YU48322B - Derivati alfa-aminokarboksamida supstituisani n-fenilalkilom i postupak za njihovo pripremanje - Google Patents
Derivati alfa-aminokarboksamida supstituisani n-fenilalkilom i postupak za njihovo pripremanjeInfo
- Publication number
- YU48322B YU48322B YU102290A YU102290A YU48322B YU 48322 B YU48322 B YU 48322B YU 102290 A YU102290 A YU 102290A YU 102290 A YU102290 A YU 102290A YU 48322 B YU48322 B YU 48322B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- phenylalkyl
- alfa
- procedure
- preparation
- derivatives substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/02—Monothiocarboxylic acids
- C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/06—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of an acyclic saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
Abstract
DERIVATI ALFA-AMINOKARBOKSAMIDA SUPSTITUISANI N-FENILALKILOM I POSTUPAK ZA NJIHOVO PRIPREMANJE J Jedinjenja formule (la) fgfio /Ru (ch2)v-n-j:-con^ II J R" R12 u kojoj R7 je C^Cg-alkil; C3-C8-cikloalkil, furil, tienil ili piridil prsten; ili fenil prsten, nesupstituisan ili supstituisan sa 1 do 4 supstituenta, nezavisno odabrana izmedu halogena, C1-C6-alkila, C1-C6-alkoksila i trifluorometila; Z je grupa-(CH2)r-ili-(CH2)s-Y-(CH2)t-, gde je r ceo broj od 1 do 4, jedan od s i t je nula, a drugi je O ili ceo broj od 1 do 4, a Y je -O-, -S- ili -NR13-, u kome je R13 vodonik ili C1-C4-alkil; v je O ili 1;svaki od R8 i R9, nezavisno je vodonik ili C1-C4-alkil; R10 je vodonik, C1-C4-alkil, nesupstituisan ili supstituisan sa hidroksilom ili sa fenil prstenom, u datom primeru supstituisanim sa 1 do 4 supstituenta, nezavisno odabrana izmedu halogena, C1-C6-alkila, C1-C6-alkoksila i trifluormetila; R10' je vodonik; ili R10 i R10' zajedno sa susednim atomom ugljenika obrazuju C3-C6-cikloalkil prsten; svaki od R11 i R12, nezavisno je vodonik ili C1-C6-alkil; i njihove farmaceutski prihvatljive soli;u kojima, a) kada R7 jeste C1-C8-alkil, tada je Z grupa-(CH2)s-Y-(CH2)t-, u kojoj i s i t jesu nula, a Y je definisano kao gore; u kojima, b) kada R7 jeste C1-C8-alkil, jednovremeno je Z grupa -(CH2)s-Y-(CH2)t-, u kojoj i s i t jesu nula, a Y je -O-, R10 je vodonik ili C1-C4-alkil, R10' je vodonik, ili R10 i R10' obrazuju, zajedno sa susednim atomom ugljenika, C3-C6-cikloalkil prsten, a v, Rg, R11 i R12 definisani su kao gore, tada R8 jeste C1-C4-alkil; u kojima, c) kada je Z grupa -(CH2)s-Y-(CH2)t-, u kojoj su s, t i Y definisani kao gore, a jednovremeno R7 je furil, tienil ili piridil prsten, ili fenil prsten, nesupstituisan ili supstituisan sa 1 ili 2 supstituenta, izabrana izmedu halogena, C1-C6-alkila, C1-C6-alkoksila i trifluorometila, R10 je vodonik ili C1-C4-alkil, R10'je vodonik, a v, R8 i R9 definisani su kao gore, tada je bar jedan od R11 i R12 razlicit od vodonika; a u kojima, d) kada je R7 fenil, nesupstituisan ili supstituisan sa 1 do 4 supstituenta, izabrana izmedu halogena i C1-C6-alkila, jednovremeno Z je grupa -CH(R14)- ili (CH2)s-Y-(CH2)t, u kojoj je R14 vodonik ili C1-C3-alkil, Y je -O- ili -S-, a i s i t jesu nula, R8 i R9 jesu vodonik, v je nula, a R10, R10', R11 i R12 definisani su kao gore, tada je R10 razlicit od vodonika ili nesupstituisanog C1-C4-alkila.-Prijava sadrzi jos 3 nezavisna i 6 zavisnih zahteva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898912071A GB8912071D0 (en) | 1989-05-25 | 1989-05-25 | N-phenylalkyl substituted-alpha-amino carboxamide derivatives and process for their preparation |
GB909007567A GB9007567D0 (en) | 1990-04-04 | 1990-04-04 | New n-substituted alpha-amino carboxamide derivatives and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
YU102290A YU102290A (sh) | 1992-07-20 |
YU48322B true YU48322B (sh) | 1998-05-15 |
Family
ID=26295400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU102290A YU48322B (sh) | 1989-05-25 | 1990-05-24 | Derivati alfa-aminokarboksamida supstituisani n-fenilalkilom i postupak za njihovo pripremanje |
Country Status (23)
Country | Link |
---|---|
US (3) | US5236957A (sh) |
EP (2) | EP0400495B1 (sh) |
JP (1) | JP2771328B2 (sh) |
KR (1) | KR0179661B1 (sh) |
CN (1) | CN1027588C (sh) |
AT (1) | ATE96775T1 (sh) |
AU (1) | AU645752B2 (sh) |
CA (1) | CA2033190C (sh) |
CZ (1) | CZ281420B6 (sh) |
DE (1) | DE69004337T2 (sh) |
DK (1) | DK0400495T3 (sh) |
ES (1) | ES2062174T3 (sh) |
FI (1) | FI114792B (sh) |
HU (2) | HUT55348A (sh) |
IE (1) | IE63934B1 (sh) |
IL (1) | IL94466A (sh) |
MY (1) | MY105618A (sh) |
NO (1) | NO179944C (sh) |
NZ (1) | NZ233785A (sh) |
PT (1) | PT94160B (sh) |
RU (1) | RU2097371C1 (sh) |
WO (1) | WO1990014334A1 (sh) |
YU (1) | YU48322B (sh) |
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GB8409015D0 (en) * | 1984-04-06 | 1984-05-16 | Eschem Ltd | Binding |
DE3416693A1 (de) * | 1984-05-05 | 1985-11-07 | Bayer Ag, 5090 Leverkusen | Verfahren zur behandlung von cellulosischen fasermaterialien |
US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4725619A (en) * | 1985-04-16 | 1988-02-16 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4715619A (en) * | 1986-01-13 | 1987-12-29 | Printmark, Inc. | Book jacket |
GB8714901D0 (en) * | 1986-07-23 | 1987-07-29 | Ici Plc | Amide derivatives |
-
1990
- 1990-05-22 IL IL9446690A patent/IL94466A/en not_active IP Right Cessation
- 1990-05-23 NZ NZ233785A patent/NZ233785A/xx unknown
- 1990-05-23 CZ CS902520A patent/CZ281420B6/cs not_active IP Right Cessation
- 1990-05-24 YU YU102290A patent/YU48322B/sh unknown
- 1990-05-24 IE IE187890A patent/IE63934B1/en not_active IP Right Cessation
- 1990-05-24 MY MYPI90000843A patent/MY105618A/en unknown
- 1990-05-25 HU HU905133A patent/HUT55348A/hu unknown
- 1990-05-25 DE DE90109950T patent/DE69004337T2/de not_active Expired - Lifetime
- 1990-05-25 KR KR1019910700086A patent/KR0179661B1/ko not_active IP Right Cessation
- 1990-05-25 AT AT90109950T patent/ATE96775T1/de not_active IP Right Cessation
- 1990-05-25 JP JP2507938A patent/JP2771328B2/ja not_active Expired - Lifetime
- 1990-05-25 RU SU925011522A patent/RU2097371C1/ru active
- 1990-05-25 AU AU57299/90A patent/AU645752B2/en not_active Expired
- 1990-05-25 CN CN90103800A patent/CN1027588C/zh not_active Expired - Lifetime
- 1990-05-25 EP EP90109950A patent/EP0400495B1/en not_active Expired - Lifetime
- 1990-05-25 PT PT94160A patent/PT94160B/pt not_active IP Right Cessation
- 1990-05-25 EP EP90908218A patent/EP0426816A1/en active Pending
- 1990-05-25 DK DK90109950.7T patent/DK0400495T3/da active
- 1990-05-25 WO PCT/EP1990/000841 patent/WO1990014334A1/en active IP Right Grant
- 1990-05-25 ES ES90109950T patent/ES2062174T3/es not_active Expired - Lifetime
- 1990-05-25 US US07/646,596 patent/US5236957A/en not_active Expired - Lifetime
- 1990-05-25 CA CA002033190A patent/CA2033190C/en not_active Expired - Lifetime
-
1991
- 1991-01-23 NO NO910270A patent/NO179944C/no not_active IP Right Cessation
- 1991-01-23 FI FI910354A patent/FI114792B/fi active
-
1993
- 1993-05-25 US US08/065,888 patent/US5391577A/en not_active Expired - Lifetime
-
1994
- 1994-11-17 US US08/343,853 patent/US5502079A/en not_active Expired - Lifetime
-
1995
- 1995-06-30 HU HU95P/P00703P patent/HU211550A9/hu unknown
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