ES2078958T3 - Derivados de aril-3 oxazolidinona, su procedimiento de preparacion y su aplicacion en terapeutica. - Google Patents
Derivados de aril-3 oxazolidinona, su procedimiento de preparacion y su aplicacion en terapeutica.Info
- Publication number
- ES2078958T3 ES2078958T3 ES90402892T ES90402892T ES2078958T3 ES 2078958 T3 ES2078958 T3 ES 2078958T3 ES 90402892 T ES90402892 T ES 90402892T ES 90402892 T ES90402892 T ES 90402892T ES 2078958 T3 ES2078958 T3 ES 2078958T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- aril
- therapeutics
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
Abstract
DERIVADOS RESPONDIENDO A LA FORMULA (I), DONDE R1 REPRESENTA H O ALQUILO EN C1-C4; X REPRESENTA UN ATOMO DE OXIGENO EN EL CASO R2=H O HALOGENO, O UN GRUPO METILENO O UN GRUPO -CH=CH-, EN EL CASO DE QUE R2 =H; N TOMA EL VALOR 1 O 2 CUANDO X ES UN ATOMO DE OXIGENO O UN GRUPO METILENO Y EL VALOR 0 O 1 CUANDO X REPRESENTA EL GRUPO -CH=CH-; R3 Y R4 REPRESENTAN CADA UNO INDEPENDIENTEMENTE UNO DEL OTRO, H, ALQUILO EN C1-C4, CICLOALQUILO EN C4-C7, FENILO O BENZILO; R5 REPRESENTA H O ALQUILO EN C1-C4; R6 REPRESENTA ALQUILO EN C1-C4, CHF2, CF3, C2F5, CICLOALQUILO EN C4-C7, FENILO O BENZILO; R4 Y R6 PUEDEN ADEMAS FORMAR JUNTOS UNA CADENA -(CH2)3ORMAR JUNTOS UNA CADENA -(CH2)4 ALQUILO EN C1-C4, ACELO EN C2-C5 O BENZILO, UTILES EN CALIDAD DE MEDICAMENTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8913555A FR2653017B1 (fr) | 1989-10-17 | 1989-10-17 | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2078958T3 true ES2078958T3 (es) | 1996-01-01 |
Family
ID=9386480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90402892T Expired - Lifetime ES2078958T3 (es) | 1989-10-17 | 1990-10-16 | Derivados de aril-3 oxazolidinona, su procedimiento de preparacion y su aplicacion en terapeutica. |
Country Status (16)
Country | Link |
---|---|
US (3) | US5036091A (es) |
EP (3) | EP0428421A1 (es) |
JP (3) | JPH04502333A (es) |
KR (3) | KR0149508B1 (es) |
AT (2) | ATE126792T1 (es) |
AU (3) | AU637413B2 (es) |
CA (3) | CA2027715A1 (es) |
DE (2) | DE69021823T2 (es) |
DK (1) | DK0424244T3 (es) |
ES (1) | ES2078958T3 (es) |
FR (1) | FR2653017B1 (es) |
GR (1) | GR3017708T3 (es) |
HK (1) | HK1005591A1 (es) |
NZ (3) | NZ235728A (es) |
WO (3) | WO1991005774A1 (es) |
ZA (3) | ZA908284B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5196543A (en) * | 1989-10-17 | 1993-03-23 | Delalande S.A. | 3-aryloxazolidinone derivatives, process for their preparation and their use in therapy |
US5235063A (en) * | 1989-10-17 | 1993-08-10 | Delalande S.A. | Process of preparing by condensation certain |
FR2653017B1 (fr) * | 1989-10-17 | 1995-05-05 | Delalande Sa | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
FR2675504B1 (fr) * | 1991-04-16 | 1995-01-27 | Delalande Sa | Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique. |
TW286317B (es) * | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
FR2715155B1 (fr) * | 1994-01-19 | 1996-07-26 | Mayoly Spindler | Inhibiteurs de la monoamine oxydase B et leurs procédés de préparation. |
FR2732679B1 (fr) * | 1995-04-07 | 1997-04-30 | Synthelabo | Procede de preparation enzymatique d'un intermediaire de synthese de la befloxatone |
ES2138346T3 (es) * | 1995-06-02 | 2000-01-01 | Sanofi Synthelabo | Derivados de 5-(hidroximetil)oxazolidin-2-ona. |
FR2734821B1 (fr) * | 1995-06-02 | 1997-07-11 | Synthelabo | Derives de 5-methoxymethyl-3-(1,2-benzisoxazol-3-yl) oxazolidin-2-one, leur preparation et leur application en therapeutique |
FR2734820B1 (fr) * | 1995-06-02 | 1997-07-11 | Synthelabo | Derives de 3-(1,2-benzisoxazol-3-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique |
FR2737206B1 (fr) * | 1995-07-24 | 1997-08-22 | Synthelabo | Derives d'oxazoloquinoleinone, leur preparation et leur application en therapeutique |
FR2741072B1 (fr) * | 1995-11-09 | 1997-12-12 | Synthelabo | Derives d'oxazolidin-2-one, leur preparation et leur application en therapeutique |
FR2741071B1 (fr) * | 1995-11-09 | 1997-12-12 | Synthelabo | Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique |
US6642409B2 (en) | 2000-01-27 | 2003-11-04 | Central Glass Company, Limited | Process for producing 4,4,4-trifluoro-3-hydroxybutyric acid derivatives |
US6444813B2 (en) * | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
WO2002018354A1 (en) * | 2000-08-31 | 2002-03-07 | Abbott Laboratories | Oxazolidinones and their use as antibacterial agents |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU80081A1 (fr) * | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
FR2506769A2 (fr) * | 1978-06-09 | 1982-12-03 | Delalande Sa | Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique |
FR2458547B2 (fr) * | 1978-06-09 | 1986-05-16 | Delalande Sa | Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique |
US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
CA1171865A (en) * | 1980-06-04 | 1984-07-31 | Alain Lacour | N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics |
FR2608604B1 (fr) * | 1986-12-19 | 1989-04-28 | Delalande Sa | Derives 5-hydroxyethyles de l'oxazolidinone-2, leurs procedes de preparation et leurs applications en therapeutique |
FR2653017B1 (fr) * | 1989-10-17 | 1995-05-05 | Delalande Sa | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
-
1989
- 1989-10-17 FR FR8913555A patent/FR2653017B1/fr not_active Expired - Fee Related
-
1990
- 1990-10-15 US US07/597,583 patent/US5036091A/en not_active Expired - Lifetime
- 1990-10-15 US US07/597,426 patent/US5036090A/en not_active Expired - Fee Related
- 1990-10-16 EP EP90402893A patent/EP0428421A1/fr not_active Withdrawn
- 1990-10-16 CA CA002027715A patent/CA2027715A1/en not_active Abandoned
- 1990-10-16 EP EP90402892A patent/EP0424244B1/fr not_active Expired - Lifetime
- 1990-10-16 EP EP90402891A patent/EP0424243B1/fr not_active Expired - Lifetime
- 1990-10-16 AT AT90402891T patent/ATE126792T1/de active
- 1990-10-16 CA CA002027783A patent/CA2027783C/en not_active Expired - Lifetime
- 1990-10-16 DK DK90402892.5T patent/DK0424244T3/da active
- 1990-10-16 DE DE69021823T patent/DE69021823T2/de not_active Expired - Fee Related
- 1990-10-16 US US07/598,254 patent/US5171747A/en not_active Expired - Fee Related
- 1990-10-16 ES ES90402892T patent/ES2078958T3/es not_active Expired - Lifetime
- 1990-10-16 AT AT90402892T patent/ATE126220T1/de not_active IP Right Cessation
- 1990-10-16 CA CA002027782A patent/CA2027782C/en not_active Expired - Fee Related
- 1990-10-16 DE DE69021498T patent/DE69021498T2/de not_active Expired - Lifetime
- 1990-10-17 AU AU64714/90A patent/AU637413B2/en not_active Expired
- 1990-10-17 WO PCT/FR1990/000745 patent/WO1991005774A1/fr unknown
- 1990-10-17 KR KR1019910700619A patent/KR0149508B1/ko not_active IP Right Cessation
- 1990-10-17 WO PCT/FR1990/000746 patent/WO1991005775A1/fr active Application Filing
- 1990-10-17 NZ NZ235728A patent/NZ235728A/en unknown
- 1990-10-17 JP JP2514787A patent/JPH04502333A/ja active Pending
- 1990-10-17 AU AU64713/90A patent/AU637150B2/en not_active Ceased
- 1990-10-17 NZ NZ235727A patent/NZ235727A/en unknown
- 1990-10-17 WO PCT/FR1990/000747 patent/WO1991005776A1/fr unknown
- 1990-10-17 NZ NZ235729A patent/NZ235729A/en unknown
- 1990-10-17 AU AU64715/90A patent/AU635779B2/en not_active Ceased
- 1990-10-17 KR KR1019910700618A patent/KR920701176A/ko active IP Right Grant
- 1990-10-17 JP JP2514788A patent/JPH07103114B2/ja not_active Expired - Lifetime
- 1990-10-17 ZA ZA908284A patent/ZA908284B/xx unknown
- 1990-10-17 ZA ZA908285A patent/ZA908285B/xx unknown
- 1990-10-17 ZA ZA908283A patent/ZA908283B/xx unknown
- 1990-10-17 JP JP2514789A patent/JPH04502335A/ja active Pending
- 1990-10-17 KR KR1019910700620A patent/KR920701178A/ko not_active Application Discontinuation
-
1995
- 1995-10-11 GR GR950402817T patent/GR3017708T3/el unknown
-
1998
- 1998-06-02 HK HK98104744A patent/HK1005591A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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