YU46723B - Ekspresija, prerada i sekrecija heterologog proteina pomoću kvasca - Google Patents

Ekspresija, prerada i sekrecija heterologog proteina pomoću kvasca

Info

Publication number
YU46723B
YU46723B YU55683A YU55683A YU46723B YU 46723 B YU46723 B YU 46723B YU 55683 A YU55683 A YU 55683A YU 55683 A YU55683 A YU 55683A YU 46723 B YU46723 B YU 46723B
Authority
YU
Yugoslavia
Prior art keywords
yeast
processing
protein
expression
secretion
Prior art date
Application number
YU55683A
Other languages
English (en)
Other versions
YU55683A (en
Inventor
R.A. Hitzeman
D.W. Leung
Original Assignee
Genentech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26998782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU46723(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc. filed Critical Genentech Inc.
Publication of YU55683A publication Critical patent/YU55683A/xx
Publication of YU46723B publication Critical patent/YU46723B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Lubricants (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)

Abstract

EKSPRESIJA, PRERADA I SEKRECIJA HETEROLOGOG PROTEINA POMOĆU KVASCA ćeliska kultura organizma kvasca sposobna za ekspresijju, preradu i lučenje proteina homolognog organizmu kvasca, naznačena time, što obuhvata sposobne za život ćelije kvasca transformisane sa ekspresionim nosaČem koji funkcionalno sadrži DNA koja kodira dati protein zajedno sa heterolognim signalnim polpeptidom koji normalno ne proizvodi ili koristi dati organizam kvasca i sredinu za održavanje date ćeliske kulture koja sadrži protein kao proizvod ekspresije, prerade i lučenja organizma kvasca. Prijava sadrži još 18 zavisnih zahteva.
YU55683A 1982-03-08 1983-03-08 Ekspresija, prerada i sekrecija heterologog proteina pomoću kvasca YU46723B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35529782A 1982-03-08 1982-03-08
US06/438,236 US4775622A (en) 1982-03-08 1982-11-01 Expression, processing and secretion of heterologous protein by yeast

Publications (2)

Publication Number Publication Date
YU55683A YU55683A (en) 1989-08-31
YU46723B true YU46723B (sh) 1994-04-05

Family

ID=26998782

Family Applications (1)

Application Number Title Priority Date Filing Date
YU55683A YU46723B (sh) 1982-03-08 1983-03-08 Ekspresija, prerada i sekrecija heterologog proteina pomoću kvasca

Country Status (28)

Country Link
US (1) US4775622A (sh)
EP (1) EP0088632B1 (sh)
JP (2) JPH0829111B2 (sh)
AU (1) AU574323B2 (sh)
BG (1) BG46159A3 (sh)
BR (1) BR8301150A (sh)
CZ (1) CZ282905B6 (sh)
DD (1) DD207220A5 (sh)
DE (2) DE3308215C2 (sh)
DK (1) DK163932C (sh)
DZ (1) DZ513A1 (sh)
ES (1) ES520416A0 (sh)
FI (1) FI830774L (sh)
FR (1) FR2523152B1 (sh)
GB (1) GB2116567B (sh)
GR (1) GR78506B (sh)
IE (1) IE55743B1 (sh)
IL (1) IL68058A (sh)
MX (1) MX163813B (sh)
NO (1) NO830780L (sh)
NZ (1) NZ203494A (sh)
OA (1) OA07338A (sh)
PH (1) PH24804A (sh)
PL (1) PL153724B1 (sh)
PT (1) PT76360B (sh)
RO (1) RO88582A (sh)
YU (1) YU46723B (sh)
ZW (1) ZW6283A1 (sh)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196194A (en) * 1979-05-24 1993-03-23 The Regents Of The University Of California Vaccines containing Hepatitis B S-protein
DE3176404D1 (en) * 1980-04-22 1987-10-08 Pasteur Institut Vaccine against viral hepatitis b, method and transformed eucaryotic cells for the preparation of this vaccine
US4769238A (en) 1981-08-04 1988-09-06 The Regents Of The University Of California Synthesis of human virus antigens by yeast
JPS58146281A (ja) * 1981-10-19 1983-08-31 Suntory Ltd 酵母細胞の形質転換法
US4943529A (en) * 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
US5618697A (en) * 1982-12-10 1997-04-08 Novo Nordisk A/S Process for preparing a desired protein
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
EP0116201B1 (en) * 1983-01-12 1992-04-22 Chiron Corporation Secretory expression in eukaryotes
US7198919B1 (en) 1983-04-25 2007-04-03 Genentech, Inc. Use of alpha factor sequences in yeast expression systems
US4859600A (en) * 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
NZ207925A (en) * 1983-04-25 1988-05-30 Genentech Inc Yeast expression vehicle consisting of a yeast promoter and signal peptide encoding region linked to a heterologus peptide coding region; expression and culture
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
PH22337A (en) * 1983-11-21 1988-08-12 Ciba Geigy Ag Synthesis of fibrinolytic agents by yeast
PH23920A (en) * 1983-12-20 1990-01-23 Cetus Corp Glucoamylase cdna
FI841500A0 (fi) * 1984-04-13 1984-04-13 Valtion Teknillinen Foerfarande foer uppbygnande av cellulolytiska jaeststammar.
US7273695B1 (en) * 1984-10-31 2007-09-25 Novartis Vaccines And Diagnostics, Inc. HIV immunoassays using synthetic envelope polypeptides
CA1341482C (en) 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses
US7285271B1 (en) 1984-10-31 2007-10-23 Novartis Vaccines And Diagnostics, Inc. Antigenic composition comprising an HIV gag or env polypeptide
EP0184575B1 (en) * 1984-12-06 1993-04-28 Fina Research S.A. Transformed yeasts producing lysozyme, plasmids used for this transformation, and uses thereof
US4902620A (en) * 1985-04-25 1990-02-20 Eli Lilly And Company Novel DNA for expression of delta-aminolevulinic acid synthetase and related method
DE3580590D1 (de) * 1985-05-29 1990-12-20 Green Cross Corp Herstellungsverfahren fuer heterogene proteine.
US5164485A (en) * 1985-08-20 1992-11-17 Takeda Chemical Industries, Ltd. Modified hepatitis B virus surface antigen P31 and production thereof
ATE117020T1 (de) * 1985-08-29 1995-01-15 Genencor Int Expression von heterologen polypeptiden in filamentösen pilzen, verfahren zu deren herstellung und vektoren zu deren herstellung.
JPS62175183A (ja) * 1985-08-29 1987-07-31 ジエネンコ−　インコ−ポレ−テツド 繊維状菌類中に発現する異種ポリペプチドとその製造方法及びその製造のためのベクタ−
US4937189A (en) * 1985-10-18 1990-06-26 Pfizer Inc. Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants
CA1295567C (en) * 1988-07-25 1992-02-11 Lawrence T. Malek Expression system for the secretion of bioactive human granulocyte, macrophage-colony stimulating factor (gm-csf) and other heterologous proteins from streptomyces
GB8530631D0 (en) 1985-12-12 1986-01-22 Ciba Geigy Ag Thrombin inhibitors
US5024941A (en) * 1985-12-18 1991-06-18 Biotechnica International, Inc. Expression and secretion vector for yeast containing a glucoamylase signal sequence
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
US5766912A (en) 1986-03-17 1998-06-16 Novo Nordisk A/S Humicola lipase produced in aspergillus
US5536661A (en) * 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
FR2599753B1 (fr) * 1986-06-05 1989-12-08 Sanofi Sa Sequence d'adn composite et son application pour la production de l'hormone de croissance
GB8615701D0 (en) * 1986-06-27 1986-08-06 Delta Biotechnology Ltd Stable gene integration vector
JPH0616716B2 (ja) * 1986-10-14 1994-03-09 塩野義製薬株式会社 酵母におけるヒトｐｓｔｉの製造法
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
US5610034A (en) * 1987-04-29 1997-03-11 Alko Group Ltd. Immunoglobulin production by trichoderma
JP2791418B2 (ja) * 1987-12-02 1998-08-27 株式会社ミドリ十字 異種蛋白質の製造方法、組換えｄｎａ、形質転換体
US7442525B1 (en) * 1987-12-24 2008-10-28 Novartis Vaccines And Diagnostics, Inc. Method for expressing HIV polypeptides
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
JPH01240191A (ja) * 1988-02-16 1989-09-25 Green Cross Corp:The 酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
US5149544A (en) * 1989-11-13 1992-09-22 Research Corporation Technologies, Inc. Method of inhibiting progenitor cell proliferation
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
WO1992005244A1 (en) 1990-09-13 1992-04-02 Duke University Expression of g protein coupled receptors in yeast
AU8740491A (en) * 1990-09-28 1992-04-28 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
US5364930A (en) * 1990-10-16 1994-11-15 Northwestern University Synthetic C1q peptide fragments
US5932483A (en) * 1990-10-16 1999-08-03 Northwestern University Synthetic peptide and its uses
FR2669931B1 (fr) * 1990-11-29 1995-03-31 Transgene Nouveaux variants derives des interferons-alpha et leur procede de production.
WO1992009691A1 (fr) * 1990-11-29 1992-06-11 Institut National De La Recherche Agronomique - I.N.R.A. Nouveaux variants derives des interferons de type i, leur procede de production, et leurs applications
CA2058820C (en) * 1991-04-25 2003-07-15 Kotikanyad Sreekrishna Expression cassettes and vectors for the secretion of human serum albumin in pichia pastoris cells
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5538863A (en) * 1993-07-01 1996-07-23 Immunex Corporation Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
JP3763924B2 (ja) * 1997-03-17 2006-04-05 フクダ電子株式会社 超音波診断装置
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
US5977076A (en) * 1997-04-14 1999-11-02 Anderson; Byron E. Method and material for inhibiting complement
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
GB2338236B (en) * 1998-06-13 2003-04-09 Aea Technology Plc Microbiological cell processing
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
US6890730B1 (en) 1999-12-10 2005-05-10 The Salk Institute Sequence and method for increasing protein expression in cellular expression systems
EP2267026A1 (en) 2000-04-12 2010-12-29 Human Genome Sciences, Inc. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US6358733B1 (en) * 2000-05-19 2002-03-19 Apolife, Inc. Expression of heterologous multi-domain proteins in yeast
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7863020B2 (en) 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
AU7684201A (en) 2000-06-28 2002-01-08 Glycofi Inc Methods for producing modified glycoproteins
US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7083787B2 (en) * 2000-11-15 2006-08-01 Globeimmune, Inc. Yeast-dendritic cell vaccines and uses thereof
US7507413B2 (en) * 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
AU2002364587A1 (en) 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
US8343502B2 (en) * 2002-12-16 2013-01-01 Globeimmune, Inc. Yeast-based vaccines as immunotherapy
EP1581174B1 (en) * 2002-12-16 2018-04-25 GlobeImmune, Inc. Yeast-based vaccines as immunotherapy
US7439042B2 (en) * 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
US7332299B2 (en) * 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
EP1660661A2 (en) * 2003-08-08 2006-05-31 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
DK1678314T3 (da) 2003-10-22 2012-12-03 Keck Graduate Inst Fremgangsmåde til syntetisering af heteromultimere polypeptider i gær ved anvendelse af en haploid parringsstrategi
CA2545855A1 (en) * 2003-11-14 2005-06-02 Baxter International Inc. Alpha 1-antitrypsin compositions and treatment methods using such compositions
US20050170457A1 (en) * 2003-12-31 2005-08-04 Chadler Pool Novel recombinant proteins with N-terminal free thiol
CN1934128B (zh) 2004-01-20 2011-01-26 财团法人化学及血清疗法研究所 在2价阳离子存在下通过加热处理制备人血清白蛋白的方法
WO2006044923A2 (en) * 2004-10-18 2006-04-27 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis c infection
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US20070105768A1 (en) * 2004-11-10 2007-05-10 Rajiv Nayar Dry recombinant human alpha 1-antitrypsin formulation
CA2614884A1 (en) * 2005-07-11 2007-01-18 Globeimmune, Inc Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
US20070172503A1 (en) * 2005-12-13 2007-07-26 Mycologics,Inc. Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines
BRPI0709340A2 (pt) * 2006-03-27 2013-04-16 Globeimmune Inc mutaÇço ras e composiÇÕes e mÉtodos de uso da mesma
JP2008174489A (ja) * 2007-01-18 2008-07-31 Nitto Denko Corp 微生物とペプチド性薬物を含む新規製剤
WO2008097863A2 (en) * 2007-02-02 2008-08-14 Globeimmune, Inc. Methods for producing yeast-based vaccines
CN101730542A (zh) * 2007-03-19 2010-06-09 环球免疫公司 用于靶向消除癌症靶向疗法的突变逃逸的组合物和方法
US8728489B2 (en) 2008-09-19 2014-05-20 Globeimmune, Inc. Immunotherapy for chronic hepatitis C virus infection
JP5759980B2 (ja) 2009-04-17 2015-08-05 グローブイミューン，インコーポレイテッド 癌および感染症に対する免疫療法組成物の組み合わせ
EP2477647B1 (en) 2009-09-14 2016-01-13 The Regents of the University of Colorado Modulation of yeast-based immunotherapy products and responses
WO2012083302A2 (en) 2010-12-17 2012-06-21 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human adenovirus-36 infection
AP2013007110A0 (en) 2011-02-12 2013-09-30 Globeimmune Inc Yeast-based therapeutic for chronic hepatitis B infection
HUE033491T2 (en) 2011-03-17 2017-12-28 Globeimmune Inc Yeast-Brachyury immunotherapy
JP2014523878A (ja) 2011-06-14 2014-09-18 グローブイミューン，インコーポレイテッド Ｄ型肝炎ウイルス感染の治療又は予防のための酵母ベースの組成物及び方法
MX352892B (es) 2011-08-17 2017-12-13 Globeimmune Inc Composiciones inmunoterapeuticas de levadura-mucina 1 (muc1) y usos de las mismas.
WO2014003853A1 (en) 2012-06-26 2014-01-03 Biodesix, Inc. Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
LT2872644T (lt) 2012-07-12 2017-10-10 Uab Baltymas Natyvių rekombinantinių sekretuojamų žmogaus endoplazminio tinklo šaperonų gamyba, panaudojant jų natyvias signalines sekas, mielių raiškos sistemose
JP6509808B2 (ja) 2013-03-19 2019-05-08 グローブイミューン，インコーポレイテッド 脊索腫のための酵母系免疫療法
US9782473B2 (en) 2013-03-26 2017-10-10 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
WO2015031778A2 (en) 2013-08-30 2015-03-05 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
JP2017507182A (ja) * 2014-02-24 2017-03-16 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｔｍｅｍ１００ペプチド及びその変異体、並びに疾患又は状態の処置又は予防におけるそれらの使用
KR102409372B1 (ko) 2014-04-11 2022-06-16 글로브이뮨 효모 면역 요법 및 타입 i 인터페론 감도
KR20180054587A (ko) 2015-08-03 2018-05-24 글로브이뮨 변형된 효모-브라큐리 면역치료학적 조성물
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN113549639B (zh) * 2021-07-21 2022-07-29 云南中烟工业有限责任公司 一种降低烟叶总蛋白及烟气苯酚含量的调控基因

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2441659A1 (fr) * 1978-11-14 1980-06-13 Anvar Nouveaux plasmides hybrides et microorganismes les contenant
US4503035B1 (en) 1978-11-24 1996-03-19 Hoffmann La Roche Protein purification process and product
ZA802992B (en) * 1979-06-01 1981-10-28 Univ California Human pre-growth hormone
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
JPS5630925A (en) * 1979-08-21 1981-03-28 Sumitomo Chem Co Ltd Purification of human growth hormone
US4443539A (en) * 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
GB2068969B (en) * 1980-02-05 1983-07-27 Upjohn Co Gene expression
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
GB2079288B (en) * 1980-05-12 1984-05-16 Biogen Nv Dna sequences recombinat dna molecules and processes for producing polypeptides with the specificity of foot and mouth disease viral antigens
CH657141A5 (de) * 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
FR2490675B1 (fr) * 1980-09-25 1985-11-15 Genentech Inc Production microbienne d'interferon de fibroplaste humain
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
US4456748A (en) * 1981-02-23 1984-06-26 Genentech, Inc. Hybrid human leukocyte interferons
US4414150A (en) * 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
US4666847A (en) * 1981-01-16 1987-05-19 Collaborative Research, Inc. Recombinant DNA means and method
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58996A (ja) * 1981-06-01 1983-01-06 ザ・ボ−ド・オブ・トラステイ−ズ・ミシガンステ−トユニバ−シテイ− 細菌中での牛成長ホルモン遺伝子のクロ−ン化
IE53517B1 (en) * 1981-06-17 1988-12-07 Celltech Ltd Process for the production of a polypeptide
DK368882A (da) * 1981-08-25 1983-02-26 Alan John Kingsman Expessions vektorer
NZ201705A (en) * 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

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MX163813B (es) 1992-06-22
GB8306285D0 (en) 1983-04-13
IE55743B1 (en) 1991-01-02
FI830774L (fi) 1983-09-09
BR8301150A (pt) 1983-11-22
FR2523152B1 (fr) 1985-08-23
EP0088632A3 (en) 1984-06-20
OA07338A (fr) 1984-08-31
PL153724B1 (en) 1991-05-31
FR2523152A1 (fr) 1983-09-16
DK163932B (da) 1992-04-21
GB2116567A (en) 1983-09-28
IL68058A0 (en) 1983-06-15
ES8500324A1 (es) 1984-11-01
NO830780L (no) 1983-09-09
DD207220A5 (de) 1984-02-22
RO88582A (ro) 1986-02-28
DZ513A1 (fr) 2004-09-13
IE830498L (en) 1983-09-08
FI830774A0 (fi) 1983-03-08
PH24804A (en) 1990-10-30
DE3308215C2 (de) 1994-01-27
IL68058A (en) 1989-12-15
DE3382694T2 (de) 1993-09-23
DK163932C (da) 1996-12-23
DK111283A (da) 1983-10-28
CZ282905B6 (cs) 1997-11-12
NZ203494A (en) 1986-06-11
PL240927A1 (en) 1983-11-07
ZW6283A1 (en) 1983-06-01
JPH0829111B2 (ja) 1996-03-27
PT76360B (en) 1986-02-12
CZ160883A3 (en) 1997-07-16
JPH06181779A (ja) 1994-07-05
GR78506B (sh) 1984-09-27
EP0088632B1 (en) 1993-06-16
DE3308215A1 (de) 1983-11-17
EP0088632A2 (en) 1983-09-14
BG46159A3 (en) 1989-10-16
DE3382694D1 (de) 1993-07-22
DK111283D0 (da) 1983-03-07
AU1215283A (en) 1983-09-15
JPS58174396A (ja) 1983-10-13
PT76360A (en) 1983-04-01
GB2116567B (en) 1986-01-02
ES520416A0 (es) 1984-11-01
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US4775622A (en) 1988-10-04
AU574323B2 (en) 1988-07-07

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