google Patents
Apparatus and process for preparing crystalline particles. Download PDFInfo
- Publication number
- ZA200105070B ZA200105070B ZA200105070A ZA200105070A ZA200105070B ZA 200105070 B ZA200105070 B ZA 200105070B ZA 200105070 A ZA200105070 A ZA 200105070A ZA 200105070 A ZA200105070 A ZA 200105070A ZA 200105070 B ZA200105070 B ZA 200105070B
- Authority
- ZA
- South Africa
- Prior art keywords
- substance
- solvent
- process according
- particles
- mixing chamber
- Prior art date
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- 239000002245 particle Substances 0.000 title claims description 103
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 239000000126 substance Substances 0.000 claims description 73
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 59
- 239000012296 anti-solvent Substances 0.000 claims description 53
- 238000002156 mixing Methods 0.000 claims description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 45
- 230000008569 process Effects 0.000 claims description 39
- 239000002904 solvent Substances 0.000 claims description 38
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 36
- 239000007788 liquid Substances 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 31
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 29
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- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical group C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 21
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
- B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
- B01F31/85—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nozzles (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9828721.2A GB9828721D0 (en) | 1998-12-24 | 1998-12-24 | Novel apparatus and process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105070B true ZA200105070B (en) | 2002-09-20 |
Family
ID=10845091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105070A ZA200105070B (en) | 1998-12-24 | 2001-06-20 | Apparatus and process for preparing crystalline particles. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6482438B1 (no) |
| EP (1) | EP1144065A1 (no) |
| JP (1) | JP3588050B2 (no) |
| KR (1) | KR20010099933A (no) |
| CN (1) | CN1335787A (no) |
| AU (1) | AU759880B2 (no) |
| BR (1) | BR9916587A (no) |
| CA (1) | CA2356897A1 (no) |
| CZ (1) | CZ20012331A3 (no) |
| GB (1) | GB9828721D0 (no) |
| HK (1) | HK1038709A1 (no) |
| HU (1) | HUP0104855A3 (no) |
| IL (1) | IL143811A (no) |
| NO (1) | NO20013039L (no) |
| NZ (1) | NZ512400A (no) |
| PL (1) | PL349345A1 (no) |
| TR (1) | TR200101845T2 (no) |
| WO (1) | WO2000038811A1 (no) |
| ZA (1) | ZA200105070B (no) |
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| US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
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| US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| FI20002215A0 (fi) * | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit |
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| US7811381B2 (en) * | 2006-06-14 | 2010-10-12 | Sirkar Kamalesh K | Antisolvent crystallization in porous hollow fiber devices and methods of use thereof |
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| DE102009008478A1 (de) | 2009-02-11 | 2010-08-19 | PHAST Gesellschaft für pharmazeutische Qualitätsstandards mbH | Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren |
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| DK3517541T3 (da) * | 2012-05-08 | 2020-09-07 | Nicox Ophthalmics Inc | Polymorf form af fluticasonpropionat |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| DE102012221219B4 (de) * | 2012-11-20 | 2014-05-28 | Jesalis Pharma Gmbh | Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel |
| US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US9452930B2 (en) * | 2013-11-04 | 2016-09-27 | New Jersey Institute Of Technology | System and method for continuous polymer coating of particles |
| CN103977593B (zh) * | 2014-05-19 | 2017-01-04 | 中国工程物理研究院化工材料研究所 | 制备纳米共晶含能材料的方法及装置 |
| CN105012237B (zh) * | 2015-08-10 | 2018-09-11 | 重庆华邦制药有限公司 | 糠酸氟替卡松鼻喷雾剂及其制备方法 |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| CN109012260B (zh) * | 2018-09-06 | 2020-10-02 | 董旭 | 一种便于配比的麻醉药物混合器 |
| WO2020205539A1 (en) | 2019-03-29 | 2020-10-08 | Vizuri Health Sciences Consumer Healthcare, Inc. | Compositions and methods for the prevention and treatment of radiation dermatitis, eczema, burns, wounds and certain cancers |
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| US3979269A (en) | 1975-02-25 | 1976-09-07 | DSO "Pharmachim | Method for obtaining tetracyclinehydrochloride |
| DE68907062T2 (de) * | 1988-10-05 | 1993-10-07 | Upjohn Co | Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel. |
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-
1998
- 1998-12-24 GB GBGB9828721.2A patent/GB9828721D0/en not_active Ceased
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1999
- 1999-07-07 US US09/348,948 patent/US6482438B1/en not_active Expired - Fee Related
- 1999-12-22 PL PL99349345A patent/PL349345A1/xx unknown
- 1999-12-22 BR BR9916587-2A patent/BR9916587A/pt not_active IP Right Cessation
- 1999-12-22 HU HU0104855A patent/HUP0104855A3/hu unknown
- 1999-12-22 KR KR1020017008081A patent/KR20010099933A/ko active IP Right Grant
- 1999-12-22 WO PCT/GB1999/004368 patent/WO2000038811A1/en not_active Application Discontinuation
- 1999-12-22 CA CA002356897A patent/CA2356897A1/en not_active Abandoned
- 1999-12-22 EP EP99962413A patent/EP1144065A1/en not_active Ceased
- 1999-12-22 AU AU18771/00A patent/AU759880B2/en not_active Ceased
- 1999-12-22 IL IL14381199A patent/IL143811A/xx not_active IP Right Cessation
- 1999-12-22 TR TR2001/01845T patent/TR200101845T2/xx unknown
- 1999-12-22 CN CN99816326A patent/CN1335787A/zh active Pending
- 1999-12-22 CZ CZ20012331A patent/CZ20012331A3/cs unknown
- 1999-12-22 NZ NZ512400A patent/NZ512400A/xx unknown
- 1999-12-22 JP JP2000590755A patent/JP3588050B2/ja not_active Expired - Fee Related
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2001
- 2001-06-19 NO NO20013039A patent/NO20013039L/no not_active Application Discontinuation
- 2001-06-20 ZA ZA200105070A patent/ZA200105070B/en unknown
-
2002
- 2002-01-09 HK HK02100141.6A patent/HK1038709A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20012331A3 (cs) | 2002-03-13 |
| AU1877100A (en) | 2000-07-31 |
| NO20013039L (no) | 2001-08-22 |
| US6482438B1 (en) | 2002-11-19 |
| BR9916587A (pt) | 2001-09-25 |
| NZ512400A (en) | 2003-02-28 |
| TR200101845T2 (tr) | 2001-10-22 |
| IL143811A (en) | 2005-06-19 |
| EP1144065A1 (en) | 2001-10-17 |
| GB9828721D0 (en) | 1999-02-17 |
| AU759880B2 (en) | 2003-05-01 |
| IL143811A0 (en) | 2002-04-21 |
| PL349345A1 (en) | 2002-07-15 |
| HUP0104855A2 (hu) | 2002-04-29 |
| NO20013039D0 (no) | 2001-06-19 |
| KR20010099933A (ko) | 2001-11-09 |
| HUP0104855A3 (en) | 2005-12-28 |
| HK1038709A1 (zh) | 2002-03-28 |
| CN1335787A (zh) | 2002-02-13 |
| JP2002533205A (ja) | 2002-10-08 |
| WO2000038811A1 (en) | 2000-07-06 |
| JP3588050B2 (ja) | 2004-11-10 |
| CA2356897A1 (en) | 2000-07-06 |
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