DE69021498D1 - 3-Aryl-Oxazolidinone-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung in der Therapie. - Google Patents

3-Aryl-Oxazolidinone-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung in der Therapie.

Info

Publication number
DE69021498D1
DE69021498D1 DE69021498T DE69021498T DE69021498D1 DE 69021498 D1 DE69021498 D1 DE 69021498D1 DE 69021498 T DE69021498 T DE 69021498T DE 69021498 T DE69021498 T DE 69021498T DE 69021498 D1 DE69021498 D1 DE 69021498D1
Authority
DE
Germany
Prior art keywords
group
alkyl
chain
groups
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69021498T
Other languages
English (en)
Other versions
DE69021498T2 (de
Inventor
Francois-Xavier Jarreau
Vincenzo Rovei
Jean-Jacques Koenig
Alain Schoofs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of DE69021498D1 publication Critical patent/DE69021498D1/de
Publication of DE69021498T2 publication Critical patent/DE69021498T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
DE69021498T 1989-10-17 1990-10-16 3-Aryl-Oxazolidinone-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung in der Therapie. Expired - Lifetime DE69021498T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913555A FR2653017B1 (fr) 1989-10-17 1989-10-17 Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.

Publications (2)

Publication Number Publication Date
DE69021498D1 true DE69021498D1 (de) 1995-09-14
DE69021498T2 DE69021498T2 (de) 1996-03-28

Family

ID=9386480

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69021823T Expired - Fee Related DE69021823T2 (de) 1989-10-17 1990-10-16 3-Aryl-Oxazolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung in der Therapie.
DE69021498T Expired - Lifetime DE69021498T2 (de) 1989-10-17 1990-10-16 3-Aryl-Oxazolidinone-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung in der Therapie.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69021823T Expired - Fee Related DE69021823T2 (de) 1989-10-17 1990-10-16 3-Aryl-Oxazolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung in der Therapie.

Country Status (16)

Country Link
US (3) US5036091A (de)
EP (3) EP0424244B1 (de)
JP (3) JPH04502335A (de)
KR (3) KR0149508B1 (de)
AT (2) ATE126792T1 (de)
AU (3) AU637150B2 (de)
CA (3) CA2027783C (de)
DE (2) DE69021823T2 (de)
DK (1) DK0424244T3 (de)
ES (1) ES2078958T3 (de)
FR (1) FR2653017B1 (de)
GR (1) GR3017708T3 (de)
HK (1) HK1005591A1 (de)
NZ (3) NZ235728A (de)
WO (3) WO1991005775A1 (de)
ZA (3) ZA908283B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2653017B1 (fr) * 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
US5196543A (en) * 1989-10-17 1993-03-23 Delalande S.A. 3-aryloxazolidinone derivatives, process for their preparation and their use in therapy
US5235063A (en) * 1989-10-17 1993-08-10 Delalande S.A. Process of preparing by condensation certain
FR2675504B1 (fr) * 1991-04-16 1995-01-27 Delalande Sa Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique.
TW286317B (de) * 1993-12-13 1996-09-21 Hoffmann La Roche
FR2715155B1 (fr) * 1994-01-19 1996-07-26 Mayoly Spindler Inhibiteurs de la monoamine oxydase B et leurs procédés de préparation.
FR2732679B1 (fr) * 1995-04-07 1997-04-30 Synthelabo Procede de preparation enzymatique d'un intermediaire de synthese de la befloxatone
FR2734821B1 (fr) * 1995-06-02 1997-07-11 Synthelabo Derives de 5-methoxymethyl-3-(1,2-benzisoxazol-3-yl) oxazolidin-2-one, leur preparation et leur application en therapeutique
AU699367B2 (en) * 1995-06-02 1998-12-03 Sanofi-Aventis Isoindole derivatives, their preparation and their application in therapy
FR2734820B1 (fr) * 1995-06-02 1997-07-11 Synthelabo Derives de 3-(1,2-benzisoxazol-3-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique
FR2737206B1 (fr) * 1995-07-24 1997-08-22 Synthelabo Derives d'oxazoloquinoleinone, leur preparation et leur application en therapeutique
FR2741072B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives d'oxazolidin-2-one, leur preparation et leur application en therapeutique
FR2741071B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique
US6642409B2 (en) 2000-01-27 2003-11-04 Central Glass Company, Limited Process for producing 4,4,4-trifluoro-3-hydroxybutyric acid derivatives
US6444813B2 (en) * 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
WO2002018354A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Oxazolidinones and their use as antibacterial agents
EP2266590A3 (de) 2002-02-22 2011-04-20 Shire LLC Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
FR2506769A2 (fr) * 1978-06-09 1982-12-03 Delalande Sa Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2458547B2 (fr) * 1978-06-09 1986-05-16 Delalande Sa Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
CA1171865A (en) * 1980-06-04 1984-07-31 Alain Lacour N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics
FR2608604B1 (fr) * 1986-12-19 1989-04-28 Delalande Sa Derives 5-hydroxyethyles de l'oxazolidinone-2, leurs procedes de preparation et leurs applications en therapeutique
FR2653017B1 (fr) * 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
DE69021823T2 (de) 1996-07-11
KR920701178A (ko) 1992-08-11
EP0424243A1 (de) 1991-04-24
JPH04502335A (ja) 1992-04-23
AU637150B2 (en) 1993-05-20
WO1991005774A1 (fr) 1991-05-02
ES2078958T3 (es) 1996-01-01
CA2027783A1 (en) 1991-04-18
CA2027783C (en) 1996-04-30
WO1991005776A1 (fr) 1991-05-02
CA2027715A1 (en) 1991-04-18
AU635779B2 (en) 1993-04-01
AU637413B2 (en) 1993-05-27
AU6471390A (en) 1991-06-20
US5036091A (en) 1991-07-30
KR920701176A (ko) 1992-08-11
EP0428421A1 (de) 1991-05-22
KR0149508B1 (ko) 1998-10-15
NZ235728A (en) 1992-04-28
CA2027782A1 (en) 1991-04-18
JPH07103114B2 (ja) 1995-11-08
JPH04502333A (ja) 1992-04-23
GR3017708T3 (en) 1996-01-31
KR920701177A (ko) 1992-08-11
NZ235729A (en) 1992-05-26
EP0424243B1 (de) 1995-08-23
US5036090A (en) 1991-07-30
ATE126792T1 (de) 1995-09-15
DE69021823D1 (de) 1995-09-28
FR2653017B1 (fr) 1995-05-05
DK0424244T3 (da) 1996-01-02
ATE126220T1 (de) 1995-08-15
AU6471490A (en) 1991-07-18
ZA908285B (en) 1991-08-28
DE69021498T2 (de) 1996-03-28
NZ235727A (en) 1992-04-28
ZA908284B (en) 1991-08-28
AU6471590A (en) 1991-06-20
ZA908283B (en) 1991-08-28
WO1991005775A1 (fr) 1991-05-02
US5171747A (en) 1992-12-15
EP0424244B1 (de) 1995-08-09
CA2027782C (en) 1996-04-30
EP0424244A1 (de) 1991-04-24
HK1005591A1 (en) 1999-01-15
FR2653017A1 (fr) 1991-04-19
JPH04502334A (ja) 1992-04-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8328 Change in the person/name/address of the agent

Free format text: MUELLER, SCHUPFNER & GAUGER, 80539 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR