YU102290A - Postopek za pripravo z n-fenilalkilom substituiranih derivatov alfa-amino karboksamida - Google Patents

Postopek za pripravo z n-fenilalkilom substituiranih derivatov alfa-amino karboksamida

Info

Publication number
YU102290A
YU102290A YU102290A YU102290A YU102290A YU 102290 A YU102290 A YU 102290A YU 102290 A YU102290 A YU 102290A YU 102290 A YU102290 A YU 102290A YU 102290 A YU102290 A YU 102290A
Authority
YU
Yugoslavia
Prior art keywords
phenylalkyl
alpha
procedure
preparation
substituted derivatives
Prior art date
Application number
YU102290A
Other languages
English (en)
Other versions
YU48322B (sh
Inventor
P. Dostert
P. Pevarello
F. Heidempergher
M. Varasi
A. Bonsignori
R. Roncucci
Original Assignee
Farmitalia Carlo Erba S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898912071A external-priority patent/GB8912071D0/en
Priority claimed from GB909007567A external-priority patent/GB9007567D0/en
Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.
Publication of YU102290A publication Critical patent/YU102290A/sh
Publication of YU48322B publication Critical patent/YU48322B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/06—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Abstract

POSTOPEK ZA PRIPRAVO Z N-FENILALKILOM SUBSTITUIRANIH DERIVATOV ALFA-AMINO KARBOKSAMIDA. Opisani so novi, z N-fenilalkilom substituirani derivati alfa-aminokarboksamida s formulo (Ia) v kateri je R7C1-C8 alkil, C3-C8 cikloalkil, furil, tienil, piridil ali nesubstituiran ali substituiran fenil; Z je skupina -(CH2)r-ali-(CH2)s-Y-(CH2)t-, kjer je Y -O-, -S- ali -NR13-; R8, R9, R10, R'10, R13, v,r,s in t so, kot je tukaj definirano; in vsak od R11 in R12 je neodvisno vodik ali C1-C6 alkil, in njihove farmacevtsko sprejemljive soli,ki učinkujejo na CNS in hih lahko uporabimo kot antiepileptike, sredstva proti Parkinsonovi bolezni, nevroprotektivna sredstva, antidopresivna sredstva, antispastike in/ali hipnotike pri sesalcih, kot tudi postopek za njihovo pripravo.
YU102290A 1989-05-25 1990-05-24 Derivati alfa-aminokarboksamida supstituisani n-fenilalkilom i postupak za njihovo pripremanje YU48322B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898912071A GB8912071D0 (en) 1989-05-25 1989-05-25 N-phenylalkyl substituted-alpha-amino carboxamide derivatives and process for their preparation
GB909007567A GB9007567D0 (en) 1990-04-04 1990-04-04 New n-substituted alpha-amino carboxamide derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
YU102290A true YU102290A (sh) 1992-07-20
YU48322B YU48322B (sh) 1998-05-15

Family

ID=26295400

Family Applications (1)

Application Number Title Priority Date Filing Date
YU102290A YU48322B (sh) 1989-05-25 1990-05-24 Derivati alfa-aminokarboksamida supstituisani n-fenilalkilom i postupak za njihovo pripremanje

Country Status (23)

Country Link
US (3) US5236957A (sh)
EP (2) EP0400495B1 (sh)
JP (1) JP2771328B2 (sh)
KR (1) KR0179661B1 (sh)
CN (1) CN1027588C (sh)
AT (1) ATE96775T1 (sh)
AU (1) AU645752B2 (sh)
CA (1) CA2033190C (sh)
CZ (1) CZ281420B6 (sh)
DE (1) DE69004337T2 (sh)
DK (1) DK0400495T3 (sh)
ES (1) ES2062174T3 (sh)
FI (1) FI114792B (sh)
HU (2) HUT55348A (sh)
IE (1) IE63934B1 (sh)
IL (1) IL94466A (sh)
MY (1) MY105618A (sh)
NO (1) NO179944C (sh)
NZ (1) NZ233785A (sh)
PT (1) PT94160B (sh)
RU (1) RU2097371C1 (sh)
WO (1) WO1990014334A1 (sh)
YU (1) YU48322B (sh)

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Also Published As

Publication number Publication date
IE63934B1 (en) 1995-06-28
YU48322B (sh) 1998-05-15
NO179944B (no) 1996-10-07
NO179944C (no) 1997-01-15
DE69004337T2 (de) 1994-02-24
AU645752B2 (en) 1994-01-27
NO910270D0 (no) 1991-01-23
KR0179661B1 (ko) 1999-05-15
IL94466A (en) 1995-01-24
JP2771328B2 (ja) 1998-07-02
EP0400495B1 (en) 1993-11-03
EP0426816A1 (en) 1991-05-15
MY105618A (en) 1994-11-30
AU5729990A (en) 1990-12-18
CZ281420B6 (cs) 1996-09-11
DK0400495T3 (da) 1993-12-06
HU211550A9 (en) 1995-12-28
FI114792B (fi) 2004-12-31
CN1047496A (zh) 1990-12-05
FI910354A0 (fi) 1991-01-23
EP0400495A1 (en) 1990-12-05
KR920701131A (ko) 1992-08-11
JPH04500215A (ja) 1992-01-16
RU2097371C1 (ru) 1997-11-27
CA2033190A1 (en) 1990-11-26
IE901878L (en) 1990-11-25
NO910270L (no) 1991-01-23
US5391577A (en) 1995-02-21
PT94160A (pt) 1991-01-08
PT94160B (pt) 1997-04-30
NZ233785A (en) 1992-12-23
ATE96775T1 (de) 1993-11-15
CA2033190C (en) 2003-04-08
US5502079A (en) 1996-03-26
HUT55348A (en) 1991-05-28
CZ252090A3 (en) 1996-06-12
CN1027588C (zh) 1995-02-08
DE69004337D1 (de) 1993-12-09
ES2062174T3 (es) 1994-12-16
US5236957A (en) 1993-08-17
IL94466A0 (en) 1991-03-10
HU905133D0 (en) 1991-04-29
WO1990014334A1 (en) 1990-11-29

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