YU54602A - Drospirenon za terapiju zamene hormona - Google Patents

Drospirenon za terapiju zamene hormona

Info

Publication number
YU54602A
YU54602A YU54602A YUP54602A YU54602A YU 54602 A YU54602 A YU 54602A YU 54602 A YU54602 A YU 54602A YU P54602 A YUP54602 A YU P54602A YU 54602 A YU54602 A YU 54602A
Authority
YU
Yugoslavia
Prior art keywords
estrogen
menopausal
drospirenone
hormone replacement
replacement therapy
Prior art date
Application number
YU54602A
Other languages
English (en)
Inventor
Wolfgang Heil
Juergen Hilmann
Ralph Lipp
Rolf Schuermann
Original Assignee
Schering Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26071749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU54602(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag. filed Critical Schering Ag.
Publication of YU54602A publication Critical patent/YU54602A/sh
Publication of RS52149B publication Critical patent/RS52149B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Farmaceutska kompozicija koja obuhvata kao prvi aktivni sastojak estrogen, kao sto je estradiol ili estradiol valerat, u dovoljnim kolicinama za tretiranja poremecaja i simptoma asociranih sa deficijentnim endogenim nivoima estrogena kod zena, i kao drugi aktivni sastojak 6ß, 7ß; 15ß;16ß-dimetilen-3-okso-17α-preg-4-ene-21,17,-karbolakton (drospirenon, DRSP) u dovoljnim kolicinama da zastiti endometrijum od negativnih efekata estrogena korisna, pored drugog, za tretiranje perimenopauzalnih, menopauzalnih i post-menopauzalnih zena. Ova kompozicija moze da se upotrebi za terapiju zamene hormona i moze da se primenjuje kao multi-fazovan farmaceutski preparat. Ova kombinaciona terapija moze da obuhvata kontinualnu, sekvencionalnu ili isprekidanu primenu, ili njihove kombinacije, DRSP i estrogen, svaki opciono u mikronizovanom obliku.
YU54602A 2000-01-18 2001-01-18 Farmaceutska kombinacija mikronizovanog drospirenona i estrogena za terapiju zamene hormona RS52149B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48402600A 2000-01-18 2000-01-18
EP00200183 2000-01-18
PCT/IB2001/000041 WO2001052857A1 (en) 2000-01-18 2001-01-18 Drospirenone for hormone replacement therapy

Publications (2)

Publication Number Publication Date
YU54602A true YU54602A (sh) 2006-01-16
RS52149B RS52149B (sr) 2012-08-31

Family

ID=26071749

Country Status (30)

Country Link
EP (2) EP1611892B1 (sh)
JP (2) JP5128743B2 (sh)
KR (2) KR100747965B1 (sh)
CN (2) CN101934078A (sh)
AT (2) ATE305789T1 (sh)
AU (3) AU2001225413B2 (sh)
BG (1) BG65849B1 (sh)
BR (1) BR0107683A (sh)
CA (1) CA2394165C (sh)
CY (1) CY1109567T1 (sh)
CZ (1) CZ20022411A3 (sh)
DE (2) DE60113809T2 (sh)
DK (2) DK1611892T3 (sh)
EE (1) EE05533B1 (sh)
ES (2) ES2332226T3 (sh)
HK (2) HK1047248B (sh)
HU (1) HUP0204291A3 (sh)
IL (3) IL150775A0 (sh)
ME (1) ME00292B (sh)
MX (1) MXPA02006613A (sh)
NO (1) NO335570B1 (sh)
NZ (1) NZ520630A (sh)
PL (1) PL201878B1 (sh)
PT (1) PT1611892E (sh)
RS (1) RS52149B (sh)
RU (2) RU2275198C2 (sh)
SI (2) SI1611892T1 (sh)
SK (2) SK288129B6 (sh)
WO (1) WO2001052857A1 (sh)
ZA (2) ZA200206551B (sh)

Families Citing this family (35)

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NZ517845A (en) * 1999-08-31 2004-12-24 Schering Ag Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
EP1216713A1 (en) * 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
WO2003006027A1 (en) 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
ATE336252T1 (de) * 2002-03-11 2006-09-15 Janssen Pharmaceutica Nv Kontinuierliche sulfatase-hemmende progestogen enthaltende hormonsubstitutions-therapie
UA87437C2 (ru) * 2002-04-26 2009-07-27 Бристол-Майерс Сквибб Компани Айседжен Инк Лечение гипертензии у женщин, которые поддаются гормонзаместительной терапии
PT1558265E (pt) * 2002-11-05 2010-03-22 Bayer Schering Pharma Ag Utilização da drospirenona para o tratamento da hipertensão
WO2004041288A1 (en) * 2002-11-05 2004-05-21 Schering Aktiengesellschaft Hormone replacement therapy with drospirenone
US7786101B2 (en) 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
MY142989A (en) 2004-03-10 2011-02-14 Bayer Schering Pharma Ag Stabilised supersaturated solids of lipophilic drugs
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DE102004023984A1 (de) * 2004-05-14 2005-12-08 Hf Arzneimittelforschung Gmbh Filmförmiges, oral zu verabreichendes Arzneimittel, enthaltend Estriol
US8022053B2 (en) 2004-11-02 2011-09-20 Bayer Schering Pharma Aktiengesellschaft Oral solid dosage forms containing a low dose of estradiol
JP2009501722A (ja) * 2005-07-15 2009-01-22 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ドロスピレノン含有経皮用薬剤供給装置及びその供給方法
DE102005056527A1 (de) * 2005-11-25 2007-07-12 Grünenthal GmbH Verwendung einer Kombination aus Ethinylestradiol und Chlormadinonacetat zur Herstellung eines Arzneimittels
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
CN101489563A (zh) * 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
DE102007011105A1 (de) * 2007-03-02 2008-09-04 Bayer Schering Pharma Aktiengesellschaft Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose
CN101623287B (zh) * 2008-07-07 2012-02-08 天津金耀集团有限公司 一种屈螺酮类似物的治疗更年期综合症的药物组合物
ES2344675B1 (es) * 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
UY32836A (es) 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
US20130140210A1 (en) * 2010-04-15 2013-06-06 Bayer Intellectual Property Gmbh Low-dosed solid oral dosage forms for hrt
BR112012026115B1 (pt) 2010-04-15 2019-12-24 Bayer Ip Gmbh forma de dosagem oral sólida, seu uso, e unidade de acondicionamento
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EA201400537A1 (ru) 2011-11-04 2014-10-30 Байер Фарма Акциенгезельшафт 18-МЕТИЛ-6,7-МЕТИЛЕН-3-ОКСО-17-ПРЕГН-4-ЕН-21,17β-КАРБОЛАКТОНЫ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ ЭНДОМЕТРИОЗА
TW201350122A (zh) * 2012-04-23 2013-12-16 Bayer Pharma AG １８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內用途，包含１８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內系統，及其於避孕及婦科治療之用途
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
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JOP20200260A1 (ar) * 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) * 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途

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Also Published As

Publication number Publication date
AU2541301A (en) 2001-07-31
EE200200401A (et) 2003-10-15
WO2001052857A1 (en) 2001-07-26
BG106915A (bg) 2003-04-30
CZ20022411A3 (cs) 2003-02-12
ME00292B (me) 2011-05-10
NZ520630A (en) 2004-09-24
EP1611892A3 (en) 2006-02-01
HK1047248B (zh) 2005-12-30
ES2247054T3 (es) 2006-03-01
RU2275198C2 (ru) 2006-04-27
NO335570B1 (no) 2014-12-29
CA2394165C (en) 2010-04-13
KR100913910B1 (ko) 2009-08-26
DE60113809D1 (de) 2006-02-16
KR100747965B1 (ko) 2007-08-08
IL191131A0 (en) 2008-11-03
HUP0204291A3 (en) 2003-05-28
NO20022966L (no) 2002-09-18
EP1257280A1 (en) 2002-11-20
HUP0204291A2 (hu) 2003-04-28
IL150775A (en) 2008-08-07
JP2009120615A (ja) 2009-06-04
DK1257280T3 (da) 2005-12-12
SI1611892T1 (sl) 2010-01-29
HK1082433A1 (en) 2006-06-09
EP1611892A2 (en) 2006-01-04
BG65849B1 (bg) 2010-03-31
NO20022966D0 (no) 2002-06-20
SI1257280T1 (sl) 2006-02-28
EE05533B1 (et) 2012-04-16
KR20070051956A (ko) 2007-05-18
PT1611892E (pt) 2009-11-20
AU2005209600A1 (en) 2005-09-29
AU2001225413B2 (en) 2005-06-23
CN1395488A (zh) 2003-02-05
ATE442147T1 (de) 2009-09-15
DE60139907D1 (de) 2009-10-22
PL201878B1 (pl) 2009-05-29
AU2005209600B2 (en) 2008-08-07
JP5563227B2 (ja) 2014-07-30
RS52149B (sr) 2012-08-31
SK287719B6 (en) 2011-07-06
JP2003520239A (ja) 2003-07-02
RU2005140938A (ru) 2007-07-10
SK288129B6 (sk) 2013-10-02
IL150775A0 (en) 2003-02-12
MEP38008A (en) 2011-02-10
CN101934078A (zh) 2011-01-05
EP1257280B1 (en) 2005-10-05
IL191131A (en) 2010-12-30
DE60113809T2 (de) 2006-06-22
DK1611892T3 (da) 2009-11-02
RU2002122113A (ru) 2004-03-10
JP5128743B2 (ja) 2013-01-23
PL356987A1 (en) 2004-07-12
HK1047248A1 (en) 2003-02-14
ES2332226T3 (es) 2010-01-29
CA2394165A1 (en) 2001-07-26
ATE305789T1 (de) 2005-10-15
BR0107683A (pt) 2002-11-12
SK10322002A3 (sk) 2003-03-04
MXPA02006613A (es) 2003-10-15
KR20020088066A (ko) 2002-11-25
ZA200206551B (en) 2006-04-29
ZA200601285B (en) 2008-01-08
EP1611892B1 (en) 2009-09-09
CY1109567T1 (el) 2014-08-13
RU2402331C2 (ru) 2010-10-27

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