YU47124B - Postupak za dobijanje novih derivata 7-(1-azetidinil)-1,4-dihidro-4-oksokinolein-3-karboks ilnih kiselina - Google Patents

Postupak za dobijanje novih derivata 7-(1-azetidinil)-1,4-dihidro-4-oksokinolein-3-karboks ilnih kiselina

Info

Publication number
YU47124B
YU47124B YU237088A YU237088A YU47124B YU 47124 B YU47124 B YU 47124B YU 237088 A YU237088 A YU 237088A YU 237088 A YU237088 A YU 237088A YU 47124 B YU47124 B YU 47124B
Authority
YU
Yugoslavia
Prior art keywords
alkyl
hydrogen atom
formula
group
atom
Prior art date
Application number
YU237088A
Other languages
English (en)
Other versions
YU237088A (en
Inventor
Pares J. Corominas
Frigola J. Constansa
Colombo A. Pinol
Original Assignee
Laboratorios Del Dr. Esteve S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8718289A external-priority patent/FR2625200A1/fr
Application filed by Laboratorios Del Dr. Esteve S.A. filed Critical Laboratorios Del Dr. Esteve S.A.
Publication of YU237088A publication Critical patent/YU237088A/xx
Publication of YU47124B publication Critical patent/YU47124B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH DERIVATA 7-(1-AZETIDINIL)-1,4-DIHIDRO-4-OKSOKINOLEIN-3-KARBOKS ILNIH KISELINA, opste formule I u kojoj R1 predstavlja C1-4 alkil, fluoro C1-4 alikil, ciklopropil, fenil ili supstituisani fenil sa jednim ili vise atoma fluora, R2 predstavlja atom vodonika, atom fluora, ili R1 i R2 mogu zajedno da obrazuju vezu predstavljenu grupom X, R3 predstavlja atom vodonika ili C1-4 alkil, R4, R5 i R6 nezavisno predstavljaju atom vodonika, C1-4 alkil, hidroksi, amino, amino C1-4 alikil, di C1-4 alkilamino, C1-4 alkilamino C1-4 alkil, C1-4 alkoksi, meziloksi, hidroksi C1-4 alkil, cijano, acetamino C1-4 alkil, karboksilna grupa, karboksiamido, karboksi C1-4 alkil, atom fluora, C1-4 alkilkarboksil kao acetoksi, acetamido ili acetamido C1-4 alkil gde slobodne krajnje alkil grupe mogu da budu fluorovane, i u acetamidoalkil radikalu atom azota moze da bude supstituisan C1-4 alkil grupom, X predstavlja -CH2-CH2-CHR7-, -O-CH2-CHR7 ili gde R7 predstavlja atom vodonika ili C1-4 alkil, R8 predstavlja atom vodonika ili atom halogena prvenstveno fluora i Y predstavlja CH ili N, izuzimajuci jedinjenja formule (I) u kojoj R1 i R4 zajedno obrazuju vezu predstavljenu grupom -O-CH2-CH(CH3)- i R3, R4 i R6 predstavljaju atom vodonika a R5 predstavlja hidroksi ili hidroksimetil grupu, i izuzimajuci jedinjenja formule (I) u kojoj R1 predstavlja etil, R2 predstavlja atom fluora, R3, R4 i R6 predstavljaju atom vodonika i R5 predstavlja etilaminometil, nazn acen time, sto heterociklicno jedinjenje formule II u kojoj R1, R2 i R3 imaju napred navedena znacenja, i Z predstavlja atom halogena, reaguje sa jedinjenjem formule III u kojoj R4, R5 i R6 imaju napred navedena znacenja, na temperaturi izmedju 50 i 250°C u rastvaracu iz grupe koju cine nizi alkoholi kao sto je etanol ili izopropanol, etri kao sto je tetrahidrofuran ili dioksan, nitrili kao sto je acetonitril ili piridin, u prisustvu akceptora kiseline kao sto su alkalni hidroksidi i karbonati ili amini kao sto je trietilamin, ili navedeno heterociklicno jedinjenje formule II u kojoj Z predstavlja amino radikal reaguje sa jedinjenjem formule IV u kojoj R4, R5 i R6 imaju navedena znacenja i A predstavlja halogen, hidroksilnu, C1-4 alkil- ili fenil-sulfoniloksi grupu, na temperaturi izmedju 10 i 150°C u aprotonskom rastvaracu kao sto je dimetilsul-foksid ili dimetilformamid, i u prisustvu akceptora kiseline kao sto su alkalni hidroksidi i karbonati ili amini kao sto je trietilamin.
YU237088A 1987-12-29 1988-12-28 Postupak za dobijanje novih derivata 7-(1-azetidinil)-1,4-dihidro-4-oksokinolein-3-karboks ilnih kiselina YU47124B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8718289A FR2625200A1 (en) 1987-12-29 1987-12-29 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
FR888809816A FR2634483B2 (fr) 1987-12-29 1988-07-20 Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments

Publications (2)

Publication Number Publication Date
YU237088A YU237088A (en) 1990-12-31
YU47124B true YU47124B (sh) 1994-12-28

Family

ID=26226417

Family Applications (1)

Application Number Title Priority Date Filing Date
YU237088A YU47124B (sh) 1987-12-29 1988-12-28 Postupak za dobijanje novih derivata 7-(1-azetidinil)-1,4-dihidro-4-oksokinolein-3-karboks ilnih kiselina

Country Status (14)

Country Link
US (1) US4927926A (sh)
EP (1) EP0324298B1 (sh)
JP (1) JPH0813811B2 (sh)
KR (1) KR920004136B1 (sh)
AU (1) AU617735B2 (sh)
DE (1) DE3876969T2 (sh)
DK (1) DK726188A (sh)
ES (1) ES2010114A6 (sh)
FR (1) FR2634483B2 (sh)
GR (1) GR3006664T3 (sh)
HU (1) HU206206B (sh)
NO (1) NO176605C (sh)
PT (1) PT89352B (sh)
YU (1) YU47124B (sh)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839355A (en) * 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
DE3814517A1 (de) * 1988-02-05 1989-08-17 Bayer Ag Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
FR2644455B1 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicaments
FR2649106A2 (fr) * 1989-06-29 1991-01-04 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament
FR2654728B2 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament.
NO177302C (no) * 1989-03-16 1995-08-23 Esteve Labor Dr Analogifremgangsmåte til fremstilling av terapeutisk aktive substituerte azetidinylkinolon(naftyridon)karboksylsyrederivater
IE912902A1 (en) * 1990-08-24 1992-02-26 Abbott Lab Quinbenzoxazine, quinobenzothiazine, and pyrido-acridine¹antineoplastic agents
FR2676445B1 (fr) * 1991-05-16 1995-02-03 Esteve Labor Dr Derives de pyridone amino acide azetidinyl substitues, leur preparation et leur application en tant que medicaments.
US5556861A (en) * 1991-10-01 1996-09-17 Laboratoire Roger Bellon 1,8 benzonaphthyridine derivatives and antimicrobial compositions
FR2690161B1 (fr) * 1992-04-16 1995-06-30 Esteve Labor Dr Derives de pyridone azetidinyl substitues avec activite antimicrobienne.
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
JP2005097116A (ja) * 1999-11-11 2005-04-14 Wakunaga Pharmaceut Co Ltd キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法
WO2005026146A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Azetidinyl quinolones as antibacterial agents
DE602005024151D1 (de) * 2004-08-02 2010-11-25 Glaxo Group Ltd Antibakterielle mittel
JP2014533744A (ja) 2011-12-01 2014-12-15 パーデュー、ファーマ、リミテッド、パートナーシップ アゼチジン置換キノキサリンタイプピペリジン化合物とその使用
BR112015008308A2 (pt) 2012-10-16 2017-12-05 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por metileno do ror-gama-t
SG11201502935VA (en) 2012-10-16 2015-09-29 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror-gamma-t
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
KR20160068956A (ko) 2013-10-15 2016-06-15 얀센 파마슈티카 엔.브이. RORyT의 퀴놀리닐 조절제
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
JP6423423B2 (ja) * 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
CA3200318A1 (en) * 2020-10-30 2022-05-05 1Cbio, Inc. Ectonucleotide pyrophosphatase-phosphodiesterase-1 (enpp1) inhibitors and uses thereof
CN113045539B (zh) * 2021-03-30 2021-12-07 苏州大学 2-(4,4-二氯-1-(8-喹啉基)-2-氮杂环丁基)羧酸酯衍生物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4540690A (en) * 1982-02-09 1985-09-10 The Upjohn Company 2-(Phenylmethylene)cycloalkylamines and -azetidines
US4777175A (en) * 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
JPS6089480A (ja) * 1983-10-21 1985-05-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体
JPS60126284A (ja) * 1983-12-09 1985-07-05 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびその塩
CA1267413A (en) * 1984-04-26 1990-04-03 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4588263A (en) * 1984-05-02 1986-05-13 International Business Machines Corporation An adjustable-optical prism with integral-polarizing beam splitter and applications thereof
JPS61137885A (ja) * 1984-12-08 1986-06-25 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン誘導体、そのエステルおよびその塩
US4617308A (en) * 1985-01-25 1986-10-14 Warner-Lambert Company 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents
CN1019114B (zh) * 1986-03-31 1992-11-18 三共株式会社 喹啉-3-羟酸衍生物的制备方法
US5039683A (en) * 1987-10-26 1991-08-13 Pfizer Inc. Azetidinyl quinolone carboxylic acids and esters
AU603936B2 (en) * 1988-02-04 1990-11-29 Chenault D. Lee Disposable vaginal speculum

Also Published As

Publication number Publication date
JPH01301677A (ja) 1989-12-05
NO176605B (no) 1995-01-23
US4927926A (en) 1990-05-22
DE3876969T2 (de) 1993-05-19
HU206206B (en) 1992-09-28
DK726188D0 (da) 1988-12-28
AU2757888A (en) 1989-06-29
NO176605C (no) 1995-05-03
KR920004136B1 (ko) 1992-05-25
KR890009911A (ko) 1989-08-04
NO885797L (no) 1989-06-30
EP0324298A1 (fr) 1989-07-19
FR2634483B2 (fr) 1994-03-04
DK726188A (da) 1989-06-30
FR2634483A2 (fr) 1990-01-26
HUT50467A (en) 1990-02-28
YU237088A (en) 1990-12-31
DE3876969D1 (de) 1993-02-04
PT89352B (pt) 1993-09-30
NO885797D0 (no) 1988-12-28
ES2010114A6 (es) 1989-10-16
JPH0813811B2 (ja) 1996-02-14
EP0324298B1 (fr) 1992-12-23
PT89352A (pt) 1989-12-29
AU617735B2 (en) 1991-12-05
GR3006664T3 (sh) 1993-06-30

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