YU40448B - Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water - Google Patents

Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water

Info

Publication number
YU40448B
YU40448B YU3155/75A YU315575A YU40448B YU 40448 B YU40448 B YU 40448B YU 3155/75 A YU3155/75 A YU 3155/75A YU 315575 A YU315575 A YU 315575A YU 40448 B YU40448 B YU 40448B
Authority
YU
Yugoslavia
Prior art keywords
triiodo
propionylamino
dihydroxy
amides
propyl
Prior art date
Application number
YU3155/75A
Other languages
English (en)
Other versions
YU315575A (en
Inventor
E Felder
D Pitre
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Priority to SI7513155A priority Critical patent/SI7513155A8/sl
Publication of YU315575A publication Critical patent/YU315575A/xx
Publication of YU40448B publication Critical patent/YU40448B/xx
Priority to HR931219A priority patent/HRP931219B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
YU3155/75A 1974-12-13 1975-12-12 Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water YU40448B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI7513155A SI7513155A8 (sl) 1974-12-13 1975-12-12 Postopek za pripravo bis-(dihidroksipropilamidov) 5-hidroksipropionilamino-2,4,6-trijod-izoftalove kisline, ki so lahko topni v vodi
HR931219A HRP931219B1 (en) 1975-12-12 1993-09-20 Process for the preparation of bis-(dihydroxypropylamides) 5-amino-2,4,6-triiodine of isophtalic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1658874A CH608189A5 (sl) 1974-12-13 1974-12-13

Publications (2)

Publication Number Publication Date
YU315575A YU315575A (en) 1982-02-28
YU40448B true YU40448B (en) 1986-02-28

Family

ID=4418593

Family Applications (2)

Application Number Title Priority Date Filing Date
YU3155/75A YU40448B (en) 1974-12-13 1975-12-12 Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water
YU1967/83A YU41540B (en) 1974-12-13 1983-09-30 Process for preparing bis-(dihydroxy-propilamides) of 5-hydroxy-propionylamido-2,4,6-triido-isophthalic acid, which are readily soluble in water

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU1967/83A YU41540B (en) 1974-12-13 1983-09-30 Process for preparing bis-(dihydroxy-propilamides) of 5-hydroxy-propionylamido-2,4,6-triido-isophthalic acid, which are readily soluble in water

Country Status (29)

Country Link
US (1) US4001323A (sl)
JP (1) JPS5182236A (sl)
AR (1) AR211853A1 (sl)
AT (2) AT340582B (sl)
AU (1) AU475785B2 (sl)
BE (1) BE836355A (sl)
BG (1) BG26512A3 (sl)
CA (1) CA1046082A (sl)
CH (1) CH608189A5 (sl)
CS (1) CS194234B2 (sl)
DD (1) DD122475A5 (sl)
DK (1) DK147336C (sl)
ES (1) ES442651A1 (sl)
FR (1) FR2293919A1 (sl)
GB (1) GB1472050A (sl)
HU (1) HU170216B (sl)
IE (1) IE42620B1 (sl)
IL (1) IL48484A (sl)
IN (1) IN142089B (sl)
MX (1) MX3174E (sl)
NL (1) NL157295B (sl)
NO (1) NO145096C (sl)
PH (1) PH12321A (sl)
PL (1) PL96082B1 (sl)
RO (1) RO69615A (sl)
SE (1) SE409993B (sl)
SU (1) SU628813A3 (sl)
YU (2) YU40448B (sl)
ZA (1) ZA757222B (sl)

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GB1495679A (en) * 1974-06-17 1977-12-21 Mallinckrodt Inc Substituted isophthalamic acids
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DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
NL8002388A (nl) * 1979-05-21 1980-11-25 Mallinckrodt Inc Roentgencontrastmiddel.
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
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DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150917A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
DE3689330T2 (de) * 1985-08-09 1994-05-19 Cook Imaging Corp Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
KR960016747B1 (ko) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
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US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
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IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
US5463080A (en) * 1992-08-27 1995-10-31 Bracco International B.V. 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents
IT1256162B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
US5424056A (en) * 1993-03-01 1995-06-13 Sterling Wintrhop Inc. X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays
US5330740A (en) * 1993-03-01 1994-07-19 Sterling Winthrop Inc. Compositions of iodoaniline derivatives in film-forming materials for visualization of the gastrointestinal tract
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1271469B (it) * 1993-09-10 1997-05-28 Zambon Spa Processo per la preparazione di 5-ammino-2,2-dialchil-1,3 diossani
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
KR100255914B1 (ko) * 1995-05-23 2000-05-01 안토니오 칸탈루피 디카르복실산 디클로라이드의 제조 방법
PL187308B1 (pl) 1995-05-23 2004-06-30 Bracco Imaging Spa Sposób wytwarzania dichlorku kwasu dikarboksylowego i sposób oczyszczania i izolacji dichlorku kwasu dikarboksylowego
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
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IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
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GB9624612D0 (en) * 1996-11-26 1997-01-15 Nycomed Imaging As Process
IT1286522B1 (it) * 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1289520B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289521B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la purificazione di un intermedio
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
DE966428T1 (de) * 1997-02-11 2000-06-29 Bracco International B.V., Amsterdam Verfahren zur kritallisation von (s)-n-n'-bis [2-hydroxy-1-(hydroxymethyl) ethyl]-5-[(2-hydroxy-1-xopropyl) amino]-2,4,6-trirodo-1,3-benzoldicarboxamid aus linearem oder verzweigtem (c5-c6) alkohol oder gemischen davon
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
US5820851A (en) * 1997-08-21 1998-10-13 Hoechst Celanese Corporation Tripodal pyridine ligands as MRI contrast agents
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
US6262303B1 (en) 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
IT1302200B1 (it) * 1998-09-11 2000-07-31 Dibra Spa PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1-
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SE520688C2 (sv) * 2000-04-11 2003-08-12 Bone Support Ab Ett injicerbart ersättningsmaterial för benmineral
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IT1319671B1 (it) * 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
SE522098C2 (sv) * 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
SE0300620D0 (sv) * 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
SE0302983D0 (sv) * 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv) 2004-06-22 2006-04-04 Bone Support Ab Anordning för framställning av härdbar massa samt användning av anordningen
EA011516B1 (ru) 2005-01-13 2009-04-28 Синвеншен Аг Композиционный материал и способ его изготовления
AU2008206953A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
US20080206862A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system bag
US7955234B1 (en) 2007-02-28 2011-06-07 Pursley Michael G Exercise device and method
EP2126040A1 (en) * 2007-02-28 2009-12-02 Cinvention Ag High surface cultivation system
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
KR101098553B1 (ko) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법
US8624061B2 (en) * 2008-11-18 2014-01-07 Bracco Imaging S.P.A. Process for the preparation of iodinated contrast agent
US20110256068A1 (en) 2009-01-09 2011-10-20 Wistand Lars-Goeran Contrast media compositions
EP2230227A1 (en) * 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
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DK2451994T3 (da) 2009-07-07 2014-01-20 Bracco Imaging Spa Fremgangsmåde til fremstilling af et ioderende middel
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
PT105770B (pt) * 2011-06-24 2013-07-08 Hovione Farmaciencia S A Novo intermediário e seu uso na preparação de agente de contrate triiodado
EP2931696B1 (en) 2012-12-11 2018-08-22 Bracco Imaging S.p.A Continuous process for the preparation of (s)-2-acetyloxypropionic acid
PT2958603T (pt) 2013-02-20 2018-06-06 Bone Support Ab Endurecimento melhorado de substituto ósseo endurecível
LT3066071T (lt) * 2013-11-05 2018-09-10 Bracco Imaging S.P.A. Jopamidolio gamybos būdas
CA2949433C (en) 2014-06-10 2022-05-03 Bracco Imaging Spa Method for the preparation of (s)-2-acetyloxypropionic acid and derivatives thereof
CN104230731B (zh) * 2014-09-24 2016-01-20 武汉理工大学 造影剂中间体三碘异酞酰氯的制备方法
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN105461581A (zh) * 2015-11-17 2016-04-06 浙江海洲制药有限公司 碘帕醇杂质a和杂质b的合成方法
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
WO2018104228A1 (en) 2016-12-05 2018-06-14 Bracco Imaging Spa Mechanochemical synthesis of radiographic agents intermediates
JP7132252B2 (ja) 2017-06-07 2022-09-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 水溶液からのヨウ素の回収方法
WO2022200247A1 (en) 2021-03-22 2022-09-29 Bracco Imaging Spa Industrial synthesis of serinol
WO2023117667A1 (en) 2021-12-20 2023-06-29 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodoisophthalic bisamides

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DE2124904C3 (de) * 1971-05-15 1980-09-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Hydroxy- und Alkoxyacetamido-trijodbenzoesäuren, deren Salze mit physiologisch verträglichen Basen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel
BE788054A (fr) * 1971-08-26 1973-02-26 Bracco Ind Chimica Spa Nouvel agent de contraste radiographique et procede pour le preparer
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Also Published As

Publication number Publication date
IE42620L (en) 1976-06-13
ES442651A1 (es) 1977-04-16
YU315575A (en) 1982-02-28
SU628813A3 (ru) 1978-10-15
CA1046082A (en) 1979-01-09
IL48484A (en) 1978-08-31
JPS5182236A (en) 1976-07-19
PH12321A (en) 1979-01-16
BG26512A3 (bg) 1979-04-12
GB1472050A (en) 1977-04-27
YU41540B (en) 1987-08-31
RO69615A (ro) 1981-06-30
ATA925075A (de) 1977-04-15
DE2547789A1 (de) 1976-06-24
NO145096C (no) 1982-01-13
SE7514076L (sv) 1976-06-14
AT342579B (de) 1978-04-10
MX3174E (es) 1980-06-09
IN142089B (sl) 1977-05-28
DK147336C (da) 1985-01-21
DK567475A (da) 1976-06-14
CH608189A5 (sl) 1978-12-29
AT340582B (de) 1977-12-27
SE409993B (sv) 1979-09-17
IE42620B1 (en) 1980-09-10
AU475785B2 (en) 1976-09-02
ZA757222B (en) 1976-11-24
DD122475A5 (sl) 1976-10-12
YU196783A (en) 1984-12-31
AU8751675A (en) 1976-09-02
NO145096B (no) 1981-10-05
NO754241L (sl) 1976-06-15
FR2293919A1 (fr) 1976-07-09
US4001323A (en) 1977-01-04
DK147336B (da) 1984-06-25
IL48484A0 (en) 1976-01-30
PL96082B1 (pl) 1977-12-31
NL7512208A (nl) 1976-06-15
ATA925175A (de) 1977-08-15
BE836355A (fr) 1976-06-08
AR211853A1 (es) 1978-03-31
CS194234B2 (en) 1979-11-30
FR2293919B1 (sl) 1980-06-20
DE2547789B2 (de) 1977-02-24
HU170216B (sl) 1977-04-28
NL157295B (nl) 1978-07-17
JPS5642581B2 (sl) 1981-10-06

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