YU155083A - Process for obtaining new anthracycline glycosides - Google Patents

Process for obtaining new anthracycline glycosides

Info

Publication number
YU155083A
YU155083A YU01550/83A YU155083A YU155083A YU 155083 A YU155083 A YU 155083A YU 01550/83 A YU01550/83 A YU 01550/83A YU 155083 A YU155083 A YU 155083A YU 155083 A YU155083 A YU 155083A
Authority
YU
Yugoslavia
Prior art keywords
obtaining new
anthracycline glycosides
new anthracycline
glycosides
obtaining
Prior art date
Application number
YU01550/83A
Other languages
English (en)
Inventor
C W Mosher
G L Tong
E M Action
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of YU155083A publication Critical patent/YU155083A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
YU01550/83A 1982-07-20 1983-07-18 Process for obtaining new anthracycline glycosides YU155083A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40012082A 1982-07-20 1982-07-20
US06/496,122 US4464529A (en) 1982-07-20 1983-05-24 Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Publications (1)

Publication Number Publication Date
YU155083A true YU155083A (en) 1986-02-28

Family

ID=27016900

Family Applications (2)

Application Number Title Priority Date Filing Date
YU01550/83A YU155083A (en) 1982-07-20 1983-07-18 Process for obtaining new anthracycline glycosides
YU01405/85A YU140585A (en) 1982-07-20 1985-09-09 Process for obtaiining morpholinyl daunorubicine and morphlinyl doxorubicine

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU01405/85A YU140585A (en) 1982-07-20 1985-09-09 Process for obtaiining morpholinyl daunorubicine and morphlinyl doxorubicine

Country Status (24)

Country Link
US (1) US4464529A (ko)
KR (1) KR880002461B1 (ko)
AT (1) AT381319B (ko)
AU (1) AU555902B2 (ko)
BE (1) BE897312A (ko)
CA (1) CA1239396A (ko)
CH (1) CH655729A5 (ko)
DE (1) DE3325816A1 (ko)
DK (1) DK158269C (ko)
ES (2) ES524271A0 (ko)
FI (1) FI75174C (ko)
FR (1) FR2530640B1 (ko)
GB (1) GB2124224B (ko)
GR (1) GR78885B (ko)
IE (1) IE55795B1 (ko)
IL (1) IL69260A (ko)
IT (1) IT1163818B (ko)
NL (1) NL188905C (ko)
NO (1) NO157146C (ko)
NZ (1) NZ204911A (ko)
PH (1) PH21860A (ko)
PT (1) PT77060B (ko)
SE (1) SE459921B (ko)
YU (2) YU155083A (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの4−デメトキシ−3′−デアミノ−3′(4−モリホリニル)誘導体
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
FR2560876B1 (fr) * 1984-03-09 1987-01-16 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
FR2565982B1 (fr) * 1984-06-15 1988-01-15 Hoechst Lab Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4705850A (en) * 1984-10-25 1987-11-10 Sri International C-glycosidic adriamycin analogs
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
WO2009124468A1 (zh) * 2008-04-11 2009-10-15 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
WO2016040825A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Anthracycline derivative linker reagents, antibody-drug conjugates and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4202967A (en) * 1978-10-02 1980-05-13 Sri International N,N-pentamethylene derivatives of daunomycin and adriamycin
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) * 1981-03-23 1982-02-02 Sri International 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin

Also Published As

Publication number Publication date
DK332983D0 (da) 1983-07-19
NO157146B (no) 1987-10-19
IT1163818B (it) 1987-04-08
CA1239396A (en) 1988-07-19
CH655729A5 (de) 1986-05-15
KR880002461B1 (ko) 1988-11-14
ATA260883A (de) 1986-02-15
PT77060A (en) 1983-08-01
ES530593A0 (es) 1985-11-01
IT8322143A1 (it) 1985-01-20
IT8322143A0 (it) 1983-07-20
GB2124224A (en) 1984-02-15
IE831680L (en) 1984-01-20
IL69260A (en) 1987-03-31
DK158269B (da) 1990-04-23
US4464529A (en) 1984-08-07
ES8501415A1 (es) 1984-11-16
GB2124224B (en) 1985-12-04
IE55795B1 (en) 1991-01-16
SE8304045L (sv) 1984-01-21
NL8302586A (nl) 1984-02-16
GR78885B (ko) 1984-10-02
DK158269C (da) 1990-10-08
KR840005443A (ko) 1984-11-12
DK332983A (da) 1984-01-21
NZ204911A (en) 1986-04-11
PT77060B (en) 1986-04-09
IL69260A0 (en) 1983-11-30
SE8304045D0 (sv) 1983-07-19
SE459921B (sv) 1989-08-21
FR2530640A1 (fr) 1984-01-27
AU555902B2 (en) 1986-10-16
YU140585A (en) 1986-02-28
FI832637A (fi) 1984-01-21
GB8319165D0 (en) 1983-08-17
PH21860A (en) 1988-03-25
BE897312A (fr) 1984-01-18
AT381319B (de) 1986-09-25
AU1694683A (en) 1984-01-26
NO832610L (no) 1984-01-23
FI832637A0 (fi) 1983-07-19
NL188905C (nl) 1992-11-02
DE3325816A1 (de) 1984-01-26
FI75174B (fi) 1988-01-29
ES8602032A1 (es) 1985-11-01
FI75174C (fi) 1988-05-09
DE3325816C2 (ko) 1990-05-03
ES524271A0 (es) 1984-11-16
FR2530640B1 (fr) 1985-07-12
NO157146C (no) 1988-01-27

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