YU44573B - Process for obtaining hypoglicemic thiazolidindione - Google Patents
Process for obtaining hypoglicemic thiazolidindioneInfo
- Publication number
- YU44573B YU44573B YU837/86A YU83786A YU44573B YU 44573 B YU44573 B YU 44573B YU 837/86 A YU837/86 A YU 837/86A YU 83786 A YU83786 A YU 83786A YU 44573 B YU44573 B YU 44573B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hypoglicemic
- thiazolidindione
- obtaining
- benzo
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Emergency Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Detergent Compositions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Saccharide Compounds (AREA)
- Soil Working Implements (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1985/000962 WO1986007056A1 (en) | 1985-05-21 | 1985-05-21 | Hypoglycemic thiazolidinediones |
Publications (2)
Publication Number | Publication Date |
---|---|
YU83786A YU83786A (en) | 1987-12-31 |
YU44573B true YU44573B (en) | 1990-10-31 |
Family
ID=22188690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU837/86A YU44573B (en) | 1985-05-21 | 1986-05-20 | Process for obtaining hypoglicemic thiazolidindione |
Country Status (26)
Country | Link |
---|---|
US (1) | US4703052A (no) |
EP (1) | EP0207605B1 (no) |
JP (1) | JPS61271287A (no) |
KR (1) | KR870000903B1 (no) |
CN (1) | CN1007248B (no) |
AT (1) | ATE50256T1 (no) |
AU (2) | AU560179B2 (no) |
CA (1) | CA1279320C (no) |
DD (1) | DD261154A5 (no) |
DE (1) | DE3668892D1 (no) |
DK (1) | DK233586A (no) |
EG (1) | EG18043A (no) |
ES (1) | ES8707210A1 (no) |
FI (1) | FI89268C (no) |
GR (1) | GR861297B (no) |
HU (1) | HU210339B (no) |
IE (1) | IE58674B1 (no) |
IL (1) | IL78831A (no) |
MY (1) | MY108496A (no) |
NO (1) | NO166448C (no) |
PH (2) | PH22313A (no) |
PL (1) | PL147479B1 (no) |
PT (1) | PT82610B (no) |
WO (1) | WO1986007056A1 (no) |
YU (1) | YU44573B (no) |
ZA (1) | ZA863762B (no) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI91869C (fi) * | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
JPS63230689A (ja) * | 1987-03-18 | 1988-09-27 | Tanabe Seiyaku Co Ltd | ベンゾオキサジン誘導体 |
GB8713861D0 (en) * | 1987-06-13 | 1987-07-15 | Beecham Group Plc | Compounds |
US4897406A (en) * | 1987-11-13 | 1990-01-30 | Nisshin Flour Milling Co., Ltd. | Rhodanine derivatives and pharmaceutical compositions |
US4791125A (en) * | 1987-12-02 | 1988-12-13 | Pfizer Inc. | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents |
US4798835A (en) * | 1987-12-02 | 1989-01-17 | Pfizer Inc. | dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent |
US5120754A (en) * | 1988-03-08 | 1992-06-09 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
MX15171A (es) * | 1988-03-08 | 1993-05-01 | Pfizer | Derivados de tiazolidinodiona hipoglicemicos |
HU217432B (hu) * | 1988-03-08 | 2000-01-28 | Pfizer Inc. | Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények |
US5061717A (en) * | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
US5130379A (en) * | 1988-03-08 | 1992-07-14 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
US5330998A (en) * | 1988-03-08 | 1994-07-19 | Pfizer Inc. | Thiazolidinedione derivatives as hypoglycemic agents |
US5223522A (en) * | 1988-03-08 | 1993-06-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
US5053420A (en) * | 1989-10-13 | 1991-10-01 | Pershadsingh Harrihar A | Thiazolidine derivatives for the treatment of hypertension |
WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
US5036079A (en) * | 1989-12-07 | 1991-07-30 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
US5089637A (en) * | 1990-03-21 | 1992-02-18 | Pfizer Inc. | Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde |
ATE205206T1 (de) * | 1990-04-27 | 2001-09-15 | Sankyo Co | Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren |
US5037842A (en) * | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
KR930701420A (ko) * | 1990-08-23 | 1993-06-11 | 알렌 제이. 스피겔 | 혈당저하제로서의 하이드록시우레아 유도체 |
US5158966A (en) * | 1991-02-22 | 1992-10-27 | The University Of Colorado Foundation, Inc. | Method of treating type i diabetes |
TW222626B (no) | 1991-07-22 | 1994-04-21 | Pfizer | |
FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
DE4142190A1 (de) * | 1991-12-20 | 1993-06-24 | Bayer Ag | Verfahren zur herstellung von optisch aktiven (alpha)-hydroxycarbonsaeuren |
FR2688220A1 (fr) * | 1992-03-06 | 1993-09-10 | Adir | Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5498621A (en) * | 1992-05-01 | 1996-03-12 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
ZA936492B (en) * | 1992-09-10 | 1995-03-02 | Lilly Co Eli | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease. |
JP2845743B2 (ja) * | 1992-12-28 | 1999-01-13 | 三菱化学株式会社 | 新規なナフタレン誘導体 |
US5594016A (en) * | 1992-12-28 | 1997-01-14 | Mitsubishi Chemical Corporation | Naphthalene derivatives |
JP3195455B2 (ja) * | 1993-01-06 | 2001-08-06 | ウェルファイド株式会社 | キノリン−3−酢酸誘導体、その製造法と用途 |
DE4317320A1 (de) * | 1993-05-25 | 1994-12-01 | Boehringer Mannheim Gmbh | Neue Thiazolidindione und diese enthaltende Arzneimittel |
US6046222A (en) * | 1993-09-15 | 2000-04-04 | Warner-Lambert Company | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
US5401761A (en) * | 1993-12-09 | 1995-03-28 | Pfizer, Inc. | Thiazolidinedione hypoglycemic agents |
GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
US6251928B1 (en) | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
US5594015A (en) * | 1994-06-22 | 1997-01-14 | Regents Of The University Of California | Thiazolidine derivatives for the treatment of psoriasis |
US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
US5708012A (en) * | 1995-04-28 | 1998-01-13 | Sankyo Company, Limited | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus |
RU2158607C2 (ru) * | 1995-07-03 | 2000-11-10 | Санкио Компани Лимитед | Лечение артериосклероза и ксантомы |
GB9604340D0 (en) * | 1996-02-29 | 1996-05-01 | Unilever Plc | Antiperspirant aerosol composition and method of making same |
NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
DK0916651T3 (da) * | 1996-04-04 | 2003-12-01 | Sankyo Co | Phenylalkylcarboxylsyrederivater |
CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
EP1006794B1 (en) * | 1997-03-12 | 2007-11-28 | Robert W. Esmond | A method for treating or preventing alzheimer's disease |
DE19711616A1 (de) | 1997-03-20 | 1998-09-24 | Boehringer Mannheim Gmbh | Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
NZ503712A (en) * | 1997-10-02 | 2003-07-25 | Sankyo Co | Amidopropionic acid derivatives |
HUP9902721A2 (hu) * | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
WO1999030739A1 (fr) * | 1997-12-16 | 1999-06-24 | Sankyo Company, Limited | Remede contre la leucemie |
US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
EP1143953A3 (en) * | 1998-11-20 | 2002-02-06 | Genentech, Inc. | Method of inhibiting angiogenesis |
US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
US5968960A (en) * | 1999-01-14 | 1999-10-19 | The Regents Of The University Of California | Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism |
JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
AU6315300A (en) * | 1999-07-26 | 2001-02-13 | Shionogi & Co., Ltd. | Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same |
US6878749B2 (en) | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
CO5200844A1 (es) | 1999-09-17 | 2002-09-27 | Novartis Ag | Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes |
US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
JP2003520226A (ja) | 2000-01-21 | 2003-07-02 | ノバルティス アクチエンゲゼルシャフト | ジペプチジルペプチダーゼ−iv阻害剤および抗糖尿病薬剤を含む組合せ物 |
US6784199B2 (en) | 2000-09-21 | 2004-08-31 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals |
US6680387B2 (en) * | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US6958355B2 (en) * | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
KR100711757B1 (ko) * | 2000-12-22 | 2007-04-25 | 재단법인 포항산업과학연구원 | 폐수처리용 활성화 슬래그 및 이를 이용한 폐수처리방법 |
US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
US20060047000A1 (en) * | 2001-04-24 | 2006-03-02 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
WO2004006916A1 (en) * | 2002-07-10 | 2004-01-22 | Applied Research Systems Ars Holding Nv | Use of compounds for increasing spermatozoa motility |
BR0312650A (pt) * | 2002-07-10 | 2005-05-03 | Applied Research Systems | Derivados de benzeno fundido azolidinona-vinila |
WO2004110458A1 (en) * | 2003-05-16 | 2004-12-23 | Board Of Regents, The University Of Texas System | Phenothiazine enantiomers as agents for the prevention of bone loss |
AR065670A1 (es) | 2007-03-09 | 2009-06-24 | Indigene Pharmaceuticals Inc | Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas |
EP2914250B1 (en) | 2012-11-05 | 2018-04-04 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Combination of an anti-cancer agent such as a tyrosinekinase inhibitor and a stat5 antagonist, preferably a thiazolidinedione, for eliminating hematologic cancer stem cells in vivo and for preventing hematologic cancer relapse |
CN116535379B (zh) * | 2023-06-29 | 2023-09-19 | 希格生科(深圳)有限公司 | 化合物及其医药用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS5697277A (en) * | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
US4342771A (en) | 1981-01-02 | 1982-08-03 | Pfizer Inc. | Hypoglycemic 5-substituted oxazolidine-2,4-diones |
JPS58118577A (ja) * | 1982-01-07 | 1983-07-14 | Takeda Chem Ind Ltd | チアゾリジン誘導体 |
ATE45574T1 (de) | 1983-01-17 | 1989-09-15 | Pfizer | Aldosereduktasehemmende 5-(2alkoxyphenyl)thiazolidinedione. |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
FI91869C (fi) * | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
-
1985
- 1985-05-21 US US07/010,081 patent/US4703052A/en not_active Expired - Lifetime
- 1985-05-21 HU HU853021A patent/HU210339B/hu not_active IP Right Cessation
- 1985-05-21 WO PCT/US1985/000962 patent/WO1986007056A1/en active IP Right Grant
-
1986
- 1986-05-14 EP EP86303648A patent/EP0207605B1/en not_active Expired - Lifetime
- 1986-05-14 DE DE8686303648T patent/DE3668892D1/de not_active Expired - Fee Related
- 1986-05-14 AT AT86303648T patent/ATE50256T1/de not_active IP Right Cessation
- 1986-05-16 CA CA000509336A patent/CA1279320C/en not_active Expired - Fee Related
- 1986-05-19 PT PT82610A patent/PT82610B/pt not_active IP Right Cessation
- 1986-05-19 IL IL78831A patent/IL78831A/xx not_active IP Right Cessation
- 1986-05-19 GR GR861297A patent/GR861297B/el unknown
- 1986-05-20 ZA ZA863762A patent/ZA863762B/xx unknown
- 1986-05-20 ES ES555147A patent/ES8707210A1/es not_active Expired
- 1986-05-20 PH PH33794A patent/PH22313A/en unknown
- 1986-05-20 AU AU57580/86A patent/AU560179B2/en not_active Ceased
- 1986-05-20 KR KR1019860003923A patent/KR870000903B1/ko not_active IP Right Cessation
- 1986-05-20 IE IE133686A patent/IE58674B1/en not_active IP Right Cessation
- 1986-05-20 DD DD86290390A patent/DD261154A5/de not_active IP Right Cessation
- 1986-05-20 DK DK233586A patent/DK233586A/da not_active Application Discontinuation
- 1986-05-20 YU YU837/86A patent/YU44573B/xx unknown
- 1986-05-21 CN CN86104075A patent/CN1007248B/zh not_active Expired
- 1986-05-21 EG EG300/86A patent/EG18043A/xx active
- 1986-05-21 JP JP61117127A patent/JPS61271287A/ja active Granted
- 1986-05-21 PL PL1986259633A patent/PL147479B1/pl unknown
-
1987
- 1987-01-20 NO NO87870241A patent/NO166448C/no unknown
- 1987-01-20 FI FI870219A patent/FI89268C/fi not_active IP Right Cessation
- 1987-07-02 AU AU75074/87A patent/AU583991B2/en not_active Ceased
- 1987-08-25 MY MYPI87001446A patent/MY108496A/en unknown
- 1987-10-22 PH PH35971A patent/PH25226A/en unknown
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