ATE185555T1 - Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung - Google Patents
Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendungInfo
- Publication number
- ATE185555T1 ATE185555T1 AT95907051T AT95907051T ATE185555T1 AT E185555 T1 ATE185555 T1 AT E185555T1 AT 95907051 T AT95907051 T AT 95907051T AT 95907051 T AT95907051 T AT 95907051T AT E185555 T1 ATE185555 T1 AT E185555T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- pct
- preparation
- monoamin
- oxydase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
- C07C281/04—Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
- C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
- C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9400557A FR2715155B1 (fr) | 1994-01-19 | 1994-01-19 | Inhibiteurs de la monoamine oxydase B et leurs procédés de préparation. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE185555T1 true ATE185555T1 (de) | 1999-10-15 |
Family
ID=9459190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95907051T ATE185555T1 (de) | 1994-01-19 | 1995-01-19 | Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung |
Country Status (8)
Country | Link |
---|---|
US (1) | US5811456A (de) |
EP (1) | EP0740654B1 (de) |
JP (1) | JPH09507673A (de) |
AT (1) | ATE185555T1 (de) |
CA (1) | CA2180956A1 (de) |
DE (1) | DE69512763D1 (de) |
FR (1) | FR2715155B1 (de) |
WO (1) | WO1995019960A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2137750C1 (ru) * | 1998-05-19 | 1999-09-20 | Институт органического синтеза Уральского отделения РАН | Замещенные ди(формиларил)полиэфиры, или их координационные соединения, или их фармацевтически приемлемые аддитивные соли, способ их получения и фармацевтическая композиция на их основе |
US6589504B1 (en) * | 2000-09-22 | 2003-07-08 | Pharmacia & Upjohn Company | Compounds and methods for diagnosing and treating amyloid-related conditions |
US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
US20040171075A1 (en) * | 2002-12-31 | 2004-09-02 | Flynn Daniel L | Modulation of protein functionalities |
US20080220497A1 (en) * | 2003-12-24 | 2008-09-11 | Flynn Daniel L | Modulation of protein functionalities |
AU2005321946B2 (en) | 2004-12-23 | 2012-08-16 | Deciphera Pharmaceuticals, Llc | Enzyme modulators and treatments |
US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
US20080248548A1 (en) * | 2007-04-09 | 2008-10-09 | Flynn Daniel L | Modulation of protein functionalities |
AU2008242697A1 (en) * | 2007-04-20 | 2008-10-30 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
US20110189167A1 (en) * | 2007-04-20 | 2011-08-04 | Flynn Daniel L | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases |
CA2742007C (en) * | 2008-10-29 | 2014-07-08 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
CA3089566A1 (en) | 2018-01-31 | 2019-08-08 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
EP3886612A4 (de) * | 2018-11-26 | 2022-08-17 | Roar Holding LLC | Verfahren zur verbesserung der getränkequalität |
WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
JP2022544234A (ja) | 2019-08-12 | 2022-10-17 | デシフェラ・ファーマシューティカルズ,エルエルシー | 胃腸間質腫瘍を治療するためのリプレチニブ |
EP4084778B1 (de) | 2019-12-30 | 2023-11-01 | Deciphera Pharmaceuticals, LLC | Formulierungen eines amorphen kinase-inhibitors und verwendungsverfahren dafür |
KR20220123058A (ko) | 2019-12-30 | 2022-09-05 | 데시페라 파마슈티칼스, 엘엘씨. | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물 |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB839610A (en) * | 1957-07-03 | 1960-06-29 | Hoffmann La Roche | Novel acid hydrazides and a process for the manufacture of same |
DE1163847B (de) * | 1958-12-23 | 1964-02-27 | Ici Ltd | Verfahren zur Herstellung von ª‡-Methylbenzylhydraziden |
FR59M (de) * | 1960-07-15 | 1961-01-09 | ||
US3177251A (en) * | 1960-07-30 | 1965-04-06 | Robert Et Carriere Lab | Hydroxy benzoic acid hydrazides |
US3419659A (en) * | 1964-07-08 | 1968-12-31 | Gaf Corp | Sun screening methods |
CH480790A (de) * | 1966-12-16 | 1969-11-15 | Agripat Sa | Mittel zur Bekämpfung von Insekten, Spinnentieren und deren Entwicklungsstadien |
US3753680A (en) * | 1970-05-14 | 1973-08-21 | Stauffer Chemical Co | Arylidene semicarbazones and their utility as herbicides |
BE795111A (fr) * | 1972-02-09 | 1973-08-07 | Philips Nv | Composes de benzylidene-semicarbazide et leur activite insecticide |
US3867425A (en) * | 1974-01-09 | 1975-02-18 | American Cyanamid Co | Substituted benzyl carbazic acid esters |
HU190795B (en) * | 1982-05-04 | 1986-11-28 | Egyt Gyogyszervegyeszeti Gyar,Hu | Process for producing carbazinic derivatives and compositions containing them for increasing weight yield |
DE3624349A1 (de) * | 1986-07-17 | 1988-01-28 | Schering Ag | Substituierte hydrazone, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
FR2631827B1 (fr) * | 1988-05-27 | 1992-03-27 | Delalande Sa | Nouveaux derives d'(hetero)aryl-5 tetrazole, leur procede de preparation et leur application en therapeutique |
CA2019162A1 (en) * | 1989-06-22 | 1990-12-22 | Adam Chi-Tung Hsu | Halopropargyl compounds, compositions, uses and processes of preparation |
FR2653017B1 (fr) * | 1989-10-17 | 1995-05-05 | Delalande Sa | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
FR2655044B1 (fr) * | 1989-11-24 | 1995-03-03 | Delalande Sa | Derives d'(hetero) arylmethyloxy-4 phenyl tetrazole et oxadiazole, leur procede de preparation et leur application en therapeutique. |
US5120347A (en) * | 1990-06-21 | 1992-06-09 | Rohm And Haas Company | Aryl triazole herbicides |
FR2675504B1 (fr) * | 1991-04-16 | 1995-01-27 | Delalande Sa | Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique. |
-
1994
- 1994-01-19 FR FR9400557A patent/FR2715155B1/fr not_active Expired - Fee Related
-
1995
- 1995-01-19 CA CA002180956A patent/CA2180956A1/fr not_active Abandoned
- 1995-01-19 US US08/676,199 patent/US5811456A/en not_active Expired - Fee Related
- 1995-01-19 AT AT95907051T patent/ATE185555T1/de not_active IP Right Cessation
- 1995-01-19 DE DE69512763T patent/DE69512763D1/de not_active Expired - Lifetime
- 1995-01-19 WO PCT/FR1995/000061 patent/WO1995019960A1/fr active IP Right Grant
- 1995-01-19 EP EP95907051A patent/EP0740654B1/de not_active Expired - Lifetime
- 1995-01-19 JP JP7519383A patent/JPH09507673A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69512763D1 (de) | 1999-11-18 |
CA2180956A1 (fr) | 1995-07-27 |
US5811456A (en) | 1998-09-22 |
JPH09507673A (ja) | 1997-08-05 |
EP0740654B1 (de) | 1999-10-13 |
FR2715155A1 (fr) | 1995-07-21 |
FR2715155B1 (fr) | 1996-07-26 |
EP0740654A1 (de) | 1996-11-06 |
WO1995019960A1 (fr) | 1995-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE185555T1 (de) | Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung | |
ATE132848T1 (de) | Verfahren zur herstellung von sertralin- zwischenprodukten | |
DE69528437T2 (de) | Substituierte azaindolylidenderivate und verfahren zu ihrer herstellung | |
GB9416897D0 (en) | Metalloproteinase inhibitors | |
HU9302795D0 (en) | Fungide compositions containing 2-(substituted phenyl)-ester of 3-metoxi-propenoic acid | |
GB9121456D0 (en) | Triazole antifungal agents | |
DE69204840T2 (de) | Verfahren zur Herstellung von Sertralin. | |
TW251285B (de) | ||
AT397654B (de) | Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung | |
PL325280A1 (en) | Amides of carbomoylcarboxylic acids | |
DE69412085D1 (de) | Neues verfahren zur herstellung von beta-alkoxyacrylsäure | |
ATE172189T1 (de) | 15-deoxyspergualin-analoge verbindungen, ihre verwendung als therapeutika und verfahren zu ihrer herstellung | |
BR9811481B1 (pt) | processo para a preparação de derivados de 1,3-diazo-spiro (4,4) non-1-en-4-ona e intermediários de 1-ciano-1-acil amino ciclopentano. | |
DE59309487D1 (de) | Isoxazolcarbonsäureamide, verfahren zu ihrer herstellung und ihre verwendung | |
DE59310218D1 (de) | Inhibitoren retroviraler proteasen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |