YU45778B - Postupak za dobijanje n(indeks 7)-amidino supstituisanih derivata mitomicina c - Google Patents

Postupak za dobijanje n(indeks 7)-amidino supstituisanih derivata mitomicina c

Info

Publication number
YU45778B
YU45778B YU70086A YU70086A YU45778B YU 45778 B YU45778 B YU 45778B YU 70086 A YU70086 A YU 70086A YU 70086 A YU70086 A YU 70086A YU 45778 B YU45778 B YU 45778B
Authority
YU
Yugoslavia
Prior art keywords
index
mitomycin
formula
derivatives
procedure
Prior art date
Application number
YU70086A
Other languages
English (en)
Other versions
YU70086A (en
Inventor
T. Kaneko
H.S.L. Wong
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of YU70086A publication Critical patent/YU70086A/xx
Publication of YU45778B publication Critical patent/YU45778B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

POSTUPAK ZA DOBIJANJE N(INDEKS 7)-AMIDINO SUPSTITUISANIH DERIVATA MITOMICINA C, formule: u kojoj R1 i R2 predstavljaju C1-3alkil grupe pravog ili račvastog niza ili, zajedno sa azotovim atomom za koji su vezane, grade pirolidinil, piperidinil ili tiomorfolinil grupu, naznačen time, što obuhvata reakciju mitomicina C sa hloroformimidinijumskom solju formule: u kojoj su R1 i R2 kao što je definisano gore, u polarnom aprotičnom rastvaraču kao što je metilen hlorid, hloroform, piridin ili rastvarač formule: gde su R1 i R2 kao što je definisano gore, u prisustvu tercijarnog amina kao što je trietilamin, na temperaturi od -50 C do +20 C i u trajanju od oko 5 minuta do jednog sata. Prijava sadrži još 5 patentnih zahteva.
YU70086A 1985-04-29 1986-04-29 Postupak za dobijanje n(indeks 7)-amidino supstituisanih derivata mitomicina c YU45778B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/728,650 US4652644A (en) 1985-04-29 1985-04-29 Process for preparation of N7 -amidino substituted mitomycin C derivatives

Publications (2)

Publication Number Publication Date
YU70086A YU70086A (en) 1987-12-31
YU45778B true YU45778B (sh) 1992-07-20

Family

ID=24927725

Family Applications (1)

Application Number Title Priority Date Filing Date
YU70086A YU45778B (sh) 1985-04-29 1986-04-29 Postupak za dobijanje n(indeks 7)-amidino supstituisanih derivata mitomicina c

Country Status (21)

Country Link
US (1) US4652644A (sh)
KR (1) KR910002080B1 (sh)
CN (1) CN1020731C (sh)
AR (1) AR242210A1 (sh)
AT (1) AT394724B (sh)
CA (1) CA1247617A (sh)
CS (1) CS271331B2 (sh)
DD (1) DD258011A5 (sh)
DK (1) DK168708B1 (sh)
ES (1) ES8706685A1 (sh)
FI (1) FI83519C (sh)
GR (1) GR861152B (sh)
HU (1) HU194243B (sh)
IT (1) IT1208605B (sh)
LU (1) LU86411A1 (sh)
NO (1) NO164543C (sh)
OA (1) OA08243A (sh)
PT (1) PT82471B (sh)
SU (1) SU1436881A3 (sh)
YU (1) YU45778B (sh)
ZW (1) ZW5386A1 (sh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPH0867676A (ja) * 1994-03-30 1996-03-12 Eisai Kagaku Kk 保護アミノチアゾリル酢酸誘導体
JP3202960B2 (ja) * 1998-02-17 2001-08-27 大塚化学株式会社 ハロゲン化剤及び水酸基のハロゲン化方法
CN104710426B (zh) * 2014-12-12 2017-08-01 常州大学 苯并吡咯里西啶生物碱及其制备方法和用途
CN104478885B (zh) * 2014-12-12 2017-08-01 常州大学 9‑氨基‑9a‑烯丙基苯并吡咯里西啶生物碱的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1135270B (it) * 1980-04-12 1986-08-20 Erba Farmitalia 3-amidino-ansamicine
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4567256A (en) * 1983-05-09 1986-01-28 Bristol-Myers Company Amidine process

Also Published As

Publication number Publication date
CS271331B2 (en) 1990-09-12
FI861720A0 (fi) 1986-04-24
IT1208605B (it) 1989-07-10
AT394724B (de) 1992-06-10
ES8706685A1 (es) 1987-07-01
HU194243B (en) 1988-01-28
GR861152B (en) 1986-09-02
KR860008201A (ko) 1986-11-12
US4652644A (en) 1987-03-24
NO861652L (no) 1986-10-30
OA08243A (fr) 1987-10-30
YU70086A (en) 1987-12-31
FI83519C (fi) 1991-07-25
DK193786D0 (da) 1986-04-28
CN1020731C (zh) 1993-05-19
NO164543C (no) 1990-10-17
HUT40665A (en) 1987-01-28
FI83519B (fi) 1991-04-15
CN86101611A (zh) 1986-12-17
ATA101886A (de) 1991-11-15
IT8620228A0 (it) 1986-04-28
AR242210A1 (es) 1993-03-31
PT82471A (en) 1986-05-01
CS311786A2 (en) 1989-12-13
ES554469A0 (es) 1987-07-01
NO164543B (no) 1990-07-09
DD258011A5 (de) 1988-07-06
DK193786A (da) 1986-10-30
KR910002080B1 (ko) 1991-04-03
CA1247617A (en) 1988-12-28
ZW5386A1 (en) 1986-10-01
PT82471B (pt) 1988-10-14
DK168708B1 (da) 1994-05-24
FI861720A (fi) 1986-10-30
SU1436881A3 (ru) 1988-11-07
LU86411A1 (fr) 1986-11-05

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