YU48934B - Supstituisani benzamidini, njihovo pripremanje i primena kao lekova - Google Patents
Supstituisani benzamidini, njihovo pripremanje i primena kao lekovaInfo
- Publication number
- YU48934B YU48934B YU45295A YU45295A YU48934B YU 48934 B YU48934 B YU 48934B YU 45295 A YU45295 A YU 45295A YU 45295 A YU45295 A YU 45295A YU 48934 B YU48934 B YU 48934B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- methyl
- imino
- amine
- pct
- phenoxymethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
1. Novi supstituisani benzamidini formule u kojoj A oznacava grupu -X1-CmH2m-X2- (II) (m je 2 do 6) ili X1 oznacava O, NH ili NCH3, X2 oznacava O, NH, NCH3 ili X3 oznacava -X-CnH2n-; X4 osnacava -CnH2n-X- (n=1 ili 2,X = O,NH ili NCH3); R1 oznacava OH, CN, COR12, COOR12 ili CHO; R2 oznacava Br, C1, F, CF3, OH, C1-C6-alkil, C5-C7-cikloalkil, aril, O-aril, CH2- aril, CR5R6-aril, C(CH3)2-R7 grupu; a takode oznacava H, kada A jeste grupa formule III, ili kada X2 jeste grupa formule IV; a takode oznacava C1-C6-alkoksi grupu, kada A jeste grupa II, X1 im su definisani kao prethodno, a X2 predstavlja NH, NCH3 ili grupu IV, ili kada A oznacava grupu III, X3 je definisano kao prethodno, au X4 oznaka X predstavlja NH ili NCH3; R3 oznacava H, C1-C6-alkil, OH, C1, F, a takode predstavlja C1-C6-alkoksi, kada R2 osnacava aril, O-aril, CH2-aril, CR5R6-aril ili C(CH3)2-R7 grupu, ili kada X2 predstavlja grupu IV; R2 i R3 mogu zajedno takode da predstavljaju i spojen aromatski ili heteroaromatski prsten; R4 oznacava H ili C1-C6-alkil grupu; R5 oznacava C1-C4-alkil, CF3, CH2OH, COOH ili COO(C1-C4-alkil) grupu; R6 oznacava H, C1-C4-alkil ili CF3 grupu; R5 i R6 mogu zajedno takode da obrazuju C4-C6-alkilen grupu; R7 oznacava CH2OH, COOH, COO(C1-C4-alkil), CONR10R11 ili CH2NR10R11 grupu; R8, R9 oznacavaju H, Br, C1, F OH, C1-C6-alkil ili C1-C6-alkoksi grupu; R10 oznacava H, C1-C6-alkil, fenil-, fenil-(C1-C6-alkil), COR12, COOR12,CHO, CONH2, CONHR12, SO2-(C1-C6-alkil), SO2-fenil grupu, pri cemu fenil grupa moze da bude jedno- ili vesestruko supstituisana sa C1, F, CF3, C1-C4-alkil, OH i/ili C1-C4-alkoksi grupom; R11 oznacava H ili C1-C6-alkil grupu; R10 i R11 mogu zajedno takode da predstavljaju C4-C6-alkilen grupu; R12 oznacava C1-C6-alkil, C5-C7-cikloalkil, aril, heteroaril, aralkil ili heteroaril-(C1-C6-alkil), pri emu aril ili heteroaril grupa moze biti jedno- ili visestruko supstituisana sa C1, F, CF3, C1-C4-alkil, OH ili C1-C4-alkoksi grupom, uz uslov, da u slucaju kada A oznacava grupu -X1-CmH2m-X2-, pri cemu m predstavlja ceo broj, 2, 3 ili 4; a X1 oznacava O, NH; X2 oznacava O, NH ili a R2 oznacava vodonik, Br, C1, F, CF3, C1-C6-alkil, fenil grupu; R3 oznacava vodonik, C1-C6-alil, hidroksi, C1, F, C1-C6-alkoksi grupu; R4 oznacava vodonik, C1-C6-alkil grupu; R1 ne moze da oznacava hidroksi grupu. Prijava sadrzi jos 7 nezavisnih i 5 zavisnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4424713A DE4424713A1 (de) | 1994-07-13 | 1994-07-13 | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU45295A YU45295A (sh) | 1997-12-05 |
| YU48934B true YU48934B (sh) | 2002-12-10 |
Family
ID=6523047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU45295A YU48934B (sh) | 1994-07-13 | 1995-07-06 | Supstituisani benzamidini, njihovo pripremanje i primena kao lekova |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US5731332A (sh) |
| EP (1) | EP0770059B1 (sh) |
| JP (1) | JP2931410B2 (sh) |
| KR (1) | KR100421580B1 (sh) |
| CN (1) | CN1083830C (sh) |
| AT (1) | ATE178590T1 (sh) |
| AU (1) | AU700585B2 (sh) |
| BG (1) | BG62090B1 (sh) |
| BR (1) | BR9508374A (sh) |
| CA (1) | CA2194885C (sh) |
| CO (1) | CO4410184A1 (sh) |
| CZ (1) | CZ289376B6 (sh) |
| DE (2) | DE4424713A1 (sh) |
| DK (1) | DK0770059T3 (sh) |
| EE (1) | EE03311B1 (sh) |
| ES (1) | ES2131830T3 (sh) |
| FI (1) | FI970094A (sh) |
| GR (1) | GR3030043T3 (sh) |
| HK (1) | HK1011966A1 (sh) |
| HR (1) | HRP950365B1 (sh) |
| HU (1) | HU224823B1 (sh) |
| IL (1) | IL114571A (sh) |
| MX (1) | MX9700273A (sh) |
| MY (1) | MY117090A (sh) |
| NO (1) | NO307373B1 (sh) |
| NZ (1) | NZ287883A (sh) |
| PE (1) | PE32496A1 (sh) |
| PL (1) | PL179595B1 (sh) |
| RO (1) | RO118653B1 (sh) |
| RU (1) | RU2159228C2 (sh) |
| SA (1) | SA95160355B1 (sh) |
| SK (1) | SK281744B6 (sh) |
| TW (1) | TW555738B (sh) |
| UA (1) | UA45351C2 (sh) |
| WO (1) | WO1996002497A1 (sh) |
| YU (1) | YU48934B (sh) |
| ZA (1) | ZA955780B (sh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486181B1 (en) | 1992-08-28 | 2002-11-26 | City Of Hope | Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states |
| US6191169B1 (en) | 1992-08-28 | 2001-02-20 | City Of Hope | Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states |
| ES2208737T3 (es) * | 1995-03-10 | 2004-06-16 | Berlex Laboratories, Inc. | Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes. |
| EP0743064A1 (en) * | 1995-05-17 | 1996-11-20 | Eli Lilly And Company | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease |
| DE19636689A1 (de) | 1996-09-10 | 1998-03-12 | Boehringer Ingelheim Kg | Neue Benzamidinderivate |
| DE19718334A1 (de) | 1997-04-30 | 1998-11-05 | Boehringer Ingelheim Pharma | Neue Benzylaminderivate und Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| TW513402B (en) * | 1997-05-30 | 2002-12-11 | Daiichi Seiyaku Co | Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives |
| CA2303935A1 (en) * | 1997-10-15 | 1999-04-22 | City Of Hope | 12(s)-hete receptor blockers |
| ID24720A (id) | 1997-12-12 | 2000-08-03 | Novartis Ag | Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis |
| DE19834713A1 (de) * | 1998-07-31 | 2000-02-03 | Boehringer Ingelheim Pharma | Neue Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6291531B1 (en) * | 1999-10-07 | 2001-09-18 | Boehringer Ingelheim Pharma Kg | LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition |
| DE10000907A1 (de) * | 2000-01-12 | 2001-07-19 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aryl-iminomethyl-carbaminsäureestern |
| US6417382B2 (en) | 2000-01-12 | 2002-07-09 | Boehringer Ingelheim Pharma Kg | Process for preparing aryl-iminomethyl-carbamino acid esters |
| US6528491B2 (en) * | 2000-10-24 | 2003-03-04 | Boehringer Ingelheim Pharma Kg | Pyranoside derivatives |
| CA2433451A1 (en) * | 2001-01-16 | 2002-07-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of an ltb4 antagonist for the treatment and/or prevention of diseases caused by increased expression of mucin genes |
| IL159493A0 (en) * | 2001-07-14 | 2004-06-01 | Boehringer Ingeiheim Pharma Gm | Pharmaceutical formulation containing an ltb4 antagonist |
| US20030119901A1 (en) * | 2001-07-14 | 2003-06-26 | Boehringer Ingelheim Pharma Kg | Pharmaceutical formulation containing an LTB4 antagonist |
| EP1420773A1 (en) * | 2001-08-31 | 2004-05-26 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| RS20050390A (en) * | 2002-11-26 | 2008-04-04 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg., | Pharmaceutical composition comprising a ltb4 antagonist and a cox-2 inhibitor or a combined cox 1/2 inhibitor |
| DE10350528A1 (de) * | 2003-10-29 | 2005-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arzneimittelformulierung, enthaltend einen LTB4-Antagonisten, sowie Verfahren zu deren Herstellung und deren Verwendung |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| CN103012200B (zh) * | 2011-09-20 | 2014-12-17 | 北京大学 | 具有β-分泌酶抑制功能的化合物及其制备方法与应用 |
| CN110869362A (zh) | 2017-05-12 | 2020-03-06 | 国立研究开发法人理化学研究所 | A类gpcr结合性化合物改性体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0518818A3 (en) * | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
| ATE125791T1 (de) * | 1991-06-11 | 1995-08-15 | Ciba Geigy Ag | Amidino-verbindungen, ihre herstellung und verwendung als arzneimittel. |
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| PT902013E (pt) * | 1992-02-05 | 2002-06-28 | Boehringer Ingelheim Pharma | Novos derivados amidina sua preparacao e utilizacao como medicamento com actividade antagonista de ltb4 |
| US5455274A (en) * | 1992-12-09 | 1995-10-03 | Ciba-Geigy Corporation | Hydroxyamidine derivatives |
-
1994
- 1994-07-13 DE DE4424713A patent/DE4424713A1/de not_active Withdrawn
-
1995
- 1995-06-03 EP EP95921824A patent/EP0770059B1/de not_active Expired - Lifetime
- 1995-06-03 UA UA97020598A patent/UA45351C2/uk unknown
- 1995-06-03 HU HU9700059A patent/HU224823B1/hu not_active IP Right Cessation
- 1995-06-03 RO RO97-00018A patent/RO118653B1/ro unknown
- 1995-06-03 DE DE59505600T patent/DE59505600D1/de not_active Expired - Lifetime
- 1995-06-03 DK DK95921824T patent/DK0770059T3/da active
- 1995-06-03 RU RU97102043/04A patent/RU2159228C2/ru not_active IP Right Cessation
- 1995-06-03 AU AU26742/95A patent/AU700585B2/en not_active Ceased
- 1995-06-03 EE EE9700066A patent/EE03311B1/xx not_active IP Right Cessation
- 1995-06-03 MX MX9700273A patent/MX9700273A/es not_active IP Right Cessation
- 1995-06-03 AT AT95921824T patent/ATE178590T1/de active
- 1995-06-03 PL PL95318115A patent/PL179595B1/pl not_active IP Right Cessation
- 1995-06-03 CA CA002194885A patent/CA2194885C/en not_active Expired - Fee Related
- 1995-06-03 CN CN95194048A patent/CN1083830C/zh not_active Expired - Fee Related
- 1995-06-03 CZ CZ199766A patent/CZ289376B6/cs not_active IP Right Cessation
- 1995-06-03 US US08/765,692 patent/US5731332A/en not_active Expired - Lifetime
- 1995-06-03 WO PCT/EP1995/002112 patent/WO1996002497A1/de active IP Right Grant
- 1995-06-03 ES ES95921824T patent/ES2131830T3/es not_active Expired - Lifetime
- 1995-06-03 SK SK19-97A patent/SK281744B6/sk not_active IP Right Cessation
- 1995-06-03 KR KR1019970700124A patent/KR100421580B1/ko not_active IP Right Cessation
- 1995-06-03 NZ NZ287883A patent/NZ287883A/xx not_active IP Right Cessation
- 1995-06-03 JP JP8504618A patent/JP2931410B2/ja not_active Expired - Lifetime
- 1995-06-03 BR BR9508374A patent/BR9508374A/pt not_active IP Right Cessation
- 1995-06-28 HR HRP4424713.3A patent/HRP950365B1/xx not_active IP Right Cessation
- 1995-07-04 TW TW084106873A patent/TW555738B/zh active
- 1995-07-06 YU YU45295A patent/YU48934B/sh unknown
- 1995-07-11 PE PE1995273519A patent/PE32496A1/es not_active Application Discontinuation
- 1995-07-12 IL IL11457195A patent/IL114571A/xx not_active IP Right Cessation
- 1995-07-12 CO CO95030618A patent/CO4410184A1/es unknown
- 1995-07-12 ZA ZA955780A patent/ZA955780B/xx unknown
- 1995-07-13 MY MYPI95001982A patent/MY117090A/en unknown
- 1995-11-01 SA SA95160355A patent/SA95160355B1/ar unknown
-
1997
- 1997-01-04 BG BG101105A patent/BG62090B1/bg unknown
- 1997-01-10 NO NO970122A patent/NO307373B1/no unknown
- 1997-01-10 FI FI970094A patent/FI970094A/fi not_active Application Discontinuation
-
1998
- 1998-12-14 HK HK98113328A patent/HK1011966A1/xx not_active IP Right Cessation
-
1999
- 1999-04-23 GR GR990401120T patent/GR3030043T3/el unknown
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