YU223490A - Novi derivati izoindolana, njihovo dobijanje i farmaceutske smeše koje ih sadrže - Google Patents

Novi derivati izoindolana, njihovo dobijanje i farmaceutske smeše koje ih sadrže

Info

Publication number
YU223490A
YU223490A YU223490A YU223490A YU223490A YU 223490 A YU223490 A YU 223490A YU 223490 A YU223490 A YU 223490A YU 223490 A YU223490 A YU 223490A YU 223490 A YU223490 A YU 223490A
Authority
YU
Yugoslavia
Prior art keywords
new
derivatives
preparation
optionally substituted
isoindolan
Prior art date
Application number
YU223490A
Other languages
English (en)
Inventor
M.C. Dubroeucq
C. Moutonnier
J.F. Peryronel
M. Tabart
A. Reuchon
Original Assignee
Rhone-Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Sante filed Critical Rhone-Poulenc Sante
Publication of YU223490A publication Critical patent/YU223490A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Novi derivati izoindolona opšte formule (I) u kojoj su radikali R atomi vodonika ili zajedno formiraju jednu vezu, simboli R su radikali fenil koji mogu biti supstituisani atomom halogena ili radikalom metil u položaju 2 ili 3, X označava atom kiseonika, sumpora ili radikal N0R3, pri čemu je R3 vodonik, alkil koji je eventualno supstituisan ili dialkilamino, R1 je fenil koji je eventualno supstituisan, cikloheksadienil, naftil, ili heterociklil, R2 je vodonik, halogen, OH, alkil, aminoalkil, alkilaminoalkil, dialkilaminoalkil, alkiloksi, alkiltio, aciloksi, karboksi, alkiloksikarbonil koji je eventualno supstituisan benziloksikarbonil, amino ili acilamino, u njihovim oblicima (3aR, 7aRS) ili u obliku (3aRS, 7aRS) ili u obliku njihovih smeša, u datom slučaju njihove soli (kada ove postoje) i njihovo dobivanje. Novi derivati izoindolona prema ovom pronalasku su naročito značajni kao antagonisti supstance P.
YU223490A 1989-11-23 1990-11-23 Novi derivati izoindolana, njihovo dobijanje i farmaceutske smeše koje ih sadrže YU223490A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8915406A FR2654725B1 (fr) 1989-11-23 1989-11-23 Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
YU223490A true YU223490A (sh) 1993-05-28

Family

ID=9387707

Family Applications (1)

Application Number Title Priority Date Filing Date
YU223490A YU223490A (sh) 1989-11-23 1990-11-23 Novi derivati izoindolana, njihovo dobijanje i farmaceutske smeše koje ih sadrže

Country Status (23)

Country Link
US (1) US5102667A (sh)
EP (1) EP0429366B1 (sh)
JP (1) JPH03176469A (sh)
KR (1) KR910009659A (sh)
AT (1) ATE102923T1 (sh)
AU (1) AU635361B2 (sh)
CA (1) CA2030569A1 (sh)
DE (1) DE69007429T2 (sh)
DK (1) DK0429366T3 (sh)
ES (1) ES2062460T3 (sh)
FI (1) FI905769A (sh)
FR (1) FR2654725B1 (sh)
HU (1) HUT56064A (sh)
IE (1) IE904235A1 (sh)
IL (1) IL96446A0 (sh)
NO (1) NO174387C (sh)
NZ (1) NZ236176A (sh)
PL (4) PL164892B1 (sh)
PT (1) PT95982A (sh)
RU (1) RU2012559C1 (sh)
TW (1) TW218378B (sh)
YU (1) YU223490A (sh)
ZA (1) ZA909369B (sh)

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Also Published As

Publication number Publication date
HU907250D0 (en) 1991-05-28
TW218378B (sh) 1994-01-01
NZ236176A (en) 1993-05-26
RU2012559C1 (ru) 1994-05-15
PT95982A (pt) 1991-09-13
DE69007429T2 (de) 1994-07-07
US5102667A (en) 1992-04-07
ATE102923T1 (de) 1994-04-15
ES2062460T3 (es) 1994-12-16
EP0429366B1 (fr) 1994-03-16
ZA909369B (en) 1991-10-30
DE69007429D1 (de) 1994-04-21
NO174387B (no) 1994-01-17
PL292279A1 (en) 1992-06-01
AU635361B2 (en) 1993-03-18
KR910009659A (ko) 1991-06-28
EP0429366A1 (fr) 1991-05-29
JPH03176469A (ja) 1991-07-31
PL292280A1 (en) 1992-06-01
NO174387C (no) 1994-04-27
FR2654725B1 (fr) 1992-02-14
PL164904B1 (pl) 1994-10-31
AU6683890A (en) 1991-05-30
NO905066L (no) 1991-05-24
PL164909B1 (pl) 1994-10-31
IL96446A0 (en) 1991-08-16
FI905769A0 (fi) 1990-11-22
FI905769A (fi) 1991-05-24
FR2654725A1 (fr) 1991-05-24
IE904235A1 (en) 1991-06-05
PL164892B1 (pl) 1994-10-31
CA2030569A1 (fr) 1991-05-24
DK0429366T3 (da) 1994-06-27
NO905066D0 (no) 1990-11-22
PL164900B1 (pl) 1994-10-31
HUT56064A (en) 1991-07-29
PL292278A1 (en) 1992-06-01

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