FR2382450A1 - Produits composes de la pyridine et leur application comme agents de liaison bifonctionnels et comme agents de formation de thiols - Google Patents

Produits composes de la pyridine et leur application comme agents de liaison bifonctionnels et comme agents de formation de thiols

Info

Publication number
FR2382450A1
FR2382450A1 FR7806161A FR7806161A FR2382450A1 FR 2382450 A1 FR2382450 A1 FR 2382450A1 FR 7806161 A FR7806161 A FR 7806161A FR 7806161 A FR7806161 A FR 7806161A FR 2382450 A1 FR2382450 A1 FR 2382450A1
Authority
FR
France
Prior art keywords
agents
pyridine
thiols
application
training
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7806161A
Other languages
English (en)
Other versions
FR2382450B1 (fr
Inventor
Jan Per Erik Carlsson
Rolf Erik Axel Verner Axen
Hakan Nils Yngve Drevin
Goran Einar Samuel Lindgren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Pharmacia Fine Chemicals AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Fine Chemicals AB filed Critical Pharmacia Fine Chemicals AB
Publication of FR2382450A1 publication Critical patent/FR2382450A1/fr
Application granted granted Critical
Publication of FR2382450B1 publication Critical patent/FR2382450B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polyamides (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés de la pyridine. Ces composés correspondent à la formule générale :
FR7806161A 1977-03-04 1978-03-03 Produits composes de la pyridine et leur application comme agents de liaison bifonctionnels et comme agents de formation de thiols Granted FR2382450A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7702462A SE430062B (sv) 1977-03-04 1977-03-04 Kopplings- eller tioleringsreagens

Publications (2)

Publication Number Publication Date
FR2382450A1 true FR2382450A1 (fr) 1978-09-29
FR2382450B1 FR2382450B1 (fr) 1982-11-05

Family

ID=20330623

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7806161A Granted FR2382450A1 (fr) 1977-03-04 1978-03-03 Produits composes de la pyridine et leur application comme agents de liaison bifonctionnels et comme agents de formation de thiols

Country Status (6)

Country Link
US (1) US4149003A (fr)
JP (2) JPS53130674A (fr)
DE (1) DE2808523A1 (fr)
FR (1) FR2382450A1 (fr)
GB (1) GB1597756A (fr)
SE (1) SE430062B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
FR2446287A1 (fr) * 1979-01-12 1980-08-08 Toyo Jozo Kk Nouveau compose disulfure polyfonctionnel
EP0064040A1 (fr) * 1981-04-06 1982-11-03 Pharmacia Aktiebolag Dérivés disulfure thérapeutiquement actifs et leur emploi
EP0074271A1 (fr) * 1981-09-08 1983-03-16 Ortho Diagnostic Systems Inc. Liaison de deux anticorps
WO1983002946A1 (fr) * 1982-02-26 1983-09-01 Relyveld, Edgar, Hans Agents antitumoraux, tels que la daunorubicine a efficacite amelioree, leur obtention et procede pour augmenter l'efficacite des agents antitumoraux
EP0234600A1 (fr) * 1983-02-25 1987-09-02 The Upjohn Company Composés pour réactions de liaison des paires ligand-récepteur
EP0240200A2 (fr) * 1986-03-17 1987-10-07 Cetus Corporation Agents de réticulation, leur usage et leur préparation
EP0283563A2 (fr) * 1983-12-24 1988-09-28 Beecham Group Plc Nouveaux dérivés
EP0405578A2 (fr) * 1989-06-29 1991-01-02 Nippon Shoji Kabushiki Kaisha Immunoessai enzymatique pour détecter les antigènes et phase solide pour sa mise en oeuvre
EP0457250A2 (fr) * 1990-05-14 1991-11-21 Bristol-Myers Squibb Company Composés de liaison bifonctionnels, conjugués et leur procédé de production

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8003732L (sv) * 1980-05-19 1981-11-20 Pharmacia Diagnostics Ab Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner
US4563304A (en) * 1981-02-27 1986-01-07 Pharmacia Fine Chemicals Ab Pyridine compounds modifying proteins, polypeptides or polysaccharides
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
FR2523445A1 (fr) * 1982-03-17 1983-09-23 Sanofi Sa Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues
SE8302758L (sv) * 1983-05-17 1984-11-18 Pharmacia Ab Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening
EP0184701B1 (fr) * 1984-12-03 1994-06-08 Hoechst Celanese Corporation Procédé pour déterminer un ligand
US4880935A (en) * 1986-07-11 1989-11-14 Icrf (Patents) Limited Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
JPS6391563A (ja) * 1986-10-07 1988-04-22 Nitsusui Seiyaku Kk 細菌由来蛋白特異抗原の検査法
US4794082A (en) * 1987-02-17 1988-12-27 Hoechst Celanese Corporation Biotinylating agents
US4709037A (en) * 1987-02-17 1987-11-24 Hoechst Celanese Corporation Biotinylating agents
US4798795A (en) * 1987-02-17 1989-01-17 Hoechst Celanese Corporation Biotinylating agents
JPS63189278U (fr) * 1987-05-28 1988-12-05
DE3809986A1 (de) * 1988-03-24 1989-10-05 Boehringer Mannheim Gmbh Verbindungen zur einfuehrung einer sh-gruppe in tyrosin
JPH0253770U (fr) * 1988-10-12 1990-04-18
WO1992001938A1 (fr) * 1990-07-20 1992-02-06 City Of Hope Derivatisation de proline a terminaison c
US5516703A (en) * 1993-08-20 1996-05-14 The University Of Utah Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
US6284503B1 (en) 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
US6552060B1 (en) 1997-08-11 2003-04-22 Prolx Pharmaceuticals, Inc. Asymmetric disulfides and methods of using same
US20030176512A1 (en) * 1998-08-11 2003-09-18 Kirkpatrick D. Lynn Asymmetric disulfides and methods of using same
AR030612A1 (es) * 2000-09-12 2003-08-27 Smithkline Beecham Corp Procedimiento e intermedios
US6913748B2 (en) * 2002-08-16 2005-07-05 Immunogen, Inc. Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
CA2503490C (fr) 2002-10-21 2012-04-03 Allvivo, Inc. Revetement de surface pour dispositifs medicaux comprenant un compose bioactif
US7858108B2 (en) 2003-10-21 2010-12-28 Richard Nagler Elutable surface coating
CN101035802A (zh) 2004-07-02 2007-09-12 健泰科生物技术公司 Iap抑制剂
EP1819359B1 (fr) 2004-12-09 2015-03-18 Janssen Biotech, Inc. Immunoconjugues anti-integrines, methodes pour leur production et leur application
EA019420B1 (ru) 2004-12-20 2014-03-31 Дженентех, Инк. Пирролидиновые ингибиторы иап (ингибиторов апоптоза)
AU2006213662B2 (en) 2005-02-11 2010-08-05 Immunogen, Inc. Process for preparing stable drug conjugates
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
BRPI0615049B1 (pt) 2005-08-24 2023-04-25 Immunogen, Inc Processo para a preparação de um conjugado de anticorpo- maitansinóide
CN101374829A (zh) * 2005-12-19 2009-02-25 健泰科生物技术公司 Iap的抑制剂
US20070260041A1 (en) * 2006-05-03 2007-11-08 David Crich Allylic disulfide rearrangement and desulfurization method for the preparation of allylic sulfides
AU2007337104A1 (en) * 2006-12-19 2008-07-03 Genentech, Inc. Imidazopyridine inhibitors of IAP
AR066348A1 (es) * 2007-04-30 2009-08-12 Genentech Inc Inhibidores de las iap
RU2010133548A (ru) * 2008-01-11 2012-02-20 Дженентек, Инк. (Us) Ингибиторы iap
NZ590550A (en) 2008-08-02 2013-05-31 Genentech Inc Inhibitors of Apoptosis (IAP) for treating cancer
DK2437790T3 (da) 2009-06-03 2019-05-20 Immunogen Inc Konjugeringsfremgangsmåder
US8795673B2 (en) 2011-03-29 2014-08-05 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
CN105209592A (zh) 2012-10-04 2015-12-30 伊缪诺金公司 使用pvdf膜纯化细胞结合剂细胞毒性剂缀合物
WO2014210267A1 (fr) 2013-06-28 2014-12-31 Immunogen, Inc. Purification d'intermédiaires utilisés pour préparer des lieurs hétérobifonctionnels
KR102325753B1 (ko) 2019-12-20 2021-11-11 주식회사 포스코 흑색 도금 강판 및 그 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2872450A (en) * 1955-12-06 1959-02-03 Bayer Ag Thio- and dithio-carboxylic acid esters and a process for their manufacture
US3950348A (en) * 1971-12-30 1976-04-13 Merck & Co., Inc. Process for preparing e-pyridyl-4-methyloxycarbonyllysine

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
FR2446287A1 (fr) * 1979-01-12 1980-08-08 Toyo Jozo Kk Nouveau compose disulfure polyfonctionnel
EP0064040A1 (fr) * 1981-04-06 1982-11-03 Pharmacia Aktiebolag Dérivés disulfure thérapeutiquement actifs et leur emploi
EP0074271A1 (fr) * 1981-09-08 1983-03-16 Ortho Diagnostic Systems Inc. Liaison de deux anticorps
WO1983002946A1 (fr) * 1982-02-26 1983-09-01 Relyveld, Edgar, Hans Agents antitumoraux, tels que la daunorubicine a efficacite amelioree, leur obtention et procede pour augmenter l'efficacite des agents antitumoraux
FR2522269A1 (fr) * 1982-02-26 1983-09-02 Pasteur Institut Agents antitumoraux, tels que la daunorubicine, a efficacite amelioree, leur obtention et procede pour augmenter l'efficacite des agents antitumoraux
EP0088022A1 (fr) * 1982-02-26 1983-09-07 Institut Pasteur Agents antitumoraux à efficacité améliorée, leur obtention et procédé pour augmenter l'efficacité des agents antitumoraux
US4625019A (en) * 1982-02-26 1986-11-25 Institut Pasteur Polymeric product of daunorubicin and glutaraldehyde
EP0234600A1 (fr) * 1983-02-25 1987-09-02 The Upjohn Company Composés pour réactions de liaison des paires ligand-récepteur
EP0283563A2 (fr) * 1983-12-24 1988-09-28 Beecham Group Plc Nouveaux dérivés
EP0283563A3 (en) * 1983-12-24 1988-11-23 Beecham Group Plc Novel derivatives
EP0240200A2 (fr) * 1986-03-17 1987-10-07 Cetus Corporation Agents de réticulation, leur usage et leur préparation
EP0240200A3 (fr) * 1986-03-17 1990-03-28 Cetus Corporation Agents de réticulation, leur usage et leur préparation
EP0405578A2 (fr) * 1989-06-29 1991-01-02 Nippon Shoji Kabushiki Kaisha Immunoessai enzymatique pour détecter les antigènes et phase solide pour sa mise en oeuvre
EP0405578A3 (en) * 1989-06-29 1991-05-29 Nippon Shoji Kabushiki Kaisha Enzyme immunoassay for antigen and solid phase used therefor
EP0620438A1 (fr) * 1989-06-29 1994-10-19 Nippon Shoji Kabushiki Kaisha Immunoessai enzymatique pour détecter les antigènes et phase solide pour sa mise en oeuvre
EP0457250A2 (fr) * 1990-05-14 1991-11-21 Bristol-Myers Squibb Company Composés de liaison bifonctionnels, conjugués et leur procédé de production
EP0457250A3 (en) * 1990-05-14 1992-07-01 Bristol-Myers Squibb Company Novel bifunctional linking compounds, conjugates and methods for their production

Also Published As

Publication number Publication date
SE430062B (sv) 1983-10-17
DE2808523A1 (de) 1978-09-07
GB1597756A (en) 1981-09-09
SE7702462L (sv) 1978-09-05
DE2808523C2 (fr) 1987-11-19
JPS53130674A (en) 1978-11-14
US4149003A (en) 1979-04-10
JPS61191675A (ja) 1986-08-26
FR2382450B1 (fr) 1982-11-05
JPS624368B2 (fr) 1987-01-30
JPS6121227B2 (fr) 1986-05-26

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Legal Events

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