ATE179709T1 - Isoxazolidindionderivate und deren verwendung - Google Patents
Isoxazolidindionderivate und deren verwendungInfo
- Publication number
- ATE179709T1 ATE179709T1 AT95903972T AT95903972T ATE179709T1 AT E179709 T1 ATE179709 T1 AT E179709T1 AT 95903972 T AT95903972 T AT 95903972T AT 95903972 T AT95903972 T AT 95903972T AT E179709 T1 ATE179709 T1 AT E179709T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- group
- represent
- lower alkyl
- hydrogen
- Prior art date
Links
- MJAMNJNCEOHYIU-UHFFFAOYSA-N 1,2-oxazolidine-3,4-dione Chemical class O=C1CONC1=O MJAMNJNCEOHYIU-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35438593 | 1993-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE179709T1 true ATE179709T1 (de) | 1999-05-15 |
Family
ID=18437208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95903972T ATE179709T1 (de) | 1993-12-27 | 1994-12-26 | Isoxazolidindionderivate und deren verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US5728720A (de) |
| EP (1) | EP0684242B1 (de) |
| KR (1) | KR0164665B1 (de) |
| AT (1) | ATE179709T1 (de) |
| CA (1) | CA2157032C (de) |
| CY (1) | CY2144B1 (de) |
| DE (1) | DE69418311T2 (de) |
| DK (1) | DK0684242T3 (de) |
| ES (1) | ES2131301T3 (de) |
| GR (1) | GR3030705T3 (de) |
| WO (1) | WO1995018125A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE179709T1 (de) * | 1993-12-27 | 1999-05-15 | Japan Tobacco Inc | Isoxazolidindionderivate und deren verwendung |
| TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
| NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
| CZ388598A3 (cs) * | 1996-05-31 | 1999-07-14 | Sankyo Company, Limited | Léčivo proti autoimunní nemoci |
| CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
| EE03765B1 (et) * | 1996-08-19 | 2002-06-17 | Japan Tobacco Inc. | Propioonhappe derivaadid ja nende kasutamine |
| DE19711616A1 (de) | 1997-03-20 | 1998-09-24 | Boehringer Mannheim Gmbh | Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
| AU9119098A (en) * | 1997-08-25 | 1999-03-16 | Richard A. Holub | A system for distributing and controlling color reproduction at multiple sites |
| HUP9902721A2 (hu) * | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
| WO1999030739A1 (en) * | 1997-12-16 | 1999-06-24 | Sankyo Company, Limited | Leukemia remedy |
| JP3163295B2 (ja) | 1998-03-30 | 2001-05-08 | 日本たばこ産業株式会社 | イソオキサゾリジンジオン化合物の製造方法 |
| CN1130361C (zh) | 1998-03-30 | 2003-12-10 | 日本烟草产业株式会社 | 异噁唑烷二酮化合物的制备方法 |
| JP3258993B2 (ja) | 1998-03-30 | 2002-02-18 | 日本たばこ産業株式会社 | ベンジリデン化合物の製造方法 |
| JP3322860B2 (ja) | 1998-03-30 | 2002-09-09 | 日本たばこ産業株式会社 | メタンスルホナート化合物の製造方法 |
| JP3258992B2 (ja) | 1998-03-30 | 2002-02-18 | 日本たばこ産業株式会社 | オキサゾリルメタノール化合物の製造方法 |
| AU2852100A (en) * | 1999-01-19 | 2000-08-29 | Tularik Inc. | Methods of modulating uric acid levels |
| US6768008B2 (en) * | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6958355B2 (en) | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| DE10029077A1 (de) * | 2000-06-13 | 2001-12-20 | Bayer Ag | Thiazolylsubstituierte Heterocyclen |
| WO2002024689A1 (en) * | 2000-09-21 | 2002-03-28 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis |
| EP1354602B1 (de) * | 2000-12-26 | 2006-10-04 | Sankyo Company, Limited | Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel |
| US20060047000A1 (en) * | 2001-04-24 | 2006-03-02 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
| US7217727B2 (en) | 2003-04-01 | 2007-05-15 | Eli Lilly And Company | Phospholipase inhibitors |
| DE10331675A1 (de) | 2003-07-14 | 2005-02-10 | Bayer Cropscience Ag | Hetarylsubstituierte Pyrazolidindion-Derivate |
| MA40868A (fr) | 2014-10-30 | 2017-09-05 | Sanovel Ilac Sanayi Ve Ticaret As | Combinaisons pharmaceutiques de sitagliptine et d'agonistes de ppar |
| MA40869A (fr) | 2014-10-30 | 2017-09-05 | Sanovel Ilac Sanayi Ve Ticaret As | Combinaisons pharmaceutiques de vildagliptine et d'agonistes de ppar |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| DE3887811T2 (de) * | 1987-10-15 | 1994-07-07 | Mitsubishi Yuka Badische | Faseriger Schichtstoff und Verfahren zur Herstellung desselben. |
| US4999366A (en) * | 1988-10-31 | 1991-03-12 | The North Carolina Central Univ. | Isoxazolidine-3,5-diones, pharmaceutical compositions and method of treatment |
| WO1991007107A1 (en) | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| GB9017218D0 (en) | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
| DK0544696T3 (da) * | 1990-08-23 | 1995-06-06 | Pfizer | Hypoglycæmiske hydroxyurinstofderivater |
| US5498621A (en) * | 1992-05-01 | 1996-03-12 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| ATE179709T1 (de) * | 1993-12-27 | 1999-05-15 | Japan Tobacco Inc | Isoxazolidindionderivate und deren verwendung |
| US5468762A (en) * | 1994-05-18 | 1995-11-21 | American Home Products Corporation | Azolidinediones as antihyperglycemic agents |
| US5572912A (en) * | 1995-05-05 | 1996-11-12 | Creative Designs In Woodworking And Metal | Anti-crimp wrench for a garden hose with a knurled coupling |
-
1994
- 1994-12-26 AT AT95903972T patent/ATE179709T1/de not_active IP Right Cessation
- 1994-12-26 ES ES95903972T patent/ES2131301T3/es not_active Expired - Lifetime
- 1994-12-26 US US08/522,264 patent/US5728720A/en not_active Expired - Fee Related
- 1994-12-26 EP EP95903972A patent/EP0684242B1/de not_active Expired - Lifetime
- 1994-12-26 KR KR1019950703626A patent/KR0164665B1/ko not_active Expired - Fee Related
- 1994-12-26 WO PCT/JP1994/002233 patent/WO1995018125A1/ja not_active Ceased
- 1994-12-26 DE DE69418311T patent/DE69418311T2/de not_active Expired - Fee Related
- 1994-12-26 DK DK95903972T patent/DK0684242T3/da active
- 1994-12-26 CA CA002157032A patent/CA2157032C/en not_active Expired - Fee Related
-
1998
- 1998-01-23 US US09/012,823 patent/US6057343A/en not_active Expired - Fee Related
- 1998-01-28 US US09/014,590 patent/US5939445A/en not_active Expired - Fee Related
-
1999
- 1999-04-14 US US09/291,203 patent/US6037359A/en not_active Expired - Fee Related
- 1999-07-07 GR GR990401788T patent/GR3030705T3/el unknown
- 1999-12-01 CY CY9900042A patent/CY2144B1/xx unknown
-
2000
- 2000-01-12 US US09/481,704 patent/US6160124A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1018164A1 (en) | 1999-12-10 |
| DK0684242T3 (da) | 1999-11-01 |
| KR960701048A (ko) | 1996-02-24 |
| DE69418311T2 (de) | 1999-11-04 |
| EP0684242B1 (de) | 1999-05-06 |
| ES2131301T3 (es) | 1999-07-16 |
| DE69418311D1 (de) | 1999-06-10 |
| US6037359A (en) | 2000-03-14 |
| CA2157032A1 (en) | 1995-07-06 |
| US6057343A (en) | 2000-05-02 |
| EP0684242A4 (de) | 1995-09-28 |
| US5728720A (en) | 1998-03-17 |
| US6160124A (en) | 2000-12-12 |
| CY2144B1 (en) | 2002-06-21 |
| EP0684242A1 (de) | 1995-11-29 |
| GR3030705T3 (en) | 1999-11-30 |
| KR0164665B1 (ko) | 1999-01-15 |
| CA2157032C (en) | 1999-09-28 |
| US5939445A (en) | 1999-08-17 |
| WO1995018125A1 (en) | 1995-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |