ZA200006370B - Humanized antibodies that recognize verotoxin II and cell line producing same. - Google Patents
Humanized antibodies that recognize verotoxin II and cell line producing same. Download PDFInfo
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- ZA200006370B ZA200006370B ZA200006370A ZA200006370A ZA200006370B ZA 200006370 B ZA200006370 B ZA 200006370B ZA 200006370 A ZA200006370 A ZA 200006370A ZA 200006370 A ZA200006370 A ZA 200006370A ZA 200006370 B ZA200006370 B ZA 200006370B
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- South Africa
- Prior art keywords
- antibody
- humanized
- verotoxin
- mouse
- variant
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8657098P | 1998-05-20 | 1998-05-20 |
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| ZA200006370B true ZA200006370B (en) | 2001-08-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200006370A ZA200006370B (en) | 1998-05-20 | 2000-11-07 | Humanized antibodies that recognize verotoxin II and cell line producing same. |
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|---|---|
| US (1) | US7846435B1 (ru) |
| EP (1) | EP1079856B1 (ru) |
| JP (1) | JP4044733B2 (ru) |
| KR (1) | KR100548167B1 (ru) |
| CN (1) | CN1330375C (ru) |
| AT (1) | ATE335504T1 (ru) |
| AU (1) | AU748852B2 (ru) |
| BR (1) | BR9910589A (ru) |
| CA (1) | CA2328485C (ru) |
| DE (1) | DE69932719T2 (ru) |
| DK (1) | DK1079856T3 (ru) |
| ES (1) | ES2270598T3 (ru) |
| HK (1) | HK1036215A1 (ru) |
| IL (2) | IL139571A0 (ru) |
| NO (1) | NO326197B1 (ru) |
| NZ (1) | NZ508119A (ru) |
| PT (1) | PT1079856E (ru) |
| RU (1) | RU2217166C2 (ru) |
| WO (1) | WO1999059629A1 (ru) |
| ZA (1) | ZA200006370B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910096B2 (en) | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
| JP2009536818A (ja) | 2006-04-20 | 2009-10-22 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 志賀毒性１型タンパク質に基づく方法および組成物 |
| CN102292098A (zh) | 2009-01-23 | 2011-12-21 | 杰克孙M.亨利基金会先进军事医学有限公司 | 基于志贺毒素2型蛋白的方法和组合物 |
| US10633639B2 (en) | 2013-05-27 | 2020-04-28 | Immunova S.A. | Chimeras of Brucella lumazine synthase and beta subunit of AB5 toxins |
| ES2747760T3 (es) * | 2014-01-16 | 2020-03-11 | Mario Umberto Francesco Mondelli | Neutralización de anticuerpos monoclonales humanos contra el antígeno de superficie del virus de la hepatitis B |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP3236667B2 (ja) | 1991-06-28 | 2001-12-10 | 三菱化学株式会社 | ヒト型モノクローナル抗体およびそれをコードする遺伝子、ハイブリドーマ並びに抗腫瘍剤 |
| GB9125979D0 (en) | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
| CA2132953C (en) | 1992-03-26 | 2001-01-30 | Howard C. Krivan | Monospecific polyclonal antibodies to shiga-like toxins |
| CA2078716A1 (en) | 1992-09-21 | 1994-03-22 | Joyce De Azavedo | Attaching and effacing protein of enterohemorrhagic e. coli |
| US5747272A (en) | 1994-02-14 | 1998-05-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Detection of shiga-like toxins of enterohemoragic Escherichia coli |
| CA2116179C (en) | 1994-02-22 | 2008-01-08 | C. A. Lingwood | Verotoxin pharmaceutical compositions and medical treatments therewith |
| CA2218601A1 (en) | 1995-03-24 | 1996-10-03 | Ophidian Pharmaceuticals, Inc. | Treatment for verotoxin-producing escherichia coli |
| CA2163716C (en) | 1995-11-24 | 2009-05-19 | Clifford A. Lingwood | Verotoxin pharmaceutical compositions and medical treatments therewith |
| DE19641466A1 (de) | 1996-10-09 | 1998-04-16 | Biotest Pharma Gmbh | Orale Anwendung eines Immunglobulinpräparates zur Prävention des Hämolytischen Urämischen Syndroms sowie Präparat hierfür |
| WO1998020903A1 (en) * | 1996-11-15 | 1998-05-22 | Trustees Of Tufts College | Humanized neutralizing antibodies against hemolytic uremic syndrome |
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
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1999
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- 1999-05-19 RU RU2000132226/14A patent/RU2217166C2/ru not_active IP Right Cessation
- 1999-05-19 JP JP2000549293A patent/JP4044733B2/ja not_active Expired - Fee Related
- 1999-05-19 AU AU40904/99A patent/AU748852B2/en not_active Ceased
- 1999-05-19 CA CA2328485A patent/CA2328485C/en not_active Expired - Fee Related
- 1999-05-19 KR KR1020007012995A patent/KR100548167B1/ko not_active IP Right Cessation
- 1999-05-19 ES ES99924395T patent/ES2270598T3/es not_active Expired - Lifetime
- 1999-05-19 US US09/700,851 patent/US7846435B1/en not_active Expired - Fee Related
- 1999-05-19 PT PT99924395T patent/PT1079856E/pt unknown
- 1999-05-19 DK DK99924395T patent/DK1079856T3/da active
- 1999-05-19 BR BR9910589-6A patent/BR9910589A/pt not_active IP Right Cessation
- 1999-05-19 IL IL13957199A patent/IL139571A0/xx unknown
- 1999-05-19 EP EP99924395A patent/EP1079856B1/en not_active Expired - Lifetime
- 1999-05-19 WO PCT/US1999/011179 patent/WO1999059629A1/en active IP Right Grant
- 1999-05-19 CN CNB998063835A patent/CN1330375C/zh not_active Expired - Fee Related
- 1999-05-19 DE DE69932719T patent/DE69932719T2/de not_active Expired - Lifetime
- 1999-05-19 AT AT99924395T patent/ATE335504T1/de active
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2000
- 2000-11-07 ZA ZA200006370A patent/ZA200006370B/en unknown
- 2000-11-09 IL IL139571A patent/IL139571A/en not_active IP Right Cessation
- 2000-11-17 NO NO20005833A patent/NO326197B1/no not_active IP Right Cessation
-
2001
- 2001-09-07 HK HK01106324A patent/HK1036215A1/xx not_active IP Right Cessation
Also Published As
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|---|---|
| EP1079856A1 (en) | 2001-03-07 |
| NZ508119A (en) | 2003-06-30 |
| EP1079856B1 (en) | 2006-08-09 |
| DK1079856T3 (da) | 2006-12-04 |
| CN1301175A (zh) | 2001-06-27 |
| DE69932719T2 (de) | 2007-09-13 |
| IL139571A (en) | 2009-09-22 |
| IL139571A0 (en) | 2002-02-10 |
| JP4044733B2 (ja) | 2008-02-06 |
| NO326197B1 (no) | 2008-10-13 |
| ATE335504T1 (de) | 2006-09-15 |
| RU2217166C2 (ru) | 2003-11-27 |
| KR20010052367A (ko) | 2001-06-25 |
| NO20005833D0 (no) | 2000-11-17 |
| JP2002515230A (ja) | 2002-05-28 |
| ES2270598T3 (es) | 2007-04-01 |
| DE69932719D1 (de) | 2006-09-21 |
| NO20005833L (no) | 2001-01-15 |
| CN1330375C (zh) | 2007-08-08 |
| HK1036215A1 (en) | 2001-12-28 |
| WO1999059629A1 (en) | 1999-11-25 |
| CA2328485A1 (en) | 1999-11-25 |
| AU748852B2 (en) | 2002-06-13 |
| PT1079856E (pt) | 2006-12-29 |
| US7846435B1 (en) | 2010-12-07 |
| CA2328485C (en) | 2011-05-03 |
| BR9910589A (pt) | 2001-01-16 |
| AU4090499A (en) | 1999-12-06 |
| EP1079856A4 (en) | 2002-03-13 |
| KR100548167B1 (ko) | 2006-01-31 |
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