YU201090A - Novi triazolo derivati i postupak za njihovo pravljenje - Google Patents

Novi triazolo derivati i postupak za njihovo pravljenje

Info

Publication number
YU201090A
YU201090A YU201090A YU201090A YU201090A YU 201090 A YU201090 A YU 201090A YU 201090 A YU201090 A YU 201090A YU 201090 A YU201090 A YU 201090A YU 201090 A YU201090 A YU 201090A
Authority
YU
Yugoslavia
Prior art keywords
4alkyl
phenyl
group
alkyl
represent
Prior art date
Application number
YU201090A
Other languages
English (en)
Inventor
J. Reiter
J. Barkoczy
L. Petocz
F. Goergnyi
M. Fekete
E. Szirt
G. Gigler
I. Gacsalyi
I. Gyertyan
K. Reiter
Original Assignee
Egis Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU542989A external-priority patent/HU205357B/hu
Priority claimed from HU542789A external-priority patent/HU206094B/hu
Application filed by Egis Gyogyszergyar filed Critical Egis Gyogyszergyar
Publication of YU201090A publication Critical patent/YU201090A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ovaj pronalazak se odnosi na nove triazolo derivate, na postupak za njihovo pravljenje, na farmaceutske preparate koji sadrže isti, na primenu pomenutih triazolo derivata za lečenje bolesti i takodje za pravljenje farmaceutskih preparata koji supodesni za lečenje pomenutih bolesti. Novi triazolo derivati opštih formula (Ia) i (Ib): Q pretstavlja vodonik ili heterocikličnu grupu koja opciono nosi jedan ili više C1-4alkil supstituenata; ili grupu formule SR1, gde R1 pretstavlja C1-4alkil pravog ili jračvastog niza ili fenil -(C1-4alkil); ili grupu formule NR2R3, gde R2 i R3 svaki pretstavljaju vodonik, C1-12alkil pravog ili račvastog niza, C2-6alkenil ili fenil-(C1-4alkil); R4 i R7 svaki pretstavljaju vodonik, C1-6alkil ili fenil-(C1-4alkil) koji opciono nose jedan ili više halogenskih supstituenata; R5 i R6 svaki pretstavljaju C1-4alkil koji je opciono supstituisan sa C1-4alkoksi karbonil grupom; heterocikličnu grupu ili fenil grupu koja opciono nosi jedan ili više halogena, hidroksilnih, cijano, nitro, di-(C1-4alkil)-amino ili C1-4alkoksi supstituenata pri čemu poslednji može nositi di -(C1-4alkil)-amino grupu; dalje jedan od R5 i R6 može pretstavljati vodonik, ili R5 i R6 zajednički pretstavljaju C4-15 alkilen ili zajedno sa susednim atomom ugljenika za koji su vezani formiraju heterocikličnu grupu koja nosi fenil-(C1-4alkil) supstituent, poseduju dragocene antianginalne i smirujuće/sedativne osobine i korisni su u terapiji.
YU201090A 1989-10-25 1990-10-25 Novi triazolo derivati i postupak za njihovo pravljenje YU201090A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU542989A HU205357B (en) 1989-10-25 1989-10-25 Process for producing tetrahydro-triazolo-tetrazepine derivatives and pharmaceutical compositions comprising same
HU542789A HU206094B (en) 1989-10-25 1989-10-25 Process for producing triazolylcarboxylic acid hydrazone derivatives and pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
YU201090A true YU201090A (sh) 1993-05-28

Family

ID=26317835

Family Applications (1)

Application Number Title Priority Date Filing Date
YU201090A YU201090A (sh) 1989-10-25 1990-10-25 Novi triazolo derivati i postupak za njihovo pravljenje

Country Status (10)

Country Link
US (1) US5135928A (sh)
EP (1) EP0425282A3 (sh)
JP (1) JPH03209369A (sh)
KR (1) KR910007894A (sh)
BG (1) BG51043A3 (sh)
CA (1) CA2028610A1 (sh)
IL (1) IL96127A0 (sh)
IN (1) IN171609B (sh)
PL (1) PL164805B1 (sh)
YU (1) YU201090A (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750545A (en) * 1993-07-23 1998-05-12 The Green Cross Corporation Triazole derivative and pharmaceutical use thereof
CA2673683C (en) 2007-01-11 2014-07-29 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
US8466151B2 (en) 2007-12-26 2013-06-18 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
KR100986904B1 (ko) * 2008-11-10 2010-10-08 한국항공우주산업 주식회사 일체형 전단 및 굽힘 시험 장치
WO2011120153A1 (en) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2352944A (en) * 1942-07-04 1944-07-04 Gen Electric Triazole derivatives
GB949170A (en) * 1960-03-15 1964-02-12 France Etat Carbamyl and thiocarbamyl substances, methods for producing same and applications thereof
US4144233A (en) * 1977-02-16 1979-03-13 The Dow Chemical Company Method for preparing benzo-(1,3,4)-benzotriazepines

Also Published As

Publication number Publication date
EP0425282A2 (en) 1991-05-02
IL96127A0 (en) 1991-07-18
JPH03209369A (ja) 1991-09-12
EP0425282A3 (en) 1991-10-16
PL287505A1 (en) 1991-07-29
KR910007894A (ko) 1991-05-30
CA2028610A1 (en) 1991-04-26
PL164805B1 (pl) 1994-10-31
BG51043A3 (en) 1993-01-15
IN171609B (sh) 1992-11-21
US5135928A (en) 1992-08-04

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