YU43628B - Process for producing 2- or 2,6-substituted penem compounds - Google Patents

Process for producing 2- or 2,6-substituted penem compounds

Info

Publication number
YU43628B
YU43628B YU2760/79A YU276079A YU43628B YU 43628 B YU43628 B YU 43628B YU 2760/79 A YU2760/79 A YU 2760/79A YU 276079 A YU276079 A YU 276079A YU 43628 B YU43628 B YU 43628B
Authority
YU
Yugoslavia
Prior art keywords
producing
penem compounds
substituted penem
substituted
compounds
Prior art date
Application number
YU2760/79A
Other languages
English (en)
Other versions
YU276079A (en
Inventor
M Menard
A Martel
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of YU276079A publication Critical patent/YU276079A/xx
Publication of YU43628B publication Critical patent/YU43628B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00Compounds containing azido groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/10Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568Four-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
YU2760/79A 1978-12-18 1979-11-12 Process for producing 2- or 2,6-substituted penem compounds YU43628B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96866378A 1978-12-18 1978-12-18

Publications (2)

Publication Number Publication Date
YU276079A YU276079A (en) 1983-02-28
YU43628B true YU43628B (en) 1989-10-31

Family

ID=25514601

Family Applications (4)

Application Number Title Priority Date Filing Date
YU2760/79A YU43628B (en) 1978-12-18 1979-11-12 Process for producing 2- or 2,6-substituted penem compounds
YU3076/79A YU43464B (en) 1978-12-18 1979-12-17 Process for producing antibacterial agents
YU2157/82A YU42125B (en) 1978-12-18 1982-09-27 Process for producing new 2-substituted and 2,6 disubstituted penem compounds
YU2153/82A YU43280B (en) 1978-12-18 1982-09-27 Process for producing substituted penem compounds

Family Applications After (3)

Application Number Title Priority Date Filing Date
YU3076/79A YU43464B (en) 1978-12-18 1979-12-17 Process for producing antibacterial agents
YU2157/82A YU42125B (en) 1978-12-18 1982-09-27 Process for producing new 2-substituted and 2,6 disubstituted penem compounds
YU2153/82A YU43280B (en) 1978-12-18 1982-09-27 Process for producing substituted penem compounds

Country Status (13)

Country Link
JP (1) JPS60222486A (fi)
AU (4) AU541717B2 (fi)
CA (2) CA1286661C (fi)
CH (2) CH643846A5 (fi)
DK (5) DK533879A (fi)
ES (1) ES487034A0 (fi)
FI (2) FI69845C (fi)
GR (2) GR81420B (fi)
IE (3) IE49876B1 (fi)
IL (2) IL58576A (fi)
SE (5) SE448995B (fi)
YU (4) YU43628B (fi)
ZA (2) ZA796812B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
DE69629152T2 (de) * 1995-02-17 2004-07-08 Daiichi Suntory Pharma Co., Ltd. Penem-derivate und sie enthaltende anti-mikrobische mittel
ATE283707T1 (de) 1998-01-13 2004-12-15 Daiichi Suntory Pharma Co Ltd Antibakterille zusammensetzung zur topischen anwendung, enthaltend faropenem
JP2005239696A (ja) 2004-01-30 2005-09-08 Daiichi Suntory Pharma Co Ltd 無機物質を配合した医薬硬質カプセル剤
CN112746066B (zh) * 2021-01-25 2023-10-31 洛阳华荣生物技术有限公司 一种l-赖氨酸脱羧酶突变体及其应用

Also Published As

Publication number Publication date
IL58804A0 (en) 1980-02-29
AU557545B2 (en) 1986-12-24
AU5371079A (en) 1980-06-26
IE851853L (en) 1980-06-18
SE461395B (sv) 1990-02-12
DK237690D0 (da) 1990-10-01
FI69845B (fi) 1985-12-31
IE49876B1 (en) 1986-01-08
IE792462L (en) 1980-06-18
SE454779B (sv) 1988-05-30
DK135291D0 (da) 1991-07-15
IL58576A (en) 1985-12-31
GR74491B (fi) 1984-06-28
YU43280B (en) 1989-06-30
ZA796813B (en) 1981-05-27
AU3288484A (en) 1985-03-07
AU563015B2 (en) 1987-06-25
FI69845C (fi) 1986-05-26
DK161520C (da) 1991-12-23
DK161520B (da) 1991-07-15
FI793905A (fi) 1980-06-19
IL58804A (en) 1986-03-31
SE8405719D0 (sv) 1984-11-14
DK237690A (da) 1990-10-01
IE49877B1 (en) 1986-01-08
DK533879A (da) 1980-06-19
IE852246L (en) 1980-06-18
IL58576A0 (en) 1980-01-31
IE50597B1 (en) 1986-05-28
AU541717B2 (en) 1985-01-17
SE464027B (sv) 1991-02-25
YU42125B (en) 1988-04-30
SE8405719L (sv) 1984-11-14
AU539983B2 (en) 1984-10-25
YU43464B (en) 1989-08-31
JPS60222486A (ja) 1985-11-07
YU215782A (en) 1983-06-30
SE7910391L (sv) 1981-06-18
DK533779A (da) 1980-06-19
FI67853C (fi) 1985-06-10
ES8101594A1 (es) 1980-12-16
FI67853B (fi) 1985-02-28
ES487034A0 (es) 1980-12-16
YU215382A (en) 1983-06-30
ZA796812B (en) 1981-05-27
SE8405813D0 (sv) 1984-11-19
DK236590D0 (da) 1990-10-01
FI793903A (fi) 1980-06-19
GR81420B (fi) 1984-12-11
AU3240884A (en) 1984-12-13
DK135291A (da) 1991-07-15
SE448995B (sv) 1987-03-30
YU276079A (en) 1983-02-28
CH643265A5 (en) 1984-05-30
CA1286661C (en) 1991-07-23
AU5378779A (en) 1980-08-28
SE8405813L (sv) 1984-11-19
YU307679A (en) 1983-02-28
SE7910390L (sv) 1981-06-18
DK161970C (da) 1992-02-03
SE8405812D0 (sv) 1984-11-19
DK236590A (da) 1990-10-01
SE8405812L (sv) 1984-11-19
CH643846A5 (en) 1984-06-29
DK161970B (da) 1991-09-02
CA1268183A (en) 1990-04-24

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