ES2067945T3 - Derivados de hidroxiurea hipoglicemica. - Google Patents

Derivados de hidroxiurea hipoglicemica.

Info

Publication number
ES2067945T3
ES2067945T3 ES91913290T ES91913290T ES2067945T3 ES 2067945 T3 ES2067945 T3 ES 2067945T3 ES 91913290 T ES91913290 T ES 91913290T ES 91913290 T ES91913290 T ES 91913290T ES 2067945 T3 ES2067945 T3 ES 2067945T3
Authority
ES
Spain
Prior art keywords
hypoglycemic
hydroxyurea
derivatives
benzofuranylmethyl
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913290T
Other languages
English (en)
Inventor
Steven Wayne Goldstein
Ruth Elsbree Mcdermott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2067945T3 publication Critical patent/ES2067945T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

SE PRESENTAN CIERTOS DERIVADOS DE LA 1-(BENZIL O 5BENZOFURANILMETIL)-1-HIDROXIUREA QUE SON UTILES COMO AGENTES HIPOGLICEMICOS E HIPOCOLESTEROLEMICOS.
ES91913290T 1990-08-23 1991-06-26 Derivados de hidroxiurea hipoglicemica. Expired - Lifetime ES2067945T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57274590A 1990-08-23 1990-08-23

Publications (1)

Publication Number Publication Date
ES2067945T3 true ES2067945T3 (es) 1995-04-01

Family

ID=24289181

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913290T Expired - Lifetime ES2067945T3 (es) 1990-08-23 1991-06-26 Derivados de hidroxiurea hipoglicemica.

Country Status (22)

Country Link
US (4) US5334604A (es)
EP (1) EP0544696B1 (es)
JP (1) JPH0678326B2 (es)
KR (1) KR930701420A (es)
AT (1) ATE116971T1 (es)
AU (1) AU645112B2 (es)
CA (1) CA2087437A1 (es)
DE (1) DE69106714T2 (es)
DK (1) DK0544696T3 (es)
ES (1) ES2067945T3 (es)
FI (1) FI930772A0 (es)
GR (1) GR3014913T3 (es)
HU (1) HUT70153A (es)
IE (1) IE64927B1 (es)
IL (2) IL99214A0 (es)
MX (1) MX9100804A (es)
NO (1) NO930615D0 (es)
NZ (1) NZ239514A (es)
PT (1) PT98732A (es)
TW (1) TW200470B (es)
WO (1) WO1992003425A1 (es)
ZA (1) ZA916644B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645112B2 (en) * 1990-08-23 1994-01-06 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
DK0696585T3 (da) * 1993-04-30 1999-08-23 Yamanouchi Pharma Co Ltd Nyt bisoxadiazolidinderivat
US5468760A (en) * 1993-11-08 1995-11-21 American Home Products Corporation Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein
US5428048A (en) * 1993-11-08 1995-06-27 American Home Products Corporation Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents
US5459154A (en) * 1993-11-08 1995-10-17 American Home Products Corporation N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein
JP3354258B2 (ja) * 1993-12-03 2002-12-09 富山化学工業株式会社 新規なインドール類またはその塩
DK0684242T3 (da) * 1993-12-27 1999-11-01 Japan Tobacco Inc Isoxazolidindionderivat og anvendelse deraf
US5480896A (en) * 1994-01-27 1996-01-02 American Home Products Corporation Aralkyl-1,2,4-oxadiazolidine-3,5-diones as antihyperglycemic agents
IL113313A (en) * 1994-04-11 1999-09-22 Sankyo Co Heterocyclic compounds and pharmaceutical compositions containing the same
US5420146A (en) * 1994-05-10 1995-05-30 American Home Products Corporation Di-oxadiazolidine derivatives as antihyperglycemic agents
US5468762A (en) * 1994-05-18 1995-11-21 American Home Products Corporation Azolidinediones as antihyperglycemic agents
US5532256A (en) * 1994-05-18 1996-07-02 American Home Products Corporation New azolidinediones and thiadiazolidinediones as antihyperglycemic agents
CZ261095A3 (en) 1994-10-07 1996-04-17 Sankyo Co Oxime derivatives, process of their preparation, pharmaceutical composition containing thereof and their use
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
IL118474A (en) * 1995-06-01 2001-08-08 Sankyo Co Benzimideol derivatives and pharmaceutical preparations containing them
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
EP0912562A1 (en) 1996-07-19 1999-05-06 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
CZ53699A3 (cs) 1996-08-19 1999-07-14 Japan Tobacco Inc. Deriváty propionové kyseliny a jejich použití
EP1006794B1 (en) * 1997-03-12 2007-11-28 Robert W. Esmond A method for treating or preventing alzheimer's disease
DE19711616A1 (de) 1997-03-20 1998-09-24 Boehringer Mannheim Gmbh Verbessertes Verfahren zur Herstellung von Thiazolidindionen
KR20080011356A (ko) 1997-06-18 2008-02-01 스미스클라인비이참피이엘시이 티아졸리딘디온 및 술포닐우레아를 사용한 당뇨병의 치료
CZ302475B6 (cs) 1997-10-08 2011-06-08 Sankyo Company Limited Substituované kumulované heterocyklické slouceniny
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
EP0992503B1 (en) 1998-03-30 2004-02-04 Japan Tobacco Inc. Process for producing isooxazolidinedione compound
AU1707700A (en) * 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
DE69939485D1 (de) 1998-11-12 2008-10-16 Smithkline Beecham Plc Arzneimittel zur gesteuerten freisetzung eines insulin sensibilisators und metformin
AR023699A1 (es) 1998-11-12 2002-09-04 Smithkline Beecham Corp Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
JP4316787B2 (ja) * 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
WO2002046154A1 (en) * 2000-12-05 2002-06-13 Nippon Chemiphar Co., Ltd. Peroxisome proliferator activated receptor d activators
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
US8268352B2 (en) * 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US8216609B2 (en) * 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3437664A (en) * 1966-03-18 1969-04-08 Velsicol Chemical Corp 1,2,4-oxadiazolidines
US3895023A (en) * 1973-02-06 1975-07-15 Du Pont Antiinflammatory 1,2,4-oxadiazolidine-3,5-diones
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4342771A (en) * 1981-01-02 1982-08-03 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4406910A (en) * 1981-06-15 1983-09-27 Shell Oil Company Pesticidal 3-(2,3-dihydro-2-alkylbenzofuran-7-yl)-5-(R-oxy)-1,3,4-oxadiazol-2(3H)-ones
US4617312A (en) * 1983-01-17 1986-10-14 Pfizer Inc. Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
HU210339B (en) * 1985-05-21 1995-03-28 Pfizer Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
US4758263A (en) * 1986-10-27 1988-07-19 Sandoz Ltd. 2-(2,5-difluorophenyl)-4-methyl-1,2,4-oxadiazolidine-3,5 diones
GB8713861D0 (en) * 1987-06-13 1987-07-15 Beecham Group Plc Compounds
US4826990A (en) * 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
US4895953A (en) * 1987-09-30 1990-01-23 American Home Products Corporation 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
HU217432B (hu) * 1988-03-08 2000-01-28 Pfizer Inc. Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények
WO1989008651A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
US5239080A (en) * 1989-02-08 1993-08-24 Takeda Chemical Industries, Ltd. Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents
AU645112B2 (en) * 1990-08-23 1994-01-06 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
US5468760A (en) * 1993-11-08 1995-11-21 American Home Products Corporation Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein
US5428048A (en) * 1993-11-08 1995-06-27 American Home Products Corporation Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents
US5459154A (en) * 1993-11-08 1995-10-17 American Home Products Corporation N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein
US5480896A (en) * 1994-01-27 1996-01-02 American Home Products Corporation Aralkyl-1,2,4-oxadiazolidine-3,5-diones as antihyperglycemic agents

Also Published As

Publication number Publication date
NO930615L (no) 1993-02-22
PT98732A (pt) 1992-07-31
US5334604A (en) 1994-08-02
FI930772A (fi) 1993-02-22
DE69106714D1 (en) 1995-02-23
NO930615D0 (no) 1993-02-22
WO1992003425A1 (en) 1992-03-05
US5763467A (en) 1998-06-09
HU9300486D0 (en) 1993-05-28
CA2087437A1 (en) 1992-02-24
EP0544696B1 (en) 1995-01-11
TW200470B (es) 1993-02-21
AU645112B2 (en) 1994-01-06
FI930772A0 (fi) 1993-02-22
KR930701420A (ko) 1993-06-11
ATE116971T1 (de) 1995-01-15
GR3014913T3 (en) 1995-05-31
MX9100804A (es) 1992-04-01
JPH05508654A (ja) 1993-12-02
IE912971A1 (en) 1992-02-26
HUT70153A (en) 1995-09-28
IL99214A0 (en) 1992-07-15
US5463070A (en) 1995-10-31
EP0544696A1 (en) 1993-06-09
AU8235391A (en) 1992-03-17
ZA916644B (en) 1993-04-28
DK0544696T3 (da) 1995-06-06
IL113141A0 (en) 1995-06-29
IE64927B1 (en) 1995-09-20
NZ239514A (en) 1993-10-26
JPH0678326B2 (ja) 1994-10-05
DE69106714T2 (de) 1995-05-11
US5646168A (en) 1997-07-08

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