YU141290A - Dihidropirimidotiazin derivati - Google Patents

Dihidropirimidotiazin derivati

Info

Publication number
YU141290A
YU141290A YU141290A YU141290A YU141290A YU 141290 A YU141290 A YU 141290A YU 141290 A YU141290 A YU 141290A YU 141290 A YU141290 A YU 141290A YU 141290 A YU141290 A YU 141290A
Authority
YU
Yugoslavia
Prior art keywords
derivatives
amino
alkyl
dihydropyrimidothiazine
novel
Prior art date
Application number
YU141290A
Other languages
English (en)
Other versions
YU47949B (sh
Inventor
D. Bozsing
P. Benko
L. Petocz
M. Szecsey
P. Tompe
G. Gigler
I. Gacsalyi
I. Gyertyan
Original Assignee
Egis Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU365989A external-priority patent/HU205123B/hu
Application filed by Egis Gyogyszergyar filed Critical Egis Gyogyszergyar
Publication of YU141290A publication Critical patent/YU141290A/sh
Publication of YU47949B publication Critical patent/YU47949B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

DIHIDROPIRIMIDOTIAZIN DERIVATI. Pronalazak se odnosi na nove dihidropirimidotiazin derivate, postupak za njihovo dobijanje, farmaceutske preparate koji obuhvata iste i nove intermedijere korisne u dobivanju pomenutih dihidropirimidotiazinskih derivata. Novi dihidropiromidotiazinski derivati opšte formule I gde R1 je C1-6alkoksi, amino ili fenilamino, R2 je C1-6alkil ili fenil, R3 je vodonik ili C1-6 alkil, i R4 označava C1-11alkil ili fenil po izboru koji nosi 1 ili više identičnih ili različitih supstituenata odabranih od halogena, nitro, amino, di-(C1-6alkil)-amino, C1-6alkil, C1-6alkoksi i hidroksi, i farmaceutski prihvatljive njihove kiselinske adicione soli koji pokazuju vredne antianginalne i/ili antiinflamatorne efekte i koji su primenljivi u terapiji.
YU141290A 1989-07-19 1990-07-18 3,4-DI-(HIDRO)-2H,6H-PIRIMIDO (2,1-b)(1,3) TIAZIN DERIVATII1,2,3,4-TETRA-(HIDRO)-PIRIMIDIN.2.TIONI I POSTUPCI ZA NJIHOVO DOBIJANJE YU47949B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU893658A HU203878B (en) 1989-07-19 1989-07-19 Process for producing tetrahydro-pyrimidine carboxylic acid derivatives
HU365989A HU205123B (en) 1989-07-19 1989-07-19 Process for producing dihydropyrimidino thiazine derivatives and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
YU141290A true YU141290A (sh) 1992-12-21
YU47949B YU47949B (sh) 1996-07-24

Family

ID=26317670

Family Applications (1)

Application Number Title Priority Date Filing Date
YU141290A YU47949B (sh) 1989-07-19 1990-07-18 3,4-DI-(HIDRO)-2H,6H-PIRIMIDO (2,1-b)(1,3) TIAZIN DERIVATII1,2,3,4-TETRA-(HIDRO)-PIRIMIDIN.2.TIONI I POSTUPCI ZA NJIHOVO DOBIJANJE

Country Status (21)

Country Link
US (1) US5071849A (sh)
EP (1) EP0409223A3 (sh)
JP (1) JPH03148284A (sh)
KR (1) KR940006637B1 (sh)
AT (1) AT399879B (sh)
BE (1) BE1004489A3 (sh)
BG (1) BG60209B2 (sh)
CA (1) CA2021556A1 (sh)
CZ (1) CZ280445B6 (sh)
DD (1) DD296930A5 (sh)
ES (1) ES2027492A6 (sh)
FR (1) FR2649981B1 (sh)
GB (1) GB2234508B (sh)
GR (1) GR910300031T1 (sh)
HU (1) HU203878B (sh)
IL (1) IL95091A (sh)
IT (1) IT1249212B (sh)
PL (1) PL163653B1 (sh)
RU (1) RU2022965C1 (sh)
YU (1) YU47949B (sh)
ZA (1) ZA905456B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677300A (en) * 1993-03-29 1997-10-14 The Green Cross Corporation Pyridothiazineacetic acid compound, production thereof and use thereof
IL132137A0 (en) * 1997-04-02 2001-03-19 Natural Drug Sciences Llc Biologically active substance on the basis of tetracyclic nitrogen heterocycles of pyrimidine row
WO2002066443A2 (en) * 2001-02-21 2002-08-29 Ono Pharmaceutical Co., Ltd. 2-thioxo-1,2,3,4-tetrahydropyrimidine derivatives
CN104844628B (zh) * 2015-04-16 2017-01-18 石家庄学院 2H,6H‑嘧啶并[2,1‑b][1,3]噻嗪类衍生物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1275804A (en) * 1969-07-03 1972-05-24 Seperic Improvements in or relating to new sulphur containing derivatives of pyrimidine, their preparation and their applications
US4753946A (en) * 1987-04-08 1988-06-28 E. R. Squibb & Sons, Inc. Pyrimidinecarboxylic acid derivatives

Also Published As

Publication number Publication date
DD296930A5 (de) 1991-12-19
EP0409223A3 (en) 1991-11-21
AT399879B (de) 1995-08-25
PL163653B1 (pl) 1994-04-29
IL95091A0 (en) 1991-06-10
GB2234508B (en) 1993-01-06
BG60209B2 (en) 1993-12-30
RU2022965C1 (ru) 1994-11-15
US5071849A (en) 1991-12-10
GB9015831D0 (en) 1990-09-05
KR940006637B1 (ko) 1994-07-23
EP0409223A2 (de) 1991-01-23
YU47949B (sh) 1996-07-24
ATA152890A (de) 1994-12-15
FR2649981A1 (fr) 1991-01-25
IT9020982A0 (it) 1990-07-19
CZ357190A3 (en) 1995-10-18
ES2027492A6 (es) 1992-06-01
GR910300031T1 (en) 1991-11-15
CA2021556A1 (en) 1991-01-20
IT1249212B (it) 1995-02-20
JPH03148284A (ja) 1991-06-25
HUT54352A (en) 1991-02-28
BE1004489A3 (fr) 1992-12-01
ZA905456B (en) 1994-08-09
IL95091A (en) 1994-11-11
IT9020982A1 (it) 1992-01-19
KR910002875A (ko) 1991-02-26
HU203878B (en) 1991-10-28
PL286086A1 (en) 1991-07-29
FR2649981B1 (fr) 1993-07-30
CZ280445B6 (cs) 1996-01-17
GB2234508A (en) 1991-02-06

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