WO2019241477A1 - Dispositif de pose de valvule cardiaque de remplacement - Google Patents

Dispositif de pose de valvule cardiaque de remplacement Download PDF

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Publication number
WO2019241477A1
WO2019241477A1 PCT/US2019/036906 US2019036906W WO2019241477A1 WO 2019241477 A1 WO2019241477 A1 WO 2019241477A1 US 2019036906 W US2019036906 W US 2019036906W WO 2019241477 A1 WO2019241477 A1 WO 2019241477A1
Authority
WO
WIPO (PCT)
Prior art keywords
proximal
inner shaft
heart valve
medical device
replacement heart
Prior art date
Application number
PCT/US2019/036906
Other languages
English (en)
Inventor
Declan LOUGHNANE
Tim O'connor
Sean O'sullivan
Original Assignee
Boston Scientific Scimed, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Scimed, Inc. filed Critical Boston Scientific Scimed, Inc.
Publication of WO2019241477A1 publication Critical patent/WO2019241477A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/243—Deployment by mechanical expansion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2439—Expansion controlled by filaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A61F2002/9511—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires

Definitions

  • the present disclosure pertains to medical devices, and methods for manufacturing and/or using medical devices. More particularly, the present disclosure pertains to a delivery device for a replacement heart valve implant.
  • intracorporeal medical devices have been developed for medical use, for example, intravascular use. Some of these devices include guidewires, catheters, medical device delivery systems (e.g., for stents, grafts, replacement valves, etc.), and the like. These devices are manufactured by any one of a variety of different manufacturing methods and may be used according to any one of a variety of methods. Of the known medical devices and methods, each has certain advantages and disadvantages. There is an ongoing need to provide alternative medical devices as well as alternative methods for manufacturing and using medical devices.
  • a medical device system may comprise a delivery device including an outer sheath and an inner shaft having a coupler fixed to a distal end of the inner shaft; and a replacement heart valve implant releasably attached to the coupler, the replacement heart valve implant including an expandable anchor member and a plurality of locking mechanisms configured to engage with the coupler.
  • the delivery device may include a plurality of collars configured to secure the coupler to the plurality of locking mechanisms.
  • the delivery device may include a stop element configured to selectively prevent disengagement of the plurality of collars from the plurality of locking mechanisms.
  • the coupler includes a proximal ring fixed to the distal end of the inner shaft and a plurality of fingers extending distally from the proximal ring.
  • the stop element includes a proximal band slidably disposed about the inner shaft proximal of the distal end of the inner shaft and a plurality of arms extending distally from the proximal band.
  • Each of the plurality of arms may include a distal loop disposed at a distal end of its respective arm, each distal loop being slidably engaged with one of the plurality of fingers.
  • At least one of the plurality of arms includes a wing element configured to selectively engage with the proximal ring of the coupler.
  • engagement of the wing element with the proximal ring of the coupler prevents proximal sliding movement of each distal loop with respect to the plurality of fingers.
  • the plurality of arms is self-biased radially outward from the inner shaft.
  • a proximal portion of the plurality of arms is configured to shift radially relative to the inner shaft between an engagement position and a disengagement position.
  • the proximal portion of the plurality of arms in the engagement position, is disposed adjacent to an outer surface of the inner shaft, and in the disengagement position, the proximal portion of the plurality of arms is spaced radially outward from the outer surface of the inner shaft.
  • the proximal portion of the plurality of arms in the engagement position, is disposed generally parallel to an outer surface of the inner shaft, and in the disengagement position, the proximal portion of the plurality of arms extends radially outward from the outer surface of the inner shaft at an oblique angle.
  • the outer sheath urges the proximal portion of the plurality of arms toward the engagement position when a distal end of the outer sheath is a disposed over the proximal portion of the plurality of arms.
  • proximal retraction of the outer sheath relative to the proximal band permits the proximal portion of the plurality of arms to shift toward the disengagement position.
  • a medical device system may comprise a delivery device including a handle having an outer shell and an interior space, an outer sheath, and an inner shaft having a coupler fixed to a distal end of the inner shaft; wherein a proximal end of the outer sheath and a proximal end of the inner shaft are each operably connected to an axial translation mechanism within the outer shell of the handle, the axial translation mechanism being configured to move to the outer sheath relative to the inner shaft; and a replacement heart valve implant releasably attached to the coupler, the replacement heart valve implant including an expandable anchor member and a plurality of locking mechanisms configured to engage with the coupler.
  • the delivery device may include a plurality of collars configured to secure the coupler to the plurality of locking mechanisms.
  • the delivery device may include a stop element configured to selectively prevent disengagement of the plurality of collars from the plurality of locking mechanisms.
  • the medical device system may further comprise a locking pin shiftable between a first configuration and a second configuration, wherein the locking pin may extend through an outer wall of the outer shell of the handle in the first configuration, and wherein the locking pin is removed from the outer shell of the handle in the second configuration.
  • the locking pin in the first configuration, in the first configuration, in the first configuration, in the first configuration, in the locking pin in configured to prevent proximal translation of the outer sheath relative to the stop element.
  • proximal translation of the outer sheath relative to the stop element is permitted.
  • a medical device system may comprise a delivery device including an outer sheath and an inner shaft having a coupler fixed to a distal end of the inner shaft, wherein the coupler includes a proximal ring fixed to the distal end of the inner shaft and a plurality of fingers extending distally from the proximal ring; and a replacement heart valve implant releasably attached to the coupler, the replacement heart valve implant including an expandable anchor member and a plurality of locking mechanisms configured to engage with the plurality of fingers.
  • the delivery device may include a plurality of collars, wherein one collar is slidably disposed on each of the plurality of fingers and is configured to maintain engagement of its respective finger with one of the plurality of locking mechanisms in an interlock position.
  • the delivery device may include a stop element configured to selectively prevent disengagement of the plurality of locking mechanisms from the plurality of fingers by maintaining the plurality of collars in the interlock position when the stop element is engaged with the proximal ring of the coupler.
  • proximal retraction of the outer sheath relative to the stop element permits the stop element to disengage the proximal ring of the coupler.
  • the plurality of collars when the stop element is disengaged from the proximal ring of the coupler, the plurality of collars is slidable relative to the plurality of fingers to a release position.
  • the stop element is disposed proximal of the replacement heart valve implant.
  • the stop element does not extend into or through any portion of the replacement heart valve implant.
  • FIG. 1 illustrates an example medical device system
  • FIG. 2 is a perspective view of selected elements of the medical device system in a deployed configuration and/or an engagement position
  • FIG. 3 illustrates selected elements of an example replacement heart valve implant in a delivery configuration and/or the engagement position
  • FIG. 4 illustrates selected elements of an example replacement heart valve implant in the deployed configuration and/or the engagement position
  • FIG. 5 illustrates an example medical device system in the deployed configuration
  • FIG. 6 is a perspective view of selected elements of the medical device system in the deployed configuration and/or a disengagement position
  • FIG. 7 illustrates selected elements of an example replacement heart valve implant in the deployed configuration and/or the disengagement position
  • FIG. 8 illustrates selected elements of an example replacement heart valve implant in the released configuration and/or the disengagement position
  • FIG. 9 is a perspective view of selected elements of the medical device system in the released configuration and/or the disengagement position.
  • FIGS . 10-11 illustrate selected elements of a delivery device shifting between a first position and a second position.
  • numeric values are herein assumed to be modified by the term“about,” whether or not explicitly indicated.
  • the term“about”, in the context of numeric values, generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (e.g., having the same function or result). In many instances, the term“about” may include numbers that are rounded to the nearest significant figure. Other uses of the term“about” (e.g., in a context other than numeric values) may be assumed to have their ordinary and customary defmition(s), as understood from and consistent with the context of the specification, unless otherwise specified.
  • Relative terms such as“proximal”,“distal”,“advance”,“retract”, variants thereof, and the like, may be generally considered with respect to the positioning, direction, and/or operation of various elements relative to a user/operator/manipulator of the device, wherein “proximal” and“retract” indicate or refer to closer to or toward the user and“distal” and “advance” indicate or refer to farther from or away from the user.
  • the terms “proximal” and“distal” may be arbitrarily assigned in an effort to facilitate understanding of the disclosure, and such instances will be readily apparent to the skilled artisan.
  • relative terms such as“upstream”,“downstream”,“inflow”, and“outflow” refer to a direction of fluid flow within a lumen, such as a body lumen, a blood vessel, or within a device.
  • Still other relative terms such as “axial”, “circumferential”, “longitudinal”,“lateral”,“radial”, etc. and/or variants thereof generally refer to direction and/or orientation relative to a central longitudinal axis of the disclosed structure or device.
  • the terms“extent” and/or“maximum extent” may be understood to mean a greatest measurement of a stated or identified dimension, while the term“minimum extent” may be understood to mean a smallest measurement of a stated or identified dimension.
  • “outer extent” may be understood to mean a maximum outer dimension
  • “radial extent” may be understood to mean a maximum radial dimension
  • “longitudinal extent” may be understood to mean a maximum longitudinal dimension
  • Each instance of an “extent” may be different (e.g., axial, longitudinal, lateral, radial, circumferential, etc.) and will be apparent to the skilled person from the context of the individual usage.
  • an“extent” or“maximum extent” may be considered a greatest possible dimension measured according to the intended usage.
  • a“minimum extent” may be considered a smallest possible dimension measured according to the intended usage.
  • an“extent” may generally be measured orthogonally within a plane and/or cross-section, but may be, as will be apparent from the particular context, measured differently - such as, but not limited to, angularly, radially, circumferentially (e.g., along an arc), etc.
  • references in the specification to “an embodiment”, “some embodiments”,“other embodiments”, etc. indicate that the embodiment(s) described may include a particular feature, structure, or characteristic, but every embodiment may not necessarily include the particular feature, structure, or characteristic. Moreover, such phrases are not necessarily referring to the same embodiment. Further, when a particular feature, structure, or characteristic is described in connection with an embodiment, it would be within the knowledge of one skilled in the art to effect the particular feature, structure, or characteristic in connection with other embodiments, whether or not explicitly described, unless clearly stated to the contrary.
  • Treatment of the cardiovascular system was often conducted by directly accessing the impacted part of the system.
  • treatment of a blockage in one or more of the coronary arteries was traditionally treated using coronary artery bypass surgery.
  • therapies are rather invasive to the patient and require significant recovery times and/or treatments.
  • less invasive therapies have been developed, for example, where a blocked coronary artery could be accessed and treated via a percutaneous catheter (e.g., angioplasty).
  • a percutaneous catheter e.g., angioplasty
  • Some relatively common medical conditions may include or be the result of inefficiency, ineffectiveness, or complete failure of one or more of the valves within the heart.
  • failure of the aortic valve or the mitral valve can have a serious effect on a human and could lead to serious health condition and/or death if not dealt with properly.
  • Treatment of defective heart valves poses other challenges in that the treatment often requires the repair or outright replacement of the defective valve.
  • Such therapies may be highly invasive to the patient.
  • a medical device system that may be used for delivering a medical device to a portion of the cardiovascular system in order to diagnose, treat, and/or repair the system.
  • At least some of the medical devices disclosed herein may be used to deliver and implant a replacement heart valve implant (e.g., a replacement aortic valve, replacement mitral valve, etc.).
  • a replacement heart valve implant e.g., a replacement aortic valve, replacement mitral valve, etc.
  • the medical device system disclosed herein may deliver the replacement heart valve implant percutaneously and, thus, may be much less invasive to the patient.
  • the device and/or system disclosed herein may also provide other desirable features and/or benefits as described below.
  • FIG. 1 The figures illustrate selected components and/or arrangements of a medical device system 10, shown schematically in FIG. 1 for example. It should be noted that in any given figure, some features of the medical device system 10 may not be shown, or may be shown schematically, for simplicity. Additional details regarding some of the components of the medical device system 10 may be illustrated in other figures in greater detail.
  • a medical device system 10 may be used to deliver and/or deploy a variety of medical devices and/or implants to one or more locations within the anatomy.
  • the medical device system 10 may include a delivery device 11 (e.g., a replacement aortic valve delivery system) that can be used for percutaneous delivery of a replacement heart valve implant 16 (e.g., a replacement mitral valve, a replacement aortic valve, etc.) to an area of interest in the anatomy, such as a native heart valve.
  • a delivery device 11 e.g., a replacement aortic valve delivery system
  • a replacement heart valve implant 16 e.g., a replacement mitral valve, a replacement aortic valve, etc.
  • the medical device system 10 and/or the delivery device 11 may also be used for other interventions including valve repair, valvuloplasty, and the like, or other similar interventions.
  • FIG. 1 illustrates the medical device system 10 including the replacement heart valve implant 16 configured to be disposed within the area of interest, such as a native heart valve (e.g., a mitral valve, an aortic valve, etc.), wherein the replacement heart valve implant 16 may be disposed within a lumen of the delivery device 11 in a delivery configuration for delivery to the area of interest, where the replacement heart valve implant 16 may be shifted to a deployed configuration.
  • a native heart valve e.g., a mitral valve, an aortic valve, etc.
  • the delivery device 11 may be disposed within a lumen of the delivery device 11 in a delivery configuration for delivery to the area of interest, where the replacement heart valve implant 16 may be shifted to a deployed configuration.
  • the delivery device e.g., a native heart valve, a mitral valve, an aortic valve, etc.
  • the delivery device 11 may include an outer sheath 12 having a lumen extending from a proximal portion and/or proximal end of the outer sheath 12 to a distal end of the outer sheath 12.
  • the replacement heart valve implant 16 may be disposed within the lumen of the outer sheath 12 proximate the distal end of the outer sheath 12 in the delivery configuration.
  • the delivery device 11 may include a handle 18 disposed proximate and/or at the proximal end of the outer sheath 12.
  • the handle 18 may have an outer shell and an interior space.
  • the handle 18 may have a control knob 19.
  • the delivery device 11 may include an inner shaft or catheter 14 disposed within the lumen of the outer sheath 12 and/or slidable with respect to the outer sheath 12 within the lumen of the outer sheath 12.
  • the handle 18 may be disposed proximate and/or at a proximal end of the inner shaft or catheter 14.
  • the inner shaft or catheter 14 may be a tubular structure having one or more lumens extending therethrough, the inner shaft or catheter 14 may be a solid shaft, or the inner shaft or catheter 14 may be a combination thereof.
  • the proximal end of the outer sheath 12 and the proximal end of the inner shaft or catheter 14 may each be operably connected, fixed, and/or secured to an axial translation mechanism disposed within the outer shell of the handle 18.
  • the axial translation mechanism may be configured to move and/or translate the outer sheath 12 relative to the inner shaft or catheter 14.
  • the delivery device 11 may include an actuator element 15 releasably connecting the replacement heart valve implant 16 to the handle 18.
  • the actuator element 15 may extend from the handle 18 to the replacement heart valve implant 16, the replacement heart valve implant 16 being disposed at a distal end of the lumen of the outer sheath 12.
  • the actuator element 15 may extend distally from the inner shaft or catheter 14 to the replacement heart valve implant 16.
  • the actuator element 15 may be slidably disposed within and/or may extend slidably through the inner shaft or catheter 14.
  • the handle 18 and/or the actuator element 15 may be configured to manipulate the position of the outer sheath 12 relative to the inner shaft or catheter 14 and/or aid in the deployment of the replacement heart valve implant 16.
  • the inner shaft or catheter 14 and/or the actuator element 15 may be used to move the replacement heart valve implant 16 with respect to the outer sheath 12 of the delivery device 11.
  • the inner shaft or catheter 14 and/or the actuator element 15 may be advanced distally within the lumen of the outer sheath 12 to push the replacement heart valve implant 16 out the distal end of the outer sheath 12 and/or the delivery device 11 to deploy the replacement heart valve implant 16 within the area of interest (e.g., the native heart valve, etc.).
  • the inner shaft or catheter 14 and/or the actuator element 15 may be held in a fixed position relative to the replacement heart valve implant 16 and the outer sheath 12 may be withdrawn proximally relative to the inner shaft or catheter 14, the actuator element 15, and/or the replacement heart valve implant 16 to deploy the replacement heart valve implant 16 within the area of interest (e.g., the native heart valve, etc.).
  • a locking pin 13 may be shiftable between a first configuration and a second configuration, wherein the locking pin 13 may extend into the handle 18 through an outer wall of the outer shell of the handle 18 in the first configuration and the locking pin 13 is removed from the outer shell of the handle 18 in the second configuration.
  • the locking pin 13 may be configured to limit proximal movement and/or translation of the outer sheath 12 relative to the inner shaft or catheter 14 and/or a stop element 86 (e.g., FIG. 2) when the locking pin 13 is in the first configuration and/or extends into the handle 18.
  • a stop element 86 e.g., FIG. 2
  • proximal movement and/or translation of the outer sheath 12 relative to the inner shaft or catheter 14 and/or the stop element 86 may be permitted.
  • the outer sheath 12 may be movable with respect to the inner shaft or catheter 14 between a first position (e.g., FIGS.
  • a distal end of the outer sheath 12 extends at least to and/or past a distal end of the inner shaft or catheter 14, and a second position (e.g., FIGS. 6 and 11), wherein the distal end of the outer sheath 12 is disposed proximal of the distal end of the inner shaft or catheter 14.
  • Removal of the locking pin 13 may permit the outer sheath 12 to shift from the first position relative to the inner shaft or catheter 14 to the second position relative to the inner shaft or catheter 14.
  • the outer sheath 12 may be prevented from shifting to the second position relative to the inner shaft or catheter 14 when the locking pin 13 is in place and/or extends into the handle 18.
  • the second position is at least 0.250 inches proximal of the first position (e.g., the distal end of the outer sheath 12 is at least 0.250 inches proximal of the distal end of the inner shaft or catheter 14). In some embodiments, the second position is at least 0.375 inches proximal of the first position (e.g., the distal end of the outer sheath 12 is at least 0.375 inches proximal of the distal end of the inner shaft or catheter 14). In some embodiments, the second position is at least 0.500 inches proximal of the first position (e.g., the distal end of the outer sheath 12 is at least 0.500 inches proximal of the distal end of the inner shaft or catheter 14).
  • the second position is at least 0.750 inches proximal of the first position (e.g., the distal end of the outer sheath 12 is at least 0.750 inches proximal of the distal end of the inner shaft or catheter 14), or more.
  • suitable but non-limiting materials for the medical device system 10, the delivery device 11, the outer sheath 12, the locking pin 13, the inner shaft or catheter 14, the actuator element 15, the handle 18, and/or components or elements thereof, are described below.
  • the delivery device 11 may include a nose cone disposed at a distal end of a guidewire extension tube, wherein the guidewire extension tube may extend distally from the shaft sheath or catheter 14 and/or the outer sheath 12.
  • the nose cone may be designed to have an atraumatic shape and/or may include a ridge or ledge that is configured to abut a distal end of the outer sheath 12 during delivery of the replacement heart valve implant 16.
  • the medical device system 10 and/or the delivery device 11 may be advanced percutaneously through the vasculature to the area of interest.
  • the medical device system 10 and/or the delivery device 11 may be advanced over a guidewire through the vasculature and across the aortic arch to a defective heart valve (e.g., aortic valve, mitral valve, etc.) ⁇
  • a defective heart valve e.g., aortic valve, mitral valve, etc.
  • Alternative approaches to treat a defective heart valve are also contemplated with the medical device system 10 and/or the delivery device 11.
  • the replacement heart valve implant 16 may be generally disposed in an elongated and low profile“delivery” configuration within the lumen of the outer sheath 12.
  • the outer sheath 12 may be retracted relative to the replacement heart valve implant 16 and/or the inner shaft or catheter 14 to expose the replacement heart valve implant 16.
  • the replacement heart valve implant 16 may be disposed in an “everted” configuration or a partially-everted configuration while disposed within the lumen of the outer sheath 12 and/or immediately upon exposure after retracting the outer sheath 12.
  • the replacement heart valve implant 16 may be everted in the“delivery” configuration.
  • The“everted” configuration may involve at least a portion of the valve leaflets (discussed below) of the replacement heart valve implant 16 being disposed outside of the expandable anchor member (discussed below) of the replacement heart valve implant 16 during delivery, thereby permitting a smaller radial profile of the replacement heart valve implant 16 and the use of a smaller overall profile of the outer sheath 12, the delivery device 11, and/or the medical device system 10.
  • the “delivery” configuration and the “everted” configuration may be substantially similar and/or may be used interchangeably herein.
  • the replacement heart valve implant 16 may be actuated using the handle 18 and/or the actuator element 15 in order to translate the replacement heart valve implant 16 into a radially expanded and larger profile“deployed” configuration suitable for implantation within the anatomy at the area of interest or the target location.
  • the replacement heart valve implant 16 may be actuated from the“delivery” configuration to the“deployed” configuration with the locking pin 13 in place and/or extending into the handle 18. After verifying placement of the replacement heart valve implant 16 using a suitable imaging technique, the locking pin 13 may be removed, and the handle 18 may be subsequently actuated to shift the replacement heart valve implant 16 into a“released” configuration.
  • the outer sheath 12 and/or the delivery device 11 can be removed from the vasculature.
  • the replacement heart valve implant 16 may be deployed within the native heart valve (e.g., the native heart valve is left in place and not excised).
  • the native heart valve may be removed and the replacement heart valve implant 16 may be deployed in its place as a replacement.
  • Disposed within a first lumen of the inner shaft or catheter 14 may be the actuator element 15, which may be used to actuate and/or translate (e.g., expand and/or elongate) the replacement heart valve implant 16 between the“delivery” configuration and the “deployed” configuration.
  • the actuator element 15 may include or comprise a plurality of actuator elements 15, two actuator elements 15, three actuator elements 15, four actuator elements 15, or another suitable or desired number of actuator elements 15.
  • each actuator element 15 may be disposed within a separate lumen of the inner shaft or catheter 14.
  • the medical device system 10, the delivery device 11, and the replacement heart valve implant 16 are shown with three actuator elements 15.
  • the three actuator elements 15 may be disposed within three separate lumens (e.g., a first lumen, a second lumen, and a third lumen) of the inner shaft or catheter 14, although such a configuration is not required.
  • FIG. 2 illustrates some selected components of the medical device system 10, the delivery device 11, and/or the replacement heart valve implant 16, shown in the“deployed” configuration.
  • the replacement heart valve implant 16 may include an expandable anchor member 17 that is reversibly actuatable between the elongated“delivery” configuration and the radially expanded and/or axially shortened “deployed” configuration.
  • the expandable anchor member 17 may be tubular and defines a lumen extending coaxially along a central longitudinal axis from a distal or inflow end of the expandable anchor member 17 and/or the replacement heart valve implant 16 to a proximal or outflow end of the expandable anchor member 17 and/or the replacement heart valve implant 16.
  • the expandable anchor member 17 may comprise an expandable stent structure and/or framework.
  • the expandable anchor member 17 may comprise a self-expanding braided and/or woven mesh structure made up of one or more filaments disposed and/or interwoven circumferentially about the lumen of the expandable anchor member 17 and/or the replacement heart valve implant 16.
  • Non-self-expanding, mechanically-expandable, and/or assisted self-expanding expandable anchor members are also contemplated.
  • the expandable anchor member 17 may be formed as a unitary structure (e.g., formed from a single filament or strand of wire, cut from a single tubular member, etc.).
  • the expandable anchor member 17 may define a generally cylindrical outer surface in the deployed configuration. Other configurations are also possible - a cross-section defining a generally elliptical outer surface, for example. Some examples of suitable but non- limiting materials for the replacement heart valve implant 16, the expandable anchor member 17, and/or components or elements thereof, are described below.
  • the replacement heart valve implant 16 may include a plurality of valve leaflets 22 disposed within the lumen of the replacement heart valve implant 16 and/or the expandable anchor member 17.
  • the plurality of valve leaflets 22 may be attached and/or secured to the expandable anchor member 17 at a plurality of locations within the lumen of the replacement heart valve implant 16 and/or the expandable anchor member 17.
  • the plurality of valve leaflets 22 may be attached and/or secured to the expandable anchor member 17 using sutures, adhesives, or other suitable means.
  • the plurality of valve leaflets 22 may include or comprise two leaflets, three leaflets, four leaflets, etc. as desired.
  • the plurality of valve leaflets 22 may comprise a first valve leaflet, a second valve leaflet, a third valve leaflet, etc. and may be referred to collectively as the plurality of valve leaflets 22.
  • the plurality of valve leaflets 22 of the replacement heart valve implant 16 may be configured to move between an open configuration permitting antegrade fluid flow through the replacement heart valve implant 16 and/or the lumen of the replacement heart valve implant 16 and/or the expandable anchor member 17, and a closed configuration preventing retrograde fluid flow through the replacement heart valve implant 16 and/or the lumen of the replacement heart valve implant 16 and/or the expandable anchor member 17.
  • the plurality of valve leaflets 22 may each have a free edge, wherein the free edges of the plurality of valve leaflets 22 coapt within the replacement heart valve implant 16, the expandable anchor member 17, and/or the lumen extending through the replacement heart valve implant 16 and/or the expandable anchor member 17 in the closed configuration.
  • suitable but non-limiting materials for the plurality of valve leaflets 22 may include bovine pericardial, polymeric materials, or other suitably flexible biocompatible materials
  • the replacement heart valve implant 16 may include a replacement heart valve commissure assembly disposed within the lumen of the replacement heart valve implant 16 and/or the expandable anchor member 17.
  • the replacement heart valve implant 16 may include more than one replacement heart valve commissure assembly.
  • each adjacent pair of valve leaflets 22 may form and/or define one replacement heart valve commissure assembly. Therefore, the number of replacement heart valve commissure assemblies may be directly related to the number of valve leaflets 22 (e.g., three valve leaflets form and/or define three replacement heart valve commissure assemblies, two valve leaflets form and/or define two replacement heart valve commissure assemblies, etc.).
  • the replacement heart valve implant 16 and/or the replacement heart valve commissure assembly may include a locking mechanism 70 configured to lock the expandable anchor member 17 in the“deployed” configuration.
  • the replacement heart valve implant 16 may include or comprise a plurality of locking mechanisms 70 (e.g., two locking mechanisms 70, three locking mechanisms 70, etc.).
  • each replacement heart valve commissure assembly may correspond to and/or include one corresponding locking mechanism 70.
  • Each locking mechanism 70 may include a first locking portion or a post member 72 secured to the expandable anchor member 17 and configured to engage with a second locking portion or a buckle member 74 secured to the expandable anchor member 17, as will be described in more detail below.
  • the actuator element 15 may be configured to releasably engage the locking mechanism 70 and/or reversibly actuate the expandable anchor member 17 and/or the replacement heart valve implant 16 between the“delivery” configuration and the “deployed” configuration and/or the “released” configuration while the actuator element 15 is engaged with the locking mechanism 70.
  • one actuator element 15 may correspond to, engage with, and/or actuate one locking mechanism 70.
  • one actuator element 15 may correspond to, engage with, and/or actuate more than one locking mechanism 70.
  • the actuator element 15 may include a proximal end and a distal end.
  • the proximal end may be operatively connected to the handle 18, and/or manipulated or otherwise actuated by a user using the handle 18, to reversibly shift the replacement heart valve implant 16 between the “delivery” configuration and the “deployed” configuration.
  • the control knob 19 rotatable relative to a handle housing may be actuatable and/or rotatable to manipulate or otherwise actuate the actuator element 15, the outer sheath 12, and/or the inner shaft or catheter 14.
  • the actuator element 15 may be axially translatable relative to the first locking portion or post member 72 and/or the second locking portion or buckle member 74 of the replacement heart valve implant 16.
  • the proximal end of the actuator element 15 may be operatively connected to a central shaft extending distally from the handle 18 within the inner shaft or catheter 14.
  • the central shaft may be actuated and/or translated by the handle 18 and/or a mechanism disposed within the handle 18 responsive to the control knob 19.
  • the actuator element 15 may extend distally from the handle 18 within the inner shaft or catheter 14.
  • the replacement heart valve implant 16 may include a seal member 20 (shown partially cutaway) disposed on and/or around at least a portion of the outer surface of the expandable anchor member 17.
  • the seal member 20 may be attached and/or secured to the distal or inflow end of the expandable anchor member 17 and/or the replacement heart valve implant 16, and/or the seal member 20 may be attached and/or secured to the plurality of valve leaflets 22 proximate the distal or inflow end of the expandable anchor member 17 and/or the replacement heart valve implant 16.
  • the seal member 20 may be sufficiently flexible and/or pliable to conform to and/or around native valve leaflets and/or the native heart valve in the deployed configuration, thereby sealing an exterior of the replacement heart valve implant 16 and/or the expandable anchor member 17 within and/or against the native heart valve and/or the native valve leaflets and preventing leakage around the replacement heart valve implant 16 and/or the expandable anchor member 17.
  • the seal member 20 may include a plurality of layers of polymeric material.
  • suitable polymeric materials may include, but are not necessarily limited to, polycarbonate, polyurethane, polyamide, polyether block amide, polyethylene, polyethylene terephthalate, polypropylene, polyvinylchloride, polytetrafluoroethylene, polysulfone, and copolymers, blends, mixtures or combinations thereof.
  • Other suitable polymeric materials are also contemplated, some of which are discussed below.
  • each finger 78 may include a collar 80 slidably disposed on and/or about its respective finger 78 and the projecting portion 108 of its respective second locking portion or buckle member 74.
  • the collar 80 may be configured to maintain engagement of its respective finger 78 with one of the plurality of locking mechanisms 70 and/or the second locking portion or buckle member 74 in an interlock position.
  • the coupler 76 may include a proximal ring 77 fixedly attached to the distal end of the inner shaft or catheter 14 and a plurality of fingers 78 extending distally from the proximal ring 77.
  • the plurality of fingers 78 may be integrally formed with the proximal ring 77 as a single, unitary structure.
  • the plurality of fingers 78 may be releasably coupled to the second locking portion or buckle members 74 of the plurality of locking mechanisms 70 by the plurality of collars 80.
  • the delivery device 11 may include a stop element 86 configured to selectively prevent disengagement of the plurality of locking mechanisms 70 from the plurality of fingers 78 by maintain the plurality of collars 80 in the interlock position.
  • the stop element configured to selectively prevent disengagement of the plurality of locking mechanisms 70 from the plurality of fingers 78 by maintain the plurality of collars 80 in the interlock position.
  • proximal band 87 may include a proximal band 87 slidably disposed about the inner shaft or catheter 14 proximal of the distal end of the inner shaft or catheter 14 and a plurality of arms 88 extending distally from the proximal band 87.
  • the proximal band 87 may include a proximal band 87 slidably disposed about the inner shaft or catheter 14 proximal of the distal end of the inner shaft or catheter 14 and a plurality of arms 88 extending distally from the proximal band 87.
  • the proximal band 87 may include a proximal band 87 slidably disposed about the inner shaft or catheter 14 proximal of the distal end of the inner shaft or catheter 14 and a plurality of arms 88 extending distally from the proximal band 87.
  • the proximal band 87 may include a proximal band 87 slidably disposed about the inner shaft or catheter 14
  • the proximal band 87 of the stop element 86 may be positioned proximal of the proximal ring 77 of the coupler 76.
  • the proximal band 87 is positioned proximal of the distal end of the outer sheath 12 when the outer sheath 12 is disposed in the second position.
  • the plurality of arms 88 may be integrally formed with the proximal band 87 as a single, unitary structure.
  • Each of the plurality of arms 88 may include a distal loop 89 disposed at a distal end of its respective arm 88, each distal loop 89 being slidably engaged with one of the plurality of fingers 78.
  • one of the plurality of fingers 78 may be slidably disposed within each or one distal loop 89.
  • At least one of the plurality of arms 88 may include a wing element 90 configured to selectively engage with a distal end, a distal edge, and/or a distal face of the proximal ring
  • the stop element 86 may be configured to selectively prevent disengagement of the plurality of locking mechanisms 70 from the plurality of fingers 78 by maintain the plurality of collars 80 in the interlock position when the wing element 90 of the plurality of arms 88 of the stop element 86 is engaged with the proximal ring 77 of the coupler 76. Engagement of the wing element 90 with the distal end, the distal edge, and/or the distal face of the proximal ring 77 of the coupler 76 may prevent sliding movement of each distal loop 89 with respect to the plurality of fingers 78 and/or the plurality of collars 80.
  • the plurality of arms 88 may be biased radially outward from the inner shaft or catheter 14. In some embodiments, the plurality of arms may be self-biased radially outward from the inner shaft or catheter 14. A proximal portion of the plurality of arms 88 may be configured to shift radially relative to the inner shaft or catheter 14 between an engagement position (e.g., FIG. 2) and a disengagement position (e.g., FIG. 6), which will be explained in more detail below. In some embodiments, proximal and distal portions of the plurality of arms 88 may be generally defined and/or separated by the wing element 90.
  • the outer sheath 12 may urge the proximal portion of the plurality of arms 88 toward the engagement position when the distal end of the outer sheath 12 is disposed over and/or distal of the proximal portion of the plurality of arms 88.
  • the proximal portion of the plurality of arms 88 may be disposed adjacent to an outer surface of the inner shaft or catheter 14.
  • the proximal portion of the plurality of arms 88 may be disposed generally parallel to the outer surface of the inner shaft or catheter 14.
  • the wing element 90 may be configured to engage with the distal end, the distal edge, and/or the distal face of the proximal ring 77 of the coupler 76 in the engagement position, thereby preventing proximal movement of the plurality of arms 88, the distal loops 89 and/or the plurality of collars 80 relative to the distal end of the inner shaft or catheter 14 and/or the coupler 76, the proximal ring 77, and/or the plurality of fingers 78.
  • the stop element 86, the proximal band 87, the plurality of arms 88, and/or the distal loops 89 may be disposed entirely proximal of the replacement heart valve implant 16, the expandable anchor member 17, the locking mechanisms 70, the first locking portion or post member 72, and/or the second locking portion or buckle member 74. In some embodiments, the stop element 86, the proximal band 87, the plurality of arms 88, and/or the distal loops 89 may not extend into or through any portion of the replacement heart valve implant 16.
  • a tubular guide member may be disposed over a distal portion of each of the plurality of arms 88 and/or the plurality of fingers 78 proximal of the slidable collar 80 and may serve to keep the distal portion of the plurality of arms 88 and/or the plurality of fingers 78 of the coupler 76 associated with their respective actuator element 15 extending adjacent to (and axially slidable relative to) the plurality of arms 88 and/or the plurality of fingers 78 of the coupler 76.
  • the control knob 19, the handle 18, and/or the actuator element 15 can be used to actuate the replacement heart valve implant 16 and/or the expandable anchor member 17 from the“delivery” configuration to the“deployed” configuration by proximally retracting the actuator element 15 relative to the second locking portion or buckle member 74 and/or the expandable anchor member 17, thereby pulling the first locking portion or post member 72 into engagement with the second locking portion or buckle member 74, as discussed below with respect to FIGS. 3 and 4.
  • FIGS. 3 and 4 illustrate selected components and/or details of an example locking mechanism 70 and/or certain components related to the locking mechanism 70, and the general operation of those components.
  • only one finger 78, only one arm 88, only one actuator element 15, only one first locking portion or post member 72, and only one second locking portion or buckle member 74 are shown and discussed (the whole replacement heart valve implant 16 and/or the expandable anchor member 17 is not shown to facilitate understanding of the locking mechanism(s) 70).
  • the following discussion may apply equally to any and/or all of the components for which there are more than one within the replacement heart valve implant 16 (i.e., the actuator elements 15, the second locking portions or buckle members 74, the first locking portions or post members 72, etc.), the delivery device 11, and/or the medical device system 10.
  • the actuator element 15 (e.g., each actuator element 15, etc.) includes an elongated rod having a flattened distal portion and a ramp 102 (e.g., FIG. 3) extending longitudinally and/or radially outward from the actuator element 15 such that the ramp 102 has a greater outer extent than the elongated rod.
  • the ramp 102 may be positioned proximate to and/or at a proximal end of the flattened distal portion of the actuator element 15.
  • the flattened distal portion of the actuator element 15 may be aligned with and/or releasably coupled to the first locking portion or post member 72. In some embodiments, the flattened distal portion of the actuator element 15 may be slidably received within a longitudinally-oriented passageway of the first locking portion or post member 72, as discussed below.
  • the handle 18 may be configured to actuate and/or translate the actuator element 15 (e.g., each actuator element 15, etc.) relative to the outer sheath 12, the replacement heart valve implant 16, the corresponding locking mechanism(s) 70 (e.g., the plurality of locking mechanisms 70, etc.), and/or the first locking portion or post member 72 in the“delivery” and/or“deployed” configuration.
  • the actuator element 15 may be axially and/or slidably translatable through and/or relative to the distal loop 89, the collar 80, and/or the second locking portion or buckle member 74.
  • the actuator element 15 and/or the elongated rod may be generally round, oblong, ovoid, rectangular, polygonal (e.g., two-sided, three-sided, four sided, five-sided, six-sided, etc.) and/or combinations thereof in shape. Other shapes, both regular and irregular, are also contemplated.
  • the actuator element 15 may be formed from a single piece of wire, round stock, or other suitable material, as discussed herein.
  • the actuator element 15 may be formed by further processing the single piece of wire, round stock, or other suitable material, such as by machining, stamping, laser cutting, etc.
  • first locking portion or post member 72 and the second locking portion or buckle member 74 may be longitudinally movable relative to each other along an inner surface of the expandable anchor member 17 in the“delivery” configuration and/or the“deployed” configuration.
  • first locking portion or post member 72 may be non-releasably secured to a distal portion and/or proximate the distal or upstream end of the expandable anchor member 17 along the inner surface of the expandable anchor member 17.
  • the second locking portion or buckle member 74 may be fixedly secured to a proximal portion and/or proximate the proximal or downstream end of the expandable anchor member 17 against the inner surface of the expandable anchor member 17.
  • the second locking portion or buckle member 74 may be configured to slidably receive at least a portion of the first locking portion or post member 72 therein. Additional discussion regarding the relative motion of these elements is provided below.
  • the first locking portion or post member 72 may include an elongated proximal portion 96, and a pair of elongate legs coupled to and extending distally from a transverse distal portion (e.g., T-bar) or other coupling element at a distal end of the elongated proximal portion 96.
  • the transverse distal portion may be integrally formed with the elongated proximal portion 96.
  • the first locking portion or post member 72 may be formed as a single unitary structure, wherein the elongated proximal portion 96, the transverse distal portion, and/or the pair of elongate legs are integrally formed with each other and/or from a single piece of material.
  • the pair of elongate legs may secure two of the plurality of valve leaflets 22 together to form the replacement heart valve commissure assembly.
  • the pair of elongate legs is not necessarily required to form a replacement heart valve commissure assembly or the first locking portion or post member 72.
  • the elongated proximal portion 96 of the first locking portion or post member 72 may include a longitudinally-oriented passageway extending at least partially through the elongated proximal portion 96 of the first locking portion or post member 72, wherein the flattened distal portion of the actuator element 15 is configured to slidably engage the longitudinally-oriented passageway of the elongated proximal portion 96 of the first locking portion or post member 72.
  • the longitudinally-oriented passageway may extend completely through the elongated proximal portion 96 of the first locking portion or post member 72.
  • a longitudinal axis of the longitudinally-oriented passageway and/or the elongated proximal portion 96 of the first locking portion or post member 72 may be arranged generally parallel to the central longitudinal axis of the expandable anchor member 17 and/or the replacement heart valve implant 16.
  • the longitudinally-oriented passageway may be configured to slidably receive the flattened distal portion of the actuator element 15.
  • the longitudinally-oriented passageway may include an internal cross-sectional shape or profile corresponding to an external cross- sectional shape or profile of the flattened distal portion of the actuator element 15.
  • the flattened distal portion of the actuator element 15 may be slidably disposed within the longitudinally-oriented passageway and/or may be releasably coupled to the first locking portion or post member 72 by a pinless securement feature, for example.
  • the elongated proximal portion 96 may include at least one aperture extending through a wall of the elongated proximal portion and into the longitudinally - oriented passageway, wherein the at least one aperture is configured to engage the pinless securement feature of the flattened distal portion of the actuator element 15.
  • at least a portion of the flattened distal portion of the actuator element 15 may extend into the longitudinally-oriented passageway when the flattened distal portion of the actuator element 15 is engaged with the longitudinally-oriented passageway of the elongated proximal portion 96 of the first locking portion or post member 72, for example in the elongated“delivery” configuration and/or the“everted” configuration.
  • the flattened distal portion of the actuator element 15 may include the pinless securement feature.
  • the pinless securement feature does not require the flattened distal portion of the actuator element 15 to be directly secured to the elongated proximal portion 96 of the first locking portion or post member 72 by a separate locking pin or other securing member, in order to secure the replacement heart valve implant 16 to the delivery device 11.
  • Some examples of a pinless securement feature may include at least one projection configured to extend into the at least one aperture of the elongated proximal portion 96 of the first locking portion or post member 72, or at least one flexible leg configured to extend into the at least one aperture of the elongated proximal portion 96 of the first locking portion or post member 72.
  • the pinless securement feature may include a threaded feature configured to rotatable engage mating threads formed in and/or on the elongated proximal portion 96 of the first locking portion or post member 72.
  • the first locking portion or post member 72 may be disposed within the lumen of the replacement heart valve implant 16 and/or the expandable anchor member 17 proximate the distal or inflow end of the replacement heart valve implant 16 and/or the expandable anchor member 17 when the expandable anchor member 17 is in the elongated “delivery” configuration and/or the “everted” configuration.
  • at least a portion of the first locking portion or post member 72 may be disposed distal of the expandable anchor member 17 when the expandable anchor member 17 is in the elongated“delivery” configuration and/or the“everted” configuration.
  • a first leg of the first locking portion or post member 72 and a second leg of the first locking portion or post member 72 may be laterally and/or circumferentially spaced apart from each other to define a longitudinally-oriented tissue slot extending through the first locking portion or post member 72 in a radial direction relative to the central longitudinal axis of the replacement heart valve implant 16 and/or the expandable anchor member 17.
  • a length of the longitudinally - oriented tissue slot may extend and/or may be oriented generally parallel with the central longitudinal axis of the expandable anchor member 17 and/or the replacement heart valve implant 16.
  • the elongated proximal portion 96 of the first locking portion or post member 72 may include a transversely-oriented depression and/or ridge 100 proximate a proximal end of the elongated proximal portion 96.
  • the transversely-oriented depression and/or ridge 100 of the elongated proximal portion 96 may be configured to engage a transversely-oriented ridge of the second locking portion or buckle member 74 to lock the replacement heart valve implant 16 and/or the expandable anchor member 17 in the“deployed” configuration.
  • the elongated proximal portion 96 of the first locking portion or post member 72 may include a keying or orienting shape formed in and/or extending longitudinally along a length and/or an outer surface of the elongated proximal portion 96 of the first locking portion or post member 72.
  • the keying or orienting shape may extend along an entire length of the elongated proximal portion 96 of the first locking portion or post member 72.
  • the keying or orienting shape may serve as an alignment and/or anti-rotation feature with respect to the second locking portion or buckle member 74.
  • the keying or orienting shape may prevent relative rotation between the first locking portion or post member 72 and the second locking portion or buckle member 74 when the elongated proximal portion 96 of the first locking portion or post member 72 is engaged with the second locking portion or buckle member 74.
  • first locking portion or post member 72 for example metallic materials or polymeric materials, are described below.
  • the second locking portion or buckle member 74 may include a base portion having a longitudinal axis extending between a proximal end and a distal end of the second locking portion or buckle member 74.
  • the second locking portion or buckle member 74 may include a body portion fixedly attached to and/or integrally formed with the base portion, the body portion defining a longitudinal channel extending through the body portion of the second locking portion or buckle member 74.
  • the longitudinal channel may be oriented substantially parallel with the longitudinal axis of the base portion.
  • at least a part of the body portion may extend away from a distal portion of a top surface of the base portion.
  • the body portion may extend radially inward from the base portion relative to the central longitudinal axis of the replacement heart valve implant 16 and/or the expandable anchor member 17.
  • the body portion of the second locking portion or buckle member 74 may include a flap portion 98 extending proximally and/or toward the proximal end of the base portion from the body portion.
  • the flap portion 98 may include a transversely-oriented ridge extending toward the base portion and laterally across the base portion, such that when the second locking portion or buckle member 74 is viewed along the longitudinal axis of the base portion, the transversely-oriented ridge obstructs at least a portion of the longitudinal channel.
  • the body portion and/or the flap portion 98 of the second locking portion or buckle member 74 may include at least one hole or aperture formed therein for attaching a radiopaque marker to the second locking portion or buckle member 74 to aid in visualization of the second locking portion or buckle member 74.
  • the flap portion 98 may be configured to deflect radially relative to the central longitudinal axis of the expandable anchor member 17 and/or the replacement heart valve implant 16.
  • the ramp 102 of the actuator element 15 may be configured to deflect the flap portion 98 of the second locking portion or buckle member 74 radially inward as the ramp (and the first locking portion or post member 72 engaged thereto) is longitudinally translated through the longitudinal channel of the body portion of the second locking portion or buckle member 74.
  • the flap portion 98 may be biased or self-biased toward a neutral position aligned with the body portion and/or may be biased or self-biased into the longitudinal channel and/or toward the base portion of the second locking portion or buckle member 74.
  • the second locking portion or buckle member 74 may include the projecting portion 108 (e.g., FIG. 7) at a proximal end of the base portion of the second locking portion or buckle member 74, the projecting portion 108 being configured to releasably attach the replacement heart valve implant 16 to the delivery device 11 and/or the plurality of fingers 78 of the coupler 76 via the collar 80.
  • the longitudinal channel may have a keyed, directional, or non-round cross-sectional profile or shape configured to slidably receive the elongated proximal portion 96 of the first locking portion or post member 72.
  • the first locking portion or post member 72 may have an external cross-sectional profile or shape corresponding to the keyed, directional, or non round internal cross-sectional profile or shape of the longitudinal channel. As such, the first locking portion or post member 72 may be non-rotatable relative to the second locking portion or buckle member 74 when the elongated proximal portion 96 of the first locking portion or post member 72 is engaged with and/or at least partially disposed within the longitudinal channel of the second locking portion or buckle member 74.
  • suitable but non-limiting materials for the second locking portion or buckle member 74 for example metallic materials or polymeric materials, are described below.
  • the replacement heart valve implant 16 may be secured at the distal end of the coupler 76 and/or the inner shaft or catheter 14 by two elongated tines 104 (e.g., FIG. 7) of the finger 78 of the coupler 76 being matingly coupled with the projecting portion 108 of the second locking portion or buckle member 74 by the collar 80, and by the actuator element 15 being coupled to its corresponding first locking portion or post member 72, for example by the pinless securement feature.
  • the outer sheath 12 may be translated and/or actuated proximally to expose the replacement heart valve implant 16.
  • a proximal end of the first locking portion or post member 72 and a distal end of the second locking portion or buckle member 74 may be longitudinally separated and/or spaced apart in the“delivery” configuration, as seen in FIG. 3 for example.
  • the first locking portion or post member 72 may be longitudinally actuatable and/or translatable relative to the second locking portion or buckle member 74 in the “delivery” configuration, and/or between the“delivery” configuration and the“deployed” configuration.
  • the actuator element 15 can be actuated (e.g., proximally retracted) to axially shorten and/or radially expand the replacement heart valve implant 16 and/or the expandable anchor member 17 from the“delivery” configuration toward the“deployed” configuration by proximally retracting and/or translating the actuator element 15 to pull the first locking portion or post member 72 into engagement with the second locking portion or buckle member 74, as seen in FIG. 4, using the handle 18 and/or the control knob 19 for example.
  • actuated e.g., proximally retracted
  • the transversely-oriented depression and/or ramp 102 proximate the proximal end of the elongated proximal portion 96 engages the transversely-oriented ridge of the flap portion 98 of the second locking portion or buckle member 74 to lock the expandable anchor member 17 and/or the replacement heart valve implant 16 into the “deployed” configuration, as seen in FIG. 4.
  • Engagement of the transversely-oriented depression and/or ramp 102 proximate the proximal end of the elongated proximal portion 96 and the transversely-oriented ridge of the flap portion 98 of the second locking portion or buckle member 74 may limit or prevent distal movement and/or axial translation of the first locking portion or post member 72 relative to the second locking portion or buckle member 50 in the“deployed” configuration after the actuator element 15 has been disengaged from the locking mechanism 70 and/or the first locking portion or post member 72.
  • positioning of the replacement heart valve implant 16 may be verified using a suitable imaging technique.
  • a clinician may urge and/or translate the actuator element 15 in a second (e.g., distal) direction to extend and/or elongate the expandable anchor member 17 back towards the“delivery” configuration.
  • Axial translation of the actuator element 15 in the second (e.g., distal) direction relative to the locking mechanism 70 may slidably engage the ramp 102 of the actuator element 15 with the flap portion 98 and/or the transversely-oriented ridge of the flap portion 98 the second locking portion or buckle member 74, thereby deflecting the flap portion 98 of the second locking portion or buckle member 74 away from the longitudinal channel of the second locking portion or buckle member 74 and/or the actuator element 15 and/or radially inward relative to the central longitudinal axis of the expandable anchor member 17, and permitting the first locking portion or post member 72 to pass back through and/or out of the longitudinal channel of the second locking portion or buckle member 74, thereby shifting the replacement heart valve implant 16 back towards the“delivery” configuration.
  • the locking pin 13 may be removed from the handle 18, as seen in FIG. 5, and the control knob 19 may be rotated and/or actuated to retract the outer sheath 12 to the second position relative to the inner shaft or catheter 14 and/or the coupler 76, as seen in FIG. 6.
  • the replacement heart valve implant 16 may be repositioned and/or redeployed as discussed above.
  • Removal of the locking pin 13 may permit the outer sheath 12 to be shifted to the second position relative to the inner shaft or catheter 14 and/or the stop element 86, thereby exposing the proximal portion of the plurality of arms 88.
  • Proximal retraction of the outer sheath 12 relative to the inner shaft or catheter 14 and/or the proximal band 87 of the stop element 86 may permit the proximal portion of the plurality of arms 88 to shift toward the disengagement position.
  • the plurality of arms 88 may be biased or self-biased to expand and/or shift radially outward relative to the inner shaft or catheter 14. Therefore, when the plurality of arms 88, and in particular the proximal portion of the plurality of arms 88, is unconstrained by the outer sheath 12, the plurality of arms 88 may be configured to shift toward and/or into the disengagement position, as seen in FIG. 6. In some embodiments, proximal retraction of the outer sheath 12 relative to the inner shaft or catheter 14 and/or the proximal band 87 of the stop element 86 may permit the stop element 86 to disengage from the proximal ring 77 of the coupler 76.
  • the proximal portion of the plurality of arms 88 may extend radially outward from the outer surface of the inner shaft or catheter 14 at an oblique angle.
  • the wing element 90 is radially spaced apart from the proximal ring 77.
  • the stop element 86 is disengaged from the proximal ring 77 of the coupler 76, the plurality of collars 80 may be slidable relative to the plurality of fingers 78 to a release position.
  • the wing element 90 may no longer prevent sliding movement of the collar 80 relative to its respective finger 78.
  • the flattened distal portion of the actuator element 15 may be permitted to be pulled proximally out of the first locking portion or post member 72 by further rotation of the control knob 19, causing the ramp 102 to subsequently engage the collar 80 and thereby retract the collar 80 from the two elongated tines 104 and the projecting portion 108 to the release position, as seen in FIG. 7, as well as shift the distal loop 89 proximally, which may also shift and/or slide the proximal band 87 proximally along the inner shaft or catheter 14.
  • the replacement heart valve implant 16 may not be repositionable.
  • the two elongated tines 104 may decouple from the proj ecting portion 108, as seen in FIG. 8, and the finger 78 of the coupler 76 may be withdrawn from the replacement heart valve implant 16 thereby leaving the replacement heart valve implant 16 (and/or the expandable anchor member 17) in the anatomy at the area of interest in a “released” configuration, as seen in FIG. 9.
  • the handle 18 may include one or more apertures and/or flush ports that can be used to flush the medical device system 10 and/or the delivery device 11.
  • the distal flush port and the proximal flush port may be accessible from an exterior of the handle 18 through the distal aperture and the proximal aperture, respectively.
  • FIGS. 10 and 11 illustrate selected aspects of certain internal components of the medical device system 10, including the distal flush port, with a portion of the handle 18 removed for viewing.
  • the outer sheath 12 may be attached to a sheath adapter 130.
  • the sheath adapter 130 may attached to a sheath carriage 132, which may be threaded onto a lead screw 134.
  • the distal flush port 126 may be disposed on the sheath adapter 130.
  • the distal flush port 126 provides access to the interior or lumen of the outer sheath 12 (e.g., access to space between the inner shaft or catheter 14 and outer sheath 12) so that a clinician can flush fluid through the lumen of outer sheath 12 to remove any unwanted materials (e.g., air, fluid, contaminants, etc.) therein prior to use of the medical device system 10 and/or the delivery device 11.
  • the distal flush port 126 has a luer type connector (e.g., a one-way luer connector) that allows a device such as a syringe with a corresponding connector to be attached for flushing.
  • the inner shaft or catheter 14 Extending through and proximally from the sheath adapter 130 is the inner shaft or catheter 14.
  • a proximal end of the inner shaft or catheter 14 is attached (e.g., fixedly attached) to an interior body or diverter 136 that may have one or more passageways or lumens formed therein.
  • the plurality of actuator elements 15 may each extend through respective passageways.
  • proximal ends of the plurality of actuator elements 15 may each be attached to a shaft or hypotube (e.g., solid in cross- section, tubular, etc.), and each of the shafts may extend through the one or more passageways.
  • the handle 18 includes the locking pin 13 extending through the outer wall of the handle 18 and/or extending into the handle 18.
  • the sheath adapter 130 may include a proximal extension 128 extending proximal from sheath adapter 130.
  • the proximal extension 128 may extend around the inner shaft or catheter 14, for example in a U-shaped configuration.
  • the proximal extension 128 may be substantially flat and/or straight. Other suitable configurations are also contemplated.
  • the proximal extension 128 may make contact with the locking pin 13 when the replacement heart valve implant 16 has been shifted into the“deployed” configuration.
  • the outer sheath 12 may be in the first position relative to the inner shaft or catheter 14.
  • the locking pin 13 may prevent the outer sheath 12 from being shifted to the second position relative to the inner shaft or catheter 14 when the locking pin 13 is in place and/or extends into the handle 18 by interfering with proximal movement of the proximal extension 128.
  • the locking pin 13 may be removed (e.g., FIG. 5). Then the control knob 19 and/or the handle 18 may be actuated to proximally retract the outer sheath 12 to the second position relative to the inner shaft or catheter 14, as shown in FIG.
  • Proximally retracting the outer sheath 12 to the second position permits the stop element 86 to shift to the disengagement position, thereafter allowing the plurality of actuator elements 15 to disengage from the plurality of locking mechanisms 70 and release the replacement heart valve implant 16 from the delivery device 11.
  • the materials that can be used for the various components of the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc. (and/or other systems disclosed herein) and the various elements thereof disclosed herein may include those commonly associated with medical devices.
  • the following discussion makes reference to the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc.
  • the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc., and/or components thereof may be made from a metal, metal alloy, polymer (some examples of which are disclosed below), a metal-polymer composite, ceramics, combinations thereof, and the like, or other suitable material.
  • suitable metals and metal alloys include stainless steel, such as 444V, 444L, and 314LV stainless steel; mild steel; nickel-titanium alloy such as linear-elastic and/or super-elastic nitinol; other nickel alloys such as nickel-chromium-molybdenum alloys (e.g., UNS: N06625 such as INCONEL® 625, UNS: N06022 such as HASTELLOY® C-22®, UNS: N10276 such as HASTELLOY® C276®, other HASTELLOY® alloys, and the like), nickel-copper alloys (e.g., UNS: N04400 such as MONEL® 400, NICKELVAC® 400, NICORROS® 400, and the like), nickel-cobalt-chromium-molybdenum alloys (e.g., UNS: R44035 such as MP35-N® and the like), nickel-molybdenum alloys (e.g.,
  • linear elastic and/or non-super-elastic nitinol may be distinguished from super elastic nitinol in that the linear elastic and/or non-super-elastic nitinol does not display a substantial "superelastic plateau” or "flag region” in its stress/strain curve like super elastic nitinol does.
  • linear elastic and/or non-super-elastic nitinol as recoverable strain increases, the stress continues to increase in a substantially linear, or a somewhat, but not necessarily entirely linear relationship until plastic deformation begins or at least in a relationship that is more linear than the super elastic plateau and/or flag region that may be seen with super elastic nitinol.
  • linear elastic and/or non-super-elastic nitinol may also be termed“substantially” linear elastic and/or non-super-elastic nitinol.
  • linear elastic and/or non-super-elastic nitinol may also be distinguishable from super elastic nitinol in that linear elastic and/or non-super-elastic nitinol may accept up to about 2-5% strain while remaining substantially elastic (e.g., before plastically deforming) whereas super elastic nitinol may accept up to about 8% strain before plastically deforming. Both of these materials can be distinguished from other linear elastic materials such as stainless steel (that can also be distinguished based on its composition), which may accept only about 0.2 to 0.44 percent strain before plastically deforming.
  • the linear elastic and/or non-super-elastic nickel -titanium alloy is an alloy that does not show any martensite/austenite phase changes that are detectable by differential scanning calorimetry (DSC) and dynamic metal thermal analysis (DMTA) analysis over a large temperature range.
  • DSC differential scanning calorimetry
  • DMTA dynamic metal thermal analysis
  • the mechanical bending properties of such material may therefore be generally inert to the effect of temperature over this very broad range of temperature.
  • the mechanical bending properties of the linear elastic and/or non-super-elastic nickel-titanium alloy at ambient or room temperature are substantially the same as the mechanical properties at body temperature, for example, in that they do not display a super-elastic plateau and/or flag region.
  • the linear elastic and/or non-super-elastic nickel -titanium alloy maintains its linear elastic and/or non-super-elastic characteristics and/or properties.
  • the linear elastic and/or non-super-elastic nickel -titanium alloy may be in the range of about 50 to about 60 weight percent nickel, with the remainder being essentially titanium. In some embodiments, the composition is in the range of about 54 to about 57 weight percent nickel.
  • a suitable nickel-titanium alloy is
  • FHP-NT alloy commercially available from Furukawa Techno Material Co. of Kanagawa, Japan.
  • suitable materials may include ULTANIUMTM (available from Neo-Metrics) and GUM METALTM (available from Toyota).
  • a superelastic alloy for example a superelastic nitinol can be used to achieve desired properties.
  • portions or all of the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc., and/or components thereof may also be doped with, made of, or otherwise include a radiopaque material.
  • Radiopaque materials are understood to be materials capable of producing a relatively bright image on a fluoroscopy screen or another imaging technique during a medical procedure. This relatively bright image aids a user in determining the location of the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc.
  • radiopaque materials can include, but are not limited to, gold, platinum, palladium, tantalum, tungsten alloy, polymer material loaded with a radiopaque filler, and the like. Additionally, other radiopaque marker bands and/or coils may also be incorporated into the design of the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc. to achieve the same result.
  • a degree of Magnetic Resonance Imaging (MRI) compatibility is imparted into the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc.
  • the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc., and/or components or portions thereof may be made of a material that does not substantially distort the image and create substantial artifacts (e.g., gaps in the image). Certain ferromagnetic materials, for example, may not be suitable because they may create artifacts in an MRI image.
  • the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc., or portions thereof, may also be made from a material that the MRI machine can image.
  • Some materials that exhibit these characteristics include, for example, tungsten, cobalt-chromium-molybdenum alloys (e.g., UNS: R44003 such as ELGILOY®, PHYNOX®, and the like), nickel-cobalt-chromium-molybdenum alloys (e.g., UNS: R44035 such as MP35-N® and the like), nitinol, and the like, and others.
  • the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc., and/or portions thereof may be made from or include a polymer or other suitable material.
  • suitable polymers may include polytetrafluoroethylene (PTFE), ethylene tetrafluoroethylene (ETFE), fluorinated ethylene propylene (FEP), polyoxymethylene (POM, for example, DELRIN® available from DuPont), polyether block ester, polyurethane (for example, Polyurethane 85A), polypropylene (PP), polyvinylchloride (PVC), polyether-ester (for example, ARNITEL® available from DSM Engineering Plastics), ether or ester based copolymers (for example, butylene/poly(alkylene ether) phthalate and/or other polyester elastomers such as HYTREL® available from DuPont), polyamide (for example, DURETHAN® available from Bayer or C
  • the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, the seal member 20, etc. and/or other elements disclosed herein may include a fabric material disposed over or within the structure.
  • the fabric material may be composed of a biocompatible material, such a polymeric material or biomaterial, adapted to promote tissue ingrowth.
  • the fabric material may include a bioabsorbable material.
  • suitable fabric materials include, but are not limited to, polyethylene glycol (PEG), nylon, polytetrafluoroethylene (PTFE, ePTFE), a polyolefmic material such as a polyethylene, a polypropylene, polyester, polyurethane, and/or blends or combinations thereof.
  • the medical device system 10, the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, the seal member 20, etc. may include and/or be formed from a textile material.
  • suitable textile materials may include synthetic yams that may be flat, shaped, twisted, textured, pre-shrunk or un-shrunk.
  • Synthetic biocompatible yams suitable for use in the present invention include, but are not limited to, polyesters, including polyethylene terephthalate (PET) polyesters, polypropylenes, polyethylenes, polyurethanes, polyolefins, polyvinyls, polymethylacetates, polyamides, naphthalene dicarboxylene derivatives, natural silk, and polytetrafluoroethylenes.
  • PET polyethylene terephthalate
  • polypropylenes polyethylenes
  • polyethylenes polyurethanes
  • polyolefins polyvinyls
  • polymethylacetates polyamides
  • naphthalene dicarboxylene derivatives polymethylacetates
  • synthetic yams may be a metallic yam or a glass or ceramic yam or fiber.
  • Useful metallic yams include those yams made from or containing stainless steel, platinum, gold, titanium, tantalum or a Ni-Co-Cr-based alloy.
  • the yams may further include carbon, glass or ceramic fibers.
  • the yams are made from thermoplastic materials including, but not limited to, polyesters, polypropylenes, polyethylenes, polyurethanes, polynaphthalenes, polytetrafluoroethylenes, and the like.
  • the yams may be of the multifilament, monofilament, or spun-types.
  • the type and denier of the yam chosen may be selected in a manner which forms a biocompatible and implantable prosthesis and, more particularly, a vascular structure having desirable properties.
  • the medical device system 10 the outer sheath 12, the inner shaft or catheter 14, the replacement heart valve implant 16, the handle 18, etc.
  • suitable therapeutic agents may include and/or be treated with a suitable therapeutic agent.
  • suitable therapeutic agents may include anti-thrombogenic agents (such as heparin, heparin derivatives, urokinase, and PPack (dextrophenylalanine proline arginine chloromethylketone)); anti proliferative agents (such as enoxaparin, angiopeptin, monoclonal antibodies capable of blocking smooth muscle cell proliferation, hirudin, and acetylsalicylic acid); anti inflammatory agents (such as dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, and mesalamine); antineoplasti c/antiproliferative/ anti-mitotic agents (such as paclitaxel, 5-fluorouracil, cisplatin, vinblastine, vincristine, epothilones, endostatin, angiostatin and thym

Abstract

La présente invention concerne un système de dispositif médical pouvant comprendre un dispositif de pose comprenant une gaine externe et un arbre interne ayant un raccord fixé à une extrémité distale de l'arbre interne, et un implant de valvule cardiaque de remplacement fixé de manière amovible au raccord, l'implant de valvule cardiaque de remplacement comprenant un élément d'ancrage extensible et une pluralité de mécanismes de verrouillage conçus pour venir en prise avec le raccord. Le dispositif de pose peut comprendre une pluralité de colliers conçus pour fixer le raccord à la pluralité de mécanismes de verrouillage. Le dispositif d'administration peut comprendre un élément d'arrêt conçu pour empêcher sélectivement le désengagement de la pluralité de colliers de la pluralité de mécanismes de verrouillage.
PCT/US2019/036906 2018-06-13 2019-06-13 Dispositif de pose de valvule cardiaque de remplacement WO2019241477A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100280495A1 (en) * 2003-12-23 2010-11-04 David Paul Medical Devices and Delivery Systems for Delivering Medical Devices
US20110257735A1 (en) * 2003-12-23 2011-10-20 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US20160067040A1 (en) * 2014-09-09 2016-03-10 Boston Scientific Scimed, Inc. Valve locking mechanism
US20170216029A1 (en) * 2016-02-02 2017-08-03 Boston Scientific Scimed, Inc. Tensioned sheathing aids

Family Cites Families (769)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US15192A (en) 1856-06-24 Tubular
US2682057A (en) 1951-07-24 1954-06-29 Harry A Lord Heart valve
US2701559A (en) 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US2832078A (en) 1956-10-17 1958-04-29 Battelle Memorial Institute Heart valve
US3029819A (en) 1959-07-30 1962-04-17 J L Mcatee Artery graft and method of producing artery grafts
US3099016A (en) 1960-08-11 1963-07-30 Edwards Miles Lowell Heart valve
US3130418A (en) 1960-11-25 1964-04-28 Louis R Head Artificial heart valve and method for making same
US3113586A (en) 1962-09-17 1963-12-10 Physio Control Company Inc Artificial heart valve
US3221006A (en) 1962-11-13 1965-11-30 Eastman Kodak Co 5-amino-3-substituted-1,2,4-thiadiazole azo compounds
US3143742A (en) 1963-03-19 1964-08-11 Surgitool Inc Prosthetic sutureless heart valve
US3367364A (en) 1964-10-19 1968-02-06 Univ Minnesota Prosthetic heart valve
US3334629A (en) 1964-11-09 1967-08-08 Bertram D Cohn Occlusive device for inferior vena cava
US3365728A (en) 1964-12-18 1968-01-30 Edwards Lab Inc Upholstered heart valve having a sealing ring adapted for dispensing medicaments
GB1127325A (en) 1965-08-23 1968-09-18 Henry Berry Improved instrument for inserting artificial heart valves
US3587115A (en) 1966-05-04 1971-06-28 Donald P Shiley Prosthetic sutureless heart valves and implant tools therefor
US3445916A (en) 1967-04-19 1969-05-27 Rudolf R Schulte Method for making an anatomical check valve
US3548417A (en) 1967-09-05 1970-12-22 Ronnie G Kischer Heart valve having a flexible wall which rotates between open and closed positions
US3540431A (en) 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3570014A (en) 1968-09-16 1971-03-16 Warren D Hancock Stent for heart valve
US3671979A (en) 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3628535A (en) 1969-11-12 1971-12-21 Nibot Corp Surgical instrument for implanting a prosthetic heart valve or the like
US3592184A (en) 1969-12-16 1971-07-13 David H Watkins Heart assist method and catheter
US3642004A (en) 1970-01-05 1972-02-15 Life Support Equipment Corp Urethral valve
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3714671A (en) 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3725961A (en) 1970-12-29 1973-04-10 Baxter Laboratories Inc Prosthetic heart valve having fabric suturing element
US3755823A (en) 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
US3868956A (en) 1972-06-05 1975-03-04 Ralph J Alfidi Vessel implantable appliance and method of implanting it
US3839741A (en) 1972-11-17 1974-10-08 J Haller Heart valve and retaining means therefor
US3795246A (en) 1973-01-26 1974-03-05 Bard Inc C R Venocclusion device
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4291420A (en) 1973-11-09 1981-09-29 Medac Gesellschaft Fur Klinische Spezialpraparate Mbh Artificial heart valve
US3983581A (en) 1975-01-20 1976-10-05 William W. Angell Heart valve stent
US3997923A (en) 1975-04-28 1976-12-21 St. Jude Medical, Inc. Heart valve prosthesis and suturing assembly and method of implanting a heart valve prosthesis in a heart
US4035849A (en) 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
CA1069652A (fr) 1976-01-09 1980-01-15 Alain F. Carpentier Valvule prosthetique avec anneau deformable
US4084268A (en) 1976-04-22 1978-04-18 Shiley Laboratories, Incorporated Prosthetic tissue heart valve
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US5876419A (en) 1976-10-02 1999-03-02 Navius Corporation Stent and method for making a stent
US4297749A (en) 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
US4233690A (en) 1978-05-19 1980-11-18 Carbomedics, Inc. Prosthetic device couplings
US4265694A (en) 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4222126A (en) 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4574803A (en) 1979-01-19 1986-03-11 Karl Storz Tissue cutter
GB2056023B (en) 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4373216A (en) 1980-10-27 1983-02-15 Hemex, Inc. Heart valves having edge-guided occluders
US4326306A (en) 1980-12-16 1982-04-27 Lynell Medical Technology, Inc. Intraocular lens and manipulating tool therefor
US4339831A (en) 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4470157A (en) 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4323358A (en) 1981-04-30 1982-04-06 Vascor, Inc. Method for inhibiting mineralization of natural tissue during implantation
US4345340A (en) 1981-05-07 1982-08-24 Vascor, Inc. Stent for mitral/tricuspid heart valve
US4501030A (en) 1981-08-17 1985-02-26 American Hospital Supply Corporation Method of leaflet attachment for prosthetic heart valves
US4865600A (en) 1981-08-25 1989-09-12 Baxter International Inc. Mitral valve holder
US4425908A (en) 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4406022A (en) 1981-11-16 1983-09-27 Kathryn Roy Prosthetic valve means for cardiovascular surgery
US4423809A (en) 1982-02-05 1984-01-03 Staar Surgical Company, Inc. Packaging system for intraocular lens structures
FR2523810B1 (fr) 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
SE445884B (sv) 1982-04-30 1986-07-28 Medinvent Sa Anordning for implantation av en rorformig protes
US4484579A (en) 1982-07-19 1984-11-27 University Of Pittsburgh Commissurotomy catheter apparatus and method
IT1212547B (it) 1982-08-09 1989-11-30 Iorio Domenico Strumento di impiego chirurgico destinato a rendere piu' facili e piu' sicuri gli interventi per l'impianto di bioprotesi in organi umani
DE3230858C2 (de) 1982-08-19 1985-01-24 Ahmadi, Ali, Dr. med., 7809 Denzlingen Ringprothese
US4885005A (en) 1982-11-12 1989-12-05 Baxter International Inc. Surfactant treatment of implantable biological tissue to inhibit calcification
US5215541A (en) 1982-11-12 1993-06-01 Baxter International Inc. Surfactant treatment of implantable biological tissue to inhibit calcification
US4680031A (en) 1982-11-29 1987-07-14 Tascon Medical Technology Corporation Heart valve prosthesis
GB8300636D0 (en) 1983-01-11 1983-02-09 Black M M Heart valve replacements
US4535483A (en) 1983-01-17 1985-08-20 Hemex, Inc. Suture rings for heart valves
US4834755A (en) 1983-04-04 1989-05-30 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
US4610688A (en) 1983-04-04 1986-09-09 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
AR229309A1 (es) 1983-04-20 1983-07-15 Barone Hector Daniel Montura para valvulas cardiacas
US4612011A (en) 1983-07-22 1986-09-16 Hans Kautzky Central occluder semi-biological heart valve
US4531943A (en) 1983-08-08 1985-07-30 Angiomedics Corporation Catheter with soft deformable tip
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4585705A (en) 1983-11-09 1986-04-29 Dow Corning Corporation Hard organopolysiloxane release coating
US5693083A (en) 1983-12-09 1997-12-02 Endovascular Technologies, Inc. Thoracic graft and delivery catheter
US4787899A (en) 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4627436A (en) 1984-03-01 1986-12-09 Innoventions Biomedical Inc. Angioplasty catheter and method for use thereof
US4617932A (en) 1984-04-25 1986-10-21 Elliot Kornberg Device and method for performing an intraluminal abdominal aortic aneurysm repair
US4592340A (en) 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US4883458A (en) 1987-02-24 1989-11-28 Surgical Systems & Instruments, Inc. Atherectomy system and method of using the same
US5007896A (en) 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4979939A (en) 1984-05-14 1990-12-25 Surgical Systems & Instruments, Inc. Atherectomy system with a guide wire
DE3426300A1 (de) 1984-07-17 1986-01-30 Doguhan Dr.med. 6000 Frankfurt Baykut Zweiwegeventil und seine verwendung als herzklappenprothese
US4580568A (en) 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
DE3442088A1 (de) 1984-11-17 1986-05-28 Beiersdorf Ag, 2000 Hamburg Herzklappenprothese
SU1271508A1 (ru) 1984-11-29 1986-11-23 Горьковский государственный медицинский институт им.С.М.Кирова Искусственный клапан сердца
US4759758A (en) 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4662885A (en) 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
GB2181057B (en) 1985-10-23 1989-09-27 Blagoveshchensk G Med Inst Prosthetic valve holder
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
DE3640745A1 (de) 1985-11-30 1987-06-04 Ernst Peter Prof Dr M Strecker Katheter zum herstellen oder erweitern von verbindungen zu oder zwischen koerperhohlraeumen
US4710192A (en) 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
SU1371700A1 (ru) 1986-02-21 1988-02-07 МВТУ им.Н.Э.Баумана Протез клапана сердца
CH672247A5 (fr) 1986-03-06 1989-11-15 Mo Vysshee Tekhnicheskoe Uchil
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
IL83966A (en) 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3750480T2 (de) 1986-11-29 1995-03-02 Terumo Corp Mit ballon versehener katheter.
US4878495A (en) 1987-05-15 1989-11-07 Joseph Grayzel Valvuloplasty device with satellite expansion means
US4872874A (en) 1987-05-29 1989-10-10 Taheri Syde A Method and apparatus for transarterial aortic graft insertion and implantation
US4796629A (en) 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4829990A (en) 1987-06-25 1989-05-16 Thueroff Joachim Implantable hydraulic penile erector
JPH088933B2 (ja) 1987-07-10 1996-01-31 日本ゼオン株式会社 カテ−テル
US4851001A (en) 1987-09-17 1989-07-25 Taheri Syde A Prosthetic valve for a blood vein and an associated method of implantation of the valve
US5159937A (en) 1987-09-30 1992-11-03 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
US4755181A (en) 1987-10-08 1988-07-05 Matrix Medica, Inc. Anti-suture looping device for prosthetic heart valves
US4819751A (en) 1987-10-16 1989-04-11 Baxter Travenol Laboratories, Inc. Valvuloplasty catheter and method
US4873978A (en) 1987-12-04 1989-10-17 Robert Ginsburg Device and method for emboli retrieval
JPH01290639A (ja) 1988-05-17 1989-11-22 Daikin Ind Ltd １，１，１−トリフルオロ−２，２−ジクロロエタンの製造法
US4909252A (en) 1988-05-26 1990-03-20 The Regents Of The Univ. Of California Perfusion balloon catheter
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US4917102A (en) 1988-09-14 1990-04-17 Advanced Cardiovascular Systems, Inc. Guidewire assembly with steerable adjustable tip
US4950227A (en) 1988-11-07 1990-08-21 Boston Scientific Corporation Stent delivery system
DE8815082U1 (fr) 1988-11-29 1989-05-18 Biotronik Mess- Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin, 1000 Berlin, De
US4927426A (en) 1989-01-03 1990-05-22 Dretler Stephen P Catheter device
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4966604A (en) 1989-01-23 1990-10-30 Interventional Technologies Inc. Expandable atherectomy cutter with flexibly bowed blades
US5425739A (en) 1989-03-09 1995-06-20 Avatar Design And Development, Inc. Anastomosis stent and stent selection system
US4994077A (en) 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
WO1990014804A1 (fr) 1989-05-31 1990-12-13 Baxter International Inc. Prothese valvulaire biologique
US5609626A (en) 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5047041A (en) 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US4986830A (en) 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US5089015A (en) 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5002559A (en) 1989-11-30 1991-03-26 Numed PTCA catheter
US5591185A (en) 1989-12-14 1997-01-07 Corneal Contouring Development L.L.C. Method and apparatus for reprofiling or smoothing the anterior or stromal cornea by scraping
US5141494A (en) 1990-02-15 1992-08-25 Danforth Biomedical, Inc. Variable wire diameter angioplasty dilatation balloon catheter
US5238004A (en) 1990-04-10 1993-08-24 Boston Scientific Corporation High elongation linear elastic guidewire
US5037434A (en) 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
US5085635A (en) 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
DK124690D0 (da) 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes til implantering i kroppen for erstatning af naturlig klap samt kateter til brug ved implantering af en saadan klapprotese
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5122154A (en) 1990-08-15 1992-06-16 Rhodes Valentine J Endovascular bypass graft
US5197979A (en) 1990-09-07 1993-03-30 Baxter International Inc. Stentless heart valve and holder
ES1015196Y (es) 1990-09-21 1992-01-01 Rosello Barbara Mariano Instrumento quirurgico.
US5161547A (en) 1990-11-28 1992-11-10 Numed, Inc. Method of forming an intravascular radially expandable stent
US5217483A (en) 1990-11-28 1993-06-08 Numed, Inc. Intravascular radially expandable stent
US6165292A (en) 1990-12-18 2000-12-26 Advanced Cardiovascular Systems, Inc. Superelastic guiding member
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5282847A (en) 1991-02-28 1994-02-01 Medtronic, Inc. Prosthetic vascular grafts with a pleated structure
CA2103592A1 (fr) 1991-03-01 1992-09-02 Terrence J. Buelna Catheter de cholangiographie
JPH05184611A (ja) 1991-03-19 1993-07-27 Kenji Kusuhara 弁輪支持器具及びその取り付け方法
US5295958A (en) 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5167628A (en) 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
US5397351A (en) 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5350398A (en) 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
IT1245750B (it) 1991-05-24 1994-10-14 Sorin Biomedica Emodialisi S R Protesi valvolare cardiaca, particolarmente per sostituzione della valvola aortica
US5209741A (en) 1991-07-08 1993-05-11 Endomedix Corporation Surgical access device having variable post-insertion cross-sectional geometry
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US6866650B2 (en) 1991-07-16 2005-03-15 Heartport, Inc. System for cardiac procedures
US5769812A (en) 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
US5571215A (en) 1993-02-22 1996-11-05 Heartport, Inc. Devices and methods for intracardiac procedures
CA2117088A1 (fr) 1991-09-05 1993-03-18 David R. Holmes Dispositif tubulaire flexible presentant des applications medicales
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
US5756476A (en) 1992-01-14 1998-05-26 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell proliferation using antisense oligonucleotides
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
EP0552579B1 (fr) 1992-01-22 1996-01-03 Guy-Henri Muller Implants prothétiques pour chirurgie esthétique
US5489297A (en) 1992-01-27 1996-02-06 Duran; Carlos M. G. Bioprosthetic heart valve with absorbable stent
US5163953A (en) 1992-02-10 1992-11-17 Vince Dennis J Toroidal artificial heart valve stent
US5258023A (en) 1992-02-12 1993-11-02 Reger Medical Development, Inc. Prosthetic heart valve
US5683448A (en) 1992-02-21 1997-11-04 Boston Scientific Technology, Inc. Intraluminal stent and graft
DE9390115U1 (de) 1992-05-08 1994-12-22 Schneider Usa Inc Ösophagusstent und Einbringinstrument
US5332402A (en) 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
FR2693366B1 (fr) 1992-07-09 1994-09-02 Celsa Lg Dispositif formant prothèse vasculaire utilisable pour le traitement des anévrismes.
US5409019A (en) 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
DE69429477T2 (de) 1993-01-14 2002-08-01 Meadox Medicals Inc Radial expandierbare tubuläre prothese
US5728151A (en) 1993-02-22 1998-03-17 Heartport, Inc. Intercostal access devices for less-invasive cardiovascular surgery
US5431676A (en) 1993-03-05 1995-07-11 Innerdyne Medical, Inc. Trocar system having expandable port
US5772609A (en) 1993-05-11 1998-06-30 Target Therapeutics, Inc. Guidewire with variable flexibility due to polymeric coatings
US5480423A (en) 1993-05-20 1996-01-02 Boston Scientific Corporation Prosthesis delivery
GB9312666D0 (en) 1993-06-18 1993-08-04 Vesely Ivan Bioprostetic heart valve
US5415633A (en) 1993-07-28 1995-05-16 Active Control Experts, Inc. Remotely steered catheterization device
US5443495A (en) 1993-09-17 1995-08-22 Scimed Lifesystems Inc. Polymerization angioplasty balloon implant device
KR970004845Y1 (ko) 1993-09-27 1997-05-21 주식회사 수호메디테크 내강확장용 의료용구
US5545209A (en) 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
BR9405622A (pt) 1993-09-30 1999-09-08 Endogad Res Pty Ltd Enxerto intraluminal
US5389106A (en) 1993-10-29 1995-02-14 Numed, Inc. Impermeable expandable intravascular stent
US5480424A (en) 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5713950A (en) 1993-11-01 1998-02-03 Cox; James L. Method of replacing heart valves using flexible tubes
DE69419877T2 (de) 1993-11-04 1999-12-16 Bard Inc C R Ortsfeste Gefässprothese
AU1091095A (en) 1993-11-08 1995-05-29 Harrison M. Lazarus Intraluminal vascular graft and method
RU2089131C1 (ru) 1993-12-28 1997-09-10 Сергей Апполонович Пульнев Стент
DE4401227C2 (de) 1994-01-18 1999-03-18 Ernst Peter Prof Dr M Strecker In den Körper eines Patienten perkutan implantierbare Endoprothese
US5476506A (en) 1994-02-08 1995-12-19 Ethicon, Inc. Bi-directional crimped graft
US5609627A (en) 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5443477A (en) 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
US5549663A (en) 1994-03-09 1996-08-27 Cordis Corporation Endoprosthesis having graft member and exposed welded end junctions, method and procedure
US5556413A (en) 1994-03-11 1996-09-17 Advanced Cardiovascular Systems, Inc. Coiled stent with locking ends
US5476510A (en) 1994-04-21 1995-12-19 Medtronic, Inc. Holder for heart valve
DE4415359C2 (de) 1994-05-02 1997-10-23 Aesculap Ag Chirurgisches Rohrschaftinstrument
US6139510A (en) 1994-05-11 2000-10-31 Target Therapeutics Inc. Super elastic alloy guidewire
US5765418A (en) 1994-05-16 1998-06-16 Medtronic, Inc. Method for making an implantable medical device from a refractory metal
CA2149290C (fr) 1994-05-26 2006-07-18 Carl T. Urban Trocart optique
US5824041A (en) 1994-06-08 1998-10-20 Medtronic, Inc. Apparatus and methods for placement and repositioning of intraluminal prostheses
US5728068A (en) 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5522881A (en) 1994-06-28 1996-06-04 Meadox Medicals, Inc. Implantable tubular prosthesis having integral cuffs
ES2340142T3 (es) 1994-07-08 2010-05-31 Ev3 Inc. Sistema para llevar a cabo un procedimiento intravascular.
DE4424242A1 (de) 1994-07-09 1996-01-11 Ernst Peter Prof Dr M Strecker In den Körper eines Patienten perkutan implantierbare Endoprothese
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5545133A (en) 1994-09-16 1996-08-13 Scimed Life Systems, Inc. Balloon catheter with improved pressure source
EP0799344A1 (fr) 1994-12-21 1997-10-08 Novo Nordisk A/S Procede de traitement enzymatique de la laine
US5674277A (en) 1994-12-23 1997-10-07 Willy Rusch Ag Stent for placement in a body tube
BE1009085A3 (fr) 1995-02-10 1996-11-05 De Fays Robert Dr Prothese intra-aortique et instrumentation chirurgicale destinee a l'introduction, la mise en place et la fixation de cette prothese dans l'aorte.
US5575818A (en) 1995-02-14 1996-11-19 Corvita Corporation Endovascular stent with locking ring
AU719980B2 (en) 1995-02-22 2000-05-18 Menlo Care, Inc. Covered expanding mesh stent
US5681345A (en) 1995-03-01 1997-10-28 Scimed Life Systems, Inc. Sleeve carrying stent
CA2218105A1 (fr) 1995-03-30 1996-10-03 Heartport, Inc. Catheter intravasculaire de decharge cardiaque et procede associe
DE69632776T2 (de) 1995-03-30 2005-08-25 Heartport, Inc., Redwood City System zur durchführung von endovaskulären eingriffen
US5709713A (en) 1995-03-31 1998-01-20 Cardiovascular Concepts, Inc. Radially expansible vascular prosthesis having reversible and other locking structures
US5667523A (en) 1995-04-28 1997-09-16 Impra, Inc. Dual supported intraluminal graft
US5824064A (en) 1995-05-05 1998-10-20 Taheri; Syde A. Technique for aortic valve replacement with simultaneous aortic arch graft insertion and apparatus therefor
US5534007A (en) 1995-05-18 1996-07-09 Scimed Life Systems, Inc. Stent deployment catheter with collapsible sheath
US5728152A (en) 1995-06-07 1998-03-17 St. Jude Medical, Inc. Bioresorbable heart valve support
US5571175A (en) 1995-06-07 1996-11-05 St. Jude Medical, Inc. Suture guard for prosthetic heart valve
US5716417A (en) 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
ZA964885B (en) 1995-06-07 1997-02-06 St Jude Medical Direct suture orifice for mechanical heart valve.
DE19532846A1 (de) 1995-09-06 1997-03-13 Georg Dr Berg Ventileinrichtung
US5769882A (en) 1995-09-08 1998-06-23 Medtronic, Inc. Methods and apparatus for conformably sealing prostheses within body lumens
US5807405A (en) 1995-09-11 1998-09-15 St. Jude Medical, Inc. Apparatus for attachment of heart valve holder to heart valve prosthesis
US5735842A (en) 1995-09-11 1998-04-07 St. Jude Medical, Inc. Low profile manipulators for heart valve prostheses
US6193745B1 (en) 1995-10-03 2001-02-27 Medtronic, Inc. Modular intraluminal prosteheses construction and methods
US5824037A (en) 1995-10-03 1998-10-20 Medtronic, Inc. Modular intraluminal prostheses construction and methods
US6287336B1 (en) 1995-10-16 2001-09-11 Medtronic, Inc. Variable flexibility stent
US5591195A (en) 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
DE19546692C2 (de) 1995-12-14 2002-11-07 Hans-Reiner Figulla Selbstexpandierende Herzklappenprothese zur Implantation im menschlichen Körper über ein Kathetersystem
US5861028A (en) 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
US5855602A (en) 1996-09-09 1999-01-05 Shelhigh, Inc. Heart valve prosthesis
US5843158A (en) 1996-01-05 1998-12-01 Medtronic, Inc. Limited expansion endoluminal prostheses and methods for their use
WO1997025002A1 (fr) 1996-01-05 1997-07-17 Medtronic, Inc. Protheses endoluminales expansibles
JP2001502605A (ja) 1996-01-30 2001-02-27 メドトロニック，インコーポレーテッド ステントを作るための物品および方法
JPH09215753A (ja) 1996-02-08 1997-08-19 Schneider Usa Inc チタン合金製自己拡張型ステント
US6402736B1 (en) 1996-02-16 2002-06-11 Joe E. Brown Apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents
US5716370A (en) 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US6402780B2 (en) 1996-02-23 2002-06-11 Cardiovascular Technologies, L.L.C. Means and method of replacing a heart valve in a minimally invasive manner
US5695498A (en) 1996-02-28 1997-12-09 Numed, Inc. Stent implantation system
US5720391A (en) 1996-03-29 1998-02-24 St. Jude Medical, Inc. Packaging and holder for heart valve prosthesis
US5891191A (en) 1996-04-30 1999-04-06 Schneider (Usa) Inc Cobalt-chromium-molybdenum alloy stent and stent-graft
US5885228A (en) 1996-05-08 1999-03-23 Heartport, Inc. Valve sizer and method of use
WO1997042879A1 (fr) 1996-05-14 1997-11-20 Embol-X, Inc. Dispositif d'occlusion aortique a filtre associe et son procede d'utilisation au cours d'une intervention chirurgicale
DE69719237T2 (de) 1996-05-23 2003-11-27 Samsung Electronics Co Ltd Flexibler, selbstexpandierbarer Stent und Verfahren zu dessen Herstellung
US7238197B2 (en) 2000-05-30 2007-07-03 Devax, Inc. Endoprosthesis deployment system for treating vascular bifurcations
EP1595513A3 (fr) 1996-06-20 2010-09-15 Vascutek Limited Reconstitution prothétique de conduits du corps humain
US5855601A (en) 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5843161A (en) 1996-06-26 1998-12-01 Cordis Corporation Endoprosthesis assembly for percutaneous deployment and method of deploying same
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5755783A (en) 1996-07-29 1998-05-26 Stobie; Robert Suture rings for rotatable artificial heart valves
US6702851B1 (en) 1996-09-06 2004-03-09 Joseph A. Chinn Prosthetic heart valve with surface modification
US6764509B2 (en) 1996-09-06 2004-07-20 Carbomedics Inc. Prosthetic heart valve with surface modification
US5800531A (en) 1996-09-30 1998-09-01 Baxter International Inc. Bioprosthetic heart valve implantation device
EP0881892B1 (fr) 1996-10-01 2005-01-26 Numed, Inc. Stent dilatable
US5749890A (en) 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
NL1004827C2 (nl) 1996-12-18 1998-06-19 Surgical Innovations Vof Inrichting voor het reguleren van de bloedsomloop.
US6206911B1 (en) 1996-12-19 2001-03-27 Simcha Milo Stent combination
US6015431A (en) 1996-12-23 2000-01-18 Prograft Medical, Inc. Endolumenal stent-graft with leak-resistant seal
EP0850607A1 (fr) 1996-12-31 1998-07-01 Cordis Corporation Prothèse de valve pour implantation dans des canaux corporels
GB9701479D0 (en) 1997-01-24 1997-03-12 Aortech Europ Ltd Heart valve
US6241757B1 (en) 1997-02-04 2001-06-05 Solco Surgical Instrument Co., Ltd. Stent for expanding body's lumen
EP1009467A4 (fr) 1997-02-19 2001-07-25 Condado Med Devices Corp Catheters polyvalents, systemes de catheter et traitement par rayonnement
US6152946A (en) 1998-03-05 2000-11-28 Scimed Life Systems, Inc. Distal protection device and method
US5830229A (en) 1997-03-07 1998-11-03 Micro Therapeutics Inc. Hoop stent
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US5817126A (en) 1997-03-17 1998-10-06 Surface Genesis, Inc. Compound stent
US5824053A (en) 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Helical mesh endoprosthesis and methods of use
US5824055A (en) 1997-03-25 1998-10-20 Endotex Interventional Systems, Inc. Stent graft delivery system and methods of use
US5928281A (en) 1997-03-27 1999-07-27 Baxter International Inc. Tissue heart valves
US5868783A (en) 1997-04-16 1999-02-09 Numed, Inc. Intravascular stent with limited axial shrinkage
US5860966A (en) 1997-04-16 1999-01-19 Numed, Inc. Method of securing a stent on a balloon catheter
US6258115B1 (en) 1997-04-23 2001-07-10 Artemis Medical, Inc. Bifurcated stent and distal protection system
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6206917B1 (en) 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
US6245102B1 (en) 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US5855597A (en) 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6162245A (en) 1997-05-07 2000-12-19 Iowa-India Investments Company Limited Stent valve and stent graft
US5911734A (en) 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6676682B1 (en) 1997-05-08 2004-01-13 Scimed Life Systems, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6258120B1 (en) 1997-12-23 2001-07-10 Embol-X, Inc. Implantable cerebral protection device and methods of use
US6007575A (en) 1997-06-06 1999-12-28 Samuels; Shaun Laurence Wilkie Inflatable intraluminal stent and method for affixing same within the human body
JP3645399B2 (ja) 1997-06-09 2005-05-11 住友金属工業株式会社 血管内ステント
AU8337898A (en) 1997-06-17 1999-01-04 Sante Camilli Implantable valve for blood vessels
US6635080B1 (en) 1997-06-19 2003-10-21 Vascutek Limited Prosthesis for repair of body passages
US5861024A (en) 1997-06-20 1999-01-19 Cardiac Assist Devices, Inc Electrophysiology catheter and remote actuator therefor
US5906619A (en) 1997-07-24 1999-05-25 Medtronic, Inc. Disposable delivery device for endoluminal prostheses
US6340367B1 (en) 1997-08-01 2002-01-22 Boston Scientific Scimed, Inc. Radiopaque markers and methods of using the same
US5984957A (en) 1997-08-12 1999-11-16 Schneider (Usa) Inc Radially expanded prostheses with axial diameter control
US6306164B1 (en) 1997-09-05 2001-10-23 C. R. Bard, Inc. Short body endoprosthesis
US5954766A (en) 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US6056722A (en) 1997-09-18 2000-05-02 Iowa-India Investments Company Limited Of Douglas Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use
US5984959A (en) 1997-09-19 1999-11-16 United States Surgical Heart valve replacement tools and procedures
US6361545B1 (en) 1997-09-26 2002-03-26 Cardeon Corporation Perfusion filter catheter
US5925063A (en) 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6071308A (en) 1997-10-01 2000-06-06 Boston Scientific Corporation Flexible metal wire stent
US6336934B1 (en) 1997-11-07 2002-01-08 Salviac Limited Embolic protection device
US6635068B1 (en) 1998-02-10 2003-10-21 Artemis Medical, Inc. Occlusion, anchoring, tensioning and flow direction apparatus and methods for use
WO1999030800A1 (fr) 1997-12-15 1999-06-24 Domnick Hunter Limited Ensemble filtre
AU1724099A (en) 1997-12-15 1999-07-05 Prolifix Medical, Inc. Vascular stent for reduction of restenosis
US6695864B2 (en) 1997-12-15 2004-02-24 Cardeon Corporation Method and apparatus for cerebral embolic protection
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
CA2315211A1 (fr) 1997-12-29 1999-07-08 The Cleveland Clinic Foundation Systeme d'insertion effractive minimale d'une bioprothese cardiaque
US6096074A (en) 1998-01-27 2000-08-01 United States Surgical Stapling apparatus and method for heart valve replacement
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
EP1054634A4 (fr) 1998-02-10 2006-03-29 Artemis Medical Inc Appareil de capture et procede d'utilisation
EP0935978A1 (fr) 1998-02-16 1999-08-18 Medicorp S.A. Cathéter d'angioplastie et de mise en place d'un stent
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US6280467B1 (en) 1998-02-26 2001-08-28 World Medical Manufacturing Corporation Delivery system for deployment and endovascular assembly of a multi-stage stented graft
US5938697A (en) 1998-03-04 1999-08-17 Scimed Life Systems, Inc. Stent having variable properties
US7491232B2 (en) 1998-09-18 2009-02-17 Aptus Endosystems, Inc. Catheter-based fastener implantation apparatus and methods with implantation force resolution
EP0943300A1 (fr) 1998-03-17 1999-09-22 Medicorp S.A. Dispositif pour la mise en place d'un stent de manière réversible
US6656215B1 (en) 2000-11-16 2003-12-02 Cordis Corporation Stent graft having an improved means for attaching a stent to a graft
US6776791B1 (en) 1998-04-01 2004-08-17 Endovascular Technologies, Inc. Stent and method and device for packing of same
EP1067883A1 (fr) 1998-04-02 2001-01-17 Salviac Limited Implant comprenant une structure de support et materiau de transition constitue d'une matiere plastique poreuse
US6074418A (en) 1998-04-20 2000-06-13 St. Jude Medical, Inc. Driver tool for heart valve prosthesis fasteners
US6450989B2 (en) 1998-04-27 2002-09-17 Artemis Medical, Inc. Dilating and support apparatus with disease inhibitors and methods for use
US6319241B1 (en) 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6059827A (en) 1998-05-04 2000-05-09 Axya Medical, Inc. Sutureless cardiac valve prosthesis, and devices and methods for implanting them
EP1076534B1 (fr) 1998-05-05 2007-04-04 Boston Scientific Limited Extenseur possedant des extremites lisses
US6352554B2 (en) 1998-05-08 2002-03-05 Sulzer Vascutek Limited Prosthetic tubular aortic conduit and method for manufacturing the same
US6093203A (en) 1998-05-13 2000-07-25 Uflacker; Renan Stent or graft support structure for treating bifurcated vessels having different diameter portions and methods of use and implantation
CA2333591C (fr) 1998-06-02 2009-12-15 Cook Incorporated Dispositif medical intracavitaire possedant des cotes multiples
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US6630001B2 (en) 1998-06-24 2003-10-07 International Heart Institute Of Montana Foundation Compliant dehyrated tissue for implantation and process of making the same
AU749930B2 (en) 1998-07-10 2002-07-04 Shin Ishimaru Stent (or stent graft) indwelling device
US6159239A (en) 1998-08-14 2000-12-12 Prodesco, Inc. Woven stent/graft structure
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6312461B1 (en) 1998-08-21 2001-11-06 John D. Unsworth Shape memory tubular stent
US6358276B1 (en) 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6475239B1 (en) 1998-10-13 2002-11-05 Sulzer Carbomedics Inc. Method for making polymer heart valves with leaflets having uncut free edges
US6051014A (en) 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US6254612B1 (en) 1998-10-22 2001-07-03 Cordis Neurovascular, Inc. Hydraulic stent deployment system
US6146366A (en) 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
WO2000027462A1 (fr) 1998-11-06 2000-05-18 The Furukawa Electric Co., Ltd. FIL-GUIDE MEDICAL DU TYPE NiTi ET PROCEDE DE PRODUCTION
US6214036B1 (en) 1998-11-09 2001-04-10 Cordis Corporation Stent which is easily recaptured and repositioned within the body
US6336937B1 (en) 1998-12-09 2002-01-08 Gore Enterprise Holdings, Inc. Multi-stage expandable stent-graft
DE19857887B4 (de) 1998-12-15 2005-05-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerungsstütze für eine Herzklappenprothese
US6363938B2 (en) 1998-12-22 2002-04-02 Angiotrax, Inc. Methods and apparatus for perfusing tissue and/or stimulating revascularization and tissue growth
FR2788217A1 (fr) 1999-01-12 2000-07-13 Brice Letac Valvule prothetique implantable par catheterisme, ou chirurgicalement
US6736845B2 (en) 1999-01-26 2004-05-18 Edwards Lifesciences Corporation Holder for flexible heart valve
US6896690B1 (en) 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
CA2361670C (fr) 1999-01-27 2010-03-30 Viacor Incorporated Procedes et dispositifs pour interventions sur valvules cardiaques
US7018401B1 (en) 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
EP1582178B1 (fr) 1999-02-01 2012-09-26 Board Of Regents, The University Of Texas System Dispositifs intravasculaires tissés et procédés de fabrication desdits dispositifs
CA2360620C (fr) 1999-02-01 2009-09-01 Hideki Hyodoh Dispositifs intravasculaires tisses, procedes de fabrication desdits dispositifs et systemes de transport desdits dispositifs
PT1148839E (pt) 1999-02-01 2008-12-12 Univ Texas Endopróteses tecidas bifurcadas e trifurcadas e métodos para produção das mesmas
DE19904975A1 (de) 1999-02-06 2000-09-14 Impella Cardiotech Ag Vorrichtung zur intravasalen Herzklappenoperation
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US20020138094A1 (en) 1999-02-12 2002-09-26 Thomas Borillo Vascular filter system
DE19907646A1 (de) 1999-02-23 2000-08-24 Georg Berg Ventileinrichtung zum Einsetzen in ein Hohlorgan
US6171327B1 (en) 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6905743B1 (en) 1999-02-25 2005-06-14 Boston Scientific Scimed, Inc. Dimensionally stable balloons
US6231551B1 (en) 1999-03-01 2001-05-15 Coaxia, Inc. Partial aortic occlusion devices and methods for cerebral perfusion augmentation
US6743196B2 (en) 1999-03-01 2004-06-01 Coaxia, Inc. Partial aortic occlusion devices and methods for cerebral perfusion augmentation
US6673089B1 (en) 1999-03-11 2004-01-06 Mindguard Ltd. Implantable stroke treating device
IL128938A0 (en) 1999-03-11 2000-02-17 Mind Guard Ltd Implantable stroke treating device
US6319281B1 (en) 1999-03-22 2001-11-20 Kumar R. Patel Artificial venous valve and sizing catheter
US7666204B2 (en) 1999-04-09 2010-02-23 Evalve, Inc. Multi-catheter steerable guiding system and methods of use
US7147663B1 (en) 1999-04-23 2006-12-12 St. Jude Medical Atg, Inc. Artificial heart valve attachment apparatus and methods
US6309417B1 (en) 1999-05-12 2001-10-30 Paul A. Spence Heart valve and apparatus for replacement thereof
AU4713200A (en) 1999-05-12 2000-11-21 Mark Ortiz Heart valve and apparatus for replacement thereof, blood vessel leak detector and temporary pacemaker lead
US6858034B1 (en) 1999-05-20 2005-02-22 Scimed Life Systems, Inc. Stent delivery system for prevention of kinking, and method of loading and using same
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
JP3755862B2 (ja) 1999-05-26 2006-03-15 キヤノン株式会社 同期位置制御装置および方法
EP1057459A1 (fr) 1999-06-01 2000-12-06 Numed, Inc. Stent expansible radialement
EP1057460A1 (fr) 1999-06-01 2000-12-06 Numed, Inc. Dispositif de soupape de remplacement et procédé d'implantation d'une telle soupape
US7628803B2 (en) 2001-02-05 2009-12-08 Cook Incorporated Implantable vascular device
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
AU6000200A (en) 1999-07-16 2001-02-05 Biocompatibles Limited Braided stent
US6312465B1 (en) 1999-07-23 2001-11-06 Sulzer Carbomedics Inc. Heart valve prosthesis with a resiliently deformable retaining member
US6544279B1 (en) 2000-08-09 2003-04-08 Incept, Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US6371970B1 (en) 1999-07-30 2002-04-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
US6142987A (en) 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6346116B1 (en) 1999-08-03 2002-02-12 Medtronic Ave, Inc. Distal protection device
US6235044B1 (en) 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US6168579B1 (en) 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
US6187016B1 (en) 1999-09-14 2001-02-13 Daniel G. Hedges Stent retrieval device
US6829497B2 (en) 1999-09-21 2004-12-07 Jamil Mogul Steerable diagnostic catheters
IT1307268B1 (it) 1999-09-30 2001-10-30 Sorin Biomedica Cardio Spa Dispositivo per interventi di riparazione o sostituzione valvolarecardiaca.
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6364895B1 (en) 1999-10-07 2002-04-02 Prodesco, Inc. Intraluminal filter
US6383171B1 (en) 1999-10-12 2002-05-07 Allan Will Methods and devices for protecting a passageway in a body when advancing devices through the passageway
FR2799364B1 (fr) 1999-10-12 2001-11-23 Jacques Seguin Dispositif d'annuloplastie utilisable par voie mini-invasive
AU1084101A (en) 1999-10-14 2001-04-23 United Stenting, Inc. Stents with multilayered struts
US6352708B1 (en) 1999-10-14 2002-03-05 The International Heart Institute Of Montana Foundation Solution and method for treating autologous tissue for implant operation
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US6585758B1 (en) 1999-11-16 2003-07-01 Scimed Life Systems, Inc. Multi-section filamentary endoluminal stent
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
FR2815844B1 (fr) 2000-10-31 2003-01-17 Jacques Seguin Support tubulaire de mise en place, par voie percutanee, d'une valve cardiaque de remplacement
FR2800984B1 (fr) 1999-11-17 2001-12-14 Jacques Seguin Dispositif de remplacement d'une valve cardiaque par voie percutanee
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
US6379383B1 (en) 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
US6663667B2 (en) 1999-12-29 2003-12-16 Edwards Lifesciences Corporation Towel graft means for enhancing tissue ingrowth in vascular grafts
US6872226B2 (en) 2001-01-29 2005-03-29 3F Therapeutics, Inc. Method of cutting material for use in implantable medical device
MXPA02007253A (es) 2000-01-27 2003-09-22 3F Therapeutics Inc Valvula cardiaca protesica.
US6622604B1 (en) 2000-01-31 2003-09-23 Scimed Life Systems, Inc. Process for manufacturing a braided bifurcated stent
US6398807B1 (en) 2000-01-31 2002-06-04 Scimed Life Systems, Inc. Braided branching stent, method for treating a lumen therewith, and process for manufacture therefor
US6652571B1 (en) 2000-01-31 2003-11-25 Scimed Life Systems, Inc. Braided, branched, implantable device and processes for manufacture thereof
MXPA02007426A (es) 2000-01-31 2003-10-14 Cook Biotech Inc Valvulas restringidas y uso de las mismas.
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
DE60111184T2 (de) 2000-02-02 2005-10-27 Robert V. Snyders Künstiche herzklappe
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
US20050267560A1 (en) 2000-02-03 2005-12-01 Cook Incorporated Implantable bioabsorbable valve support frame
US6540768B1 (en) 2000-02-09 2003-04-01 Cordis Corporation Vascular filter system
US6344044B1 (en) 2000-02-11 2002-02-05 Edwards Lifesciences Corp. Apparatus and methods for delivery of intraluminal prosthesis
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
ES2211791T3 (es) 2000-03-03 2004-07-16 Cook Incorporated Dispositivo endovascular que tiene un stent.
ATE353604T1 (de) 2000-03-10 2007-03-15 Michael Anthony T Don Filterentfaltungsvorrichtung zur verhütung von vaskulärer embolie
US6695865B2 (en) 2000-03-20 2004-02-24 Advanced Bio Prosthetic Surfaces, Ltd. Embolic protection device
US6468303B1 (en) 2000-03-27 2002-10-22 Aga Medical Corporation Retrievable self expanding shunt
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
GB2369575A (en) 2000-04-20 2002-06-05 Salviac Ltd An embolic protection system
US6729356B1 (en) 2000-04-27 2004-05-04 Endovascular Technologies, Inc. Endovascular graft for providing a seal with vasculature
CA2403276C (fr) 2000-05-04 2009-10-20 Oregon Health Sciences University Endoprothese vasculaire
IL136213A0 (en) 2000-05-17 2001-05-20 Xtent Medical Inc Selectively expandable and releasable stent
US20050043757A1 (en) 2000-06-12 2005-02-24 Michael Arad Medical devices formed from shape memory alloys displaying a stress-retained martensitic state and method for use thereof
SE522805C2 (sv) 2000-06-22 2004-03-09 Jan Otto Solem Stentappliceringssystem
US6527800B1 (en) 2000-06-26 2003-03-04 Rex Medical, L.P. Vascular device and method for valve leaflet apposition
US6676698B2 (en) 2000-06-26 2004-01-13 Rex Medicol, L.P. Vascular device with valve for approximating vessel wall
EP1401358B1 (fr) 2000-06-30 2016-08-17 Medtronic, Inc. Appareil permettant d'effectuer une intervention sur une valvule cardiaque
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US6572643B1 (en) 2000-07-19 2003-06-03 Vascular Architects, Inc. Endoprosthesis delivery catheter assembly and method
EP1305078B1 (fr) 2000-07-24 2011-06-29 Jeffrey Grayzel Sonde a ballonnet rigide de dilatation et de mise en place de stent
US6773454B2 (en) 2000-08-02 2004-08-10 Michael H. Wholey Tapered endovascular stent graft and method of treating abdominal aortic aneurysms and distal iliac aneurysms
US6485501B1 (en) 2000-08-11 2002-11-26 Cordis Corporation Vascular filter system with guidewire and capture mechanism
US6572652B2 (en) 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
WO2002019951A1 (fr) 2000-09-07 2002-03-14 Viacor, Inc. Bande de fixation pour fixer une valvule cardiaque prothetique au tissu
US7510572B2 (en) 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6543610B1 (en) 2000-09-12 2003-04-08 Alok Nigam System for packaging and handling an implant and method of use
US6893459B1 (en) 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
DE10049813C1 (de) 2000-10-09 2002-04-18 Universitaetsklinikum Freiburg Vorrichtung zum lokalen Abtrag einer Aortenklappe am menschlichen oder tierischen Herz
DE10049814B4 (de) 2000-10-09 2006-10-19 Universitätsklinikum Freiburg Vorrichtung zur Unterstützung chirurgischer Maßnahmen innerhalb eines Gefäßes, insbesondere zur minimalinvasiven Explantation und Implantation von Herzklappen
DE10049815B4 (de) 2000-10-09 2005-10-13 Universitätsklinikum Freiburg Vorrichtung zum lokalen Abtrag einer Aortenklappe am menschlichen oder tierischen Herz
DE10049812B4 (de) 2000-10-09 2004-06-03 Universitätsklinikum Freiburg Vorrichtung zum Ausfiltern makroskopischer Teilchen aus der Blutbahn beim lokalen Abtrag einer Aortenklappe am menschlichen oder tierischen Herz
AU2002213231A1 (en) 2000-10-18 2002-04-29 Nmt Medical, Inc. Over-the-wire interlock attachment/detachment mechanism
US6814754B2 (en) 2000-10-30 2004-11-09 Secant Medical, Llc Woven tubular graft with regions of varying flexibility
WO2002064012A2 (fr) 2000-11-07 2002-08-22 Artemis Medical, Inc. Ensemble et procede de localisation de tissu cible
US6482228B1 (en) 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
US6843802B1 (en) 2000-11-16 2005-01-18 Cordis Corporation Delivery apparatus for a self expanding retractable stent
US7267685B2 (en) 2000-11-16 2007-09-11 Cordis Corporation Bilateral extension prosthesis and method of delivery
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
JP4328093B2 (ja) 2000-11-21 2009-09-09 レックス メディカル リミテッド パートナーシップ 経皮的な大動脈弁
WO2002041931A2 (fr) 2000-11-27 2002-05-30 Medtronic, Inc. Tuteurs et procedes de preparation de tuteurs a partir de fils recouverts de couches de revetement hydrogel
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
US6663588B2 (en) 2000-11-29 2003-12-16 C.R. Bard, Inc. Active counterforce handle for use in bidirectional deflectable tip instruments
US6494909B2 (en) 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
ATE310470T1 (de) 2000-12-15 2005-12-15 Angiomed Ag Stent mit herzklappe
US20020120328A1 (en) 2000-12-21 2002-08-29 Pathak Chandrashekhar Prabhakar Mechanical heart valve packaged in a liquid
US6471708B2 (en) 2000-12-21 2002-10-29 Bausch & Lomb Incorporated Intraocular lens and additive packaging system
US6468660B2 (en) 2000-12-29 2002-10-22 St. Jude Medical, Inc. Biocompatible adhesives
WO2002056955A1 (fr) 2001-01-18 2002-07-25 Edwards Lifesciences Corporation Canule artérielle à lumière de filtre perforée
EP1363560A4 (fr) 2001-01-19 2007-04-04 Walid Najib Aboul-Hosn Appareil et methode permettant de maintenir la circulation dans un vaisseau ou un canal
US6610077B1 (en) 2001-01-23 2003-08-26 Endovascular Technologies, Inc. Expandable emboli filter and thrombectomy device
US6863688B2 (en) 2001-02-15 2005-03-08 Spinecore, Inc. Intervertebral spacer device utilizing a spirally slotted belleville washer having radially spaced concentric grooves
US6623518B2 (en) 2001-02-26 2003-09-23 Ev3 Peripheral, Inc. Implant delivery system with interlock
US20020123755A1 (en) 2001-03-01 2002-09-05 Scimed Life Systems, Inc. Embolic protection filter delivery sheath
US6562058B2 (en) 2001-03-02 2003-05-13 Jacques Seguin Intravascular filter system
US6488704B1 (en) 2001-05-07 2002-12-03 Biomed Solutions, Llc Implantable particle measuring apparatus
JP2005508201A (ja) 2001-03-08 2005-03-31 アトリテック， インコーポレイテッド 心房フィルターインプラント
US6503272B2 (en) 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US7374571B2 (en) 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US7556646B2 (en) 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US6773456B1 (en) 2001-03-23 2004-08-10 Endovascular Technologies, Inc. Adjustable customized endovascular graft
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
ATE272369T1 (de) 2001-03-27 2004-08-15 Cook William Europ Gefässtransplantat für die aorta
JP2002293678A (ja) 2001-03-28 2002-10-09 Fuji Photo Film Co Ltd 画像形成方法
US6911036B2 (en) 2001-04-03 2005-06-28 Medtronic Vascular, Inc. Guidewire apparatus for temporary distal embolic protection
EP1379177A2 (fr) 2001-04-17 2004-01-14 Salviac Limited Catheter
US6676692B2 (en) 2001-04-27 2004-01-13 Intek Technology L.L.C. Apparatus for delivering, repositioning and/or retrieving self-expanding stents
JP2004532074A (ja) 2001-04-27 2004-10-21 シー・アール・バード・インコーポレーテッド 医療用カテーテル用ハンドルの設計
US6746469B2 (en) 2001-04-30 2004-06-08 Advanced Cardiovascular Systems, Inc. Balloon actuated apparatus having multiple embolic filters, and method of use
DE10121210B4 (de) 2001-04-30 2005-11-17 Universitätsklinikum Freiburg Verankerungselement zur intraluminalen Verankerung eines Herzklappenersatzes und Verfahren zu seiner Herstellung
US20050021123A1 (en) 2001-04-30 2005-01-27 Jurgen Dorn Variable speed self-expanding stent delivery system and luer locking connector
US7374560B2 (en) 2001-05-01 2008-05-20 St. Jude Medical, Cardiology Division, Inc. Emboli protection devices and related methods of use
US6682558B2 (en) 2001-05-10 2004-01-27 3F Therapeutics, Inc. Delivery system for a stentless valve bioprosthesis
US6716238B2 (en) 2001-05-10 2004-04-06 Scimed Life Systems, Inc. Stent with detachable tethers and method of using same
US6663663B2 (en) 2001-05-14 2003-12-16 M.I. Tech Co., Ltd. Stent
US6936067B2 (en) 2001-05-17 2005-08-30 St. Jude Medical Inc. Prosthetic heart valve with slit stent
US6821291B2 (en) 2001-06-01 2004-11-23 Ams Research Corporation Retrievable stent and method of use thereof
KR100393548B1 (ko) 2001-06-05 2003-08-02 주식회사 엠아이텍 의료용 스텐트
CA2446596C (fr) 2001-06-08 2010-03-30 Rex Medical, L.P. Dispositif vasculaire comportant une soupape destinee a rapprocher les parois vasculaires
US7510571B2 (en) 2001-06-11 2009-03-31 Boston Scientific, Scimed, Inc. Pleated composite ePTFE/textile hybrid covering
US6818013B2 (en) 2001-06-14 2004-11-16 Cordis Corporation Intravascular stent device
GB0114918D0 (en) 2001-06-19 2001-08-08 Vortex Innovation Ltd Devices for repairing aneurysms
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US7377938B2 (en) 2001-07-19 2008-05-27 The Cleveland Clinic Foundation Prosthetic cardiac value and method for making same
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US6755854B2 (en) 2001-07-31 2004-06-29 Advanced Cardiovascular Systems, Inc. Control device and mechanism for deploying a self-expanding medical device
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US6896002B2 (en) 2001-08-21 2005-05-24 Scimed Life Systems, Inc Pressure transducer protection valve
WO2003018100A1 (fr) 2001-08-22 2003-03-06 Hasan Semih Oktay Stent d'expansion commande actionne par des systemes microelectromecaniques (mems) flexibles
US7097665B2 (en) 2003-01-16 2006-08-29 Synecor, Llc Positioning tools and methods for implanting medical devices
US20030229390A1 (en) 2001-09-17 2003-12-11 Control Delivery Systems, Inc. On-stent delivery of pyrimidines and purine analogs
US6616682B2 (en) 2001-09-19 2003-09-09 Jomed Gmbh Methods and apparatus for distal protection during a medical procedure
US20030065386A1 (en) 2001-09-28 2003-04-03 Weadock Kevin Shaun Radially expandable endoprosthesis device with two-stage deployment
US6976974B2 (en) 2002-10-23 2005-12-20 Scimed Life Systems, Inc. Rotary manifold syringe
US7172572B2 (en) 2001-10-04 2007-02-06 Boston Scientific Scimed, Inc. Manifold system for a medical device
WO2003030830A2 (fr) 2001-10-09 2003-04-17 Endoscopic Technologies, Inc. Procede et appareil permettant l'amelioration de la rigidite de l'ensemble de timonerie d'un bras souple
US6790237B2 (en) 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US6939352B2 (en) 2001-10-12 2005-09-06 Cordis Corporation Handle deployment mechanism for medical device and method
US6866669B2 (en) 2001-10-12 2005-03-15 Cordis Corporation Locking handle deployment mechanism for medical device and method
US7192441B2 (en) 2001-10-16 2007-03-20 Scimed Life Systems, Inc. Aortic artery aneurysm endovascular prosthesis
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
GB0125925D0 (en) 2001-10-29 2001-12-19 Univ Glasgow Mitral valve prosthesis
US6712843B2 (en) 2001-11-20 2004-03-30 Scimed Life Systems, Inc Stent with differential lengthening/shortening members
US6890340B2 (en) 2001-11-29 2005-05-10 Medtronic Vascular, Inc. Apparatus for temporary intraluminal protection
US7294146B2 (en) 2001-12-03 2007-11-13 Xtent, Inc. Apparatus and methods for delivery of variable length stents
CA2472374C (fr) 2001-12-05 2012-02-14 Sagax, Inc. Dispositif endovasculaire d'enclavement d'une matiere particulaire et sa methode d'utilisation
US7041139B2 (en) 2001-12-11 2006-05-09 Boston Scientific Scimed, Inc. Ureteral stents and related methods
US6676668B2 (en) 2001-12-12 2004-01-13 C.R. Baed Articulating stone basket
US7189258B2 (en) 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
US20030130729A1 (en) 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US6723116B2 (en) 2002-01-14 2004-04-20 Syde A. Taheri Exclusion of ascending/descending aorta and/or aortic arch aneurysm
US20030135162A1 (en) 2002-01-17 2003-07-17 Scimed Life Systems, Inc. Delivery and retrieval manifold for a distal protection filter
US6730377B2 (en) 2002-01-23 2004-05-04 Scimed Life Systems, Inc. Balloons made from liquid crystal polymer blends
US6911040B2 (en) 2002-01-24 2005-06-28 Cordis Corporation Covered segmented stent
US6689144B2 (en) 2002-02-08 2004-02-10 Scimed Life Systems, Inc. Rapid exchange catheter and methods for delivery of vaso-occlusive devices
US6974464B2 (en) 2002-02-28 2005-12-13 3F Therapeutics, Inc. Supportless atrioventricular heart valve and minimally invasive delivery systems thereof
EP1482860B1 (fr) 2002-03-05 2007-11-14 Salviac Limited Systeme de filtre d'emboles a collet de recuperation
US20030176884A1 (en) 2002-03-12 2003-09-18 Marwane Berrada Everted filter device
US7163556B2 (en) 2002-03-21 2007-01-16 Providence Health System - Oregon Bioprosthesis and method for suturelessly making same
US20030187495A1 (en) 2002-04-01 2003-10-02 Cully Edward H. Endoluminal devices, embolic filters, methods of manufacture and use
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US7052511B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Delivery system and method for deployment of foreshortening endoluminal devices
US20030195609A1 (en) 2002-04-10 2003-10-16 Scimed Life Systems, Inc. Hybrid stent
US7125418B2 (en) 2002-04-16 2006-10-24 The International Heart Institute Of Montana Foundation Sigmoid valve and method for its percutaneous implantation
WO2003088873A1 (fr) 2002-04-16 2003-10-30 Viacor, Inc. Bande de fixation permettant de fixer une valvule cardiaque prothetique a un tissu
US20030199759A1 (en) 2002-04-18 2003-10-23 Richard Merwin F. Coronary catheter with radiopaque length markers
US20030199971A1 (en) 2002-04-23 2003-10-23 Numed, Inc. Biological replacement valve assembly
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US20030204249A1 (en) 2002-04-25 2003-10-30 Michel Letort Endovascular stent graft and fixation cuff
US7331993B2 (en) 2002-05-03 2008-02-19 The General Hospital Corporation Involuted endovascular valve and method of construction
US8070769B2 (en) 2002-05-06 2011-12-06 Boston Scientific Scimed, Inc. Inverted embolic protection filter
US6830575B2 (en) 2002-05-08 2004-12-14 Scimed Life Systems, Inc. Method and device for providing full protection to a stent
US7141064B2 (en) 2002-05-08 2006-11-28 Edwards Lifesciences Corporation Compressed tissue for heart valve leaflets
US7351256B2 (en) 2002-05-10 2008-04-01 Cordis Corporation Frame based unidirectional flow prosthetic implant
AU2003225291A1 (en) 2002-05-10 2003-11-11 Cordis Corporation Method of making a medical device having a thin wall tubular membrane over a structural frame
DE10221076A1 (de) 2002-05-11 2003-11-27 Ruesch Willy Gmbh Stent
US20030225445A1 (en) 2002-05-14 2003-12-04 Derus Patricia M. Surgical stent delivery devices and methods
US7585309B2 (en) 2002-05-16 2009-09-08 Boston Scientific Scimed, Inc. Aortic filter
US20040117004A1 (en) 2002-05-16 2004-06-17 Osborne Thomas A. Stent and method of forming a stent with integral barbs
WO2003096932A1 (fr) 2002-05-17 2003-11-27 Bionethos Holding Gmbh Dispositif médical pour le traitement d'un vaisseau corporel ou d'une autre structure tubulaire corporelle
EP1513440A2 (fr) 2002-05-30 2005-03-16 The Board of Trustees of The Leland Stanford Junior University Appareil et procede pour acceder au sinus coronaire
US7264632B2 (en) 2002-06-07 2007-09-04 Medtronic Vascular, Inc. Controlled deployment delivery system
US7717934B2 (en) 2002-06-14 2010-05-18 Ev3 Inc. Rapid exchange catheters usable with embolic protection devices
US7044962B2 (en) 2002-06-25 2006-05-16 Scimed Life Systems, Inc. Implantable prosthesis with displaceable skirt
US7166120B2 (en) 2002-07-12 2007-01-23 Ev3 Inc. Catheter with occluding cuff
US7232452B2 (en) 2002-07-12 2007-06-19 Ev3 Inc. Device to create proximal stasis
US7141063B2 (en) 2002-08-06 2006-11-28 Icon Medical Corp. Stent with micro-latching hinge joints
US6969395B2 (en) 2002-08-07 2005-11-29 Boston Scientific Scimed, Inc. Electroactive polymer actuated medical devices
EP1388328A1 (fr) 2002-08-07 2004-02-11 Abbott Laboratories Vascular Enterprises Limited Dispositif de mise en place et le déploiement d'un stent dans un vaisseau sanguin
DE20321838U1 (de) 2002-08-13 2011-02-10 JenaValve Technology Inc., Wilmington Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
US7041132B2 (en) 2002-08-16 2006-05-09 3F Therapeutics, Inc, Percutaneously delivered heart valve and delivery means thereof
US6863668B2 (en) 2002-08-16 2005-03-08 Edwards Lifesciences Corporation Articulation mechanism for medical devices
WO2004017866A1 (fr) 2002-08-20 2004-03-04 Cook Incorporated Endoprothese a extremite proximale amelioree
AU2003262938A1 (en) 2002-08-27 2004-03-19 Amir Belson Embolic protection device
CA2714875C (fr) 2002-08-28 2014-01-07 Heart Leaflet Technologies, Inc. Methode et dispositif de traitement d'une valvule malade
PT1531762E (pt) 2002-08-29 2010-07-21 St Jude Medical Cardiology Div DISPOSITIVOS IMPLANTáVEIS PARA CONTROLAR A CIRCUNFERNCIA INTERNA DE UM ORIFICIO OU LUMEN ANATËMICO
US7083633B2 (en) 2002-09-03 2006-08-01 Advanced Vascular Technologies Llc Arterial embolic filter deployed from catheter
KR100442330B1 (ko) 2002-09-03 2004-07-30 주식회사 엠아이텍 스텐트 및 이 스텐트의 제조방법
US6875231B2 (en) 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
CO5500017A1 (es) 2002-09-23 2005-03-31 3F Therapeutics Inc Valvula mitral protesica
US20040059409A1 (en) 2002-09-24 2004-03-25 Stenzel Eric B. Method of applying coatings to a medical device
AU2003277115A1 (en) 2002-10-01 2004-04-23 Ample Medical, Inc. Device and method for repairing a native heart valve leaflet
US7998163B2 (en) 2002-10-03 2011-08-16 Boston Scientific Scimed, Inc. Expandable retrieval device
US6824041B2 (en) 2002-10-21 2004-11-30 Agilent Technologies, Inc. High temperature eutectic solder ball attach
EP1553897A1 (fr) 2002-10-24 2005-07-20 Boston Scientific Limited Appareil valve veineuse et procede
US7481823B2 (en) 2002-10-25 2009-01-27 Boston Scientific Scimed, Inc. Multiple membrane embolic protection filter
US6814746B2 (en) 2002-11-01 2004-11-09 Ev3 Peripheral, Inc. Implant delivery system with marker interlock
WO2004041126A1 (fr) 2002-11-08 2004-05-21 Jacques Seguin Prothese endovasculaire en bifurcation
EP2345380B1 (fr) 2002-11-13 2018-01-10 Medtronic, Inc. Dispositifs de procédure de valvule cardiaque
AU2003287638A1 (en) 2002-11-13 2004-06-03 Rosengart, Todd, K. Apparatus and method for cutting a heart valve
US20040098022A1 (en) 2002-11-14 2004-05-20 Barone David D. Intraluminal catheter with hydraulically collapsible self-expanding protection device
US7527636B2 (en) 2002-11-14 2009-05-05 Medtronic Vascular, Inc Intraluminal guidewire with hydraulically collapsible self-expanding protection device
US7141061B2 (en) 2002-11-14 2006-11-28 Synecor, Llc Photocurable endoprosthesis system
US7485143B2 (en) 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
US7001425B2 (en) 2002-11-15 2006-02-21 Scimed Life Systems, Inc. Braided stent method for its manufacture
FR2847155B1 (fr) 2002-11-20 2005-08-05 Younes Boudjemline Procede de fabrication d'un implant medical a structure ajouree et implant obtenu par ce procede
AU2003283792A1 (en) 2002-11-29 2004-06-23 Mindguard Ltd. Braided intraluminal device for stroke prevention
US7025791B2 (en) 2002-12-02 2006-04-11 Gi Dynamics, Inc. Bariatric sleeve
US7678068B2 (en) 2002-12-02 2010-03-16 Gi Dynamics, Inc. Atraumatic delivery devices
US6984242B2 (en) 2002-12-20 2006-01-10 Gore Enterprise Holdings, Inc. Implantable medical device assembly
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
US6830585B1 (en) 2003-01-14 2004-12-14 3F Therapeutics, Inc. Percutaneously deliverable heart valve and methods of implantation
US20040138694A1 (en) 2003-01-15 2004-07-15 Scimed Life Systems, Inc. Intravascular filtering membrane and method of making an embolic protection filter device
US7753945B2 (en) 2003-01-17 2010-07-13 Gore Enterprise Holdings, Inc. Deployment system for an endoluminal device
EP1589902A1 (fr) 2003-01-27 2005-11-02 Medtronic Vascular Connaught Emballage ameliore pour systemes de pose d'endoprothese
GB2398245B (en) 2003-02-06 2007-03-28 Great Ormond Street Hospital F Valve prosthesis
US7740644B2 (en) 2003-02-24 2010-06-22 Boston Scientific Scimed, Inc. Embolic protection filtering device that can be adapted to be advanced over a guidewire
EP1605866B1 (fr) 2003-03-03 2016-07-06 Syntach AG Implant de bloc electrique
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
EP1605871B1 (fr) 2003-03-20 2008-07-23 Aortech International PLC Valvule
US20060271081A1 (en) 2003-03-30 2006-11-30 Fidel Realyvasquez Apparatus and methods for valve repair
EP1610728B1 (fr) 2003-04-01 2011-05-25 Cook Incorporated Valves vasculaires deployees par voie percutanee
US7530995B2 (en) 2003-04-17 2009-05-12 3F Therapeutics, Inc. Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7175656B2 (en) 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US7591832B2 (en) 2003-04-24 2009-09-22 Medtronic, Inc. Expandable guide sheath and apparatus with distal protection and methods for use
EP1472996B1 (fr) 2003-04-30 2009-09-30 Medtronic Vascular, Inc. Valvule temporaire pouvant etre delivree par voie percutanee
US6969396B2 (en) 2003-05-07 2005-11-29 Scimed Life Systems, Inc. Filter membrane with increased surface area
US7235093B2 (en) 2003-05-20 2007-06-26 Boston Scientific Scimed, Inc. Mechanism to improve stent securement
US20040243221A1 (en) 2003-05-27 2004-12-02 Fawzi Natalie V. Endovascular graft including substructure for positioning and sealing within vasculature
US7625364B2 (en) 2003-05-27 2009-12-01 Cardia, Inc. Flexible center connection for occlusion device
US7041127B2 (en) 2003-05-28 2006-05-09 Ledergerber Walter J Textured and drug eluting coronary artery stent
DE602004029159D1 (fr) 2003-05-28 2010-10-28 Cook Inc
WO2005004753A1 (fr) 2003-06-09 2005-01-20 3F Therapeutics, Inc. Valvule atrioventriculaire et systemes de mise en place peu effractifs
EP1648339B2 (fr) 2003-07-08 2020-06-17 Ventor Technologies Ltd. Prothèses implantables en particulier destinées à la pose par voie transartérielle pour le traitement de la sténose aortique et méthodes d'implantation desdites prothèses
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
US7744620B2 (en) 2003-07-18 2010-06-29 Intervalve, Inc. Valvuloplasty catheter
US7621948B2 (en) 2003-07-21 2009-11-24 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
DE10334868B4 (de) 2003-07-29 2013-10-17 Pfm Medical Ag Implantierbare Einrichtung als Organklappenersatz, dessen Herstellungsverfahren sowie Grundkörper und Membranelement dafür
WO2005011535A2 (fr) 2003-07-31 2005-02-10 Cook Incorporated Valve prothetique conçue pour etre implantee dans un vaisseau corporel
EP1659992B1 (fr) 2003-07-31 2013-03-27 Cook Medical Technologies LLC Dispositifs a valvules prothetiques et procedes de fabrication de ces dispositifs
DE10340265A1 (de) 2003-08-29 2005-04-07 Sievers, Hans-Hinrich, Prof. Dr.med. Prothese zum Ersatz der Aorten- und/oder Mitralklappe des Herzens
US20050049692A1 (en) 2003-09-02 2005-03-03 Numamoto Michael J. Medical device for reduction of pressure effects of cardiac tricuspid valve regurgitation
WO2005023358A1 (fr) 2003-09-03 2005-03-17 Acumen Medical, Inc. Gaine expansible servant a delivrer des instruments et des agents dans une lumiere corporelle
US8535344B2 (en) 2003-09-12 2013-09-17 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection and removing embolic material
US7993384B2 (en) 2003-09-12 2011-08-09 Abbott Cardiovascular Systems Inc. Delivery system for medical devices
US7758625B2 (en) 2003-09-12 2010-07-20 Abbott Vascular Solutions Inc. Delivery system for medical devices
EG24012A (en) 2003-09-24 2008-03-23 Wael Mohamed Nabil Lotfy Valved balloon stent
US10219899B2 (en) 2004-04-23 2019-03-05 Medtronic 3F Therapeutics, Inc. Cardiac valve replacement systems
US20050075720A1 (en) 2003-10-06 2005-04-07 Nguyen Tuoc Tan Minimally invasive valve replacement system
CA2545874C (fr) 2003-10-06 2012-02-21 3F Therapeutics, Inc. Systeme de remplacement valvulaire minimalement effractif
EP2361984A1 (fr) 2003-10-09 2011-08-31 E. I. du Pont de Nemours and Company Silençage génique au moyen de micro-molecules d'ARN modifiés
WO2005037338A1 (fr) 2003-10-14 2005-04-28 Cook Incorporated Dispositif medical a revetement hydrophile
WO2005037142A2 (fr) 2003-10-15 2005-04-28 Cook Incorporated Dispositif de retenue de systeme de deploiement de prothese
US7175654B2 (en) 2003-10-16 2007-02-13 Cordis Corporation Stent design having stent segments which uncouple upon deployment
US7004176B2 (en) 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US7419498B2 (en) 2003-10-21 2008-09-02 Nmt Medical, Inc. Quick release knot attachment system
US7070616B2 (en) 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
US7347869B2 (en) 2003-10-31 2008-03-25 Cordis Corporation Implantable valvular prosthesis
WO2005048883A1 (fr) 2003-11-13 2005-06-02 Fidel Realyvasquez Procedes et dispositif de reparation de valvules
US6972025B2 (en) 2003-11-18 2005-12-06 Scimed Life Systems, Inc. Intravascular filter with bioabsorbable centering element
US7186265B2 (en) 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US20050137683A1 (en) 2003-12-19 2005-06-23 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US7261732B2 (en) 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US20050137694A1 (en) 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US20050137696A1 (en) 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
US8052749B2 (en) 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
ES2617542T3 (es) 2003-12-23 2017-06-19 Boston Scientific Scimed, Inc. Válvula cardiaca recolocable
US20120041550A1 (en) 2003-12-23 2012-02-16 Sadra Medical, Inc. Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US20050137691A1 (en) 2003-12-23 2005-06-23 Sadra Medical Two piece heart valve and anchor
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7329279B2 (en) 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
CN100589779C (zh) 2003-12-23 2010-02-17 萨德拉医学公司 可再定位的心脏瓣膜
US20050137687A1 (en) 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
US7824442B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US20050228495A1 (en) 2004-01-15 2005-10-13 Macoviak John A Suspended heart valve devices, systems, and methods for supplementing, repairing, or replacing a native heart valve
US7468070B2 (en) 2004-01-23 2008-12-23 Boston Scientific Scimed, Inc. Stent delivery catheter
US20050203818A9 (en) 2004-01-26 2005-09-15 Cibc World Markets System and method for creating tradeable financial units
US7597711B2 (en) 2004-01-26 2009-10-06 Arbor Surgical Technologies, Inc. Heart valve assembly with slidable coupling connections
WO2005076973A2 (fr) 2004-02-05 2005-08-25 Children's Medical Center Corporation Apport par catheter d'une valvule cardiaque de remplacement
US7311730B2 (en) 2004-02-13 2007-12-25 Shlomo Gabbay Support apparatus and heart valve prosthesis for sutureless implantation
US8128692B2 (en) 2004-02-27 2012-03-06 Aortx, Inc. Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
US20050203549A1 (en) 2004-03-09 2005-09-15 Fidel Realyvasquez Methods and apparatus for off pump aortic valve replacement with a valve prosthesis
EP1734903B2 (fr) 2004-03-11 2022-01-19 Percutaneous Cardiovascular Solutions Pty Limited Prothese de valvule cardiaque percutanee
WO2005096993A1 (fr) 2004-03-31 2005-10-20 Med Institute, Inc. Greffe endoluminale avec valve prothetique
US7637937B2 (en) 2004-04-08 2009-12-29 Cook Incorporated Implantable medical device with optimized shape
BRPI0510107A (pt) 2004-04-23 2007-09-25 3F Therapeutics Inc válvula protéica implantável
ATE367132T1 (de) 2004-05-25 2007-08-15 Cook William Europ Stent und stentbeseitigungsvorrichtung
US7122020B2 (en) 2004-06-25 2006-10-17 Mogul Enterprises, Inc. Linkage steering mechanism for deflectable catheters
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
US8500785B2 (en) 2004-07-13 2013-08-06 Boston Scientific Scimed, Inc. Catheter
FR2874813B1 (fr) 2004-09-07 2007-06-22 Perouse Soc Par Actions Simpli Prothese valvulaire
US6951571B1 (en) 2004-09-30 2005-10-04 Rohit Srivastava Valve implanting device
US7641687B2 (en) 2004-11-02 2010-01-05 Carbomedics Inc. Attachment of a sewing cuff to a heart valve
WO2006055982A2 (fr) 2004-11-22 2006-05-26 Avvrx Dispositif de fixation de protheses valvulaires en forme d'anneau
US7989157B2 (en) 2005-01-11 2011-08-02 Medtronic, Inc. Solution for storing bioprosthetic tissue used in a biological prosthesis
ITTO20050074A1 (it) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl Protesi valvola cardiaca
US7918880B2 (en) 2005-02-16 2011-04-05 Boston Scientific Scimed, Inc. Self-expanding stent and delivery system
ES2558534T3 (es) 2005-02-18 2016-02-05 The Cleveland Clinic Foundation Aparato para sustituir una válvula cardíaca
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
JP4912395B2 (ja) 2005-05-24 2012-04-11 エドワーズ ライフサイエンシーズ コーポレイション 迅速配置式補綴用心臓弁
US8974523B2 (en) 2005-05-27 2015-03-10 Hlt, Inc. Stentless support structure
US7938851B2 (en) 2005-06-08 2011-05-10 Xtent, Inc. Devices and methods for operating and controlling interventional apparatus
US20060287668A1 (en) 2005-06-16 2006-12-21 Fawzi Natalie V Apparatus and methods for intravascular embolic protection
EP1981432B1 (fr) 2005-06-30 2012-10-03 Abbott Laboratories Systeme d'administration pour un dispositif medical
US8968379B2 (en) 2005-09-02 2015-03-03 Medtronic Vascular, Inc. Stent delivery system with multiple evenly spaced pullwires
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
US20080188928A1 (en) 2005-09-16 2008-08-07 Amr Salahieh Medical device delivery sheath
CA2626697A1 (fr) 2005-09-30 2007-04-05 Incept, Llc Appareil pour la localisation d'un ostium d'un vaisseau
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
EP2583640B1 (fr) 2006-02-16 2022-06-22 Venus MedTech (HangZhou), Inc. Valvule cardiaque de remplacement minimalement invasive
EP2023860A2 (fr) 2006-04-29 2009-02-18 Arbor Surgical Technologies, Inc. Ensembles de valves cardiaques prosthétiques à composants multiples et appareil et procédés pour leur implantation
CA2657433A1 (fr) 2006-06-20 2007-12-27 Aortx, Inc. Arbre de torsion et transmission de couple
US20080033541A1 (en) 2006-08-02 2008-02-07 Daniel Gelbart Artificial mitral valve
US8052750B2 (en) 2006-09-19 2011-11-08 Medtronic Ventor Technologies Ltd Valve prosthesis fixation techniques using sandwiching
WO2008040014A2 (fr) 2006-09-28 2008-04-03 Heart Leaflet Technologies, Inc. Outil d'installation pour installation percutanée d'une prothèse
CA2664557C (fr) 2006-11-07 2015-05-26 David Stephen Celermajer Dispositifs et procedes pour le traitement d'une insuffisance cardiaque
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
CA2677648C (fr) 2007-02-16 2015-10-27 Medtronic, Inc. Valvules cardiaques prothetiques de remplacement, et procedes d'implantation
US20080208328A1 (en) 2007-02-23 2008-08-28 Endovalve, Inc. Systems and Methods For Placement of Valve Prosthesis System
US8070802B2 (en) 2007-02-23 2011-12-06 The Trustees Of The University Of Pennsylvania Mitral valve system
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
ES2375426T3 (es) 2007-06-26 2012-02-29 St. Jude Medical, Inc. Aparato para la implantación de v�?lvulas protésicas de corazón replegables / expansibles.
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US8192351B2 (en) 2007-08-13 2012-06-05 Paracor Medical, Inc. Medical device delivery system having integrated introducer
CA2698388C (fr) 2007-09-07 2015-11-24 Edwards Lifesciences Corporation Support actif pour mise en place d'anneau d'annuloplastie
WO2009067432A1 (fr) 2007-11-19 2009-05-28 Cook Incorporated Cadre de valve
US20090171456A1 (en) 2007-12-28 2009-07-02 Kveen Graig L Percutaneous heart valve, system, and method
US8157852B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8052607B2 (en) 2008-04-22 2011-11-08 St. Jude Medical, Atrial Fibrillation Division, Inc. Ultrasound imaging catheter with pivoting head
US8696743B2 (en) 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
AU2009240565B2 (en) 2008-04-23 2013-08-22 Medtronic, Inc. Stented heart valve devices
US8323335B2 (en) * 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
EP2901966B1 (fr) 2008-09-29 2016-06-29 Edwards Lifesciences CardiAQ LLC Valvule cardiaque
EP2341871B1 (fr) 2008-10-01 2017-03-22 Edwards Lifesciences CardiAQ LLC Système de mise en place pour implant vasculaire
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
ES2551694T3 (es) 2008-12-23 2015-11-23 Sorin Group Italia S.R.L. Válvula protésica expansible dotada de apéndices de anclaje
US9402720B2 (en) 2009-01-12 2016-08-02 Valve Medical Ltd. Modular percutaneous valve structure and delivery method
US20100217382A1 (en) 2009-02-25 2010-08-26 Edwards Lifesciences Mitral valve replacement with atrial anchoring
WO2010098857A1 (fr) 2009-02-27 2010-09-02 St. Jude Medical, Inc. Caractéristiques de stent pour valvules cardiaques prothétiques pliables
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
EP2810620B1 (fr) 2009-04-15 2022-09-14 Edwards Lifesciences CardiAQ LLC Implant vasculaire et système de distribution
CN102665612B (zh) 2009-11-05 2015-04-08 宾夕法尼亚大学理事会 瓣膜假体
EP3300695B1 (fr) 2009-12-08 2023-05-24 Avalon Medical Ltd. Dispositif et système de remplacement de valvule mitrale par transcathéter
DE102010008360A1 (de) 2010-02-17 2011-09-29 Transcatheter Technologies Gmbh Medizinisches Implantat, in welchem beim Crimpen bzw. Falten Lücken verbleiben, Verfahren und Einrichtung zum Verbringen
PT3335670T (pt) 2010-03-05 2022-07-27 Edwards Lifesciences Corp Mecanismos de retenção para válvulas protéticas
US8623079B2 (en) 2010-04-23 2014-01-07 Medtronic, Inc. Stents for prosthetic heart valves
US8579964B2 (en) * 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
AU2011257298B2 (en) 2010-05-25 2014-07-31 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
JP2014527425A (ja) 2011-07-12 2014-10-16 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 医療機器用の連結システム
US9339384B2 (en) 2011-07-27 2016-05-17 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
WO2013028387A2 (fr) 2011-08-11 2013-02-28 Tendyne Holdings, Inc. Améliorations apportées à des valves prothétiques et inventions associées
US9131926B2 (en) * 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US8940014B2 (en) * 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
CN104039272A (zh) 2011-11-15 2014-09-10 波士顿科学国际有限公司 带有键控锁定结构的医疗装置
WO2013086413A1 (fr) 2011-12-09 2013-06-13 Edwards Lifesciences Corporation Supports de commissures améliorés pour valve cardiaque prothétique
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9393114B2 (en) 2011-12-20 2016-07-19 Boston Scientific Scimed Inc. Apparatus for endovascularly replacing a heart valve
US10172708B2 (en) 2012-01-25 2019-01-08 Boston Scientific Scimed, Inc. Valve assembly with a bioabsorbable gasket and a replaceable valve implant
WO2013169748A1 (fr) 2012-05-09 2013-11-14 Boston Scientific Scimed, Inc. Valvule à profil réduit avec éléments de verrouillage
JP6014250B2 (ja) 2012-07-12 2016-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 低プロファイル心臓弁送達システム及び方法
US9757232B2 (en) 2014-05-22 2017-09-12 Edwards Lifesciences Corporation Crimping apparatus for crimping prosthetic valve with protruding anchors
US9901445B2 (en) * 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
WO2016115375A1 (fr) * 2015-01-16 2016-07-21 Boston Scientific Scimed, Inc. Mécanisme de libération et de verrouillage en fonction d'un déplacement
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US10426617B2 (en) * 2015-03-06 2019-10-01 Boston Scientific Scimed, Inc. Low profile valve locking mechanism and commissure assembly
AU2016370459B2 (en) * 2015-12-14 2019-06-06 Medtronic Vascular Inc. Devices and methods for transcatheter valve loading and implantation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100280495A1 (en) * 2003-12-23 2010-11-04 David Paul Medical Devices and Delivery Systems for Delivering Medical Devices
US20110257735A1 (en) * 2003-12-23 2011-10-20 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US20160067040A1 (en) * 2014-09-09 2016-03-10 Boston Scientific Scimed, Inc. Valve locking mechanism
US20170216029A1 (en) * 2016-02-02 2017-08-03 Boston Scientific Scimed, Inc. Tensioned sheathing aids

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