YU51692A - Novi derivati perhidroizoindola i njihovo dobijanje - Google Patents

Novi derivati perhidroizoindola i njihovo dobijanje

Info

Publication number
YU51692A
YU51692A YU51692A YU51692A YU51692A YU 51692 A YU51692 A YU 51692A YU 51692 A YU51692 A YU 51692A YU 51692 A YU51692 A YU 51692A YU 51692 A YU51692 A YU 51692A
Authority
YU
Yugoslavia
Prior art keywords
denotes
halogen atom
obtaining
symbol
preparation
Prior art date
Application number
YU51692A
Other languages
English (en)
Serbo-Croatian (sh)
Inventor
S. Grisoni
S. Hanessian
C. Moutonnier
Y.F. Peyronel
M. Tabart
A. Truchon
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of YU51692A publication Critical patent/YU51692A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
YU51692A 1991-05-17 1992-05-15 Novi derivati perhidroizoindola i njihovo dobijanje YU51692A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.

Publications (1)

Publication Number Publication Date
YU51692A true YU51692A (sh) 1994-06-10

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
YU51692A YU51692A (sh) 1991-05-17 1992-05-15 Novi derivati perhidroizoindola i njihovo dobijanje

Country Status (23)

Country Link
US (1) US5508433A (https=)
EP (2) EP0586471B1 (https=)
JP (1) JPH06507628A (https=)
AT (1) ATE116295T1 (https=)
AU (1) AU1884092A (https=)
CA (1) CA2109297A1 (https=)
CZ (1) CZ244893A3 (https=)
DE (1) DE69201058T2 (https=)
DK (1) DK0586471T3 (https=)
ES (1) ES2066620T3 (https=)
FI (1) FI935072A7 (https=)
FR (1) FR2676443B1 (https=)
HU (1) HUT68913A (https=)
IE (1) IE921579A1 (https=)
IL (1) IL101867A0 (https=)
MX (1) MX9202288A (https=)
NO (1) NO933976L (https=)
NZ (1) NZ242773A (https=)
SK (1) SK126893A3 (https=)
TW (1) TW226991B (https=)
WO (1) WO1992020654A1 (https=)
YU (1) YU51692A (https=)
ZA (1) ZA923541B (https=)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
MXPA02004330A (es) 1999-11-03 2004-07-30 Albany Molecular Res Inc Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
KR100821410B1 (ko) 2000-07-11 2008-04-10 에이엠알 테크놀로지, 인크. 4-페닐 치환된 테트라하이드로이소퀴놀린 및 이의치료학적 용도
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
UA91341C2 (ru) 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
WO2006123182A2 (en) 2005-05-17 2006-11-23 Merck Sharp & Dohme Limited Cyclohexyl sulphones for treatment of cancer
UA95454C2 (uk) 2005-07-15 2011-08-10 Амр Текнолоджи, Інк. Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AR064777A1 (es) 2007-01-10 2009-04-22 Inst Di Reserche D Biolog Mole Indazoles sustituidos con amida como inhibidores de poli (adp- ribosa) polimerasa (parp)
EP3103791B1 (en) 2007-06-27 2018-01-31 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
AU2010247763B2 (en) 2009-05-12 2015-12-24 Albany Molecular Research, Inc. 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
US8815894B2 (en) 2009-05-12 2014-08-26 Bristol-Myers Squibb Company Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
EP2429295B1 (en) 2009-05-12 2013-12-25 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
US8859776B2 (en) 2009-10-14 2014-10-14 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
CA2805265A1 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
WO2012024170A2 (en) 2010-08-17 2012-02-23 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
WO2012143879A1 (en) 2011-04-21 2012-10-26 Piramal Healthcare Limited A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
WO2013165816A2 (en) 2012-05-02 2013-11-07 Merck Sharp & Dohme Corp. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
ME02925B (me) 2012-11-28 2018-04-20 Merck Sharp & Dohme Kompozicije i postupci za liječenje kancera
TW201429969A (zh) 2012-12-20 2014-08-01 Merck Sharp & Dohme 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3706747B1 (en) 2017-11-08 2025-09-03 Merck Sharp & Dohme LLC Prmt5 inhibitors
WO2020033282A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2020033288A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
EP0093805B1 (en) * 1981-02-17 1987-05-13 Warner-Lambert Company Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
AU1884092A (en) 1992-12-30
FR2676443B1 (fr) 1993-08-06
IL101867A0 (en) 1992-12-30
ATE116295T1 (de) 1995-01-15
IE921579A1 (en) 1992-11-18
CZ244893A3 (en) 1994-04-13
DE69201058D1 (de) 1995-02-09
EP0514274A1 (fr) 1992-11-19
MX9202288A (es) 1992-11-01
NO933976D0 (no) 1993-11-03
ES2066620T3 (es) 1995-03-01
ZA923541B (en) 1993-01-27
HUT68913A (en) 1995-08-28
DK0586471T3 (da) 1995-06-06
NZ242773A (en) 1994-06-27
US5508433A (en) 1996-04-16
JPH06507628A (ja) 1994-09-01
TW226991B (https=) 1994-07-21
FI935072A0 (fi) 1993-11-16
CA2109297A1 (fr) 1992-11-18
EP0586471A1 (fr) 1994-03-16
FR2676443A1 (fr) 1992-11-20
HU9303250D0 (en) 1994-03-28
WO1992020654A1 (fr) 1992-11-26
FI935072L (fi) 1993-11-16
NO933976L (no) 1993-11-03
SK126893A3 (en) 1994-11-09
DE69201058T2 (de) 1995-05-11
FI935072A7 (fi) 1993-11-16
EP0586471B1 (fr) 1994-12-28

Similar Documents

Publication Publication Date Title
YU51692A (sh) Novi derivati perhidroizoindola i njihovo dobijanje
YU223590A (sh) Novi derivati izoindolona i njihovo dobijanje
YU51092A (sh) Novi derivati tiopiranopirola i njihovo dobijanje
YU223490A (sh) Novi derivati izoindolana, njihovo dobijanje i farmaceutske smeše koje ih sadrže
MX9202287A (es) Nuevos derivados de perhidroisoindol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9301986A (es) Derivados de perhidroisoindol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
YU6992A (sh) Novi herbicidi
HRP20041042A2 (hr) Novi supstituirani derivati sulfamata kao antikonvulzivi
ATE245644T1 (de) 1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a
DK0532515T3 (da) Fremstilling af substituerede piperidiner
ATE268330T1 (de) Azaidole mit serotonin rezeptor affinität
YU120991A (sh) Postupak za dobivanje cikličnih sulfata
YU45993A (sh) Fenilbenzamidni fungicidi i postupci za njihovo pripremanje
YU47694B (sh) Novi derivati 1,8-benzonaftiridina, postupak za njihovo dobivanje i postupak za dobivanje farmaceutske smeše
ATE210642T1 (de) 2-substituierte vitamin-d3-derivate
BR0213359A (pt) Aralquiltetrahidropiridinas, sua preparação e composições farmacêuticas contendo as mesmas
HRP20030810B1 (en) Novel fungicide compositions based on pyridylmethylbenzamide and propamocarb derivative
YU37597A (en) New pyranosid derivatives
AR009105A1 (es) Derivados de n-(benzotiazol-2-il) piperidina-1-etanamina, su preparacion y aplicacion en terapeutica
YU48443B (sh) Novi derivati fluorhinolin-3-karboksilne kiseline postupak za njihovo dobijanje i njihova primena kao intermedijera
FR2616433B1 (fr) Nouveaux derives piperazinyl alkyl piperazine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
MEP12408A (en) Acyloxypyrrolidine derivatives and use thereof as ligands of v1b or both v1b and v1a receptors
DE69222143D1 (de) Indanderivate
FI925618A0 (fi) Etanoladdukter av 6-sulfonylsubstituerade 3-hydroxikromaner och deras anvaendning som inhalationsmedel vid sjukdomar
GR1001566B (el) Μέ?οδος παρασκευής νέων παραγώγων βενζοφουρανυλιμιδαζόλης.